Ukushoda kwe-Factor VII

Ukushoda kwe-Factor VII (eziyisikhombisa) yisifo esidalwa ukuntuleka kweprotheni ebizwa nge-factor VII egazini. Kuholela ezinkingeni zokuqina kwegazi (coagulation).

Lapho wopha, uchungechunge lwezinto ezenzekayo emzimbeni olusiza ukwakheka kwamahlule egazi. Le nqubo ibizwa ngokuthi yi-coagulation cascade. Kubandakanya amaprotheni akhethekile abizwa ngokuthi yi-coagulation, noma ama-clotting factor. Ungaba nethuba eliphakeme lokopha ngokweqile uma eyodwa noma eziningi zalezi zinto zilahlekile noma zingasebenzi ngendlela efanele.

I-Factor VII ingenye yezinto ezinje ngokujiya. Ukushoda kwe-Factor VII kusebenza emindenini (kuzuzwe njengefa) futhi akuvamile. Bobabili abazali kumele babe nesakhi sokudlulisela lesi sifo ezinganeni zabo. Umlando womndeni wesifo esopha kungaba yingozi.

Ukuntuleka kwe-Factor VII kungabangelwa esinye isimo noma ukusetshenziswa kwemithi ethile. Lokhu kubizwa ngokushoda kwe-factor VII okutholakele. Kungabangelwa:

• I-vitamin K ephansi (ezinye izingane zizalwa zinokushoda kukavithamini K)
• Isifo esibi sesibindi
• Ukusetshenziswa kwemithi evimbela ama-clotting (ama-anticoagulants anjenge-warfarin)

Izimpawu zingafaka noma yikuphi okulandelayo:

• Ukopha kwizingqimba zamafinyila
• Ukopha emalungeni
• Ukopha emisipheni
• Ukulimaza kalula
• Ukopha okukhulu kokuya esikhathini
• Ukopha okungapheli kalula
• Umbilical cord opha ngemuva kokuzalwa

Ukuhlolwa okungenziwa kufaka phakathi:

• Isikhathi esithile se-thromboplastin (PTT)
• Umsebenzi wePlasma factor VII
• Isikhathi se-Prothrombin (PT)
• Ukuxuba ukutadisha, ukuhlolwa okukhethekile kwe-PTT ukuqinisekisa ukuntuleka kwe-factor VII

Ukopha kungalawulwa ngokuthola ukumuncwa ngemithambo yegazi (i-IV) kwe-plasma ejwayelekile, ukugxila kwe-factor VII, noma isakhi se-VII esikhiqizwe ngofuzo.

Uzodinga ukwelashwa kaningi ngezikhathi zeziqephu zokopha ngoba i-factor VII ayihlali isikhathi eside ngaphakathi emzimbeni. Uhlobo lwe-factor VII olubizwa nge-NovoSeven lungasetshenziswa futhi.

Uma unenkinga ye-factor VII ngenxa yokushoda kukavithamini K, ungathatha le vithamini ngomlomo, ngemijovo ngaphansi kwesikhumba, noma ngomthambo (ngemithambo).

Uma unale nkinga yokopha, qiniseka ukuthi:

• Tshela abahlinzeki bakho bokunakekelwa kwezempilo ngaphambi kokuba ube nenqubo ethile, okubandakanya ukuhlinzwa nomsebenzi wamazinyo.
• Tshela amalungu omndeni wakho ngoba angahle abe nokuphazamiseka okufanayo kepha awazi okwamanje.

Lezi zinsizakusebenza zinganikeza imininingwane eminingi ngokushoda kweFactor VII:

• INational Hemophilia Foundation: Okunye Ukushoda Kwesici - www.hemophilia.org/Bleeding-Disorders/Typees-of-Beeding-Disorders/Other-Factor-Deficiencies
• Inhlangano Kazwelonke Yezinkinga Ezingajwayelekile - rarediseases.org/rare-diseases/factor-vii-deficiency
• Isethenjwa sasekhaya seNLM Genetics - ghr.nlm.nih.gov/condition/factor-vii-deficiency

Ungalindela umphumela omuhle ngokwelashwa okufanele.

Ukuntuleka kwesici VII esizuzwe njengefa yisimo sempilo yonke.

Umbono wokuntuleka kwe-factor VII okutholakele kuncike embangela. Uma sibangelwa yisifo sesibindi, umphumela uncike ekutheni isifo sakho sesibindi singelashwa kanjani. Ukuthatha izithasiselo zikavithamini K kuzokwelapha ukushoda kwevithamini K.

Izinkinga zingafaka:

• Ukopha ngokweqile (ukopha)
• Ukushaywa unhlangothi noma ezinye izinkinga zesistimu yezinzwa ukuphuma kwegazi
• Izinkinga ezihlangene ezimeni ezinzima lapho ukuphuma kwegazi kwenzeka kaningi

Thola ukwelashwa okuphuthumayo ngokushesha uma unegazi elibi, elingaqondakali.

Akukho ukuvimbela okwaziwayo ngokushoda kwe-factor VII. Lapho ukuntuleka kukavithamini K kuyimbangela, ukusebenzisa uvithamini K kungasiza.

Ukushoda kweproconvertin; Ukushoda kwesici se-extrinsic; Ukushoda kwe-accelerator yokuguqula i-serum prothrombin; Isifo i-Alexander

• Ukwakheka kwegazi
• Amahlule egazi

UGailani D, Wheeler AP, Neff AT. Ukukhubazeka okujwayelekile kwe-coagulation factor. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 137.

IHholo JE. I-hemostasis negazi coagulation. EHholo JE, ed. Incwadi kaGuyton neHholo yePhysical Physiology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 37.

I-Ragni MV. Ukuphazamiseka kokopha: ukuswela kwe-coagulation factor. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 174.