UVincristine: yini, iyini nemiphumela engemihle

-Delile

• Yenzelwe ini
• Isetshenziswa kanjani
• Izimo
• Imiphumela emibi engaba khona

I-Vincristine iyisithako esisebenzayo kumuthi olwa neplastiki owaziwa ngokuthengisa njengo-Oncovin, okhonjiswe ekwelapheni izinhlobo ezahlukahlukene zomdlavuza, kufaka phakathi i-leukemia, umdlavuza wamaphaphu nowebele.

Isenzo saso ukuphazamisa imetabolism yama-amino acid nokuvimbela ukwahlukana kwamaseli, kunciphisa amathuba okuba umdlavuza usabalale emzimbeni.

Lo muthi uyatholakala njengomjovo futhi kufanele unikezwe uchwepheshe wezokunakekelwa kwempilo.

Yenzelwe ini

IVincristine yisidakamizwa esikhonjiswe ekwelapheni lezi zinhlobo zomdlavuza ezilandelayo:

• I-leukemia enamandla ye-lymphoid;
• Neuroblastoma;
• Isimila sikaWilms;
• Umdlavuza webele;
• Umdlavuza wamaphaphu;
• Umdlavuza wesibeletho;
• Umdlavuza wesibeletho;
• Umdlavuza we-Colorectal;
• IHodgkin's kanye ne-non-Hodgkin's lymphoma;
• I-sarcoma ka-Ewing;
• I-Osteosarcoma;
• I-melanoma ebulalayo.

Ngaphezu kwalokho, leli thuluzi liboniswa ekwelapheni i-mycosis fungoides ne-idiopathic thrombocytopenic purpura. Funda ukuthi kuyini nokuthi ungazibona kanjani izimpawu ze-idiopathic thrombocytopenic purpura.

Isetshenziswa kanjani

Lo muthi kufanele unikezwe ngemithambo yegazi, nguchwepheshe wezempilo, futhi umthamo nesikhathi sokwelapha kufanele kunqunywe yi-oncologist.

Ngokuvamile, umthamo unje:

Abantu abadala

• 0.01 kuya ku-0.03 mg weVincristine nge-kg yesisindo somzimba, njengomthamo owodwa, njalo ezinsukwini eziyi-7.

Izingane

• Ngenhla kwe-10 kg: Lawula u-1.5 kuya ku-2 mg weVincristine ngemitha eyisikwele engaphezulu yomzimba, njengomthamo owodwa, njalo ezinsukwini eziyi-7;
• Ngama-10 kg noma ngaphansi: Lawula u-0.05 mg weVincristine nge-kg yesisindo somzimba, njengomthamo owodwa, njalo ezinsukwini eziyi-7.

Isikhathi sokwelashwa kufanele sinqunywe yi-oncologist.

Izimo

Lo muthi uphikisiwe kubantu abane-hypersensitivity ezingxenyeni zefomula nasezigulini ezinefomu lokudonswa phansi kwe-Charcot-Marie-Tooth syndrome.

Ngaphezu kwalokho, akufanele futhi isetshenziswe ngabesifazane abakhulelwe nabesifazane abancelisayo okufanele bayeke ukuncelisa ngenkathi belashwa nge-vincristine.

Imiphumela emibi engaba khona

Eminye yemiphumela emibi kakhulu engenzeka ngesikhathi sokwelashwa nge-vincristine ukulahleka kwezinwele, ukuqunjelwa, ubuhlungu bomzimba, ukwehla kwamaseli amhlophe egazi, ukulahlekelwa umuzwa, ubunzima bokuhamba nokulahleka kwengqondo.

Imiphumela emibi kakhulu engaba khona yizinkinga ze-neuromuscular.