I-Felty syndrome

I-Felty syndrome yisifo esifaka phakathi isifo samathambo, ubende obuvuvukele, kwehle isibalo samaseli amhlophe egazi, kanye nokutheleleka okuphindaphindiwe. Akuvamile.

Imbangela ye-Felty syndrome ayaziwa. Kuvame kakhulu kubantu asebenesikhathi eside benesifo samathambo (RA). Abantu abanalesi sifo basengozini yokutheleleka ngoba banenani eliphansi lamaseli amhlophe egazi.

Izimpawu zifaka:

• Ukuzizwa okuvamile kokungahambi kahle (i-malaise)
• Ukukhathala
• Ubuthakathaka emlenzeni noma engalweni
• Ukuphelelwa isifiso sokudla
• Ukwehla kwesisindo ngokungenhloso
• Izilonda esikhunjeni
• Ukuvuvukala okuhlangene, ukuqina, ubuhlungu, nokukhubazeka
• Izifo eziphindaphindayo
• Iso elibomvu ngokushisa noma ukukhipha

Ukuhlolwa komzimba kuzobonisa:

• Ukuvuvukala ubende
• Amalunga akhombisa izimpawu zeRA
• Kungenzeka ukuvuvukala kwesibindi nama-lymph node

Isibalo segazi esiphelele (CBC) esinomehluko sizokhombisa inani eliphansi lamaseli amhlophe egazi abizwa ngama-neutrophils. Cishe bonke abantu abane-Felty syndrome banokuhlolwa okuhle kwe-rheumatoid factor.

I-ultrasound yesisu ingaqinisekisa ubende obuvuvukile.

Ezimweni eziningi, abantu abanalesi sifo abatholi ukwelashwa okunconyelwe i-RA. Bangadinga eminye imithi ukucindezela amasosha abo omzimba nokunciphisa umsebenzi weRA yabo.

I-Methotrexate ingathuthukisa inani eliphansi le-neutrophil. I-rituximab yezidakamizwa iphumelele kubantu abangayiphenduli i-methotrexate.

IGranulocyte-colony factor stimulating factor (G-CSF) ingakhuphula isibalo se-neutrophil.

Abanye abantu bayazuza ekususweni kobende (splenectomy).

Ngaphandle kokwelashwa, izifo zingaqhubeka zenzeka.

I-RA kungenzeka ibe yimbi kakhulu.

Ukwelapha i-RA, noma kunjalo, kufanele kuthuthukise i-Felty syndrome.

Ungaba nokutheleleka okuhlala kubuya.

Abanye abantu abane-Felty syndrome banamanani akhuphukile ama-lymphocyte amakhulu we-granular, abizwa nangokuthi i-LGL leukemia. Lokhu kuzophathwa nge-methotrexate ezimweni eziningi.

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma uba nezimpawu zalesi sifo.

Ukwelashwa ngokushesha kwe-RA ngemithi enconywe njengamanje kunciphisa kakhulu amathuba okuba ne-Felty syndrome.

Isifo samathambo esingaqondakali (i-RA); Isifo sikaFelty

• Amasosha omzimba

UBellistri JP, uMuscarella P. Splenectomy wezifo ze-hematologic. Ku: UCameron JL, uCameron AM, ama-eds. Ukwelashwa Kwamanje. Umhla ka-12. IPhiladelphia, PA: Elsevier; 2017: 603-610.

U-Erickson AR, uCannella AC, uMikuls TR. Izici zomtholampilo zesifo samathambo. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, abahleli. Incwadi kaKelley noFirestein yeRheumatology. Umhlaka 10. IPhiladelphia, PA: Elsevier; 2017: isahluko 70.

I-Gazitt T, iLoughran TP Jr. I-neutropenia engapheli ku-LGL leukemia ne-rheumatoid arthritis. IHematology Am Soc Hematol Educ Uhlelo. I-2017; 2017 (1): 181-186. I-PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

UMyasoedova E, uTuresson C, uMatteson EL. Izici ezingaphezulu zesifo samathambo. Ku: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, abahleli. I-Rheumatology. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2019: isahluko 95.

USavola P, uBrück O, u-Olson T, et al. Okuzenzakalelayo STAT3 ukuguquka kwesifo ku-Felty syndrome: okushiwo yi-pathogenesis ejwayelekile ene-leukemia enkulu ye-granular lymphocyte. I-Haematologica. 2018; 103 (2): 304-312. PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

U-Wang CR, u-Chiu YC, u-Chen YC. Ukwelashwa okuphumelelayo kwe-neutropenia ekhanyayo ku-Felty's syndrome ene-rituximab. Scand J Rheumatol. I-2018; 47 (4): 340-341. I-PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.