Umphumela we-Entourage: I-CBD ne-THC zisebenza kanjani ngokubambisana

-Delile

• Umphumela we-Entourage
• Uthini ucwaningo?
• Ukuthatha ama-phytocannabinoids nama-terpenes ndawonye kungahlinzeka ngezinzuzo ezengeziwe zokwelapha
• I-CBD ingasiza ekunciphiseni imiphumela engafuneki ye-THC
• Ama-phytochemicals afana ne-terpenes nama-flavonoids angaba lusizo empilweni yengqondo
• Ucwaningo olwengeziwe luyadingeka
• Yisiphi isilinganiso se-THC ne-CBD esingcono kakhulu?
• Amathiphu wokuzama i-CBD ne-THC
• Ingabe i-CBD isazuzisa ngaphandle kwe-THC?
• Ukudla okudlela endlini

Izitshalo zensangu ziqukethe ama-phytocannabinoid angaphezu kwama-120 ahlukene. Lawa ma-phytocannabinoids asebenza ohlelweni lwakho lwe-endocannabinoid, olusebenza ukugcina umzimba wakho ku-homeostasis, noma ibhalansi.

I-Cannabidiol (i-CBD) ne-tetrahydrocannabinol (iTHC) yizinto ezimbili ze-phytocannabinoids ezicwaningisiswe kahle. Abantu bathatha i-CBD ne-THC ngezindlela ezahlukahlukene, futhi bangadliwa ngokwehlukana noma ndawonye.

Kodwa-ke, olunye ucwaningo lukhombisa ukuthi ukuwahlanganisa - kanye nezinhlanganisela ezincane zezinto eziphilayo esitshalweni se-cannabis, esaziwa ngokuthi i-terpenes noma i-terpenoids - kusebenza kakhulu kunokuthatha i-CBD noma i-THC kuphela.

Lokhu kungenxa yokusebenzisana phakathi kwe-phytocannabinoids ne-terpenes ebizwa ngokuthi "umphumela we-entourage."

Umphumela we-Entourage

Le yinkolelo yokuthi wonke amakhemikhali e-cannabis asebenza ndawonye, ​​futhi uma ehlanganiswa ndawonye akhiqiza umphumela ongcono kunalapho ethathwa yedwa.

Ngakho-ke, ngabe lokho kusho ukuthi kufanele uthathe i-CBD ne-THC ndawonye, ​​noma ingabe zisebenza ngendlela efanayo uma zithathwa ngokwehlukana? Qhubeka ufunde ukuze ufunde kabanzi.

Uthini ucwaningo?

Ukuthatha ama-phytocannabinoids nama-terpenes ndawonye kungahlinzeka ngezinzuzo ezengeziwe zokwelapha

Kunezimo eziningi ezifundwe ngokuhlangana nomphumela weqembu. Ukubuyekezwa kwezifundo zika-2011 kwiBritish Journal of Pharmacology kutholakale ukuthi ukuthatha ama-terpenes nama-phytocannabinoids ndawonye kungasiza:

• ubuhlungu
• ukukhathazeka
• ukuvuvukala
• isithuthwane
• umdlavuza
• ukutheleleka kwefungal

I-CBD ingasiza ekunciphiseni imiphumela engafuneki ye-THC

Abanye abantu baba nemiphumela emibi njengokukhathazeka, indlala, nokuthanjiswa ngemuva kokuthatha i-THC. Amagundane nezifundo zabantu ezihlanganiswe ekubuyekezweni okufanayo kuka-2011 ziphakamisa ukuthi i-CBD ingasiza ekunciphiseni le miphumela emibi.

Ama-phytochemicals afana ne-terpenes nama-flavonoids angaba lusizo empilweni yengqondo

Ucwaningo oluvela ku-2018 luthole ukuthi ama-flavonoids athile nama-terpenes angahlinzeka ngemiphumela yokuvikela ukuvuvukala. Abaphenyi bahlongoza ukuthi lezi zinhlanganisela zingathuthukisa amandla okwelapha e-CBD.

Ucwaningo olwengeziwe luyadingeka

Njengokuningi esikwaziyo nge-cannabis yezokwelapha, umphumela we-entourage uyinkolelo esekelwa kahle manje. Futhi akusilo lonke ucwaningo olutholile ubufakazi bokukuxhasa.

Ucwaningo lwango-2019 luhlolisise ama-terpenes ayisithupha ajwayelekile wedwa futhi ehlanganisiwe. Abaphenyi bathole ukuthi imiphumela ye-THC kuma-cannabinoid receptors i-CB1 ne-CB2 ayishintshanga ngokufakwa kwe-terpenes.

Lokhu akusho ukuthi umphumela we-entourage awukho nhlobo. Kusho nje ukuthi kudingeka olunye ucwaningo. Kungenzeka ukuthi i-terpenes interface ne-THC kwenye indawo ebuchosheni noma emzimbeni, noma ngenye indlela.

Yisiphi isilinganiso se-THC ne-CBD esingcono kakhulu?

Yize kungenzeka ukuthi i-THC ne-CBD basebenza kangcono ngokubambisana kunabodwa, kubalulekile ukukhumbula ukuthi i-cannabis ithinta wonke umuntu ngokuhlukile - futhi izinhloso zawo wonke umuntu zokusebenzisa insangu zihlukile.

Umuntu onesifo sikaCrohn osebenzisa umuthi osuselwa ku-cannabis ukukhululeka kwesicanucanu mhlawumbe uzoba nesilinganiso esifanelekile esihlukile se-THC kuya ku-CBD kunompetha wempelasonto osisebenzisela izinhlungu zemisipha. Akukho mkhawulo noma isilinganiso esisodwa esisebenza kuwo wonke umuntu.

Uma ufuna ukuzama ukuthatha i-CBD ne-THC, qala ngokukhuluma nomhlinzeki wakho wezokunakekelwa kwempilo. Bangakwazi ukunikeza isincomo, futhi bangakweluleka ngokusebenzisana okungenzeka kube khona kwezidakamizwa uma uthatha noma imuphi umuthi.

Futhi, khumbula ukuthi i-THC ne-CBD kungadala imiphumela emibi. I-THC iyasebenza, futhi ingadala ukukhathala, umlomo owomile, izikhathi zokuphendula kancane, ukulahleka kwememori yesikhashana, nokukhathazeka kwabanye abantu. I-CBD ingadala imiphumela emibi njengokushintshwa kwesisindo, isicanucanu, nohudo.

Enye into ebalulekile okufanele uyiqaphele ukuthi insangu ayikho emthethweni ezingeni likahulumeni, kodwa isemthethweni ngaphansi kweminye imithetho yombuso. Uma ufuna ukuzama umkhiqizo oqukethe i-THC, hlola imithetho lapho uhlala khona kuqala.

Amathiphu wokuzama i-CBD ne-THC

• Qala ngomthamo ophansi bese ukhuphuka uma kudingeka.
  • Nge-THC, zama ama-milligram ama-5 (mg) noma ngaphansi uma ungumuntu oqalayo noma umsebenzisi ongajwayelekile.
  • Nge-CBD, zama u-5 kuye ku-15 mg.
• Linga isikhathiukubona ukuthi yini okusebenzelayo. Ungathola ukuthi ukuthatha i-THC ne-CBD ngasikhathi sinye kusebenza kahle kakhulu. Noma, ungakhetha ukusebenzisa i-CBD ngemuva kwe-THC.
• Zama izindlela ezahlukahlukene zokulethwa. I-CBD ne-THC zingathathwa ngezindlela eziningi, kufaka phakathi:
  • amaphilisi
  • izinsizi
  • imikhiqizo yokudla
  • izithako zokuthambisa
  • Izihloko
  • amafu

Inothi mayelana nokuvutha: Hlala wazi ukuthi kunezingozi ezihambisana nokuqhuma. I uncoma ukuthi abantu bagweme iTHC imikhiqizo vape. Uma ukhetha ukusebenzisa umkhiqizo we-THC vape, ziqaphele ngokucophelela. Bona udokotela wakho ngokushesha uma uba nezimpawu ezifana nokukhwehlela, ukuphefumula okuncane, ubuhlungu besifuba, isicanucanu, umkhuhlane, nokwehla kwesisindo.

Ingabe i-CBD isazuzisa ngaphandle kwe-THC?

Abanye abantu abafuni ukuthatha i-THC, kodwa banesifiso sokuzama i-CBD. Kusekhona ucwaningo oluningi oluphakamisa ukuthi i-CBD ingazuzisa yodwa.

Uma ufuna ukuzama i-CBD kodwa ungafuni ukuthatha i-THC, funa umkhiqizo ohlukanisa i-CBD kunomkhiqizo ogcwele we-CBD. Imikhiqizo ephelele ye-CBD iqukethe uhla olubanzi lwama-cannabinoids futhi ingaba ne-0.3% ye-THC. Lokho akwanele ukukhiqiza okuphezulu, kepha kusengabonakala ekuhlolweni kwezidakamizwa.

Ngaphambi kokuba uthenge, qiniseka ukuthi uhlola izithako ukuze uqiniseke ngalokho okutholayo.

Ukudla okudlela endlini

Ama-cannabinoids kanye ne-terpenoids ku-cannabis kucatshangwa ukuthi kuhlangana komunye nomunye kanye nama-receptors obuchopho. Lokhu kusebenzisana kubhalwe ngokuthi "umphumela wabangenela."

Kunobunye ubufakazi bokuthi umphumela we-entourage wenza ukuthatha i-THC ne-CBD ndawonye kuphumelele kangcono kunokodwa.

Kodwa-ke, umphumela wokungena kusengumbono. Ucwaningo oluningi ngesitshalo se-cannabis nokwakhiwa kwalo kwamakhemikhali luyadingeka ngaphambi kokuthi sazi ngokugcwele ngezinzuzo zalo zokwelashwa.

Ingabe i-CBD isemthethweni? Imikhiqizo ye-CBD eyenziwe nge-Hemp (engaphansi kwamaphesenti angu-0,3 iTHC) isemthethweni ezingeni likahulumeni, kepha namanje ayikho emthethweni ngaphansi kweminye imithetho yezwe. Imikhiqizo ye-CBD etholakala ngensangu ayikho emthethweni ezingeni likahulumeni, kodwa isemthethweni ngaphansi kweminye imithetho yezwe.Hlola imithetho yesifundazwe sakho naleyo yanoma iyiphi indawo ohamba kuyo. Khumbula ukuthi imikhiqizo ye-CBD engabhalisiwe ayivunyelwe yi-FDA, futhi ingabhalwa ngokunganembile.

URaj Chander ungumbhali wezeluleko nowokuzimela osebenza kakhulu kwezentengiso yedijithali, ukuqina, nezemidlalo. Usiza amabhizinisi ukuhlela, ukudala, nokusabalalisa okuqukethwe okukhiqiza ukuhola. URaj uhlala eWashington, D.C., lapho ajabulela khona ukuqeqeshwa kwe-basketball namandla ngesikhathi sakhe sokuphumula. Mlandele Twitter.