Ukuhlolwa kwe-peptide yobuchopho be-natriuretic

Ukuhlolwa kwe-Brain natriuretic peptide (BNP) ukuhlolwa kwegazi okukala amazinga eprotheni abizwa nge-BNP enziwa inhliziyo nemithambo yegazi. Amazinga e-BNP aphakeme kunokujwayelekile uma unokwehluleka kwenhliziyo.

Kudingeka isampula yegazi. Igazi lithathwa emthanjeni (venipuncture).

Lokhu kuhlolwa kuvame ukwenziwa egumbini labezimo eziphuthumayo noma esibhedlela. Imiphumela ithatha imizuzu engafika kwengu-15. Kwezinye izibhedlela, ukuhlolwa komunwe ngemiphumela esheshayo kuyatholakala.

Lapho inaliti ifakwa ukuze kudonswe igazi, ungase uzwe ubuhlungu obuncane. Iningi labantu lizwa kuphela ukubhoboza noma ukuzwa okuhlabayo. Ngemuva kwalokho kungahle kube nokushaywa noma ukulinyazwa.

Ungadinga lokhu kuhlolwa uma unezimpawu zokwehluleka kwenhliziyo. Izimpawu zifaka phakathi ukuphefumula okuncane nokuvuvukala kwemilenze noma isisu sakho. Ukuhlolwa kusiza ekuqinisekiseni ukuthi izinkinga zibangelwa inhliziyo yakho hhayi amaphaphu akho, izinso, noma isibindi.

Akucaci ukuthi ukuhlolwa kwe-BNP okuphindaphindwayo kuyasiza yini ekuqondiseni ukwelashwa kulabo asebevele batholakala ukuthi banenkinga yenhliziyo.

Ngokuvamile, imiphumela engaphansi kwama-picograms / milliliter ayi-100 (pg / mL) iwuphawu lokuthi umuntu akanakho ukwehluleka kwenhliziyo.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Amazinga e-BNP akhuphuka lapho inhliziyo ingakwazi ukumpompa ngendlela okufanele.

Umphumela omkhulu kune-100 pg / mL awujwayelekile. Lapho iphakama inani, maningi amathuba okuthi ukwehluleka kwenhliziyo kube khona futhi kubi kakhulu.

Kwesinye isikhathi ezinye izimo zingadala amazinga aphezulu we-BNP. Lokhu kufaka phakathi:

• Ukuhluleka kwezinso
• I-embolism yamaphaphu
• Umfutho wegazi ophezulu wamaphaphu
• Ukutheleleka okukhulu (sepsis)
• Izinkinga zamaphaphu

Izingozi ezihambisana nokudonswa igazi zincane kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ukuhlolwa okuhlobene, okubizwa ngokuthi yi-N-terminal pro-BNP test, kwenziwa ngendlela efanayo. Inikeza imininingwane efanayo, kepha ububanzi obujwayelekile buhlukile.

I-Bock JL. Ukulimala kwenhliziyo, i-atherosclerosis, nesifo se-thrombotic. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 18.

UFelker GM, Teerlink JR. Ukuxilongwa nokuphathwa kokuhluleka kwenhliziyo okunamandla. Ku: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, ama-eds. Isifo Senhliziyo SikaBraunwald: Incwadi Yemithi Yezinhliziyo Nemithambo. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2019: isahluko 24.

UYancy CW, uJessup M, uBozkurt B, et al. Umhlahlandlela we-ACCF / AHA ka-2013 wokuphathwa kokuhluleka kwenhliziyo: umbiko we-American College of Cardiology Foundation / American Heart Association Task Force ngemikhombandlela yokusebenza. Ukujikeleza. 2013; 128 (16): e240-e327. I-PMID: 23741058 pubmed.ncbi.nlm.nih.gov/23741058/.