Okudingeka Ukwazi Ngaphambi Kokuthatha I-Trazodone Yokulala

-Delile

• Yini i-trazodone?
• Ingabe ivunyelwe ukusetshenziswa njengosizo lokulala?
• Yisiphi isilinganiso esivamile se-trazodone njengosizo lokulala?
• Yiziphi izinzuzo ze-trazodone yokulala?
• Yiziphi izingqinamba zokuthatha i-trazodone?
• Ingabe zikhona izingozi zokuthatha i-trazodone ukulala?
• Okubalulekile

Ukuqwasha kungaphezu kokungakwazi ukulala kahle ebusuku. Ukuba nenkinga yokulala noma ukulala kungathinta zonke izici zempilo yakho, kusuka emsebenzini nokudlala kuye empilweni yakho. Uma unenkinga yokulala, udokotela wakho kungenzeka ukuthi uxoxile ngokunquma i-trazodone ukusiza.

Uma ucabanga ukuthatha i-trazodone (Desyrel, Molipaxin, Oleptro, Trazorel, neTrittico), nansi imininingwane ebalulekile ongayicabangela.

Yini i-trazodone?

I-Trazodone ngumuthi kadokotela ovunyelwe ukusetshenziswa yi-Food and Drug Administration (FDA) njenge-anti-depressant.

Lo muthi usebenza ngezindlela eziningi emzimbeni wakho. Esinye sezenzo zayo ukulawula i-neurotransmitter serotonin, esiza amangqamuzana obuchopho ukuthi axhumane futhi athonye imisebenzi eminingi njengokulala, imicabango, imizwa, ukuthanda ukudla nokuziphatha.

Ngisho nasemithamo ephansi, i-trazodone ingakwenza uzizwe ukhululekile, ukhathele futhi ulale. Lokhu ikwenza ngokuvimba amakhemikhali ebuchosheni asebenzisana ne-serotonin namanye ama-neurotransmitters, njenge, 5-HT2A, alpha1 adrenergic receptors, kanye ne-H1 histamine receptors.

Lo mphumela ungaba esinye sezizathu eziyinhloko i-trazodone esebenza njengosizo lokulala.

Njengama-anti-depressants amaningi, i-trazodone ikhishwe "I-Black Box Warning" yi-FDA.

Ukuthatha i-trazodone kukhuphule ubungozi bemicabango yokuzibulala nokuziphatha ezigulini zezingane kanye nabantu abadala. Abantu abathatha lo muthi kufanele babhekwe ngeso lokhozi ukuthola izimpawu eziya ziba zimbi nokuvela kwemicabango yokuzibulala nokuziphatha. I-Trazodone ayivunyelwe ukusetshenziswa ezigulini zezingane.

Ingabe ivunyelwe ukusetshenziswa njengosizo lokulala?

Yize i-FDA ivume i-trazodone ukuthi isetshenziswe njengokwelashwa kokucindezeleka kubantu abadala, iminyaka eminingi odokotela beyibeke futhi njengosizo lokulala.

I-FDA igunyaza imithi yokwelapha izimo ezithile ngokususelwa ekuhlolweni kwemitholampilo. Lapho odokotela bebeka umuthi ngezimo ezingezona ezavunywa yi-FDA, kwaziwa ngokuthi yi-off-label prescribing.

Ukusetshenziswa komuthi ngaphandle kwelebula kuwumkhuba owandile. Amaphesenti angamashumi amabili emithi anikezwe ngaphandle kwelebula. Odokotela bangakhipha imithi ngaphandle kwelebula ngokuya ngesipiliyoni sabo nokwahlulela.

Yisiphi isilinganiso esivamile se-trazodone njengosizo lokulala?

I-Trazodone ivame ukunikezwa ngemithamo phakathi kwe-25mg kuya ku-100mg njengosizo lokulala.

Kodwa-ke, bonisa imithamo ephansi ye-trazodone iyasebenza futhi ingadala ukulala okuncane emini nemiphumela emibi embalwa ngoba umuthi usebenza okufushane.

Yiziphi izinzuzo ze-trazodone yokulala?

Ochwepheshe bancoma ukwelashwa kokuziphatha kwengqondo kanye nokunye ukuguqulwa kokuziphatha njengokwelashwa kokuqala kwezinkinga zokuqwasha nokulala.

Uma lezi zinketho zokwelashwa zingasebenzi kuwe, udokotela wakho angakunikeza i-trazodone yokulala. Udokotela wakho angakubeka futhi uma eminye imithi yokulala, njenge-Xanax, i-Valium, i-Ativan, neminye (imithi emincane ye-benzodiazepine esebenza kancane), ayikakusebenzeli.

Izinzuzo ezimbalwa ze-trazodone zifaka:

• Ukwelashwa okuphumelelayo kokuqwasha. Ukusetshenziswa kwe-trazodone kokuqwasha kutholakale ukuthi umuthi ubusebenza kahle ekuqwashiseni okuyisisekelo kanye nokwesibili ngamanani aphansi.
• Izindleko ezincishisiwe. I-Trazodone ibiza kancane kunemithi ethile yokuqwasha emisha ngoba itholakala ngokujwayelekile.
• Hhayi umlutha. Uma kuqhathaniswa neminye imithi, njengeklasi le-benzodiazepine lemithi efana neValium neXanax, i-trazodone ayiluthisi.
• Kungasiza ukuvimbela ukwehla kwengqondo okuhlobene nobudala. I-Trazodone ingasiza ukuthuthukisa ukulala okuhamba kancane kwe-wave. Lokhu kunganciphisa izinhlobo ezithile zokwehla kwengqondo okuhlobene nobudala njengememori kubantu abadala.
• Kungaba ukukhetha okungcono uma une-apnea yokulala. Eminye imithi yokulala ingathinta kabi ukuvuthwa kokuphefumula kokulala nokuvuka kokulala. Ucwaningo oluncane luka-2014 luthole ukuthi i-100mg ye-trazodone ibe nomthelela omuhle ekuvukeni kokulala.

Yiziphi izingqinamba zokuthatha i-trazodone?

I-Trazodone ingadala imiphumela emibi ethile, ikakhulukazi lapho kuqala umuthi.

Lolu akulona uhlu oluphelele lwemiphumela emibi. Xoxa ngezinto ezikukhathazayo nodokotela wakho noma usokhemisi uma uzizwa uhlangabezana nemiphumela engemihle noma unezinye izinkathazo ngomuthi wakho.

Eminye imiphumela emibi ejwayelekile ye-trazodone ifaka:

• ubuthongo
• isiyezi
• ukukhathala
• uvalo
• umlomo owomile
• izinguquko zesisindo (cishe amaphesenti ama-5 abantu abasithathayo)

Ingabe zikhona izingozi zokuthatha i-trazodone ukulala?

Yize kungavamile, i-trazodone ingadala ukusabela okungathi sína. Shayela u-911 noma abezimo eziphuthumayo zendawo uma uhlangabezana nanoma yiziphi izimpawu ezisongela ukuphila njengokuphefumula kanzima.

Ngokusho kwe-FDA, izingozi ezinkulu zifaka:

• Imicabango yokuzibulala. Le ngozi iphezulu kubantu abadala abasha nasezinganeni.
• Isifo se-Serotonin. Lokhu kwenzeka lapho i-serotonin eningi yakhela emzimbeni futhi ingaholela ekuphenduleni okungathi sína. Ubungozi be-serotonin syndrome bukhulu uma uthatha eminye imithi noma izithasiselo eziphakamisa amazinga e-serotonin njengemithi ethile ye-migraine. Izimpawu zifaka:
  • ukusangana, ukuyaluza, isiyezi, isithuthwane
  • ukukhuphuka kwenhliziyo, ukushisa komzimba, ikhanda
  • ukuthuthumela kwemisipha, ukuqina, inkinga ngokulinganisela
  • isicanucanu, ukuhlanza, isifo sohudo
• Ama-arrhythmias enhliziyo. Ubungozi bokushintshwa kwesigqi senhliziyo bukhulu uma usunezinkinga zenhliziyo.

• Okubalulekile

  I-Trazodone ngumuthi omdala ovunyelwe ukusetshenziswa yi-FDA ngo-1981 njenge-anti-depressant. Yize ukusetshenziswa kwe-trazodone ukulala kuvamile, ngokusho kwemihlahlandlela yakamuva ekhishwe yi-American Academy of Sleep Medicine, i-trazodone akufanele ibe umugqa wokuqala wokwelashwa kokuqwasha.

  Njengoba kunikezwe ngamanani aphansi, kungadala ukulala okuncane emini noma ukozela. I-Trazodone ayiluthisi, futhi imiphumela emibi ejwayelekile ngumlomo owomile, ukozela, isiyezi, nekhanda elikhanyayo.

  I-Trazodone ingahlinzeka ngezinzuzo ezimweni ezithile ezifana ne-apnea yokulala ngaphezu kwezinye izinsiza zokulala.