I-Biologics kanye neCrohn's Disease Remission: Okudingeka Ukwazi

-Delile

• Ukuthi i-biologics ihlose kanjani ukuvuvukala
• Ungasho kanjani ukuthi usuthethelelweni
• Isebenza kanjani i-biologics?
• Yini ama-biosimilars?
• Ukwelashwa ngenkathi uxolelwe
• Ukuthatha

Ukubuka konke

Ngo-1932, uDkt Burrill Crohn nozakwabo ababili baletha iphepha ku-American Medical Association bachaza imininingwane yalokho manje esikubiza ngokuthi isifo sikaCrohn.

Kusukela lapho, izinketho zokwelashwa ziye zavela ukuze zifake i-biologics, okuyizidakamizwa ezenziwe ngamaseli aphilayo enzelwe ukukhomba ukuvuvukala.

Ukuvuvukala kuyimbangela eyinhloko yezimpawu zesifo sikaCrohn nezinkinga. Uma ukhululekile, ukuvuvukala kwakho kuyaphela. Lapho uhlangabezana nokuqubuka kukaCrohn, ukuvuvukala kwakho kuyabuya.

Yize lungekho ikhambi likaCrohn's, inhloso yokwelashwa ukunciphisa ukuvuvukala ukuze kufakwe lesi sifo ekuxolelweni, nokusigcina lapho.

Ukuthi i-biologics ihlose kanjani ukuvuvukala

I-tumor necrosis factor, noma i-TNF, yiprotheni elenza ukuvuvukala njengengxenye yempendulo yesistimu yomzimba. I-anti-TNF biologics isebenza ngokukhomba le protein ukunciphisa izakhiwo zayo zokuvuvukala.

Uma uthatha i-Remicade (infliximab), i-Humira (i-adalimumab), i-Cimzia (i-certolizumab), noma i-Simponi (i-golimumab), uthatha i-anti-TNF biologic.

Ngesifo sikaCrohn, amasosha akho omzimba athumela amangqamuzana amhlophe egazi amaningi kakhulu emgudwini wamathumbu (GI), odala ukuvuvukala. Enye indlela i-biologics ekhomba ngayo ukuvuvukala ukubhekana nodaba lokuba namaseli egazi amhlophe amaningi kakhulu ku-GI tract.

I-Entyvio (vedolizumab) neTysabri (natalizumab) zisebenza ngale ndlela. Avimba amaseli amhlophe egazi angene esiswini. Lesi senzo sokuvimba sigcina amangqamuzana amhlophe egazi kude namathumbu, lapho abengadala khona ukuvuvukala. Ngokulandelayo, lokhu kuvumela indawo ukuthi yelapheke.

I-Biologics ingakhomba ezinye izindlela emzimbeni eziholela ekuvukeleni. I-Stelara (ustekinumab) iyi-interleukin inhibitor. Ihlose amaprotheni amabili akhethekile okucatshangwa ukuthi abangela ukuvuvukala. Abantu abane-Crohn's banamazinga aphezulu ala maprotheni emzimbeni wabo.

Ngokukhomba lawa maprotheni, uStenara uvimba ukuvuvukala kwepheshana le-GI futhi anciphise izimpawu zesifo sikaCrohn.

Ungasho kanjani ukuthi usuthethelelweni

Kujwayelekile ukuba nezinsuku ezinhle nezinsuku ezimbi lapho une-Crohn's, ngakho-ke wazi kanjani ukuthi usethethelelweni hhayi nje ukuba nezinsuku ezimbalwa ezinhle?

Kunezici ezimbili zokuxolelwa. Ukuxolelwa komtholampilo kusho ukuthi awunazo izimpawu ezibonakalayo. Ukuthethelelwa kwezicubu kusho ukuthi ukuhlolwa kukhombisa ukuthi izilonda zakho ziyaphola kanti negazi lakho linamazinga ajwayelekile okuvuvukala.

Udokotela wakho usebenzisa okuthile okubizwa ngokuthi yi-Crohn's disease activity index (CDAI) ukukala izinga iCrohn's yakho elisebenza ngalo noma elithethelelwa ngalo. I-CDAI ibheka izimpawu zakho, njengenombolo yokuhamba kwamathumbu nokuthi uzizwa kanjani.

Kubuye kubheke nezinkinga zesifo sikaCrohn nemiphumela yokuhlolwa kwakho.

Noma ngabe usethethelelweni, kujwayelekile ukuthi i-biopsy ikhombise ushintsho oluncane kwizicubu zakho ezibonisa ukuvuvukala kwangaphambilini. Kwesinye isikhathi, esimweni sokuxolelwa isikhathi eside futhi okujulile, imiphumela ye-biopsy ijwayelekile, kepha lokhu akuvamile ukwenzeka.

Isebenza kanjani i-biologics?

Ama-biologics akugcina ekuxolelweni ngokuvimbela impendulo yokuvuvukala ngokweqile kwesistimu yakho yomzimba. Uma uyeka imithi yakho ngenkathi uxolelwe, usengozini enkulu yokuphendula ku-trigger nge-flare.

Ngezinye izikhathi izimbangela kungaba nzima ukubikezela. Ezinye, ezifana nokulandelayo, kulula ukuzibona:

• izinguquko zokudla
• ukubhema ugwayi
• imithi iyashintsha
• ukucindezeleka
• ukungcoliswa komoya

Uma unemithi ngenkathi uvezwa yizimbangela, isifo sakho seCrohn mancane amathuba okuthi sisebenze.

Yini ama-biosimilars?

Ama-biosimilars yizinguqulo zakamuva ze-biologics ezinesakhiwo esifanayo, ukuphepha nokusebenza kahle. Akuzona izinhlobo ezijwayelekile zama-biologics woqobo. Esikhundleni salokho, angamakhophi e-biologics yoqobo amalungelo awo obunikazi aphelelwe yisikhathi.

Ngokuvamile zibiza kancane futhi ziyasebenza ekugcineni ukuxolelwa.

Ukwelashwa ngenkathi uxolelwe

Uma usuthethelele, ungalingeka ukuthi uyeke ukwelashwa. Uma wenza kanjalo, uzibeka engcupheni yokuthola ukuvuleka okusha.

Uma uyeka ukuthatha imishanguzo yakho, kunethuba lokuthi kungenzeka ingasebenzi futhi ngokuzayo lapho usunenkani. Lokhu kungenxa yokuthi uma uyeka ukuthatha i-biologic, umzimba wakho ungakhula amasosha omzimba alwa nalesi sidakamizwa, okwenza kungasebenzi kahle ngokuzayo.

Kungaholela nasekuziphenduleni okubi.

I-biologics icindezela amasosha akho omzimba, okubeka engcupheni yokutheleleka. Ngenxa yalokhu, kunezimo ezithile lapho udokotela wakho angakweluleka ukuthi uthathe ikhefu lemithi. Lokhu kufaka phakathi:

• ukuhlinzwa
• imigomo
• ukukhulelwa

Ngaphandle kwalokho, umkhuba onconywayo ukuhlala emithini noma ngabe uthethelelwe.

Ucwaningo lukhombisile ukuthi cishe isigamu nje sabantu abayekayo ukusebenzisa i-anti-TNF biologic yabo ngenkathi bekhululiwe empeleni bahlala ekuxolelweni isikhathi esingaphezu kweminyaka emibili, futhi lelo nani liyancipha ngokuhamba kwesikhathi.

Ukuthatha

Umgomo wokwelashwa kukaCrohn ukuthola nokugcina ukuxolelwa. Imithi ephuthelwe ingaholela ekuqhumeni. Kubalulekile ukusebenza nodokotela wakho ukusungula isu elihle kakhulu lokuhlala uxolelwe. Lokhu kufaka phakathi ukuhlolwa njalo nokugcina umuthi wakho wemithi.