Ukuhlolwa kwe-T3RU

Ukuhlolwa kwe-T3RU kukala izinga lamaprotheni athwala i-hormone yegilo egazini. Lokhu kungasiza umhlinzeki wakho wezokunakekelwa kwempilo ahumushe imiphumela yokuhlolwa kwegazi kwe-T3 ne-T4.

Ngenxa yokuthi izivivinyo ezibizwa nge-free T4 blood test kanye ne-thyroxine binding globulin (TBG) blood test isiyatholakala, ukuhlolwa kwe-T3RU akuvamile ukusetshenziswa kulezi zinsuku.

Kudingeka isampula yegazi.

Umhlinzeki wakho uzokutshela uma udinga ukuyeka ukusebenzisa noma yimiphi imithi ngaphambi kokuhlolwa okungathinta imiphumela yakho yokuhlolwa. UNGAYEKISI ukuthatha noma imuphi umuthi ngaphandle kokuqala ukhulume nomhlinzeki wakho.

Eminye imithi engakhuphula amazinga we-T3RU ifaka phakathi:

• Ama-Anabolic steroids
• I-Heparin
• Phenytoin
• Ama-salicylates (umthamo omkhulu)
• I-Warfarin

Eminye imishanguzo enganciphisa amazinga we-T3RU ifaka phakathi:

• Imithi ye-Antithyroid
• Amaphilisi okuvimbela inzalo
• Clofibrate
• I-Estrogen
• AmaThiyazide

Ukukhulelwa nakho kunganciphisa amazinga we-T3RU.

Lezi zimo zinganciphisa amazinga e-TBG (bheka isigaba esingezansi "Kungani Ukuhlolwa Kwenziwa" ukuthola okuningi nge-TBG):

• Ukugula okungathi sína
• Isifo sezinso lapho kulahleka amaprotheni emchameni (nephrotic syndrome)

Eminye imithi ebopha amaprotheni egazini nayo ingathinta imiphumela yokuhlolwa.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kwenziwa ukuhlola umsebenzi wakho wegilo. Umsebenzi wendlala yegilo uncike esenzweni samahomoni amaningi ahlukahlukene, kufaka phakathi i-hormone ekhuthaza i-thyroid (TSH), T3, ne-T4.

Lokhu kuhlolwa kusiza ukuhlola inani le-T3 i-TBG ekwazi ukulibopha. I-TBG yiprotheni ethwala iningi le-T3 ne-T4 egazini.

Umhlinzeki wakho angancoma ukuhlolwa kwe-T3RU uma unezimpawu zesifo se-thyroid, kufaka phakathi:

• I-Hyperthyroidism (i-thyroid engasebenzi ngokweqile)
• I-Hypothyroidism (i-thyroid engasebenzi)
• Ukukhubazeka ngezikhathi ezithile kwe-Thyrotoxic (ubuthakathaka bemisipha obubangelwa amazinga aphezulu e-hormone yegilo egazini)

Amanani ajwayelekile avela ku-24% kuya ku-37%.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izinga eliphakeme kunokujwayelekile lingaveza:

• Ukuhluleka kwezinso
• Indlala yegilo eyeqile (hyperthyroidism)
• I-Nephrotic syndrome
• Amaprotheni ukungondleki

Amazinga aphansi kunokujwayelekile angaveza:

• I-hepatitis enamandla (isifo sesibindi)
• Ukukhulelwa
• I-Hypothyroidism
• Ukusetshenziswa kwe-estrogen

Imiphumela engajwayelekile futhi ingabangelwa yisimo esizuzwe njengefa samazinga aphezulu e-TBG. Imvamisa ukusebenza kwe-thyroid kuyinto ejwayelekile kubantu abanalesi simo.

Lokhu kuhlolwa kungenzelwa futhi:

• I-thyroiditis engapheli (ukuvuvukala noma ukuvuvukala kwendlala yegilo, kufaka phakathi isifo sikaHashimoto)
• I-hypothyroidism ebangelwa izidakamizwa
• Isifo samathuna
• Subacute thyroiditis
• Ukukhubazeka ngezikhathi ezithile kwe-Thyrotoxic
• I-goiter nodular enobuthi

Kunobungozi obuncane obubandakanyekile ekuthatheni igazi lakho.Imithambo yegazi nemithambo yegazi iyehluka ngosayizi komunye umuntu iye kolunye uhlangothi nangolunye uhlangothi lomzimba. Ukuthola isampula yegazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (i-blood buildup ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ukuthathwa kwe-Resin T3; Ukuthathwa kwenhlaka ka-T3; Isilinganiso sokubopha i-hormone yegilo

• Ukuhlolwa kwegazi

UGuber HA, uFarag AF. Ukuhlolwa komsebenzi we-endocrine. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 24.

UKiefer J, uMythen M, uRoizen MF, uFleisher LA. Imiphumela ye-Anesthetic yezifo ezifanayo. Ku: Gropper MA, ed. I-Anesthesia kaMiller. Umhlaka 9. IPhiladelphia, PA: Elsevier; 2020: isahluko 32.

USalvatore D, uCohen R, uKopp PA, uLarsen PR. I-pathophysiology ye-thyroid nokuhlolwa kokuxilongwa. Ku: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 14. IPhiladelphia, PA: Elsevier; 2020: isahluko 11.

I-Weiss RE, Refetoff S. Ukuhlolwa komsebenzi we-Thyroid. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 78.