Umlobi: Eugene Taylor
Usuku Lokudalwa: 16 Agasti 2021
Ukuvuselela Usuku: 14 Unovemba 2024
Anonim
Ixekizumab for the treatment of biologic-naive patients with active psoriatic arthritis
Ividiyo: Ixekizumab for the treatment of biologic-naive patients with active psoriatic arthritis

-Delile

Yini iTaltz?

I-Taltz ngumuthi kadokotela wegama lomuthi. Kuvunyelwe ukuphatha le mibandela elandelayo:

Nge-plaque psoriasis, i-Taltz ingabhalwa kubantu abadala nezingane ezineminyaka engu-6 nangaphezulu. Kepha kukho konke okunye ukusetshenziswa kwayo okuvunyiwe, iTaltz ingabekelwa abantu abadala kuphela.


I-Taltz iqukethe isidakamizwa esisebenzayo i-ixekizumab. Luhlobo lwesidakamizwa se-biologic (umuthi owenziwe ngamaseli aphilayo) obizwa ngokuthi yi-humanized monoclonal antibody.

I-Taltz iza ngezindlela ezimbili: isirinji ekhethiwe kanye nepeni le-autoinjector eligcwalisiwe. Umuthi unikezwa ngomjovo ngaphansi kwesikhumba sakho (umjovo ongaphansi). Umhlinzeki wakho wezokunakekelwa kwempilo uzokunika umjovo ekuqaleni. Ngemuva kwalokho bangakufundisa ukuthi ungazinikeza kanjani umjovo ekhaya.

Ukusebenza ngempumelelo

Ngemininingwane mayelana nokusebenza kweTaltz ekwelapheni izimo ezibalwe ngenhla, bheka isigaba esingezansi esithi "Taltz uses".

I-Taltz ejwayelekile

I-Taltz itholakala kuphela njengomuthi wegama lomkhiqizo. Okwamanje ayitholakali ngendlela ejwayelekile. (Umuthi ojwayelekile uyikhophi eqondile yomuthi osebenzayo emithini enegama lomkhiqizo.)

I-Taltz iqukethe isithako somuthi esisodwa esisebenzayo: ixekizumab.

Isilinganiso se-Taltz

Umthamo we-Taltz odonswa udokotela wakho uncike esimweni esiphathwayo.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha umthamo bese ulandela uhlelo lokulinganisa udokotela wakho akubekela lona.


Amafomu wezidakamizwa namandla

I-Taltz itholakala ngamandla owodwa: ama-milligram angama-80 nge-milliliter (mg / mL).

Lesi sidakamizwa siza ngezindlela ezimbili: isipetu esisebenzisayo esisodwa sokusebenzisa kanye nepeni elisebenzisayo elisebenzisayo elilodwa. Ungathola ukuthi ifomu elilodwa kulula ukuthi ulisebenzise kunenye. Khuluma nodokotela wakho mayelana nokuthi iyiphi ifomu ekulungele kakhulu.

Umuthi unikezwa ngomjovo ngaphansi kwesikhumba sakho (umjovo ongaphansi).Umhlinzeki wakho wezokunakekelwa kwempilo uzokunika umjovo ekuqaleni. Ngemuva kwalokho bangakufundisa ukuthi ungazinikeza kanjani umjovo ekhaya.

Isilinganiso se-psoriatic arthritis

Kwi-psoriatic arthritis, umthamo wakho wokuqala we-Taltz uzonikezwa njengemijovo emibili engama-80-mg (yenani elingu-160 mg) ngosuku olufanayo. Ngemuva kwalokho, isilinganiso sakho sesondlo sizoba umjovo owodwa we-80-mg kanye njalo emavikini e-4 inqobo nje uma udokotela wakho encoma.

Qaphela: Ukuze ufunde kabanzi nge-psoriatic arthritis, bona isigaba esithi “Taltz uses” ngezansi.

Umthamo we-plaque psoriasis olinganiselayo kuya kokunzima

Nge-plaque psoriasis, umthamo wakho wokuqala we-Taltz uzoba imijovo emibili engama-80-mg (yenani elingu-160 mg) ngosuku olufanayo. Ngemuva kwalokho, uzoba nomjovo owodwa we-80-mg kanye njalo emavikini ama-2 amasonto ayi-12. Ngemuva kwalokho isilinganiso sakho sesondlo sizoba umjovo owodwa kanye njalo emavikini ama-4 inqobo nje uma udokotela wakho encoma.


Qaphela: Ukuze ufunde kabanzi nge-plaque psoriasis, bheka isigaba esithi “Taltz uses” ngezansi.

Isilinganiso se-psoriatic arthritis kanye ne-plaque psoriasis elinganiselayo kuya kwelinzima

Uma une-psoriatic arthritis ne-plaque psoriasis, uzosebenzisa isilinganiso somthamo we-Taltz kanye nomthamo wokulinganisa isilinganiso se-plaque psoriasis esilinganiselwe. Bona isigaba ngenhla ukuthola imininingwane ngalokhu.

Qaphela: Ukuze ufunde kabanzi nge-psoriatic arthritis ne-plaque psoriasis, bona isigaba esithi “Taltz uses” ngezansi.

Isilinganiso se-non-radiographic axial spondyloarthritis

Nge-non-radiographical axial spondyloarthritis (nr-axSpA), uzothola umjovo ongu-80-mg weTaltz kanye njalo emavikini amane.

Qaphela: Ukuze ufunde kabanzi nge-nr-axSpA, bona isigaba esithi “Taltz uses” ngezansi.

Isilinganiso se-ankylosing spondylitis esebenzayo

Nge-ankylosing spondylitis (AS), umthamo wakho wokuqala we-Taltz uzoba imijovo emibili engama-80-mg (yenani elingu-160 mg) ngosuku olufanayo. Ngemuva kwalokho, isilinganiso sakho sesondlo sizoba umjovo owodwa we-80-mg kanye njalo emavikini amane.

Qaphela: Ukuze ufunde kabanzi nge-AS, bona isigaba esithi “Taltz uses” ngezansi.

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa umjovo, kufanele ube nawo ngokushesha okukhulu. Ngemuva kwalokho vele uthathe umjovo wakho olandelayo lapho bekufanele ube njalo. Kodwa uma uphuthelwa umjovo futhi kungathathi isikhathi eside kuze kube yilapho sekufanele olandelayo wakho, cela iseluleko kudokotela wakho ngalokho okufanele ukwenze.

Ukusiza ukuqinisekisa ukuthi awuphuthelwa umthamo, zama ukusetha isikhumbuzi efonini yakho. Isikhathi semithi singasiza, futhi.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

I-Taltz yenzelwe ukuthi isetshenziswe njengokwelashwa kwesikhathi eside. Uma wena nodokotela wakho ninquma ukuthi i-Taltz ikusebenzela kahle, kungenzeka ukuthi uzoqhubeka nokuyisebenzisa isikhathi eside.

Imiphumela emibi ye-Taltz

I-Taltz ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engase ivele ngenkathi uthatha iTaltz. Lolu hlu alubandakanyi yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela engemihle ye-Taltz, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu okuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi engase ikukhathaze.

Qaphela: Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kulandelela imiphumela emibi yezidakamizwa eyivumile. Uma ungathanda ukubika kwi-FDA imiphumela eseceleni obukade unayo nge-Taltz, ungakwenza lokho nge-MedWatch.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Taltz ingafaka:

  • ukuphendula kwesiza somjovo (ububomvu nobuhlungu obuzungeze indawo yomjovo)
  • izifo eziphezulu zokuphefumula, njengomkhuhlane ovamile noma umkhuhlane
  • isicanucanu
  • izifo zokukhunta, ezinyaweni zomdlali
  • i-conjunctivitis (iso elibomvana)

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela ku-Taltz ayijwayelekile, kodwa ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela ku-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi ebucayi, echazwe ngokuningiliziwe ngezansi ku- “Side effect imininingwane,” ifaka:

  • ukusabela okweqile komzimba
  • isifo sokuvuvukala kwamathumbu (IBD), njengesifo sikaCrohn noma i-ulcerative colitis
  • ingozi eyengeziwe yokutheleleka, njengesifo sofuba (i-TB)

Imiphumela emibi ezinganeni

Ucwaningo lomtholampilo lubheke izingane ezineminyaka engama-6 kuya kwengu-18 ubudala ezine-plaque psoriasis. Kulolu cwaningo, izinhlobo zemiphumela emibi ebonwe ezinganeni nokuthi zenzeka kangaki zazicishe zifane nalezo ezibonakala kubantu abadala. Ngaphandle kwalokhu, imiphumela emibi elandelayo yenzeke kaningi ezinganeni kunabantu abadala:

  • i-conjunctivitis (iso elibomvana)
  • umkhuhlane
  • isifuba (ukuqubuka kwesikhumba)

Esicwaningweni esifanayo, isifo sikaCrohn senzeka kaningi ngo-0.9% ezinganeni ezithatha i-Taltz kunangendlela ezenzeka ngayo ezinganeni ezithatha i-placebo. (I-placebo iyindlela yokwelapha engenaso isidakamizwa esisebenzayo.)

Imininingwane yomphumela oseceleni

Ungazibuza ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi, noma ukuthi imiphumela ethile engemihle ihlobene nawo yini. Nayi imininingwane ngeminye imiphumela engemihle lo muthi ongadala noma ongabanga ngayo.

Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangaba ne-allergen reaction ngemuva kokuthatha iTaltz. Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa
  • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Izimpawu zokuphendula okweqile kakhulu zingabandakanya:

  • i-angioedema (ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, noma izihlathi)
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula
  • ukuqina kwesifuba
  • ngizizwe ngiphela amandla

Ezifundweni zokwelashwa, ukusabela okweqile kwenzeka ngo-0.1% noma ngaphansi kwabantu abathola i-Taltz. Lokhu kusabela kokungezwani komzimba kwakuhlanganisa i-angioedema ne-urticaria (ukuqubuka kwesikhumba okwaziwa nangokuthi isifuba).

Shayela udokotela wakho ngokushesha uma une-reaction engathi sína ku-Taltz. Kodwa shayela ku-911 noma inombolo yakho ephuthumayo yasendaweni uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Ukuphendula kwesayithi lokujova

Ungaba nokuphendula kwesikhumba endaweni lapho ujova khona imithamo yeTaltz. Futhi lokhu kusabela kungadala izimpawu ezinjengokubomvu noma ubuhlungu.

Ezifundweni zokwelashwa, i-17% yabantu abane-plaque psoriasis abathola i-Taltz babenokuphendula, njengokubomvu noma ubuhlungu, endaweni yokujova. Iningi lalokhu kuphendula bekumnene noma kungaphakathi futhi akubanga ukuthi abantu bayeke ukwelashwa.

Ngaso sonke isikhathi uma ufaka i-Taltz, kufanele ukhethe indawo ehlukile emzimbeni wakho kunomjovo wokugcina. Uma une-reaction yesikhumba enzima noma engapheli ezinsukwini ezimbalwa, bheka udokotela wakho.

Ingozi eyengeziwe yokutheleleka

I-Taltz inganciphisa amasosha akho omzimba. Lapho amasosha akho omzimba engaqine ngokwanele ukulwa namagciwane, ungahle ube sethubeni lokuthola ukutheleleka.

Ezifundweni zomtholampilo, ama-27% abantu abane-plaque psoriasis abathole i-Taltz amasonto ayi-12 bathola ukutheleleka. Nakhu okunye okutholakele kwezifundo:

  • Iningi lalezi zifo zazincane. Kuphela yi-0.4% yokutheleleka ebithathwa njengeyingozi, njenge-pneumonia.
  • Ukutheleleka okuvame kakhulu kwakuyizifo zokuphefumula ezifana nokukhwehlela, imikhuhlane noma ukutheleleka komphimbo.
  • Ezinye izifo zazihlanganisa i-conjunctivitis (iso elibomvana) kanye nezifo zefungal, njenge-oral thrush noma unyawo lomsubathi.
  • Kulezi zifundo, ama-23% abantu abathole i-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo) nabo bathole ukutheleleka.
  • Kubantu abathole ukwelashwa kwe-Taltz amasonto angama-60, ama-57% athola ukutheleleka uma kuqhathaniswa nama-32% athola i-placebo.

Ukuqapha nokuhlola izifo

Uma unezimpawu zokutheleleka, khuluma nodokotela wakho noma usokhemisi. Bangancoma ukwelashwa. Izimpawu zezifo ezincane zingafaka:

  • imfiva
  • ukukhwehlela
  • Umphimbo obuhlungu
  • amehlo abomvu futhi abuhlungu
  • izindawo ezibomvu nezibuhlungu zesikhumba
  • amabala amhlophe emlonyeni wakho
  • ukusha noma ubuhlungu lapho uchama

Kubaluleke kakhulu ukubona udokotela wakho uma ukutheleleka kungabonakali. Ngaphandle kwalokho, kungaba kubi ngokwengeziwe.

Ngaphambi kokuba uqale ukwelashwa nge-Taltz, udokotela wakho uzohlola noma yiziphi izifo, njengesifo sofuba (i-TB), isifo samaphaphu. Uma unezimpawu ze-TB ngesikhathi sokwelashwa kwakho, kubalulekile ukubiza udokotela wakho ngokushesha. Lezi zimpawu zifaka:

  • imfiva
  • ubuhlungu bemisipha
  • ukuncipha ngaphandle kokuzama
  • ukukhwehlela okubi okuhlala amasonto ama-3 noma ngaphezulu
  • ukukhwehlela igazi noma amafinyila
  • ubuhlungu esifubeni
  • ukujuluka ebusuku

Ukugwema ukutheleleka ngesikhathi sokwelashwa kweTaltz

Ukusiza ukugwema ukuthola ukutheleleka ngenkathi uthatha i-Taltz, geza izandla zakho kaningi. Futhi, gwema ukuxhumana okuseduze nabantu abanesifo (ikakhulukazi ukukhwehlela, imikhuhlane noma umkhuhlane).

Buza nodokotela wakho ukuthi ngabe ikhona yini imigomo okufanele uyithole ngaphambi kokuba uqale ukuthatha i-Taltz. (Bheka i- "Taltz nemithi yokugoma ebukhoma" esigabeni esithi "Ukusebenzisana kweTaltz" ngezansi ukuze ufunde kabanzi.)

Isifo samathumbu esivuthayo

Uma uthatha iTaltz, kunengozi encane yokuthi uzoba nesifo samathumbu esivuthayo (IBD). I-IBD yiqembu lezifo ezidala ukuvuvukala (ukuvuvukala) endaweni yakho yokugaya ukudla. Lezi zifo zihlanganisa isifo sikaCrohn nesifo sezilonda emathunjini.

Uma usuvele unayo i-IBD, iTaltz ingayenza ibe yimbi kakhulu, kepha lokhu akuvamile. Ezifundweni zomtholampilo, isifo sikaCrohn senzeke kubantu abangu-0.1% abathola iTaltz. Futhi abantu abangu-0,2% abathole i-Taltz babene-colitis entsha noma eqhubeka iba yimbi.

Kufanele ubone udokotela wakho uma unezimpawu ezintsha noma eziya ziba zimbi ze-IBD. Lokhu kungafaka:

  • ubuhlungu esiswini sakho (esiswini)
  • uhudo, noma ngaphandle kwegazi
  • ukuncipha komzimba

Ukuzuza kwesisindo noma ukunciphisa umzimba (hhayi umphumela ohlangothini)

Ukuzuza kwesisindo kanye nokwehla kwesisindo akukabikwa ezifundweni zokwelashwa zeTaltz. Kodwa-ke, ukwehla kwesisindo kungaba uphawu lwesifo sofuba (i-TB) noma isifo sokuvuvukala kwamathumbu (IBD). Futhi lezi zimo zombili imiphumela emibi engaba khona yeTaltz. Ngakho-ke uma ulahlekelwa isisindo ngenkathi uthatha i-Taltz, kubaluleke kakhulu ukubona udokotela wakho.

Uma unanoma yikuphi ukukhathazeka mayelana nokuzuza kwesisindo noma ukunciphisa umzimba, khuluma nodokotela wakho.

Ukulahleka kwezinwele (hhayi umphumela ohlangothini)

Ukulahleka kwezinwele akuzange kubonwe ezifundweni zokwelashwa zaseTaltz. Kodwa-ke, ukulahleka kwezinwele kungaba ngumphumela we-scalp psoriasis enamandla, uhlobo lwe-plaque psoriasis olungaphathwa nge-Taltz. Ngokunwaya isikhumba sakho noma ngokukhipha esikalini, ungakhipha izinwele zakho.

Uma ukhathazekile ngokulahleka kwezinwele, khuluma nodokotela wakho.

Ukucindezeleka (hhayi umphumela ohlangothini)

Ukudangala akuzange kubikwe njengomphumela oseceleni ezifundweni zokwelashwa zaseTaltz. Kodwa-ke, ukucindezeleka kuvamile kubantu abane-psoriasis noma i-psoriatic arthritis, iTaltz esetshenziselwa ukuyelapha.

Ucwaningo oluthile luhlolisise ukuthi iTaltz izithinte kanjani izimpawu zokudangala kubantu abane-psoriasis. Abaphenyi bathola ukuthi cishe abantu abangama-40% abathola i-Taltz amasonto ayi-12 balulama ezinkampanini zabo zokucindezeleka.

Izifo zesikhumba ezifana ne-psoriasis zingaba nomthelela obalulekile ngokwengqondo. Uma uzizwa udangele, ucindezelekile, noma ukhathazekile, qiniseka ukuthi ukhuluma nodokotela wakho ngakho. Kwesinye isikhathi ukumane ukhulume ngezinto ezikukhathazayo kungasiza. Kepha uma udokotela wakho ecabanga ukuthi ubhekene nokudangala, ungadinga ukwelashwa ngakho. Lokhu kungavela ngendlela yokwelashwa kwengqondo noma imithi.

Izinduna (hhayi umphumela ohlangothini)

Izinduna azibikwanga njengomphumela oseceleni ezifundweni zokwelashwa zaseTaltz. Kodwa-ke, ngemuva kokuthi iTaltz ivunyelwe, abantu abambalwa babika i- [KD1] [AK2] inezinduna noma izigaxa zesikhumba. Kodwa lawa macala ayengandile, futhi akucaci ukuthi iTaltz yayibangela induna yini.

Imithi ye-Psoriasis kwesinye isikhathi isetshenziselwa ukwelapha uhlobo olunzima lwezinduna, olubizwa nge-acne inversa (noma i-hidradenitis suppurativa). Lokho kungenxa yokuthi i-acne inversa ibandakanya isikhumba esibuhlungu, esivuvukile, njenge-psoriasis.

Kepha iTaltz ayikaze ifundelwe abantu abananoma yiluphi uhlobo lwezinduna. Njengamanje, umuthi okuwukuphela kwawo ovunyelwe ukwelapha i-acne inversa yiHumira (adalimumab).

Uma ukhathazekile ngenduna, khuluma nodokotela wakho. Bangaphakamisa izindlela zokusiza ukuselapha.

Izindleko ze-Taltz

Njengayo yonke imithi, izindleko ze-Taltz zingahluka. Ukuthola izintengo zamanje zeTaltz endaweni yangakini, hlola i-WellRx.com. Izindleko ozithola ku-WellRx.com yilokho ongakukhokha ngaphandle komshwalense.Intengo yangempela ozoyikhokha incike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela i-Taltz, noma uma udinga usizo lokuqonda umshuwalense wakho, usizo luyatholakala.

U-Eli Lilly neNkampani, umenzi weTaltz, unikeza ikhadi lokonga nohlelo lokusekela olubizwa ngeTaltz Together. Ukuthola eminye imininingwane nokuthola ukuthi ukulungele yini ukuthola usizo, shayela ku-844-825-8966 noma uvakashele iwebhusayithi yohlelo.

I-Taltz isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana neTaltz ukwelapha izimo ezithile. I-Taltz nayo ingasetshenziswa ngaphandle kwelebula kwezinye izimo. Ukusetshenziswa okungekho kwelebula kulapho umuthi ovunyelwe ukwelapha umbandela owodwa usetshenziselwa ukwelapha isimo esihlukile.

I-Taltz yesifo samathambo se-psoriatic

I-Taltz ivunyelwe yi-FDA ukwelapha i-psoriatic arthritis esebenzayo kubantu abadala.

I-Psoriatic arthritis uhlobo lwesifo samathambo lapho ilunga elilodwa noma amaningi evuvukala, ababuhlungu futhi aqine. Isimo sikhula cishe kubantu abangama-30% abane-psoriasis. Kungenzeka futhi ukuthuthukisa isifo samathambo se-psoriatic ngaphambi kokuba ube ne-psoriasis esikhunjeni sakho.

I-Psoriatic arthritis ivame ukuthinta amalunga ku:

  • iminwe
  • izinzwane
  • amadolo
  • amaqakala
  • izihlakala
  • emuva emuva

I-Taltz inciphisa ukuvuvukala (ukuvuvukala) nobuhlungu emajoyintini akho. Isidakamizwa singenza futhi kube lula kuwe ukuhamba nokwenza imisebenzi yansuku zonke, njengokugqoka, ukuwasha, ukudla nokuhamba.

Ukusebenza kwe-psoriatic arthritis

Ucwaningo lwezemitholampilo lubheke ukuthi iTaltz ithinte kanjani izimpawu zesifo samathambo i-psoriatic. Abaphenyi baqaphele ukuthi abantu babika ubuhlungu obungakanani nokuthi baqeda kahle kangakanani imisebenzi yansuku zonke. Abaphenyi baphinde bahlulela ukuthi mangaki amalunga abantu ayethambile noma evuvukile.

Ngemuva kwamasonto angama-24, iTaltz yathuthukisa lezi zimpawu ngo:

  • okungenani ama-20% kuma-53% kuya kuma-58% abantu
  • okungenani ama-50% kuma-35% kuya kuma-40% wabantu
  • okungenani ama-70% kuma-22% kuya kuma-23% wabantu

I-Taltz ye-plaque psoriasis ephakathi nendawo

I-Taltz igunyazwe yi-FDA ukwelapha i-plaque psoriasis elinganiselayo kuya kwabadala nakubantwana abaneminyaka engu-6 nangaphezulu. Ilungele abantu i-psoriasis yabo engazuza ekwelashweni kwesistimu (ukwelashwa okuthinta umzimba wakho wonke) noma i-phototherapy (ukwelashwa okulula).

I-plaque psoriasis iyindlela ejwayelekile kakhulu ye-psoriasis. Kungaba kusuka kumnene kuya kokubi. Udokotela wakho angakutshela ukuthi i-psoriasis yakho inzima kangakanani nokuthi iTaltz ikulungele yini. I-psoriasis yakho ingakulungela ukwelashwa nge-Taltz uma:

  • unamabala (aminyene, abomvu, anezikhala ezinamakhasi) ngaphezu kuka-3% womzimba wakho
  • unamaphepha ezandleni, ezinyaweni, noma ezithweni zangasese
  • i-psoriasis yakho iyithinta kakhulu impilo yakho
  • Ukwelashwa okuyisihloko (okusetshenziswe esikhumbeni sakho) akulethanga i-psoriasis yakho ukuthi ilawulwe

I-Taltz isiza ukunciphisa inani lamapuleti e-psoriasis nokuthi aqine kangakanani.

Ukusebenza ngempumelelo kwe-plaque psoriasis kubantu abadala

Ucwaningo lwezemitholampilo lubheke ukuthi iTaltz izithinte kanjani izimpawu ze-plaque psoriasis kubantu abadala abaneminyaka eyi-18 nangaphezulu. Ngemuva kwamasonto ayi-12, uTaltz wehlise izimpawu ngo:

  • okungenani ama-75% kuma-87% kuya kuma-90% wabantu
  • okungenani ama-90% kuma-68% kuya kuma-71% wabantu
  • I-100% kubantu abangama-35% kuya kuma-40%

Abaphenyi baphinde babheka ukuthi uTaltz wasebenza kahle kangakanani kubantu abanezimpawu ze-psoriasis ezazisuliwe, noma zazincane nje, ngemuva kwamasonto ayi-12 ekwelashwa. Ngemuva kwamasonto angama-60 ethathe i-Taltz, ama-75% alaba bantu abesenezimpawu ezincane noma ezingekho nhlobo ze-psoriasis.

Futhi ocwaningweni lomtholampilo lwe-psoriasis yesitho sangasese, abantu abangama-73% abathola i-Taltz babenezimpawu nje ezincane noma izimpawu zabo zacaca ngemuva kwamasonto ayi-12.

Ukusebenza ngempumelelo kwe-plaque psoriasis ezinganeni

Ucwaningo lomtholampilo lubheke ukuthi uTaltz uzithinte kanjani izimpawu ze-plaque psoriasis ezinganeni ezineminyaka eyisithupha kuya kwengu-18 ubudala. Ngemuva kwamasonto ayi-12, uTaltz wehlise izimpawu ngo:

  • okungenani ama-75% ezinganeni ezingama-89%
  • okungenani ama-90% kuma-78% ezingane
  • 100% ezinganeni ezingama-50%

I-Taltz ye-spondyloarthritis

I-Taltz ivunyelwe yi-FDA ukwelapha izinhlobo ezimbili ze-spondyloarthritis (SA) kubantu abadala. Ngokuqondile, i-Taltz ivunyelwe ukuphatha lezi zinhlobo ezimbili ezilandelayo ze-SA, ezichazwe ngokuningiliziwe ngezansi:

  • i-non-radiographic axial spondyloarthritis (nr-axSpA)
  • i-ankylosing spondylitis esebenzayo (AS) noma i-radiographic axial spondyloarthritis (r-axSpA)

I-SA yisifo sokuvuvukala kanye nohlobo lwe-arthritis olubangela ukuvuvukala emgogodleni wakho. Imvamisa, amalunga aseduze nawo ayathinteka, ikakhulukazi amalunga amabili axhuma umgogodla wakho ophansi okhalweni (amalunga we-sacropelvic). Lapho ukulimala kwamalunga kungabonakali kuma-X-ray (ama-radiographs), ifomu le-SA libizwa ngokuthi i-nr-axSpA.

Lapho i-SA iqhubeka, ukuvuvukala okungapheli (okuhlala isikhathi eside) kungadala ukuthi amathambo omgogodla wakho ahlangane ndawonye. Ngenxa yalokho, umgogodla wakho awuguquki kangako. Ubuhlungu beqolo nokukhathala kuyizimpawu ezijwayelekile ze-SA ezithuthukile. Ngalolu hlobo lwe-SA, ukulimala okuhlangene kungabonakala kuma-X-ray. Leli fomu le-SA libizwa ngokuthi yi-AS esebenzayo, noma i-r-axSpA.

Ukusebenza kwe-non-radiographic axial spondyloarthritis

Ucwaningo lomtholampilo lubheke abantu abadala abaneminyaka eyi-18 nangaphezulu nge-nr-axSpA. Lolu cwaningo lubheke ukwelashwa nge-Taltz uma kuqhathaniswa nokwenziwa nge-placebo (ukwelashwa ngaphandle kwesidakamizwa esisebenzayo).

Ngemuva kokwelashwa amasonto angama-52:

  • Abantu abangama-30% abasebenzisa i-Taltz izimpawu zabo zehliswe ngo-40% noma ngaphezulu. Lezi zimpawu zibandakanya ukuqina emajoyintini nasemgogodleni.
  • Ngokuqhathanisa, i-13% yabantu abasebenzisa i-placebo babe nomphumela ofanayo.

Ukusebenza kwe-ankylosing spondylitis esebenzayo

Izifundo ezimbili zokwelashwa zabheka abantu abadala abaneminyaka eyi-18 noma ngaphezulu nge-AS esebenzayo. Lezi zifundo zabheka ukwelashwa nge-Taltz uma kuqhathaniswa nokwenziwa nge-placebo.

Ngemuva kwamasonto ayi-16 ekwelashwa:

  • Ama-25% kuya kuma-48% abantu abasebenzisa i-Taltz izimpawu zabo zehliswe ngo-40% noma ngaphezulu. Lezi zimpawu zifaka ukuqina emajoyintini nasemgogodleni.
  • Uma kuqhathaniswa, i-13% kuya ku-18% yabantu abasebenzisa i-placebo babe nomphumela ofanayo.

Ngaphezu kwalokho, abantu abathathe i-Taltz baba nobuhlungu obuncane futhi ngokomzimba bazizwa bengcono uma kuqhathaniswa nabantu abathathe i-placebo.

UTaltz nezingane

I-Taltz ivunyelwe yi-FDA ukwelapha i-plaque psoriasis ezinganeni ezineminyaka engama-6 nangaphezulu. Ukuthola imininingwane ngalokhu kusetshenziswa, bheka isigaba esingenhla esibizwa nge- “Taltz ukuthola i-plaque psoriasis elinganiselayo nesinzima.”

I-Taltz yezinye izimo

Ngaphezu kokusetshenziswa okubalwe ngenhla, i-Taltz ingasetshenziswa ngaphandle kwelebula kokunye okuhlosiwe. Ukusetshenziswa kwezidakamizwa ezingekho ilebula kulapho umuthi ovunyelwe ukusetshenziswa kokunye usetshenziselwa okwehlukile okungavunyelwe. Futhi ungazibuza ukuthi ngabe iTaltz isetshenziselwa ezinye izimo ezithile yini.

I-Taltz yesifo samathambo (ukusetshenziswa kwelebula)

I-Taltz ayivunyelwe ukwelapha i-rheumatoid arthritis (RA). Kodwa-ke, udokotela wakho angakunika umuthi ongekho ilebula uma ezinye izindlela zokwelapha ezivunyiwe zingakusebenzelanga.

I-RA isifo lapho amasosha akho omzimba ehlasela amalunga akho, awenze avuvuke, aqine futhi abe buhlungu. Ucwaningo oluningi lubheke ukuthi ngabe iTaltz ingasiza yini ekwelapheni i-RA. I-Taltz isebenza engxenyeni yesistimu yomzimba eyaziwa ukuthi ibangele okunye kwalokhu kuvuvukala okuhlangene (ukuvuvukala).

Ukubuyekezwa kwezifundo kuphethe ngokuthi iTaltz yayisebenza ekwelapheni i-RA.

Uma ungathanda ukwazi okwengeziwe ngokusebenzisa i-Taltz ukwelapha i-RA, khuluma nodokotela wakho.

I-Taltz ye-osteoarthritis (hhayi ukusetshenziswa okufanele)

I-Taltz ayivunyelwe noma ayisetshenziswanga ngaphandle kwelebuli yokwelapha i-osteoarthritis. Leli fomu lesifo samathambo lidalwa ukuwohloka kwamalunga akho. Akubangelwa ukuvuvukala. Ngakho-ke i-osteoarthritis yayingeke isizwe yizidakamizwa, ezinjengeTaltz, ezithinta amasosha akho omzimba.

Uma unemibuzo mayelana nezinketho zokwelashwa kwe-osteoarthritis, khuluma nodokotela wakho.

UTaltz notshwala

Utshwala abuthinti ngqo ukuthi iTaltz isebenza kanjani, ngakho-ke azikho izixwayiso ezithile mayelana nokugwema utshwala ngesikhathi sokwelashwa kweTaltz.

Kodwa-ke, ukuphuza utshwala kungahle kube kubi kakhulu i-psoriasis, esetshenziselwa ukwelashwa yi-Taltz. Ngaphezu kwalokho, utshwala bungenza ukwelashwa kwe-psoriasis kungasebenzi kahle futhi kungenza amasosha akho omzimba angakwazi ukulwa nezifo.

Imihlahlandlela yamanje yokwelapha nokuphatha i-psoriasis incoma ukunciphisa ukuthi uphuza kangakanani utshwala.

Uma uphuza utshwala, buza udokotela wakho ukuthi kungakanani okuphephile ongakudla ngenkathi uthatha iTaltz.

Ezinye izindlela zeTaltz

Ezinye izidakamizwa ziyatholakala ezingelapha isimo sakho. Ezinye zingakulungela kangcono kunabanye. Uma unentshisekelo yokuthola enye indlela kune-Taltz, khuluma nodokotela wakho. Bangakutshela ngeminye imithi engakusebenzela kahle.

Qaphela: Eminye yemithi efakwe kuhlu lapha isetshenzisiwe ngaphandle kwelebula ukwelapha lezi zimo ezithile.

Ezinye izindlela ze-psoriatic arthritis

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-psoriatic arthritis zifaka:

  • i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall)
  • i-apremilast (Otezla)
  • infliximab (i-Remicade)
  • i-adalimumab (Humira)
  • i-etanercept (Enbrel)
  • i-tofacitinib (Xeljanz)
  • golimumab (Simponi)
  • isitifiketi (Cimzia)
  • secukinumab (Cosentyx)
  • ustekinumab (Stelara)
  • brodalumab (Siliq)
  • i-guselkumab (Tremfya)
  • i-sulfasalazine (i-Azulfidine)

Qaphela: Ukuze ufunde kabanzi nge-psoriatic arthritis, bheka isigaba esithi “Taltz uses” ngenhla.

Ezinye izindlela zamapuleti we-plaque psoriasis aphakathi nendawo

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-plaque psoriasis elinganiselayo kuya kwezimbi zifaka:

  • i-apremilast (Otezla)
  • infliximab (i-Remicade)
  • i-adalimumab (Humira)
  • i-etanercept (Enbrel)
  • isitifiketi (Cimzia)
  • ustekinumab (Stelara)
  • secukinumab (Cosentyx)
  • brodalumab (Siliq)
  • i-guselkumab (Tremfya)
  • golimumab (Simponi)
  • i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall)
  • i-sulfasalazine (i-Azulfidine)

Qaphela: Ukuze ufunde kabanzi nge-plaque psoriasis, bheka isigaba esithi "Taltz uses" ngenhla.

Ezinye izindlela ze-ankylosing spondylitis

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-ankylosing spondylitis (AS) zifaka:

  • infliximab (i-Remicade)
  • i-adalimumab (Humira)
  • i-etanercept (Enbrel)
  • secukinumab (Cosentyx)
  • isitifiketi (Cimzia)
  • golimumab (Simponi)
  • ustekinumab (Stelara)
  • brodalumab (Siliq)
  • i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall)
  • i-sulfasalazine (i-Azulfidine)

Qaphela: Ukuze ufunde kabanzi nge-AS, bona isigaba esithi “Taltz uses” ngenhla.

Ezinye izindlela ze-non-radiographic axial spondyloarthritis

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-non-radiographic axial spondyloarthritis (nr-axSpA) zifaka:

  • isitifiketi (Cimzia)
  • i-adalimumab (Humira)
  • secukinumab (Cosentyx)
  • i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall)
  • i-sulfasalazine (i-Azulfidine)

Qaphela: Ukuze ufunde kabanzi nge-nr-axSpA, bona isigaba esithi “Taltz uses” ngenhla.

I-Taltz vs. Cosentyx

Ungase uzibuze ukuthi iTaltz iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi iTaltz neCosentyx zifana futhi zehlukile kanjani.

Mayelana

I-Taltz neCosentyx zombili izidakamizwa ze-biologic (izidakamizwa ezenziwe ngezingxenye zezinto eziphilayo). Zisebenza ngokukhomba ingxenye ethile yamasosha akho omzimba.

ITaltz iqukethe isidakamizwa ixekizumab, kanti iCosentyx iqukethe isidakamizwa secukinumab. Le mithi emibili ibizwa ngama-antibody monoclonal. Vimba ukusebenza kweprotheni kumasosha akho omzimba abizwa nge-interleukin-17. I-Interleukin-17 ibangela ukuthi amasosha omzimba wakho ahlasele amaseli esikhunjeni nasamalunga akho. Lokhu kubangela ukuvuvukala okubonakala ngezifo ezifana ne-plaque psoriasis, i-psoriatic arthritis, ne-spondyloarthritis.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume kokubili i-Taltz neCosentyx ukwelapha i-plaque psoriasis ngokulinganisela. Le mithi ilungele abantu i-psoriasis yabo engazuza ekwelashweni okuhleliwe (ukwelashwa okuthinta umzimba wakho wonke) noma i-phototherapy (ukwelashwa okulula).

Nge-plaque psoriasis, iTaltz ivunyelwe ukusetshenziswa kubantu abadala nezingane ezineminyaka engu-6 nangaphezulu. Kodwa-ke, iCosentyx ivunyelwe kuphela ukuthi isetshenziswe kubantu abadala abanalesi simo.

Kokubili iTaltz neCosentyx nakho kuvunyelwe yi-FDA ukwelapha i-psoriatic arthritis esebenzayo kubantu abadala. ("Ukusebenza" kusho ukuthi njengamanje unezimpawu.)

Ngaphezu kwalokho, i-Taltz neCosentyx zivunyelwe ukwelapha i-non-radiographic axial spondyloarthritis kanye ne-ankylosing spondylitis esebenzayo kubantu abadala.

Qaphela: Ukuthola eminye imininingwane ngemibandela ebalulwe lapha, bheka isigaba esithi “Taltz uses” ngenhla.

Amafomu wezidakamizwa nokuphathwa

Kokubili iTaltz neCosentyx kunikezwa ngomjovo ngaphansi kwesikhumba sakho (umjovo ongaphansi). Umhlinzeki wakho wezokunakekelwa kwempilo uzokunika umjovo ekuqaleni. Ngemuva kwalokho bangakufundisa ukuthi ungazinikeza kanjani umjovo ekhaya.

I-Taltz iza ngezindlela ezimbili: isirinji esetshenzisiwe esetshenziswa kanye kanye nepeni elisebenzisayo elisebenzisayo elilodwa.

ICosentyx iza ngezindlela ezintathu:

  • ipeni le-Sensoready elisetshenziswa kanye
  • isirinji esetshenzisiwe esetshenziswa kanye
  • isitsha sokusetshenziswa esisodwa esinikezwa njengomjovo ngumhlinzeki wakho wezokunakekelwa kwempilo

Imiphumela emibi kanye nezingozi

I-Taltz neCosentyx zingadala imiphumela emibi efanayo futhi ezinye ziyehluka. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeTaltz, neCosentyx, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka ngeTaltz:
    • ukuphendula kwesiza somjovo (ububomvu nobuhlungu obuzungeze indawo yomjovo)
    • i-conjunctivitis (iso elibomvana)
  • Kungenzeka ngeCosentyx:
    • isifo sohudo
    • izilonda zomlomo
    • ukuqubuka kwesikhumba
  • Kungenzeka ngamabili iTaltz neCosentyx:
    • izifo zokukhunta, ezinyaweni zomdlali
    • izifo eziphezulu zokuphefumula, njengomkhuhlane ovamile
    • isicanucanu

Imiphumela emibi kakhulu

Lolu hlu luqukethe izibonelo zemiphumela emibi engaba khona ngeTaltz neCosentyx (uma ithathwa ngawodwana).

  • ingozi eyengeziwe yokutheleleka okungaba yingozi, njengesifo sofuba (i-TB)
  • isifo esisha noma esibuhlungu sokuvuvukala kwamathumbu (IBD), njengesifo sikaCrohn noma isifo sezilonda esilimaza ulcerative
  • ukusabela okweqile komzimba

Ukusebenza ngempumelelo

I-Taltz neCosentyx zinokusetshenziswa okwehlukile okuvunyelwe yi-FDA, kodwa zombili zisetshenziselwa ukwelapha lezi zimo ezilandelayo:

  • i-plaque psoriasis elinganiselayo kuya kwelinzima
  • i-psoriatic arthritis esebenzayo (okwamanje ebangela izimpawu)
  • i-spondyloarthritis engeyona i-radiographic axial
  • i-ankylosing spondylitis esebenzayo

Le mithi ayikaze iqhathaniswe ngqo ezifundweni zokwelashwa. Kodwa-ke, ukubukezwa okukodwa kokuhlolwa kwe-plaque psoriasis kutholakale ukuthi iTaltz yayisebenza kangcono kuneCosentyx ekwehliseni izimpawu ze-psoriasis.

Imihlahlandlela yokwelashwa evela ku-2018 no-2019 incoma zombili lezi zidakamizwa njengezinketho zabantu abadinga ukwelashwa ngemvelo kwe-psoriasis noma i-psoriatic arthritis. I-Biologics wuhlobo lwemithi ehlose izingxenye zesistimu yakho yomzimba ezibandakanyeka ku-psoriasis ne-psoriatic arthritis.

Udokotela wakho angancoma i-biologic uma ezinye izindlela zokwelapha zingasebenzi kahle ngokwanele. Isibonelo, i-biologic ingakulungela uma:

  • une-plaque psoriasis futhi ukwelashwa okulula noma izindlela zokwelapha ezisetshenziswe esikhumbeni sakho azikasebenzi
  • une-psoriatic arthritis kanye nemithi elwa nokuvuvukala (esiza ukunciphisa ukuvuvukala) njengokunciphisa izinhlungu noma i-steroids ayisebenzi

ICosentyx ingaba ngcono kuneTaltz ye-plaque psoriasis ethinta izipikili. I-Taltz ingaba yindlela engcono ye-erythrodermic psoriasis, uhlobo olungavamile kakhulu lwe-psoriasis.

Izindleko

I-Taltz neCosentyx zombili lezi zidakamizwa ezinamagama. Okwamanje azikho izinhlobo ezijwayelekile zomuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-WellRx.com, iTaltz neCosentyx ngokuvamile kubiza ngokufana. Inani langempela ozolikhokhela noma imuphi umuthi lincike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

I-Taltz vs. Humira

Ngaphezu kweCosentyx (ngenhla), uHumira ungomunye umuthi osebenzisa okunye okufana nalokho kweTaltz. Lapha sibheka ukuthi iTaltz neHumira bafana futhi bahlukile kanjani.

Mayelana

I-Taltz ne-Humira zombili izidakamizwa ze-biologic (izidakamizwa ezenziwe ngezingxenye zezinto eziphilayo). Zisebenza ngakunye ngokukhomba izingxenye ezahlukahlukene, kepha eziqondile, zamasosha akho omzimba.

I-Taltz iqukethe ixekizumab, okuwuhlobo lomuthi obizwa ngokuthi i-monoclonal antibody. Kuvimba ukusebenza kweprotheni kumasosha omzimba abizwa nge-interleukin-17. I-Interleukin-17 ibangela ukuthi amasosha omzimba ahlasele amaseli esikhunjeni nasemalungeni. Lokhu kubangela ukuvuvukala okubonakala ngezifo ezifana ne-plaque psoriasis, i-psoriatic arthritis, ne-spondyloarthritis.

I-Humira iqukethe i-adalimumab, okuwuhlobo lomuthi obizwa nge-tumor necrosis factor-alpha (TNF-α) blocker. Ivimba ukusebenza kweprotheni ebizwa nge-TNF-α. Le phrotheni ibandakanyekile ekudaleni ukuvuvukala ezimeni ezahlukahlukene, kufaka phakathi i-psoriasis ne-psoriatic arthritis.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kugunyaze bobabili uTaltz noHumira ukuthi belaphe i-plaque psoriasis elinganiselayo. Udokotela wakho angakunikeza esinye salezi zidakamizwa uma i-psoriasis yakho ingazuza ekwelashweni kwesistimu (ukwelashwa okuthinta umzimba wakho wonke) noma i-phototherapy (ukwelashwa okulula).

Nge-plaque psoriasis, iTaltz ivunyelwe ukusetshenziswa kubantu abadala nezingane ezineminyaka engu-6 nangaphezulu. Noma kunjalo, iHumira ivunyelwe kuphela ukusetshenziswa kubantu abadala abanalesi simo.

Kokubili iTaltz neHumira nakho kuvunyelwe yi-FDA ukwelapha i-psoriatic arthritis esebenzayo kubantu abadala. ("Ukusebenza" kusho ukuthi njengamanje unezimpawu.)

Ngaphezu kwalokho, bobabili uTaltz noHumira bavunyelwe ukwelapha i-ankylosing spondylitis esebenzayo kubantu abadala. Kepha i-Taltz kuphela evunyelwe ukwelapha i-non-radiographic axial spondyloarthritis kubantu abadala.

UHumira futhi unemvume ye-FDA yokwelapha lezi zimo ezilandelayo:

  • isifo samathambo (RA)
  • imaphakathi nesifo samathambo esentsha esilinganiselayo nesinzima
  • Isifo sikaCrohn
  • ukulinganisela kuya kokuqinile kwesifo sezilonda
  • i-hidradenitis suppurativa, isimo sesikhumba esibuhlungu esibizwa nangokuthi i-acne inversa
  • ezinye izinhlobo ze-uveitis engatheleleki (uhlobo lokuvuvukala kwamehlo), kufaka phakathi i-uveitis ephakathi, i-posterior uveitis, ne-panuveitis

Qaphela: Ukuze ufunde kabanzi mayelana nesimo i-Taltz evunyelwe ukuselapha, bheka isigaba esithi “Taltz uses” ngenhla.

Amafomu wezidakamizwa nokuphathwa

Kokubili iTaltz neHumira kunikezwa ngomjovo ngaphansi kwesikhumba sakho (umjovo ongaphansi). Umhlinzeki wakho wezokunakekelwa kwempilo uzokunika umjovo ekuqaleni. Ngemuva kwalokho bangakufundisa ukuthi ungazinikeza kanjani umjovo ekhaya.

I-Taltz iza ngezindlela ezimbili: isirinji esetshenzisiwe esetshenziswa kanye kanye nepeni elisebenzisayo elisebenzisayo elilodwa.

I-Humira iza ngezindlela ezintathu:

  • ipeni eligcwalisiwe elisetshenziswa kanye
  • isirinji esetshenzisiwe esetshenziswa kanye
  • isitsha sokusetshenziswa esisodwa esinikezwa njengomjovo ngumhlinzeki wakho wezokunakekelwa kwempilo

Imiphumela emibi kanye nezingozi

I-Taltz ne-Humira ingadala imiphumela emibi efanayo futhi eminye yehluke. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeTaltz, neHumira, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka ngeTaltz:
    • ukutheleleka kwe-tinea fungal, okufana nonyawo lomsubathi
    • i-conjunctivitis (iso elibomvana)
  • Kungenzeka ngeHumira:
    • ikhanda
    • ukuqubuka
  • Kungenzeka ngeTaltz neHumira:
    • ukuphendula kwesiza somjovo, njengokubomvu nobuhlungu obuzungeze indawo yomjovo
    • izifo eziphezulu zokuphefumula, njengomkhuhlane ovamile
    • isicanucanu

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi kakhulu engenzeka ngeTaltz, neHumira, noma ngazo zombili izidakamizwa (uma zithathwa ngazodwana).

  • Kungenzeka ngeTaltz:
    • isifo esisha noma esibuhlungu sokuvuvukala kwamathumbu (IBD), njengesifo sikaCrohn noma isifo sezilonda esilimaza ulcerative
  • Kungenzeka ngeHumira:
    • izinkinga zesibindi, njengokuhluleka kwesibindi
    • izinkinga zesistimu yezinzwa, njenge-multiple sclerosis (MS)
    • izinkinga zegazi, ezinjengezinombolo ezincishisiwe zamaseli abomvu egazi, amaseli amhlophe egazi, noma ama-platelets
    • ukuhluleka kwenhliziyo
    • izifo zokukhunta, njenge-histoplasmosis
    • ingozi eyengeziwe yeminye umdlavuza, njengomdlavuza wesikhumba, i-leukemia, ne-lymphoma
    • i-psoriasis entsha noma ekhulayo
  • Kungenzeka ngeTaltz neHumira:
    • ingozi eyengeziwe yokutheleleka okungaba yingozi, njengesifo sofuba (i-TB)
    • ukusabela okweqile komzimba

Ukusebenza ngempumelelo

I-Taltz ne-Humira zinokusetshenziswa okwehlukile okuvunyelwe yi-FDA, kodwa zombili zisetshenziselwa ukwelapha lezi zimo ezilandelayo:

  • i-plaque psoriasis elinganiselayo kuya kwelinzima
  • i-psoriatic arthritis esebenzayo
  • i-ankylosing spondylitis esebenzayo

Le mithi ayikaze iqhathaniswe ngqo kubantu abane-plaque psoriasis, kodwa izifundo zithole ukuthi uTaltz noHumira basebenza kahle ekwelapheni lesi simo.

Isifundo esisodwa somtholampilo sabheka bobabili uTaltz noHumira kubantu abane-psoriatic arthritis esebenzayo. Ngemuva kwamasonto angama-24, izimpawu ze-psoriatic arthritis zancipha okungenani ama-20% kuma-58% kuya kuma-62% wabantu abathathe iTaltz. Lokhu kwaqhathaniswa nabantu abangama-57% abathathe uHumira kwathi abangama-30% bathatha i-placebo (akukho lashwa).

Imihlahlandlela yokwelashwa evela ku-2018 no-2019 incoma zombili lezi zidakamizwa njengezinketho zabantu abadinga ukwelashwa nge-biologic ye-psoriasis noma i-psoriatic arthritis. I-Biologics wuhlobo lwemithi ehlose izingxenye zesistimu yakho yomzimba ezibandakanyeka ku-psoriasis ne-psoriatic arthritis.

Udokotela wakho angancoma i-biologic uma ezinye izindlela zokwelapha zingasebenzi kahle ngokwanele. Isibonelo, i-biologic ingakulungela uma:

  • une-plaque psoriasis futhi ukwelashwa okulula noma izindlela zokwelapha ezisetshenziswe esikhumbeni sakho azikasebenzi
  • une-psoriatic arthritis kanye nemithi elwa nokuvuvukala (esiza ukunciphisa ukuvuvukala) njengokunciphisa izinhlungu noma i-steroids ayisebenzi

Kubantu abaningi abaqala ukwelashwa kwe-psoriatic arthritis esebenzayo, izinkombandlela ze-2018 zincoma ukusebenzisa i-TNF-alpha blockers (efana neHumira) ngaphezulu kwe-interleukin-17 blockers (njengeTaltz). Imihlahlandlela ka-2019 ithi uHumira futhi angaba ngcono kuneTaltz ye-plaque psoriasis ethinta isikhumba sasekhanda kanye ne-erythrodermic psoriasis (uhlobo olungavamile kakhulu lwe-psoriasis).

Ucwaningo lomtholampilo luqhathanise ukuthi iTaltz neHumira zisebenza kanjani ekwelapheni i-psoriatic arthritis ne-plaque psoriasis. Ucwaningo lubike ukuthi ukwelashwa okungaphezu kwamasonto angama-24, abantu abangama-36% abathathe iTaltz izimpawu zabo zithuthuke okungenani ngama-50%. Uma kuqhathaniswa, ama-28% abantu abathathe uHumira izimpawu zabo zithuthuke okungenani ngama-50%.

Izindleko

UTaltz noHumira bobabili izidakamizwa zomuthi. Okwamanje azikho izinhlobo ezijwayelekile zomuthi. Imithi enegama lomkhiqizo ivame ukubiza ngaphezu kwama-generic.

Ngokuya ngokulinganiselwa ku-WellRx.com, iTaltz neHumira ngokuvamile kubiza ngokufana. Inani langempela ozolikhokhela noma imuphi umuthi lincike ohlelweni lwakho lomshuwalense, indawo okuyo nasekhemisi oyisebenzisayo.

Ukusebenzisana kweTaltz

I-Taltz ingaxhumana neminye imithi. Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukusebenza kwesidakamizwa. Okunye ukuxhumana kungakhuphula imiphumela emibi noma kuyenze ibe nzima kakhulu.

Taltz neminye imithi

Ngezansi kunohlu lwemithi engasebenzisana neTaltz. Lolu hlu aluqukethe yonke imishanguzo engasebenzisana ne-Taltz.

Ngaphambi kokuthatha iTaltz, khuluma nodokotela wakho kanye nosokhemisi. Batshele ngayo yonke imishanguzo oyinikezwa ngudokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

I-Taltz ne-warfarin

I-Warfarin (i-Coumadin, i-Jantoven) wuhlobo lwegazi oluncane, umuthi osiza ukuvimbela amahlule egazi. Ukuthatha iTaltz nge-warfarin kungenza i-warfarin yakho ingasebenzi kahle.

Uma uthatha i-warfarin, udokotela wakho angahle afune ukuqapha ukuthi kuthatha isikhathi esingakanani ukuthi igazi lakho livaleke ngemuva kokuqala i-Taltz, ngesikhathi sokwelashwa kwakho, futhi uma uyeka iTaltz. Bangaguqula isilinganiso sakho se-warfarin uma kudingeka.

I-Taltz ne-cyclosporine

I-Cyclosporine yisidakamizwa sokuzivikela emzimbeni. Uyithatha ukunciphisa ukusebenza kwamasosha akho omzimba. Ukuthatha i-Taltz nge-cyclosporine kungenza i-cyclosporine yakho ingasebenzi kahle.

Uma uthatha i-cyclosporine, udokotela wakho angafuna ukubheka izinga lomuthi osegazini lakho ngemuva kokuqala i-Taltz, ngesikhathi sokwelashwa kwakho futhi uma uyeka iTaltz. Bangaguqula isilinganiso sakho se-cyclosporine uma kudingeka.

ICyclosporine iyatholakala njengemithi elandelayo enegama lomkhiqizo:

  • Cequa
  • IGengraf
  • I-Neoral
  • I-Restasis
  • USandimmune

Taltz nokugoma okubukhoma

Ukuthola umuthi wokugoma bukhoma ngenkathi uthatha i-Taltz kungadala ukutheleleka okungathi sína.

Imishanguzo ebukhoma iqukethe izinhlobo ezibuthakathaka zamagciwane noma amabhaktheriya, kodwa azibangeli izifo kubantu abanamasosha omzimba aphilile. Kodwa-ke, imithi yokugoma ephilayo ingadala ukutheleleka kubantu amasosha abo omzimba athinteka ukwelashwa nge-Taltz.

Ngenkathi uthatha iTaltz, akufanele uthole imigomo ebukhoma efana nale:

  • inqubulunjwana
  • i-yellow fever
  • isifo sofuba (TB)
  • isimungumungwane, imvukuzane, ne-rubella (MMR)

Kuhle ukuthola imigomo engasebenzi (hhayi bukhoma), efana nomkhuhlane, ngesikhathi sokwelashwa kwakho kweTaltz. Kodwa-ke, imijovo yokugoma engasebenzi kungenzeka ingasebenzi kahle njengoba ijwayele ukusebenza. (Imithi yokugoma isebenza ngokubangela ukuthi amasosha omzimba wakho akhiqize amasosha omzimba asiza ukulwa nezifo. I-Taltz ingenza amasosha akho omzimba angakwazi ukukhiqiza ama-antibodies.)

Uma udokotela wakho efuna ukuthi uthathe i-Taltz, buza ukuthi unolwazi lwakamuva ngayo yonke imigomo enconywayo.

I-Taltz namakhambi nezithako

Awekho amakhambi noma izengezo ezibikwe ngokukhethekile ukuthi zisebenzisana neTaltz. Kepha qiniseka ukuthi ubuza nosokhemisi wakho ngaphambi kokusebenzisa noma yini.

Ungayithatha kanjani iTaltz

Umuthi unikezwa ngomjovo ngaphansi kwesikhumba sakho (umjovo ongaphansi). Umhlinzeki wakho wezokunakekelwa kwempilo uzokunika umjovo ekuqaleni. Ngemuva kwalokho bangakufundisa ukuthi ungazinikeza kanjani umjovo ekhaya. Ungathatha umjovo wakho we-Taltz nganoma yisiphi isikhathi sosuku ngosuku olufanele.

I-Taltz iza njengesirinji ekhethwe ngomthamo owodwa kanye nepeni lokusebenzisa i-autoinjector elisebenzisayo elilodwa. Buza udokotela wakho okungcono kakhulu kuwe. Womabili la mafomu aqukethe umthamo owodwa. Ujova umthamo ophelele bese ulahla isirinji noma ipeni le-autoinjector.

Ukuthatha nini

Lapho uzodinga ukuthatha imithamo ye-Taltz kuya ngesimo eselashwa. Ngokuvamile, uzothola umthamo wakho wokuqala we-Taltz ehhovisi likadokotela wakho. Ngemuva kwalokho uzokwazi ukunikeza imijovo elandelayo kuwe.

Ngezansi, sichaza amashejuli wokulinganisa we-Taltz ngokusetshenziswa kwawo okuvunyiwe.

  • Uma une-psoriasis: Ngomthamo wakho wokuqala we-Taltz, uzothola imijovo emibili ngosuku olufanayo. Ngemuva komthamo wokuqala we-Taltz, uzoba nomjovo owodwa njalo emavikini amabili amasonto ayi-12. Lokhu kuzolandelwa umjovo owodwa njalo emavikini amane uma nje udokotela wakho ekuncoma.
  • Uma une-psoriatic arthritis: Ngomthamo wakho wokuqala we-Taltz, uzothola imijovo emibili ngosuku olufanayo. Ngemuva komthamo wokuqala we-Taltz, uzoba nomjovo owodwa njalo emavikini e-4 inqobo nje uma udokotela wakho encoma.
  • Uma une-psoriasis ne-psoriatic arthritis: Uzothola imithamo ye-Taltz ngokuya ngesheduli yokuncoma ye-psoriasis, echazwe ngenhla.
  • Uma une-non-radiographic axial spondyloarthritis (nr-axSpA): Ngemuva komthamo wakho wokuqala we-Taltz, uzoba nomjovo owodwa njalo emavikini amane.
  • Uma une-ankylosing spondylitis (AS) esebenzayo: Ngomthamo wakho wokuqala we-Taltz, uzothola imijovo emibili ngosuku olufanayo. Ngemuva komthamo wokuqala we-Taltz, uzoba nomjovo owodwa njalo emavikini amane.

Ukuze i-Taltz isebenze kahle, kubalulekile ukuyithatha njengoba udokotela wakho ekuyalela. Ukuze uqiniseke ukuthi uyakhumbula ukuthatha umuthi, kuwumqondo omuhle ukubhala uhlelo lwakho lokujova ekhalendeni. Ungasebenzisa futhi ithuluzi lokukhumbuza imithi ukuze ungakhohlwa.

Qaphela: Ukuthola eminye imininingwane ngemibandela ebhalwe lapha, bheka isigaba esithi “Taltz uses” ngenhla.

Ungayijova kanjani

Umhlinzeki wakho wezokunakekelwa kwempilo uzokuyalela ukuthi ungayisebenzisa kanjani isirinji noma ipeni le-autoinjector. Ngeminye imininingwane, amavidiyo, nezithombe zemiyalo yomjovo, bona iwebhusayithi yomkhiqizi.

Khumbula ukuthi izingosi ezifanele ukujova i-Taltz zingaphambili kwamathanga akho noma isisu sakho (isisu). Ungasebenzisa futhi emuva kwezingalo zakho ezingaphezulu, kepha ungadinga omunye umuntu ukukunikeza umjovo.

Isebenza kanjani iTaltz

I-Psoriasis, i-psoriatic arthritis, ne-spondyloarthritis yizimo ezizimele. Babangela ukuthi amasosha omzimba wakho (ukuzivikela komzimba wakho ezifweni) ahlasele amaseli aphilile ngephutha.

Ukuthola eminye imininingwane ngalezi zimo, bheka isigaba esithi “Taltz uses” ngenhla.

Izingxenye ezahlukahlukene zamasosha omzimba ziyabandakanyeka kulezi zimo. Inqubo eyodwa ethize ihlobene neprotheyini ebizwa nge-interleukin-17A. Le phrotheni itshela amasosha akho omzimba ukuthi ahlasele amaseli esikhunjeni nasamalunga akho.

I-Taltz iqukethe ixekizumab, okuwuhlobo lomuthi obizwa ngokuthi yi-humanized monoclonal antibody. Isebenza ngokubopha (ukunamathisela) ku-interleukin-17A. Ngokwenza lokhu, i-Taltz ivimba isenzo sephrotheni. Iyayimisa ekutsheleni amasosha akho omzimba ukuthi ahlasele amaseli esikhunjeni nasemalungeni akho.

Ngokuvimbela amasosha omzimba wakho ekuhlaseleni amaseli, iTaltz iyasiza:

  • ukunciphisa ukwakheka kwamapuleti esikhunjeni sakho ku-plaque psoriasis
  • ukunciphisa ukuvuvukala (ukuvuvukala) kwamalunga akho ku-psoriatic arthritis, i-non-radiographic axial spondyloarthritis, ne-ankylosing spondylitis esebenzayo

Kuthatha isikhathi esingakanani ukusebenza?

I-Taltz iqala ukusebenza ngokushesha nje lapho uqala ukwelashwa. Kodwa-ke, kuzothatha amasonto ambalwa ukuthi uqaphele noma iziphi izinguquko.

Ezifundweni zokwelashwa, abantu abaningi abane-plaque psoriasis babenezikhumba ezicacile noma ezicishe zicace emasontweni ayi-12 ngemuva kokuqala ukwelashwa noma ngokushesha. Futhi cishe isigamu sabantu abane-psoriatic arthritis abathathe i-Taltz babenezimpawu ezinzima kakhulu nokusebenza ngokomzimba okungcono emasontweni ayi-12 ngemuva kokuqala kokwelashwa.

Ucwaningo lomtholampilo lwabantu abadala abane-non-radiographic axial spondyloarthritis lubheke ukwelashwa nge-Taltz kanye nokwelashwa nge-placebo. (I-placebo iyindlela yokwelashwa engenawo umuthi osebenzayo.) Ngemuva kokwelashwa amasonto angama-52, abantu abangama-30% abasebenzisa i-Taltz bancishiswa izimpawu zabo ngama-40% ngaphezulu. Ngokuqhathanisa, i-13% yabantu abasebenzisa i-placebo babe nomphumela ofanayo.

Izifundo ezimbili zokwelashwa kwabantu abadala abane-ankylosing spondylitis esebenzayo babheka ukwelashwa nge-Taltz uma kuqhathaniswa nokwenziwa nge-placebo. Ngemuva kwamasonto ayi-16 elashwa, ama-25% kuya kuma-48% abantu abasebenzisa i-Taltz izimpawu zabo zehliswe ngama-40% noma ngaphezulu. Uma kuqhathaniswa, i-13% kuya ku-18% yabantu abasebenzisa i-placebo babe nomphumela ofanayo.

Taltz nokukhulelwa

I-Taltz ayizange ifundwe kwabesifazane abakhulelwe, ngakho-ke akwaziwa ukuthi umuthi uphephile yini ukuwuthatha ngesikhathi sokukhulelwa.

Qiniseka ukuthi utshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa ngaphambi kokuqala ukwelashwa. Uma ucabanga ukuthi ungakhulelwa ngenkathi uthatha i-Taltz, khuluma nodokotela wakho khona manjalo.

I-Taltz nokulawulwa kokuzalwa

Akwaziwa ukuthi iTaltz iphephile yini ukuyithatha ngesikhathi sokukhulelwa. Uma uhlanganyela ocansini futhi wena noma umlingani wakho ningakhulelwa, khuluma nodokotela wakho ngezidingo zakho zokulawula ukubeletha ngenkathi usebenzisa i-Taltz.

Ukuthola eminye imininingwane ngokuthatha i-Taltz ngesikhathi ukhulelwe, bheka isigaba “seTaltz nokukhulelwa” ngenhla.

I-Taltz nokuncelisa

Akwaziwa ukuthi i-Taltz idlula ubisi lwebele lomuntu noma uma kuthinta indlela umzimba wakho owenza ngayo ubisi lwebele. I-Taltz itholakale obisini lwebele ezifundweni zezilwane, kepha izifundo ezilwazini azikhombisi njalo ukuthi kuzokwenzekani kubantu.

Uma uncelisa futhi ucabanga ukuthatha i-Taltz, khuluma nodokotela wakho. Bangakhuluma nawe ngezingozi nezinzuzo zomuthi.

Imibuzo ejwayelekile ngeTaltz

Nazi izimpendulo zemibuzo ebuzwa njalo ngeTaltz.

Ingabe iTaltz yi-biologic?

Yebo. I-Taltz ngumuthi we-biologic. Lokhu kusho ukuthi isidakamizwa esenziwe ngamaprotheni hhayi ngamakhemikhali (njengoba iningi lemithi likhona). Izidakamizwa ze-biologic zikhiqizwa ebhodini kusetshenziswa amaseli ezilwane.

Ngabe ngisazodinga ukusebenzisa okhilimu be-topical be-psoriasis ngenkathi ngisebenzisa iTaltz?

Kungenzeka. Kepha kufanele ulandele imiyalo kadokotela wakho maqondana nalokhu.

Uma isikhumba sakho sihlanza ngokuphelele ngemuva kokuthatha i-Taltz, lapho-ke kungenzeka ungadingi ukuqhubeka usebenzisa imishanguzo yokwelapha. Kepha kwezinye izimo, ungahle ube namacwecwe e-psoriasis (aminyene, abomvu, ama-scaly patches esikhunjeni sakho). Uma lokhu kwenzeka, udokotela wakho angancoma ukuthi uqhubeke usebenzisa ama-moisturizers noma ezinye izindlela zokwelapha uma kudingeka. Hlala ulandela iseluleko udokotela wakho akunikeza sona.

Ngabe ukusebenzisa i-Taltz kungadala isifo esisha noma esibi sokuvuvukala kwamathumbu?

Yebo angakwazi, yize lokhu kungavamile. Isifo samathumbu esivuthayo (IBD) yiqembu lezifo ezidala ukuvuvukala (ukuvuvukala) emkhakheni wokugaya ukudla. Lezi zifo zihlanganisa isifo sikaCrohn nesifo sezilonda emathunjini.

Ezifundweni zokwelashwa, isifo sikaCrohn senzeke kubantu abangu-0.1% abane-plaque psoriasis abathola iTaltz. I-ulcerative colitis yenzeke ku-0.2% wabantu abane-plaque psoriasis abathole iTaltz.

Uma unezimpawu ezintsha noma eziya ziba zimbi ze-IBD, bheka udokotela wakho. Izimpawu zingafaka ubuhlungu esiswini sakho (esiswini), isifo sohudo noma ngaphandle kwegazi, nokwehla kwesisindo.

Yini engingayenza ukuvimbela izifo ngenkathi ngithatha i-Taltz?

I-Taltz inganciphisa ingxenye yamasosha akho omzimba, ngakho-ke umuthi ungakhuphula ubungozi bokuthola izifo. Nawa amanye amathiphu okusiza ukugcina amasosha akho omzimba aqinile futhi akusize ugweme izifo:

  • Ngaphambi kokuba uqale ukwelashwa, khuluma nodokotela wakho mayelana nokwazi ngemithi yokugoma enconyiwe.
  • Geza izandla zakho njalo, ikakhulukazi uma ngabe ubusendaweni yomphakathi.
  • Zama ukugwema ukuxhumana okuseduze nabantu abanesifo, ikakhulukazi ukukhwehlela, umkhuhlane noma umkhuhlane.
  • Gwema ukwabelana ngamathawula noma izindwangu zokugeza nanoma ngubani onesifo sefungal noma isifo esibandayo.
  • Yidla ukudla okunempilo.
  • Lala ngokwanele.
  • Ungabhemi.

Ingabe iTaltz yelapha i-plaque psoriasis noma i-psoriatic arthritis?

Cha, iTaltz ayizelaphi lezi zimo. Okwamanje alikho ikhambi le-plaque psoriasis noma i-psoriatic arthritis. Kodwa ukwelashwa kwesikhathi eside nge-Taltz kungasiza ekulawuleni izimpawu zalezi zimo.

Ucwaningo lomtholampilo luhlolisise abantu abane-plaque psoriasis abathathe iTaltz. Izimpawu zabanye abantu zisule ngokuphelele noma zaba zincane ngemuva kwamasonto ayi-12. Ingxenye yaleli qembu yathatha iTaltz amanye amasonto angama-48. Esinye isigamu seqembu sithathe i-placebo (akukho ukwelashwa) amasonto angama-48.

Kubantu ababelokhu bethatha i-Taltz, ama-75% ayengasenazo noma nje izimpawu ezincane ekupheleni kocwaningo. Kwabaningi babantu abathathe i-placebo, izimpawu zabo zaphinde zaba zimbi kakhulu. Kuphela yi-7% yeqembu le-placebo ebingenazo noma izimpawu ezincane. Isikhathi esimaphakathi esithathile ukuthi izimpawu ziba zimbi kubantu abathathe i-placebo kwakuyizinsuku eziyi-164. Kepha lapho beqala kabusha ukuthatha i-Taltz, i-66% yalaba bantu, i-psoriasis yabo yaqedwa kungakapheli amasonto ayi-12.

Ukuqapha kweTaltz

Ngaphambi kokuthatha iTaltz, khuluma nodokotela wakho ngomlando wakho wezempilo. I-Taltz kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha. Lokhu kufaka phakathi:

  • Noma yikuphi ukutheleleka, kodwa isifo sofuba ikakhulukazi. I-Taltz ingenza amasosha akho omzimba angakwazi ukulwa namagciwane, ngakho ukutheleleka okunjengesifo sofuba (i-TB) kungaba kubi kakhulu.
    • Uma njengamanje une-TB noma uke waba ne-TB esikhathini esedlule, kungadingeka ukuthi uphuze imithi yokwelapha. Lapho i-TB iselashiwe, ungakwazi ukuqala ukuthatha i-Taltz.
    • Uma unezimpawu zokunye ukutheleleka, njengomkhuhlane, noma uma uthola izifo eziqhubeka zibuya, tshela udokotela wakho. Lezi zifo zingadinga ukwelashwa ngaphambi kokuqala ukwelashwa nge-Taltz.
  • Isifo samathumbu esivuthayo. Ezimweni ezingavamile, i-Taltz ingazilimaza kakhulu izimpawu zesifo samathumbu esivuthayo (IBD). I-IBD iyiqembu lezifo ezibandakanya isifo sikaCrohn nesifo sezilonda emathunjini. Uma une-IBD, khuluma nodokotela wakho. Bangabheka izimpawu zakho ngenkathi uthatha iTaltz. Uma i-IBD yakho iba yimbi, kungadingeka ukuthi umise iTaltz. Kuneminye imithi ye-biologic engayimbi i-IBD ongase ukwazi ukuyizama.

Qaphela: Ukuthola eminye imininingwane ngemiphumela emibi engaba khona ye-Taltz, bheka isigaba "seTaltz side effects" ngenhla.

Ukudlula ngokweqile kweTaltz

Ipeni ngalinye lesipetu eligcwalisiwe ne-autoinjector liqukethe inani elifanele lemithi yedosi eyodwa. Ngakho-ke ukweqisa ngokweqile kungenzeka kuphela uma uzinika imijovo eminingi noma uma uthatha iTaltz kaningi.

Izimpawu zokudlula ngokweqile

Izimpawu zokweqisa ngokweqile zingafaka imiphumela emibi eba kaningi noma ibe nzima kakhulu, njenge:

  • izifo eziphezulu zokuphefumula, njengomkhuhlane ovamile
  • isicanucanu
  • izifo zokukhunta, ezinyaweni zomdlali
  • ukusabela okweqile komzimba
  • isifo sokuvuvukala kwamathumbu (IBD), njengesifo sikaCrohn noma i-ulcerative colitis
  • ingozi eyengeziwe yokutheleleka, njengesifo sofuba (i-TB)

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho. Ungashayela futhi i-American Association of Poison Control Centers ku-800-222-1222 noma usebenzise ithuluzi labo eliku-inthanethi. Kepha uma izimpawu zakho zinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.

Ukuphelelwa yisikhathi kwe-Taltz, ukugcina nokulahla

Uma uthola i-Taltz ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esebhodleleni. Lolu suku luvame unyaka owodwa kusukela ngosuku abakhipha ngalo umuthi.

Usuku lokuphelelwa isikhathi lusiza ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi. Uma ngabe usebenzise umuthi ongasadluli usuku lokuphelelwa yisikhathi, buza usokhemisi wakho ukuthi usengakwazi yini ukuwusebenzisa.

Isitoreji

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi uwugcina kanjani futhi kuphi umuthi.

Ama-syringe we-Taltz agcwalisiwe kanye nezibaya ze-autoinjector kufanele zigcinwe esiqandisini ku-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). Qiniseka ukuthi azifinyeleleki ezinganeni. Ungamisi iTaltz. Futhi ungasebenzisi umuthi uma ngabe umisiwe.

Kwezinye izimo, kungadingeka ukuthi ukhiphe iTaltz esiqandisini ngaphambi kokuyisebenzisa. Isibonelo, uma uhamba izinsuku ezimbalwa futhi uzodinga umjovo ngaleso sikhathi. Yazi ukuthi ungagcina iTaltz ekamelweni lokushisa kuze kufike ku-86 ° F (30 ° C) kuze kube yizinsuku ezi-5.

Qiniseka ukuthi ugcina isiponji noma ipeni le-autoinjector kwikhathoni laso loqobo ukuze usivikele ekukhanyeni. Uma ungasebenzisi isirinji noma ipeni ezinsukwini ezingama-5, kuzodingeka usilahle ngokuphepha. Akufanele uyibuyisele iTaltz esiqandisini uma igcinwe kufudumele.

Ukulahlwa

Ngemuva kokusebenzisa isiponji esigcwalisiwe se-Taltz noma ipeni ye-autoinjector, isifake esitsheni sokulahla esivunyelwe i-FDA. Lokhu kusiza ukuvimbela abanye, kufaka phakathi izingane nezilwane ezifuywayo, ekuthatheni lesi sidakamizwa ngengozi. Kuyasiza futhi ukugcina umuthi ungalimazi imvelo.

Uma ungenaso isiqukathi esibukhali, ungasithenga ku-inthanethi ekhemisi langakini.

Ungathola amathiphu awusizo ngokulahlwa kwemithi lapha. Ungabuza futhi usokhemisi wakho amathiphu okuthi ungayilahla kanjani imithi yakho.

Imininingwane yobungcweti yeTaltz

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume iTaltz ukuthi yelaphe:

  • i-plaque psoriasis elinganiselayo kuya kokuqinile efanele ukwelashwa kwesistimu noma i-phototherapy; ngalokhu kusetshenziswa, lesi sidakamizwa singabekelwa abantu abadala nezingane ezineminyaka engu-6 nangaphezulu
  • i-psoriatic arthritis esebenzayo kubantu abadala
  • i-non-radiographic axial spondyloarthritis (nr-axSpA) kubantu abadala
  • i-ankylosing spondylitis (AS) esebenzayo, ebizwa nangokuthi i-radiographic axial spondyloarthritis (r-axSpA); ngalokhu kusetshenziswa, lesi sidakamizwa singabekelwa abantu abadala

Indlela yokusebenza

I-Taltz iqukethe i-ixekizumab, eyi-anti-IgG monoclonal antibody. Ixekizumab ihlose ngokukhetha futhi ibophezele ku-interleukin-17A (IL-17A). I-IL-17A ingenye yama-cytokines okuvuvukala aziwa ukuthi ahilelekile ekukhiqizeni izimpendulo zokuvuvukala kanye nezokuzivikela ezifweni ezibangela isifo se-psoriatic kanye ne-ankylosing spondylitis. Ngokubophezela ku-IL-17A, ixekizumab iyayivimba ekusebenzisaneni ne-IL-17A receptor ngakho-ke ivimbela lezi zimpendulo.

I-Pharmacokinetics ne-metabolism

Ukutholakala kwe-Ixekizumab kusuka ku-60% kuya ku-81% kulandela umjovo ongaxutshiwe ezifundweni ze-plaque psoriasis. Ukutholakala okuphezulu kwe-bioavailability kufinyelelwe ngomjovo ethangeni uma kuqhathaniswa nezinye izingosi zomjovo ezifana nengalo nesisu.

Impilo yesigamu kusho izinsuku eziyi-13 ezifundweni ezine-plaque psoriasis.

Indlela yokuqeda umzimba ayikaziwa, kepha kulindeleke ukuthi ifane naleyo ye-IgG engapheli enezindlela ezihamba phambili ezikhiqiza ama-peptide amancane nama-amino acid.

Izimo

I-Taltz iyaphikiswa kubantu abane-reaction hypersensitivity eyedlule, njenge-anaphylaxis, eya ku-ixekizumab noma izinciphisi zayo.

Isitoreji

I-Taltz autoinjector nesipontsho esigcwalisiwe kufanele sigcinwe esiqandisini ku-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C).

Ungafrizi. Vikela ekukhanyeni. Unganyakazisi. I-Taltz ingagcinwa ekamelweni lokushisa kuze kufike ku-86 ° F (30 ° C) kuze kube yizinsuku ezinhlanu. Uma igcinwe ekamelweni lokushisa, akufanele ibuyiselwe esiqandisini.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane ilungile ngokweqiniso, ibanzi, futhi isesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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