Ukuhlolwa kwegazi kwe-Alpha-1 antitrypsin

I-Alpha-1 antitrypsin (AAT) ukuhlolwa kwelabhoratri ukukala inani le-AAT egazini lakho. Ukuhlolwa kwenziwa futhi ukubheka amafomu angajwayelekile we-AAT.

Kudingeka isampula yegazi.

Akukho ukulungiselela okukhethekile.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kuyasiza ekuboneni uhlobo olungavamile lwe-emphysema kubantu abadala kanye nohlobo olungavamile lwesifo sesibindi (i-cirrhosis) ezinganeni nakubantu abadala ezibangelwa ukuntuleka kwe-AAT. Ukushoda kwe-AAT kudluliselwa emindenini. Isimo senza ukuthi isibindi senze okuncane kakhulu nge-AAT, iphrotheni evikela amaphaphu nesibindi ekulimaleni.

Wonke umuntu unamakhophi amabili wesakhi esenza i-AAT. Abantu abanamakhophi amabili angajwayelekile esakhiweni banezifo ezinzima kakhulu namazinga aphansi egazi.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izinga eliphansi kunokujwayelekile le-AAT lingahlotshaniswa ne:

• Ukulimala kwemigwaqo yomoya emikhulu emaphashini (i-bronchiectasis)
• Ukuqubuka kwesibindi (i-cirrhosis)
• Isifo esingapheliyo se-pulmonary disease (COPD)
• Izimila zesibindi
• Ukuphuzi kwesikhumba namehlo ngenxa yokugeleza kwe-bile okuvinjiwe (i-jaundice evimbelayo)
• Umfutho wegazi ophezulu emthanjeni omkhulu uholela esibindini (i-portal hypertension)

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo iyehluka ngobukhulu ukusuka komunye umuntu iye komunye, futhi kusukela kolunye uhlangothi lomzimba kuye kolunye. Ukuthatha igazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ukuhlolwa kwe-A1AT

IChernecky CC, iBerger BJ. I-Alpha₁-antitrypsin - i-serum. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 121-122.

UWinnie GB, uBoas SR. a₁ - Ukushoda kwe-Antitrypsin ne-emphysema. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahluko 421.