Isimila sepancreatic islet cell

Isigaxa se-pancreatic islet cell isimila esingajwayelekile samanyikwe esiqala ngohlobo lweseli elibizwa ngokuthi i-islet cell.

Kuma-pancreas anempilo, amaseli abizwa ngokuthi ama-islet cells akhiqiza ama-hormone alawula imisebenzi eminingana yomzimba. Lokhu kufaka phakathi izinga likashukela egazini nokukhiqizwa kwesisu esiswini.

Izimila ezivela kumaseli we-islet of the pancreas nazo zingakhiqiza izinhlobo ezahlukahlukene zamahomoni, ezingaholela ezimpawu ezithile.

Izidumbu zesifo se-Pancreatic islet cancancerous (benign) noma umdlavuza (ebulalayo).

Izicubu ze-Islet cell zifaka:

• I-Gastrinoma (iZollinger-Ellison syndrome)
• IGlucagonoma
• Insulinoma
• Somatostatinoma
  
• I-VIPoma (Verner-Morrison syndrome)

Umlando womndeni we-endocrine neoplasia eminingi, yohlobo I (MEN I) iyinto eyingozi ekuthuthukiseni izicubu zamaseli we-islet.

Izimpawu zincike ekutheni i-hormone yenziwa yiphi isimila.

Isibonelo, ama-insulinomas akhiqiza i-insulin, eyehlisa izinga likashukela egazini. Izimpawu zingafaka:

• Ukuzizwa ukhathele noma ubuthakathaka
• Ukuthuthumela noma ukujuluka
• Ubuhlungu bekhanda
• Indlala
• Ukwesaba, ukukhathazeka, noma ukuzwa ukucasuka
• Ukucabanga okungacacile noma ukuzizwa ungakhululekile
• Umbono ophindwe kabili noma ofiphele
• Ukushaya kwenhliziyo okusheshayo noma okushaya ngamandla

Uma izinga likashukela egazini lakho liphansi kakhulu, ungaquleka, uquleke, noma uze uquleke.

I-Gastrinomas yenza i-hormone gastrin, etshela umzimba ukuthi wenze i-asidi esiswini. Izimpawu zingafaka:

• Ubuhlungu besisu
• Uhudo
• Izilonda esiswini kanye namathumbu amancane
• Ukuhlanza igazi (ngezikhathi ezithile)

Ama-glucose enza i-hormone glucagon, esiza umzimba ukukhulisa izinga likashukela egazini. Izimpawu zingafaka:

• Isifo sikashukela
• Okubomvu, ukuqubuka kwamabhamuza emgodini noma ezinqeni
• Ukwehla kwesisindo
• Ukuchama kaningi nokoma

AmaSomatostatinomas enza i-hormone somatostatin. Izimpawu zingafaka:

• Ushukela ophakeme wegazi
• Amatshe amatshe amade
• Ukubukeka okuphuzi kwesikhumba, namehlo
• Ukwehla kwesisindo
• Uhudo olunezihlalo ezinuka kabi

I-VIPomas yenza i-hormone vasoactive intestinal peptide (i-VIP) ebandakanyeka ekugcineni ibhalansi kasawoti, i-sodium, i-potassium namanye amaminerali asepheshaneni le-GI. Ama-VIPomas angadala:

• Uhudo olunamandla olungase luholele ekuphelelweni amanzi emzimbeni
• Izinga eliphansi le-potassium yegazi, namazinga aphezulu e-calcium
• Amajaqamba esiswini
• Ukwehla kwesisindo

Umhlinzeki wakho wokunakekelwa kwezempilo uzothatha umlando wakho wezokwelapha futhi enze ukuhlolwa komzimba.

Ukuhlolwa kwegazi kungahluka, kuye ngezimpawu, kepha kungafaka:

• Ukuzila izinga le-glucose
• Izinga le-Gastrin
• Ukuhlolwa kokubekezelelana kwe-glucose
• Isivivinyo se-Secretin sokukhuthaza amanyikwe
• Izinga le-glucagon yegazi
• I-insulin yegazi C-peptide
• Izinga le-insulin yegazi
• Ukuzila i-serum somatostatin level
• Izinga le-Serum vasoactive intestinal peptide (VIP)

Ukulingisa ukuhlolwa kungenziwa:

• Iskena se-CT esiswini
• I-ultrasound yesisu
• I-endoscopic ultrasound
• I-MRI yesisu

Isampula yegazi nayo ingathathwa emthanjeni osezinyeni ukuze kuhlolwe.

Kwesinye isikhathi, kudingeka ukuhlinzeka ukuze kutholakale lesi sifo. Phakathi nale nqubo, udokotela ohlinzayo uhlola amanyikwe ngesandla nange-ultrasound.

Ukwelashwa kuya ngohlobo lwesimila futhi uma kunomdlavuza.

Izimila ezinomdlavuza zingakhula ngokushesha futhi zisabalale ziye kwezinye izitho zomzimba. Kungenzeka zingalapheki. Izicubu zivame ukususwa ngokuhlinzwa, uma kungenzeka.

Uma amangqamuzana omdlavuza esakazekela esibindi, ingxenye yesibindi nayo ingasuswa, uma kungenzeka. Uma umdlavuza usabalele, i-chemotherapy ingasetshenziselwa ukuzama ukuncipha izicubu.

Uma ukukhiqizwa okungajwayelekile kwamahomoni kudala izimpawu, ungathola imithi yokulwisana nemiphumela yawo. Isibonelo, ngama-gastrinomas, ukukhiqizwa ngokweqile kwe-gastrin kuholela ku-asidi omningi esiswini. Imithi evimba ukukhishwa kwe-asidi esiswini inganciphisa izimpawu.

Unganciphisa ukucindezela kokugula ngokujoyina iqembu lokusekela umdlavuza. Ukwabelana nabanye abanokuhlangenwe nakho okuvamile nezinkinga kungakusiza ungazizwa uwedwa.

Ungalapheka uma izicubu zisuswa ngokuhlinzwa ngaphambi kokuba zisabalalele kwezinye izitho. Uma izimila zinomdlavuza, i-chemotherapy ingasetshenziswa, kepha imvamisa ayikwazi ukwelapha abantu.

Izinkinga ezisongela impilo (njengoshukela wegazi ophansi kakhulu) zingenzeka ngenxa yokukhiqizwa kwehomoni ngokweqile, noma uma umdlavuza usakazeka emzimbeni wonke.

Izinkinga zalezi zicubu zifaka:

• Isifo sikashukela
• Izinkinga zeHormone (uma isimila sikhipha izinhlobo ezithile zamahomoni)
• Ishukela eliphansi kakhulu legazi (kusuka kuma-insulinomas)
• Izilonda ezinzima esiswini nasemathunjini amancane (kusuka kuma-gastrinomas)
• Ukusabalala kwesimila esibindini

Shayela umhlinzeki wakho uma uthuthukisa izimpawu zalezi zicubu, ikakhulukazi uma unomlando womndeni we-MEN I.

Akukho ukuvimbela okwaziwayo kwalezi zicubu.

Umdlavuza - amanyikwe; Umdlavuza - i-pancreatic; Umdlavuza wePancreatic; Izimila zeseli ze-Islet; Islet of Langerhans isimila; Izimila ze-neuroendocrine; Peptic ulcer - islet cell isimila; I-Hypoglycemia - isimila seseli se-islet; I-Zollinger-Ellison syndrome; Isifo se-Verner-Morrison; Isisu; Insulinoma; I-VIPoma; Somatostatinoma; IGlucagonoma

• Izindlala ze-Endocrine
• Amapancreas

I-Foster DS, iNorton JA. Ukuphathwa kwezicubu zeseli ze-pancreatic islet ngaphandle kwe-gastrinoma. Ku: UCameron AM, uCameron JL, ama-eds. Ukwelashwa Kwamanje. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2020: 581-584.

Iwebhusayithi yeNational Cancer Institute. Ukwelashwa komdlavuza wepancreatic (PDQ) - inguqulo yezobuchwepheshe yezempilo. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Kubuyekezwe uJanuwari 2, 2020. Kufinyelelwe ngoFebhuwari 25, 2020.

Iwebhusayithi ye-National Comprehensive Cancer Network. Imikhombandlela ye-NCCN yokwenza imitholampilo ku-oncology (imihlahlandlela ye-NCCN). Neuroendocrine futhi izimila adrenal. Inguqulo 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Kubuyekezwe ngoMashi 5, 2019. Kufinyelelwe ngoFebhuwari 25, 2020.

Iwebhusayithi ye-National Comprehensive Cancer Network. Imihlahlandlela ye-NCCN yeziguli. Izimila ze-Neuroendocrine. 2018. www.nccn.org/patients/guidelines/content/PDF/neuroendocrine-patient.pdf.