I-Zika Virus Kungenzeka Isetshenziselwe Ukwelapha Izinhlobo Ezihlukumezayo Zomdlavuza Wengqondo Esikhathini Esizayo

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Igciwane leZika belilokhu libhekwa njengosongo oluyingozi, kodwa ekuphendukeni okumangalisayo kwezindaba zeZika, abacwaningi baseWashington University School of Medicine nase-University of California School of Medicine manje bakholelwa ukuthi leli gciwane lingasetshenziswa njengekhambi lokubulala. amangqamuzana anomdlavuza okunzima ukuwaphatha ebuchosheni.

I-Zika igciwane elithwalwa omiyane elikhathaza kakhulu abesifazane abakhulelwe ngenxa yezixhumanisi zalo ku-microcephaly, ukukhubazeka kokuzalwa okwenza ikhanda lomntwana libe lincane kakhulu. Abantu abadala abadalulwe yigciwane futhi bangaba nezizathu zokukhathazeka ngoba kungenzeka kube nomthelela ezimweni ezinjengokulahleka kwememori yesikhathi eside nokudangala. (Kuhlobene: Icala Lokuqala Lokutheleleka Kwe-Zika Kwasendaweni Kulo nyaka Lisanda Kubikwa E-Texas)

Kuzo zombili lezi zimo, iZika ithinta amangqamuzana ezinhlayiya ebuchosheni, yingakho ososayensi bekholelwa ukuthi leli gciwane lingasiza ekubulaleni amaseli ama-stem afanayo ezicutshini zobuchopho.

"Sithatha igciwane, sifunde ukuthi lisebenza kanjani bese siyalisebenzisa," kusho uMichael S. Diamond, MD, Ph.D., uprofesa wezokwelapha eWashington University School of Medicine kanye nombhali omkhulu wocwaningo, kusho ezindabeni. ukukhululwa. "Ake sisebenzise lokho okuhle ekusetshenzisweni, sikusebenzise ukuqeda amaseli esingafuni. Thatha amagciwane angajwayela ukwenza umonakalo othile futhi awenze enze okuhle."

Besebenzisa imininingwane abayiqoqe ngokuthi iZika isebenza kanjani, ososayensi benze enye inguqulo yegciwane amasosha omzimba wethu angalihlasela ngempumelelo, uma kungenzeka lixhumane namaseli aphilile. Babe sebejova le nguqulo entsha emangqamuzaneni e-glioblastoma (okuyindlela ejwayelekile yomdlavuza wobuchopho) ebisuswe ezigulini zomdlavuza.

Leli gciwane likwazile ukubulala amangqamuzana esiqu somdlavuza avame ukumelana nezinye izinhlobo zokwelashwa, kubandakanya nokwelashwa ngamakhemikhali. Iphinde yahlolwa kumagundane anezimila ebuchosheni futhi yakwazi ukunciphisa izingxenyana ezinomdlavuza. Akukhona lokho kuphela, kodwa amagundane athola ukwelashwa okuphefumulelwe i-Zika aphila isikhathi eside kunalawo aphathwa nge-placebo.

Ngenkathi kungakaze kube nokuhlolwa komtholampilo komuntu, lokhu kuyimpumelelo enkulu yabantu abangu-12,000 abathinteka yi-glioblastoma ngonyaka.

Isinyathelo esilandelayo ukubona ukuthi ngabe leli gciwane lingabulala amangqamuzana ama-tumor stem kumagundane. Ukusuka lapho, abacwaningi bazodinga ukuqonda iZika kangcono futhi bafunde kahle Kanjani futhi ngani iqondise kumaseli omdlavuza ebuchosheni futhi uma ingasetshenziswa ukwelapha nezinye izinhlobo zomdlavuza onamandla.

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