Leflunomide

-Delile

• Ngaphambi kokuthatha i-leflunomide,
• I-Leflunomide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO noma SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Ungathathi i-leflunomide uma ukhulelwe noma uhlela ukukhulelwa. I-Leflunomide ingalimaza umbungu. Akufanele uqale ukuthatha i-leflunomide uze uthathe isivivinyo sokukhulelwa esinemiphumela emibi futhi udokotela wakho ekutshela ukuthi awukhulelwe. Kufanele usebenzise indlela esebenzayo yokulawula ukubeletha ngaphambi kokuthi uqale ukuthatha i-leflunomide, ngesikhathi sokwelashwa kwakho ne-leflunomide, kanye neminyaka emi-2 ngemuva kokwelashwa. Uma isikhathi sakho siphuzile noma uphuthelwa yisikhathi ngesikhathi sokwelashwa nge-leflunomide, shayela udokotela wakho ngokushesha. Khuluma nodokotela wakho uma uhlela ukukhulelwa kungakapheli iminyaka emibili ngemuva kokuyeka ukwelashwa nge-leflunomide. Udokotela wakho angakunikeza umuthi ozosiza ukususa le mithi ngokushesha okukhulu emzimbeni wakho.

I-Leflunomide ingadala ukulimala kwesibindi okungasongela impilo futhi kubangele nokufa. Ingozi yokulimala kwesibindi inkulu kakhulu kubantu abathatha eminye imithi eyaziwa ngokudala ukulimala kwesibindi, nakubantu asebavele benesifo sesibindi. Tshela udokotela wakho ukuthi uke waba yini noma uke waba ne-hepatitis noma olunye uhlobo lwesifo sesibindi futhi uma uphuza noma uke waphuza utshwala obuningi. Tshela udokotela kanye nosokhemisi wakho uma uthatha i-acetaminophen (Tylenol, kweminye imikhiqizo ethengiswayo), i-aspirin neminye imishanguzo yokulwa nokuvuvukala (ama-NSAID afana ne-ibuprofen [Advil, Motrin] ne-naproxen [Aleve, Naprosyn], cholesterol Imithi yokunciphisa amandla (ama-statins), i-hydroxychloroquine, imikhiqizo yensimbi, i-isoniazid (i-Laniazid, e-Rifamate, e-Rifater), i-methotrexate (i-Trexall), i-niacin (i-nicotinic acid), noma i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, e-Rifater). uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, fonela udokotela wakho ngokushesha: isicanucanu, ukukhathala ngokweqile, ukopha okungavamile noma ukulimaza, ukungabi namandla, ukulahlekelwa isifiso sokudla, izinhlungu engxenyeni engakwesokudla esiswini, ukuphuzi kwesikhumba noma kwamehlo, umbala onsundu umchamo, noma izimpawu ezifana nomkhuhlane.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-leflunomide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-leflunomide.

I-Leflunomide isetshenziswa yodwa noma ihlanganiswe neminye imithi yokwelapha i-rheumatoid arthritis (isimo lapho umzimba uhlasela khona amalunga ayo, ubangele izinhlungu, ukuvuvukala, nokulahlekelwa ngumsebenzi). I-Leflunomide isekilasini lemithi ebizwa ngokuthi yimishanguzo yokuguqula izifo (i-DMARDs). Isebenza ngokunciphisa ukuvuvukala futhi inciphise ukuqhubeka kwesimo, okungasiza ekuthuthukiseni ukusebenza komzimba kwabantu abane-arthritis ye-rheumatoid.

ILeflunomide iza njengethebhulethi ezothathwa ngomlomo. Kuvame ukuthathwa kanye ngosuku. Udokotela wakho angakutshela ukuthi uthathe umthamo omkhulu we-leflunomide ngezinsuku zokuqala ezintathu zokwelashwa. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-leflunomide njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho angadinga ukwehlisa umthamo wakho noma ayeke ukwelashwa uma uhlangabezana nemiphumela emibi ethile. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

I-Leflunomide ingasiza ekulawuleni izimpawu zesifo samathambo kodwa ayiyelaphi. Qhubeka uthathe i-leflunomide noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-leflunomide ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-leflunomide,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-leflunomide, teriflunomide (Aubagio), noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-leflunomide. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: ama-anticoagulants ('blood thinner') afana ne-warfarin (Coumadin Jantoven); cholestyramine (Prevalite); izinhlanganisela zegolide ezifana ne-auranofin (Ridaura); imithi yokwelapha umdlavuza; eminye imithi ecindezela amasosha omzimba njenge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ne-tacrolimus (Astagraf, Prograf); i-penicillamine (Cuprimine, Depen), ne-tolbutamide. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke waba nezifo ezimbi noma wake waba nazo noma uthola njalo izifo, umdlavuza noma ezinye izimo ezithinta umnkantsha noma amasosha omzimba (kufaka phakathi igciwane lengculazi lomzimba [i-HIV] kanye ne-immunodeficiency syndrome [i-AIDS]), isifo sikashukela, noma isifo sezinso.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-leflunomide.
• uma uhlela ukuba nobaba wengane, kufanele ukhulume nodokotela wakho ngokumisa i-leflunomide nokuthola ukwelashwa okusiza ukususa le mithi emzimbeni wakho ngokushesha okukhulu.
• buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-leflunomide.
• Ukuthatha i-leflunomide kunganciphisa ikhono lakho lokulwa nokutheleleka. Tshela udokotela wakho uma unesifo manje noma uma unezimpawu zokutheleleka ezifana nomkhuhlane, ukukhwehlela, noma izimpawu ezifana nomkhuhlane. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ngenkathi welashwa nge-leflunomide, shayela udokotela wakho: umkhuhlane; Umphimbo obuhlungu; ukukhwehlela; izimpawu ezinjengomkhuhlane; indawo yesikhumba esifudumele, esibomvu, esivuvukile, noma esibuhlungu; ukuchama okubuhlungu, okunzima, noma okuvamile; noma ezinye izimpawu zokutheleleka. Ukwelashwa kwakho nge-leflunomide kungadinga ukuphazanyiswa uma unesifo.
• Kungenzeka ukuthi usungenwe yisifo sofuba (i-TB; ukutheleleka okungathi sína kwamaphaphu) kodwa ungenazo izimpawu zesifo. Kulokhu, i-leflunomide ingenza ukutheleleka kwakho kube kubi kakhulu futhi ikwenze ube nezimpawu. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela izwe lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB noma owake waba nayo. Ngaphambi kokuba uqale ukwelashwa kwakho nge-leflunomide, udokotela wakho uzokuhlolela isikhumba ukuze abone ukuthi unayo yini i-TB. Uma une-TB, udokotela wakho uzokwelapha lesi sifo ngama-antibiotic ngaphambi kokuba uqale ukuthatha i-leflunomide.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho.
• kufanele wazi ukuthi i-leflunomide ingadala umfutho wegazi ophezulu. Kufanele uhlolwe umfutho wegazi ngaphambi kokuqala ukwelashwa futhi njalo ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi sedosi yakho elandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Leflunomide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuhlanza
• isilungulela
• ikhanda
• isiyezi
• ukuncipha komzimba
• ukuhlungu obusemhlane
• ubuhlungu bemisipha noma ubuthakathaka
• ubuhlungu, ukuvutha, ukuba ndikindiki, noma ukuncinza ezandleni noma ezinyaweni
• ukulahleka kwezinwele
• amajaqamba omlenze
• isikhumba esomile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO noma SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka noma ngaphandle komkhuhlane
• isifuba
• amabhamuza noma ukuxebuka kwesikhumba
• izilonda zomlomo
• ukulunywa
• ukuphefumula kanzima
• ukukhwehlela okusha noma okuba kubi kakhulu
• ubuhlungu besifuba
• isikhumba esiphaphathekile

Ukwemukela imishanguzo ecindezela amasosha omzimba kungakhuphula ubungozi bokuba nezinhlobo ezithile zomdlavuza. Ukwanda komdlavuza akubikwanga ezifundweni zokwelashwa nge-leflunomide kuze kube manje. Khuluma nodokotela wakho ngezingozi zokuthola i-leflunomide.

I-Leflunomide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokushisa okweqile nomswakama (hhayi endlini yangasese) nokukhanya.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isifo sohudo
• ubuhlungu besisu
• ukukhathala ngokweqile
• ubuthakathaka
• isikhumba esiphaphathekile
• ukushaya kwenhliziyo okusheshayo
• ukuphelelwa umoya

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Arava^®