I-nephropathy ye-IgA

I-IgA nephropathy yisifo sezinso lapho amasosha omzimba abizwa ngokuthi yi-IgA akha khona ezicutshini zezinso. I-nephropathy ukulimala, izifo, noma ezinye izinkinga ezinso.

I-nephropathy ye-IgA ibizwa nangokuthi isifo seBerger.

I-IgA yiprotheni, ebizwa nge-antibody, esiza umzimba ukulwa nezifo. I-nephropathy ye-IgA yenzeka lapho iningi laleli phrotheni lifakwa ezinso. I-IgA yakha ngaphakathi kwemithambo yegazi encane yezinso. Izakhiwo zezinso ezibizwa ngokuthi i-glomeruli ziyavuvukala futhi zilimale.

Lesi sifo singavela ngokuzumayo (acute), noma siqhubeke ngokuya sihambe kancane eminyakeni eminingi (i-glomerulonephritis engapheli).

Izici zobungozi zifaka:

• Umlando womuntu siqu noma womndeni we-IgA nephropathy noma i-Henoch-Schönlein purpura, uhlobo lwe-vasculitis oluthinta izingxenye eziningi zomzimba
• Ubuhlanga obumhlophe noma obase-Asia

I-nephropathy ye-IgA ingenzeka kubantu bayo yonke iminyaka, kepha imvamisa ithinta abesilisa abasebasha kuze kube sekupheleni kweminyaka engama-30.

Kungase kungabikho zimpawu zeminyaka eminingi.

Uma kunezimpawu, zingafaka:

• Umchamo onegazi oqala ngesikhathi noma ngemuva nje kokutheleleka okuphefumula
• Iziqephu eziphindaphindwayo zomchamo omnyama noma onegazi
• Ukuvuvukala kwezandla nezinyawo
• Izimpawu zesifo esingapheliyo sezinso

I-nephropathy ye-IgA ivame ukutholakala lapho umuntu ongenazo ezinye izimpawu zezinkinga zezinso enesiqephu esisodwa noma eziningi zomchamo omnyama noma onegazi.

Azikho izinguquko ezithile ezibonwe ngesikhathi sokuhlolwa komzimba. Kwesinye isikhathi, umfutho wegazi ungaphakama noma kube nokuvuvukala komzimba.

Izivivinyo zifaka:

• Ukuhlolwa kwegazi urea nitrogen (BUN) ukukala ukusebenza kwezinso
• Ukuhlolwa kwegazi kwe-Creatinine ukukala ukusebenza kwezinso
• Ukuhlolwa kwezinso ukuqinisekisa ukuxilongwa
• Ukuhlolwa komchamo
• Umchamo we-immunoelectrophoresis

Umgomo wokwelashwa ukunciphisa izimpawu nokuvimbela noma ukubambezela ukwehluleka okungapheli kwezinso.

Ukwelashwa kungafaka:

• I-Angiotensin-converting enzyme (ACE) inhibitors kanye ne-angiotensin receptor blockers (ARBs) ukulawula umfutho wegazi ophezulu nokuvuvukala (edema)
• I-Corticosteroids, ezinye izidakamizwa ezicindezela amasosha omzimba
• Amafutha ezinhlanzi
• Imithi yokwehlisa i-cholesterol

Usawoti namanzi kungavinjelwa ukulawula ukuvuvukala. Ukudla kwamaprotheni okuphansi kuya kokulingene kunganconywa kwezinye izimo.

Ekugcineni, abantu abaningi kumele belashelwe izifo ezingamahlalakhona zezinso futhi bangadinga i-dialysis.

I-nephropathy ye-IgA iba kubi kancane. Ezimweni eziningi, akubi kubi nhlobo. Isimo sakho kungenzeka sibe sibi kakhulu uma une:

• Umfutho wegazi ophezulu
• Inani elikhulu lamaprotheni emchameni
• Izinga le-BUN noma le-creatinine elandisiwe

Shayela umhlinzeki wakho wezempilo uma unomchamo onegazi noma uma ukhiqiza umchamo omncane kunokujwayelekile.

I-Nephropathy - IgA; Isifo seBerger

• Ukwakheka kwezinso

UFeehally J, Floege J. Immunoglobulin A nephropathy kanye ne-IgA vasculitis (Henoch-Schönlein purpura). Ku: Feehally J, Floege J, Tonelli M, Johnson RJ, abahleli. I-Nephrology Yomtholampilo Ephelele. Umhlaka 6. IPhiladelphia, PA: Elsevier; 2019: isahluko 23.

USaha MK, iPendergraft WF, uJennette JC, uFalk RJ. Isifo esiyisisekelo se-glomerular. Ku: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, ama-eds. IBrenner neRector's The Kidney. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2020: isahluko 31.