I-C1 esterase inhibitor

I-C1 esterase inhibitor (C1-INH) yiprotheni etholakala engxenyeni engamanzi yegazi lakho. Ilawula iprotheni ebizwa nge-C1, okuyingxenye yohlelo lokugcwalisa.

Uhlelo lokuncoma luyiqembu lamaprotheni acishe abe ngama-60 akwi-plasma yegazi noma ebusweni bamanye amangqamuzana. Amaprotheni agcwalisanayo asebenza namasosha akho omzimba ukuvikela umzimba ezifweni. Zisiza nokususa amaseli afile nezinto zangaphandle. Kunamaprotheni ayisishiyagalolunye amakhulu ahambisanayo. Zibhalwe ukuthi yi-C1 nge-C9. Imvamisa, abantu bangazuza njengefa ukuswela kwamanye amaprotheni ahambisanayo. Laba bantu bathambekele ezifweni ezithile noma ekuphazamisekeni komzimba.

Lo mbhalo ukhuluma ngokuhlolwa okwenziwayo ukukala inani le-C1-INH egazini lakho.

Kudingeka isampula yegazi. Lokhu kuvame ukuthathwa ngomthambo. Inqubo ibizwa ngokuthi i-venipuncture.

Akukho ukulungiselela okukhethekile okudingekayo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bangazizwa nje ngokuhlatshwa noma ukuzwa okuhlabayo. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

Ungadinga lokhu kuhlolwa uma unezimpawu ze-angioedema yefa noma ye-angioedema. Zombili lezi zinhlobo ze-angioedema zibangelwa amazinga aphansi e-C1-INH.

Izici zokugcwalisa nazo zingabalulekile ekuhlolweni kwezifo ezizimele, njenge-systemic lupus erythematosus.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Umhlinzeki wakho wezokunakekelwa kwempilo uzolinganisa izinga lomsebenzi elisebenzayo le-C1 esterase inhibitor yakho. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Amazinga aphansi e-C1-INH angadala izinhlobo ezithile ze-angioedema. I-Angioedema ibangela ukuvuvukala okungazelelwe kwezicubu zobuso, umphimbo ongaphezulu nolimi. Kungadala nobunzima bokuphefumula. Ukuvuvukala emathunjini nasezinhlungwini zesisu nakho kungenzeka. Kunezinhlobo ezimbili ze-angioedema ezibangelwa ukwehla kwamazinga we-C1-INH. I-angioedema yefa ifinyelela izingane kanye nabantu abadala abangaphansi kweminyaka engama-20. I-angioedema etholakele ibonakala kubantu abadala abaneminyaka engaphezu kwengama-40. Abantu abadala abane-angioedema etholakele banamathuba amaningi okuthi babe nezinye izimo ezifana nomdlavuza noma isifo se-autoimmune.

Izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Isici esivimbela i-C1; I-C1-INH

• Ukuhlolwa kwegazi

UCicardi M, Aberer W, Banerji A, et al. Ukwahlukaniswa, ukuxilongwa, kanye nendlela yokwelashwa kwe-angioedema: umbiko wokuvumelana ovela eHereditary Angioedema International Working Group. Ukungezwani komzimba. 2014; 69 (5): 602-616. I-PMID: 24673465 www.ncbi.nlm.nih.gov/pubmed/24673465.

I-Leslie TA, i-Greaves MW. I-angioedema yefa. Ku: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, abahleli. Ukwelashwa Kwezifo Zesikhumba: Amasu Wokwelashwa Okuphelele. Umhlaka 5. IPhiladelphia, PA: Elsevier; 2018: isahluko 101.

UZanichelli A, Azin GM, Wu MA, et al. Ukuxilongwa, inkambo, kanye nokuphathwa kwe-angioedema ezigulini ezinokuntuleka kwe-C1-inhibitor. J Ukungezwani komzimba ne-Immunol Pract. 2017; 5 (5): 1307-1313. PMID: 28284781 www.ncbi.nlm.nih.gov/pubmed/28284781.