I-Efavirenz, iLamivudine, neTenofovir

-Delile

• Ngaphambi kokuthatha i-efavirenz, lamivudine, ne-tenofovir,
• I-Efavirenz, lamivudine, ne-tenofovir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Efavirenz, i-lamivudine ne-tenofovir akumele isetshenziselwe ukwelapha ukutheleleka ngegciwane le-hepatitis B (i-HBV; ukutheleleka kwesibindi okuqhubekayo). Tshela udokotela wakho uma unayo noma ucabanga ukuthi ungaba ne-HBV. Udokotela wakho angakuhlola ukuthi unayo yini i-HBV ngaphambi kokuba uqale ukwelashwa kwakho nge-efavirenz, lamivudine ne-tenofovir. Uma une-HBV futhi uthatha i-efavirenz, lamivudine ne-tenofovir, isimo sakho singase sibe sibi ngokungazelelwe lapho uyeka ukuthatha i-efavirenz, lamivudine ne-tenofovir. Udokotela wakho uzokuhlola futhi a-oda izivivinyo zelebhu njalo ezinyangeni ezimbalwa ngemuva kokuyeka ukuthatha i-efavirenz, i-lamivudine ne-tenofovir ukubona ukuthi i-HBV yakho iye yaba yimbi yini.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-efavirenz, lamivudine, naku-tenofovir.

Inhlanganisela ye-efavirenz, lamivudine, ne-tenofovir isetshenziselwa ukwelapha i-HIV kubantu abadala nasezinganeni. I-Efavirenz isekilasini lemithi ebizwa nge-non-nucleoside reverse transcriptase inhibitors (NNRTIs). ILamivudine ne-tenofovir basesigabeni semithi ebizwa nge-nucleoside ne-nucleotide reverse transcriptase inhibitors (NRTIs). Basebenza ngokunciphisa inani le-HIV emzimbeni. Yize i-efavirenz, i-lamivudine ne-tenofovir ingeke iyelaphe i-HIV, le mithi inganciphisa amathuba okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengokutheleleka okunzima noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko kwimpilo yakho kunganciphisa ubungozi bokuthola noma ukudlulisela igciwane le-HIV kwabanye abantu.

Inhlanganisela ye-efavirenz, lamivudine, ne-tenofovir iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku esiswini esingenalutho (okungenani ihora eli-1 ngaphambi noma amahora amabili ngemuva kokudla). Thatha i-efavirenz, lamivudine, ne-tenofovir cishe ngesikhathi esifanayo nsuku zonke. Ukuthatha i-efavirenz, i-lamivudine, ne-tenofovir ngesikhathi sokulala kungenza imiphumela ethile engemihle ingakhathazi kangako. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-efavirenz, lamivudine, ne-tenofovir njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Qhubeka nokudla i-efavirenz, lamivudine, ne-tenofovir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-efavirenz, lamivudine, ne-tenofovir ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-efavirenz, i-lamivudine, ne-tenofovir ngisho noma isikhashana, noma weqa imithamo, igciwane lingazwela emithini futhi kungaba nzima ukuselapha.

Inhlanganisela ye-efavirenz, lamivudine, ne-tenofovir iyatholakala ngamagama ezimpawu weSymfi neSymfi Lo. Le mikhiqizo emibili iqukethe inani elihlukile lomuthi ofanayo, futhi alikwazi ukufakwa endaweni yomunye. Qiniseka ukuthi uthola kuphela uphawu lwe-efavirenz, lamivudine, ne-tenofovir obunikezwe udokotela wakho. Buza usokhemisi wakho uma unemibuzo ngohlobo lwe-efavirenz, lamivudine, ne-tenofovir onikezwe yona.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-efavirenz, lamivudine, ne-tenofovir,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-efavirenz, i-lamivudine, i-tenofovir, noma imuphi omunye umuthi, noma iziphi izithako ezikwi-tablet ye-efavirenz, lamivudine, ne-tenofovir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• kufanele wazi ukuthi i-efavirenz, i-lamivudine ne-tenofovir nayo iyatholakala ngawodwa ngamagama ezimpawu we-Sustiva, Epivir, Epivir-HBV (esetshenziselwa ukwelapha i-hepatitis B), i-Vemlidy (esetshenziselwa ukwelapha i-hepatitis B), ne-Viread, kanye nokuhlanganiswa neminye imithi enamagama ezimpawu e-Atripla, Biktarvy, Combivir, Complera, Descovy, Epzicom, Genvoya, Odefsey, Stribild, Symfi, Triumeq, Trizivir, neTruvada. Tshela udokotela wakho uma uthatha noma iyiphi yale mithi ukuze uqiniseke ukuthi awutholi umuthi ofanayo kabili.
• Tshela udokotela wakho uma uthatha i-elbasvir / grazoprevir (Zepatier). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-efavirenz, lamivudine, ne-tenofovir uma uthatha lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokunganikezwa imishanguzo, amavithamini, izithako zokudla okunempilo ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: acyclovir (Sitavig, Zovirax); i-adefovir (Hepsera); ama-aminoglycosides afana ne-gentamicin; i-artemether / lumefantine (Coartem); i-aspirin neminye imishanguzo yokulwa nokuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); i-atorvastatin (Lipitor, eCaduet); i-atovaquone / proguanil (Malarone); i-bupropion (Forfivo, Wellbutrin, Zyban, abanye); ama-calcium channel blocker afana ne-diltiazem (Cardizem, Cartia, Diltzac, abanye), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), kanye ne-verapamil (Calan, Verelan, eTarka); carbamazepine (Carbatrol, Equetro, Tegretol, abanye); cidofovir; i-cyclosporine (Gengraf, Neoral, Sandimmune); i-ganciclovir (i-cytovene); glecaprevir / pibrentasvir (Mavynet); itraconazole (Sporanox, Onmel); ketoconazole; ledipasvir / sofosbuvir (Harvoni); ama-antibiotic e-macrolide njenge-clarithromycin (i-Biaxin, e-Prevpac); i-methadone (i-Dolophine, i-Methadose); i-phenobarbital; i-phenytoin (iDilantin, ePhenytek); i-posaconazole (Noxafil); i-pravastatin (Pravachol); i-rifabutin (i-Mycobutin); i-rifampin (Rimactane, eRifamate, Rifater); i-sertraline (iZoloft); simeprevir (Olyslo); simvastatin (Flolopid, Zocor, eVytorin); i-sirolimus (i-Rapamune); i-sofosbuvir / velpatasvir (i-Epculsa); i-sofosbuvir / velpatasvir / voxilaprevir (i-Vosevi); i-sorbitol noma imishanguzo enziwe nge-sorbitol; tacrolimus (Astagraf, Envarsus, Prograf); i-trimethoprim (Primsol, eBactrim, Septra); i-valacyclovir (iValtrex); i-valganciclovir (iValcyte); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-efavirenz, lamivudine ne-tenofovir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma unanoma yimiphi imibandela eshiwo esigabeni ESIBALULEKILE SESEXWAYISO, noma uma uke waba nesikhathi sokuphumula se-QT noma isikhathi eside (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe), izinga eliphansi i-potassium noma i-magnesium egazini lakho, izinkinga zamathambo ezibandakanya i-osteoporosis (isimo lapho amathambo eba mncane futhi abuthakathaka futhi aphuke kalula) noma ukuqhekeka kwamathambo, ukuxhuzula, i-hepatitis C noma esinye isifo sesibindi, noma isifo sezinso.Phinda utshele udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, wasebenzisa noma wake wasebenzisa izidakamizwa zasemgwaqweni, wasebenzisa ngokweqile noma wasebenzisa ngokweqile imithi kadokotela, noma wake waba nokudangala noma esinye isifo sengqondo. Ezinganeni ezithatha le mithi, tshela udokotela wakho uma ngabe bake baba ne-pancreatitis noma bake bathola ukwelashwa ngemithi ye-nucleoside analog efana ne-NRTI esikhathini esedlule.
• utshele udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho. Uma ungakhulelwa, kuzofanele ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuthi uqale ukusebenzisa le mithi futhi usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho. I-Efavirenz, lamivudine, ne-tenofovir kungaphazamisa ukusebenza kwemithi yokuvimbela inzalo yamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa, noma imijovo), ngakho-ke akufanele usebenzise lokhu njengendlela yakho kuphela yokulawula ukubeletha ngesikhathi sokwelashwa kwakho. Kufanele usebenzise indlela yokuvimbela yokulawula ukubeletha kanye nanoma iyiphi enye indlela yokulawula ukubeletha oyikhethile ngesikhathi sokwelashwa kwakho kanye namasonto ayi-12 ngemuva komthamo wakho wokugcina. Buza udokotela wakho ukuthi akusize ukhethe indlela yokulawula ukubeletha ezokusebenzela. Uma ukhulelwa ngenkathi uthatha i-efavirenz, i-lamivudine, ne-tenofovir, shayela udokotela wakho ngokushesha.
• akufanele uncelise ibele uma utheleleke nge-HIV noma uthatha i-efavirenz, lamivudine, ne-tenofovir.
• kufanele wazi ukuthi amafutha omzimba wakho angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho, njengasemhlane wakho ongaphezulu, entanyeni (’’ inyathi ’), amabele, nasesizungeze isisu sakho. Ungaqaphela ukulahleka kwamafutha omzimba ebusweni bakho, emilenzeni nasezingalweni.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho noma zidale ukuthi ezinye izimo zivele. Lokhu kungadala ukuthi uthuthukise izimpawu zalezo zifo noma izimo. Uma unezimpawu ezintsha noma eziya ziba zimbi phakathi nokwelashwa kwakho nge-efavirenz, lamivudine, ne-tenofovir qiniseka ukutshela udokotela wakho.
• kufanele wazi ukuthi i-efavirenz, i-lamivudine, ne-tenofovir kungakwenza ube nesiyezi, ukozele, ungakwazi ukugxilisa ingqondo, ube nenkinga yokulala noma ukulala, ube namaphupho angajwayelekile noma ube nemibono (ukubona izinto noma ukuzwa amazwi angekho). Le miphumela emibi ivame ukuphela emavikini amabili kuya kwamane emva kokuqala ukwelashwa. Le miphumela emibi ingaba mibi kakhulu uma uphuza notshwala, noma uphuza eminye imishanguzo efana ne-anti-depressants, imishanguzo yokukhathazeka, imishanguzo yokugula ngengqondo, imishanguzo yokuxhuzula, i-sedatives, amaphilisi okulala noma ama-tranquilizers. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• kufanele wazi ukuthi i-efavirenz, lamivudine, ne-tenofovir kungadala ushintsho emicabangweni yakho, ekuziphatheni, noma empilweni yengqondo. Shayela udokotela wakho ngokushesha uma uba nezimpawu ezilandelayo ngenkathi uthatha i-efavirenz, lamivudine ne-tenofovir: ukudangala, ukucabanga ukuzibulala noma ukuhlela noma ukuzama ukwenza kanjalo, ukuziphatha okuthukuthele noma okunolaka, ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi enza engekho), imicabango engajwayelekile, ukulahleka kokuthintana neqiniso, noma ukungakwazi ukunyakaza noma ukukhuluma ngokujwayelekile. Qiniseka ukuthi umndeni wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukushayela udokotela wakho uma ungakwazi ukufuna ukwelashwa wedwa.
• kufanele wazi ukuthi i-efavirenz ingadala izinkinga zesistimu yezinzwa ezingaba yingozi, kufaka phakathi i-encephalopathy (isifo esibi futhi esingaba yingozi ebuchosheni) izinyanga noma iminyaka ngemuva kokuthatha i-efavirenz, lamivudine, ne-tenofovir kuqala. Yize izinkinga zesistimu yezinzwa zingaqala ngemuva kokuthatha i-efavirenz, lamivudine, ne-tenofovir isikhathi esithile, kubalulekile ukuthi wena nodokotela wakho nazi ukuthi zingabangelwa yi-efavirenz. Shayela udokotela wakho ngokushesha uma uhlangabezana nezinkinga ngebhalansi noma ngokudidiyela, ukudideka, izinkinga zememori, nobunye ubunzima obubangelwa ukusebenza kobuchopho okungavamile, nganoma yisiphi isikhathi ngesikhathi sokwelashwa kwakho nge-efavirenz, lamivudine, ne-tenofovir. Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-efavirenz, i-lamivudine, ne-tenofovir.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Efavirenz, lamivudine, ne-tenofovir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubuhlungu besisu
• isifo sohudo
• isilungulela
• isicanucanu
• ukuhlanza
• iqolo, ukuhlangana, noma ubuhlungu bemisipha
• ukungabi namandla
• ukuluma, ukushisa, noma ukuzwa okubuhlungu ezingalweni noma emilenzeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isifuba, ukuphefumula kanzima noma ukugwinya, ukuvuvukala kobuso, umphimbo, ulimi, izindebe, noma amehlo, ukubhonga
• ukuqubuka, ukuxebuka noma isikhumba esikhanyayo, ukulunywa, umkhuhlane, ukuvuvukala kobuso, izilonda emlonyeni, amehlo abomvu noma avuvukile
• Ubuhlungu obungavamile bemisipha, ukuphefumula kanzima, ubuhlungu besisu, isicanucanu, ukuhlanza, ukuzwa ukubanda ikakhulukazi ezingalweni noma emilenzeni, ukuzwa isiyezi noma ikhanda elikhanyayo, ukukhathala ngokweqile noma ubuthakathaka, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama, izitulo ezinombala okhanyayo, isicanucanu, ukuhlanza, ukulahlekelwa isifiso sokudla, ubuhlungu, ukuqaqanjelwa, noma ubumnene engxenyeni engakwesokudla esiswini, isisu esivuvukele, ukukhathala ngokweqile, ubuthakathaka, ukudideka
• ukuncipha kokuchama, ukuvuvukala kwemilenze
• ubuhlungu bamathambo, ubuhlungu ezingalweni noma emilenzeni, ukuphuka kwethambo, ubuhlungu bemisipha noma ubuthakathaka, ubuhlungu bamalunga
• isithuthwane
• ukuzizwa uphela amandla, unekhanda elincane, noma unesiyezi; ukushaya kwenhliziyo okungajwayelekile noma okusheshayo
• ubuhlungu obuqhubekayo obuqala ngaphezulu kwesobunxele noma maphakathi nesisu kepha bungadlulela emuva, isicanucanu, ukuhlanza

I-Efavirenz, lamivudine, ne-tenofovir kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isiyezi
• unenkinga yokugxila
• ubuthongo
• ubunzima bokulala noma ukulala
• amaphupho angajwayelekile
• ukubona noma ukuzwa izinto ezingekho
• ukunyakaza kwemisipha noma ukuqhaqhazela ongeke ukwazi ukukulawula

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-efavirenz, lamivudine, ne-tenofovir.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Gcina i-efavirenz, i-lamivudine, ne-tenofovir esandleni. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Symfi^®
• Symfi Lo^®

• I-EFV, 3TC ne-TDF