Izimpawu Nezimpawu Ze-Zinc Overdose

-Delile

• 1. Ukucanuzela kwenhliziyo nokuHlanza
• 2. Ubuhlungu besisu nohudo
• 3. Izimpawu Ezinjengomkhuhlane
• 4. I-cholesterol Engaphansi Ye-HDL
• 5. Izinguquko ekunambithekeni kwakho
• 6. Ukushoda Kwethusi
• 7. Ukutheleleka Njalo
• Izinketho Zokwelapha
• Okusemqoka

I-Zinc iyiminerali ebalulekile ebandakanyeka ekuphenduleni kwamakhemikhali angaphezu kwekhulu emzimbeni wakho.

Kuyadingeka ekukhuleni, ukuhlanganiswa kwe-DNA nokubona ukunambitheka okujwayelekile. Iphinde isekele ukuphulukiswa kwesilonda, ukusebenza komzimba kanye nempilo yokuzala (1).

Iziphathimandla zezempilo zibeke izinga lokudla okuphezulu elibekezelelekayo (i-UL) le-zinc ku-40 mg ngosuku kubantu abadala. I-UL inani eliphakanyisiwe nsuku zonke lomsoco. Kubantu abaningi, leli nani akunakwenzeka ukuthi lidale imiphumela emibi (1, 2).

Imithombo yokudla ephezulu ye-zinc ifaka inyama ebomvu, izinkukhu, izinhlanzi zasolwandle, okusanhlamvu okuphelele nokusanhlamvu okuqinisiwe. Ama-oysters aqukethe inani eliphakeme kakhulu, kuze kufike kuma-493% wenani lansuku zonke nge-3-ounce (85-gram) ekhonza (1).

Yize okunye ukudla kunganikeza amanani ngaphezulu kwe-UL, awekho amacala abikiwe obuthi be-zinc avela ku-zinc eyenzeka ngokwemvelo ekudleni (2).

Kodwa-ke, ubuthi be-zinc bungavela kwizithako zokudla, kufaka phakathi ama-multivitamin, noma ngenxa yokungeniswa ngengozi kwemikhiqizo yasendlini equkethe i-zinc.

Nazi izimpawu nezimpawu ezi-7 zokudlula ngokweqile kwe-zinc.

1. Ukucanuzela kwenhliziyo nokuHlanza

I-nausea nokuhlanza kuvame ukubikwa ngemiphumela emibi yobuthi be-zinc.

Ukubuyekezwa kwezifundo eziyi-17 ngokusebenza kwezithako ze-zinc ekwelapheni umkhuhlane ovamile kwatholakala ukuthi i-zinc inganciphisa isikhathi somkhuhlane, kepha imiphumela emibi yayijwayelekile. Eqinisweni, ama-46% wabahlanganyeli bokutadisha abike isicanucanu ().

Imithamo emikhulu kuno-225 mg ine-emetic, okusho ukuthi ukuhlanza kungenzeka futhi kungenzeka ngokushesha. Kwesinye isimo, isicanucanu esinzima nokuhlanza kwaqala emizuzwini engama-30 ngemuva komthamo owodwa we-zinc ka-570 mg (4,).

Kodwa-ke, ukuhlanza kungenzeka nasemazingeni aphansi. Esifundweni esisodwa samasonto ayisithupha kubantu abangama-47 abaphilile abathatha ama-150 mg we-zinc ngosuku, ngaphezu kwengxenye abanesicanucanu nokuhlanza ().

Yize ukuhlanza kungasiza ukukhipha umzimba kumanani anobuthi we-zinc, kungahle kunganele ukuvimbela ezinye izinkinga.

Uma udle amanani anobuthi we-zinc, funa usizo lwezokwelapha khona manjalo.

I-nausea nokuhlanza kuyinto ejwayelekile futhi evame ukusabela ngokushesha lapho kufakwa amanani anobuthi we-zinc.

2. Ubuhlungu besisu nohudo

Imvamisa, ubuhlungu besisu nohudo kwenzeka ngokubambisana nesicanucanu nokuhlanza.

Kokunye ukubuyekezwa kwezifundo eziyi-17 mayelana nezithasiselo ze-zinc nokubanda okuvamile, cishe abahlanganyeli abangama-40% babike ubuhlungu besisu nohudo ().

Yize kungajwayelekile kangako, ukubikwa kwamathumbu nokopha kwamathumbu nakho kubikiwe.

Kokunye ukufundwa, umuntu othile wezwa ukopha emathunjini ngemuva kokuthatha ama-220 mg we-zinc sulfate kabili ngosuku ukwelashwa induna ().

Ngaphezu kwalokho, ukugxila kwe-zinc chloride enkulu kune-20% kuyaziwa ukuthi kubangele ukulimala okubanzi kwepheshana lesisu (,).

I-zinc chloride ayisetshenziswanga kwizithasiselo zokudla, kepha ubuthi bungavela ekungenisweni ngengozi kwemikhiqizo yasendlini. Ama-adhesives, ama-sealant, ama-soldering flux, amakhemikhali okuhlanza kanye nemikhiqizo yokuqeda ukhuni konke kuqukethe i-zinc chloride.

Ubuhlungu besisu kanye nohudo yizimpawu ezivamile zobuthi be-zinc. Kwezinye izimo, umonakalo omkhulu wamathumbu nokopha kungenzeka.

3. Izimpawu Ezinjengomkhuhlane

Ukuthatha i-zinc eningi kune-UL esunguliwe kungadala izimpawu ezinjengomkhuhlane, njengomkhuhlane, ukugodola, ukukhwehlela, ikhanda elibuhlungu nokukhathala ().

Lezi zimpawu zenzeka ezimweni eziningi, kufaka phakathi nezinye izinto ezinobuthi zamaminerali. Ngakho-ke, ukuxilonga ubuthi be-zinc kungaba nzima.

Udokotela wakho angadinga umlando wakho oningiliziwe wezokwelapha nowokudla, kanye nokuhlolwa kwegazi, ukuthola ubuthi obusolwa ngamaminerali.

Uma uthatha izithasiselo, qiniseka ukuthi uzidalula kumhlinzeki wakho wezokunakekelwa kwempilo.

Izimpawu ezinjengomkhuhlane zingenzeka ngenxa yamanani anobuthi wamaminerali amaningana, kufaka phakathi i-zinc. Ngakho-ke, kubalulekile ukudalula zonke izithako kumhlinzeki wakho wezokunakekelwa kwempilo ukuqinisekisa ukwelashwa okufanele.

4. I-cholesterol Engaphansi Ye-HDL

“Okulungile” i-cholesterol ye-HDL yehlisa ingozi yesifo senhliziyo ngokususa i-cholesterol kumaseli akho, ngaleyo ndlela ivimbele ukwakheka kocwecwe lwemithambo.

Kubantu abadala, iziphathimandla zezempilo zincoma ukuthi i-HDL ibe ngaphezu kuka-40 mg / dL. Amazinga aphansi akubeka engcupheni ephezulu yesifo senhliziyo.

Ukubuyekezwa kwezifundo eziningana emazingeni e-zinc ne-cholesterol kusikisela ukuthi ukufaka ngaphezu kuka-50 mg we-zinc ngosuku kunganciphisa amazinga akho “amahle” e-HDL futhi kungabi namthelela ku-cholesterol yakho “embi” ye-LDL (,,).

Ukubuyekezwa futhi kusho ukuthi imithamo ye-30 mg ye-zinc ngosuku - engaphansi kwe-UL ye-zinc - ayizange ibe nemiphumela ku-HDL lapho ithathwa kuze kube amasonto ayi-14 ().

Ngenkathi izinto eziningana zithinta amazinga e-cholesterol, lokhu okutholakele kuyinto okufanele uyicabangele uma uthatha izithasiselo ze-zinc njalo.

Ukufakwa njalo kwe-zinc ngaphezu kwamazinga anconyiwe kungadala ukwehla kwamazinga “amahle” e-HDL cholesterol, okungakubeka engcupheni enkulu yesifo senhliziyo.

5. Izinguquko ekunambithekeni kwakho

I-Zinc ibalulekile emuzwa wakho wokunambitha. Eqinisweni, ukuntuleka kwe-zinc kungaholela esimweni esibizwa nge-hypogeusia, ukungasebenzi ekhonweni lakho lokunambitha (1).

Kuyathakazelisa ukuthi i-zinc edlula amazinga anconyiwe nayo ingadala ukuguqulwa kokunambitha, kufaka phakathi ukunambitheka okungalungile noma kwensimbi emlonyeni wakho.

Imvamisa, lolu phawu lubikwa ezifundweni eziphenya i-zinc lozenges (amaconsi okukhwehlela) noma izithasiselo zoketshezi zokwelapha umkhuhlane ovamile.

Ngenkathi ezinye izifundo zibika imiphumela ezuzisayo, imithamo esetshenzisiwe ivame ukuba ngaphezu kwe-UL ka-40 mg ngosuku, futhi imiphumela emibi ijwayelekile ().

Isibonelo, i-14% yabahlanganyeli ocwaningweni lwesonto elilodwa bakhala ngokuhlanekezelwa kokunambitheka ngemuva kokuqedwa kwamaphilisi e-25-mg zinc emlonyeni wabo njalo emahoreni amabili ngenkathi bevukile ().

Kwesinye isifundo kusetshenziswa isengezo samanzi, abahlanganyeli abangama-53% babike ukunambitheka kwensimbi. Kodwa-ke, akucaci ukuthi lezi zimpawu zihlala isikhathi esingakanani ().

Uma usebenzisa ama-lozenji e-zinc noma izengezo zoketshezi, yazi ukuthi lezi zimpawu zingavela noma ngabe umkhiqizo uthathwa njengokuyalelwa (16).

IZinc idlala indima ekuboneni ukunambitheka. I-zinc eyeqile ingadala ukunambitheka kwensimbi emlonyeni wakho, ikakhulukazi uma kuthathwa njenge-lozenge noma isengezo soketshezi.

6. Ukushoda Kwethusi

Zinc nethusi zincintisana nokumuncwa emathunjini akho amancane.

Imithamo ye-zinc ngenhla kwe-UL esunguliwe ingaphazamisa amandla omzimba wakho wokuthola ubhedu. Ngokuhamba kwesikhathi, lokhu kungadala ukushoda kwethusi (2).

Njenge-zinc, ithusi liyiminerali ebalulekile. Isiza ukumuncwa kwensimbi kanye ne-metabolism, okwenza kudingeke ukwakheka kwamangqamuzana egazi abomvu. Iphinde ibambe iqhaza ekwakheni amangqamuzana amhlophe egazi ().

Amangqamuzana abomvu egazi athutha umoya-mpilo emzimbeni wakho, kuyilapho amangqamuzana amhlophe egazi engabadlali abalulekile ekusebenzeni komzimba wakho.

Ukushoda kwethusi okwenziwe yi-Zinc kuhlotshaniswa nokuphazamiseka kwegazi okuningana (,,):

• Ukushoda kwe-iron anemia: Ukuntuleka kwamaseli abomvu abomvu enempilo ngenxa yenani elinganele lensimbi emzimbeni wakho.
• I-anemia ye-Sideroblastic: Ukushoda kwamaseli abomvu abomvu enempilo ngenxa yokwehluleka ukusebenzisa i-iron ngendlela efanele.
• I-Neutropenia: Ukushoda kwamaseli egazi amhlophe anempilo ngenxa yokuphazamiseka ekwakhekeni kwawo.

Uma ushoda ngethusi, ungaxubi izengezo zakho zethusi ne-zinc.

Imithamo ejwayelekile ye-zinc engaphezulu kwama-40 mg ngosuku ingavimbela ukumunca ithusi. Lokhu kungaholela ekushodeni kwethusi, okuhambisana nokuphazamiseka kwegazi okuningana.

7. Ukutheleleka Njalo

Yize i-zinc idlala indima ebalulekile ekusebenzeni kwamasosha omzimba, i-zinc eningi ingacindezela ukuphendula komzimba wakho ().

Lokhu kuvame ukuba nomphumela oseceleni we-anemias kanye ne-neutropenia, kepha futhi kukhonjisiwe ukuthi kwenzeka ngaphandle kokuphazamiseka kwegazi okubangelwa i-zinc.

Ezifundweni ze-test-tube, i-zinc eyeqile inciphise ukusebenza kwamaseli we-T, uhlobo lweseli elimhlophe legazi. Amaseli we-T adlala indima enkulu ekuphenduleni komzimba wakho ngokunamathisela nokubhubhisa amagciwane ayingozi (,,).

Izifundo zabantu nazo ziyakusekela lokhu, kepha imiphumela ayihambisani kangako.

Ucwaningo oluncane emadodeni ayi-11 enempilo luthole ukuncipha kokuphendula komzimba ngemuva kokumunca u-150 mg we-zinc kabili ngosuku amasonto ayisithupha ().

Kodwa-ke, ukwengeza nge-110 mg ye-zinc kathathu ngosuku inyanga eyodwa kube nemiphumela exubile kubantu abadala asebekhulile. Abanye babhekana nokuncipha kokuphendula komzimba, kanti abanye banempendulo ethuthukisiwe ().

Ukuthatha izithasiselo ze-zinc ngemithamo engaphezulu kwe-UL kunganciphisa ukuphendula komzimba wakho, kukushiye usengozini yokugula kanye nezifo.

Izinketho Zokwelapha

Uma ukholwa ukuthi kungenzeka ukuthi uhlangabezana nobuthi be-zinc, xhumana nendawo yakho yokulawula ubuthi ngokushesha.

Ubuthi beZinc bungasongela impilo. Ngakho-ke, kubalulekile ukufuna usizo lwezokwelapha ngokushesha.

Ungase weluleke ukuthi uphuze ubisi, ngoba inani eliphakeme le-calcium ne-phosphorus ekulo lingasiza ekuvimbeleni ukumuncwa kwe-zinc engxenyeni yamathumbu. Amalahle asebenzayo anomthelela ofanayo ().

Ama-Chelating agents nawo asetshenzisiwe ezimeni ezinobuthi ezinzima. Lokhu kusiza ukususa umzimba nge-zinc eyeqile ngokuwubophela egazini. Bese ixoshwa emchameni wakho, kunokungena kumaseli akho.

Ubuthi be-Zinc buyisimo esisongela impilo. Kubalulekile ukufuna usizo lwezokwelapha ngokushesha.

Okusemqoka

Yize okunye ukudla kuqukethe i-zinc ngenhla kwe-UL yama-40 mg ngosuku, awekho amacala obuthi be-zinc avela ku-zinc eyenzeka ngokwemvelo ekudleni abikiwe.

Kodwa-ke, ukweqisa ngokweqile kwe-zinc kungenzeka kusuka kwizengezo zokudla noma ngenxa yokungenisa ngokweqile ngengozi.

Ubuthi beZinc bungaba nemiphumela emibi futhi engalapheki. Ubukhulu bezimpawu zakho buxhomeke kakhulu ebangeni nasikhathi sokudla.

Ngokungeniswa okunamandla kwamanani aphezulu e-zinc, kungenzeka izimpawu zesisu. Ezimweni ezimbi kakhulu, njengokungeniswa ngengozi kwemikhiqizo yasendlini equkethe i-zinc, ukugqwala kwamathumbu nokopha.

Ukusetshenziswa kwesikhathi eside kungadala imiphumela engemihle ngokushesha kodwa ebucayi, njenge-cholesterol enhle “enhle” ye-HDL, ukuntuleka kwethusi kanye nohlelo lokuvikela omzimba olucindezelwe.

Sekukonke, kufanele weqe kuphela i-UL esungulwe ngaphansi kweso lophiko lwezokwelapha.