I-Mifepristone (Mifeprex)

-Delile

• Ngaphambi kokuthatha i-mifepristone,
• I-Mifepristone ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Ukopha okungathi sína noma okusongela ukuphila kwesitho sangasese sowesifazane kungenzeka lapho ukukhulelwa kuqedwa ukukhulelwa kwesisu noma ngokukhipha isisu kwezokwelapha noma ngokuhlinzwa. Akwaziwa ukuthi ukuthatha i-mifepristone kuyandisa yini ingozi yokuthi uzopha kakhulu. Tshela udokotela wakho uma uke waba nezinkinga zokopha, i-anemia (ngaphansi kwenani elijwayelekile lamaseli abomvu egazi), noma uma uthatha ama-anticoagulants ('ama-blood thinner') njenge-aspirin, apixaban (Eliquis), dabigatran (Pradaxa) , Dalteparin (Fragmin), edoxaban (Savaysa). enoxaparin (Lovenox), Fondaparinux (Arixtra), heparin, rivaroxaban powder (Xarelto), noma warfarin (Coumadin, Jantoven). Uma kunjalo, udokotela wakho uzokutshela ukuthi ungathathi i-mifepristone. Uma uhlangabezana nokopha okukhulu kwesitho sangasese sowesifazane, njengokungena emapheshini ama-sanitary agcwele usayizi ogcwele njalo ngehora amahora amabili aqhubekayo, shayela udokotela wakho ngokushesha noma ufune usizo oluphuthumayo lwezokwelapha.

Izifo ezibucayi noma ezisongela impilo zingenzeka lapho ukukhulelwa kuqedwa ukukhulelwa kwesisu noma ngokukhipha isisu kwezokwelapha noma ngokuhlinzwa. Inani elincane leziguli lashona ngenxa yokutheleleka abakuthola ngemuva kokusebenzisa i-mifepristone ne-misoprostol ukuqeda ukukhulelwa kwabo. Akwaziwa ukuthi i-mifepristone kanye / noma i-misoprostol idale lezi zifo noma ukufa. Uma uba nokutheleleka okungathi sína, ungahle ungabi nezimpawu eziningi futhi izimpawu zakho kungenzeka zingabi zimbi kakhulu. Kufanele ushayele udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo uma uhlangabezana nalezi zimpawu ezilandelayo: umkhuhlane ongaphezu kuka-100.4 ° F (38 ° C) ohlala isikhathi esingaphezu kwamahora amane, ubuhlungu obukhulu noma isisa endaweni engezansi kwesinqe, Ukugodola, ukushaya kwenhliziyo okusheshayo, noma ukuquleka.

Kufanele futhi ushayele udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo uma unezimpawu ezijwayelekile zokugula njengobuthakathaka, isicanucanu, ukuhlanza, isifo sohudo, noma ukuzizwa ugula isikhathi esingaphezu kwamahora angama-24 ngemuva kokuthatha i-mifepristone noma ngabe awunawo umkhuhlane noma ubuhlungu endaweni engezansi kwesinqe sakho.

Ngenxa yobungozi bezinkinga ezinkulu, i-mifepristone itholakala kuphela ngohlelo olukhawulelwe. Uhlelo olubizwa nge-Mifeprex Risk Evaluation and Mitigation Strategies (REMS) Program lubekelwe zonke iziguli zesifazane ezinikezwe i-mifepristone. Udokotela wakho uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) ukuze ulifunde ngaphambi kokuba uqale ukwelashwa nge-mifepristone. Uzodinga nokusayina isivumelwano sesiguli ngaphambi kokuthatha i-mifepristone. Tshela udokotela wakho uma unemibuzo mayelana nokwelashwa nge-mifepristone noma uma ungakwazi ukulandela imihlahlandlela esivumelwaneni sesiguli. IMifepristone itholakala kuphela emitholampilo, emahhovisi ezokwelapha nasezibhedlela futhi ayinikezwa ngamakhemisi athengisa.

Khuluma nodokotela wakho bese unquma ukuthi uzoshayela bani nokuthi wenzeni uma kunesimo esiphuthumayo ngemuva kokuthatha i-mifepristone. Tshela udokotela wakho uma ungacabangi ukuthi uzokwazi ukulandela lolu hlelo noma uthole ukwelashwa ngokushesha esimeni esiphuthumayo phakathi namasonto amabili okuqala ngemuva kokuthatha i-mifepristone. Phatha umhlahlandlela wakho wemithi uma uvakashela igumbi labezimo eziphuthumayo noma ufuna usizo lwezimo eziphuthumayo ukuze odokotela abakwelaphayo baqonde ukuthi ukhipha isisu.

Gcina wonke ama-aphoyintimenti nodokotela wakho. Lokhu kubekwa kuyadingeka ukuqinisekisa ukuthi ukukhulelwa kwakho sekuphelile nokuthi awuzange ube nezinkinga ezinkulu zokukhipha isisu ngokwezokwelapha.

Khuluma nodokotela wakho ngezingozi zokuthatha i-mifepristone.

I-Mifepristone isetshenziswa ngokuhlangana ne-misoprostol (Cytotec) ukuqeda ukukhulelwa kwasekuqaleni. Ukukhulelwa kwasekuqaleni kusho ukuthi sekunezinsuku ezingama-70 noma ngaphansi selokhu isikhathi sakho sokugcina sokuya esikhathini siqale. UMifepristone usesigabeni semithi ebizwa ngama-antiprogestational steroids. Isebenza ngokuvimba umsebenzi weprogesterone, into eyenziwa umzimba wakho ukusiza ukuqhubeka nokukhulelwa.

I-Mifepristone iyatholakala futhi njengomunye umkhiqizo (i-Korlym), osetshenziselwa ukulawula i-hyperglycemia (ushukela ophakeme wegazi) kubantu abanohlobo oluthile lwe-Cushing’s Syndrome lapho umzimba wenza khona kakhulu i-hormone cortisol. Le monograph inikezela kuphela ngemininingwane mayelana ne-mifepristone (Mifeprex), esetshenziswa yodwa noma ihlanganiswe nomunye umuthi wokuqeda ukukhulelwa ngaphambi kwesikhathi. Uma usebenzisa i-mifepristone ukulawula i-hyperglycemia ebangelwa yi-Cushing’s syndrome, funda i-monograph enesihloko esithi mifepristone (Korlym) ebhalwe ngalo mkhiqizo.

I-Mifepristone iza njengethebhulethi ezothathwa ngomlomo. Uzothatha ithebhulethi eyodwa ye-mifepristone kanye ngosuku lokuqala. Kungakapheli amahora angama-24 kuye kwangama-48 ngemuva kokuthatha i-mifepristone, uzofaka amaphilisi amane esewonke umuthi obizwa ngokuthi yi-misoprostol buccally (phakathi kwenhlama nesihlathi) ngokubeka amaphilisi amabili esikhwameni ngasinye sesihlathi imizuzu engama-30, bese ugwinya okuqukethwe okusele ngamanzi noma okunye ketshezi. Qiniseka ukuthi usendaweni efanele lapho uthatha i-misoprostol ngoba ukuphuma kwegazi esithweni sangasese, amajaqamba, isicanucanu, nohudo kuvame ukuqala kungakapheli amahora amabili kuya kwangama-24 ngemuva kokukuthatha kepha kungaqala kungakapheli amahora amabili.Ukopha kwesitho sangasese sowesifazane noma ukubonwa kuvame ukuhlala izinsuku eziyi-9 kuya kwezingu-16 kepha kungahlala izinsuku ezingama-30 noma ngaphezulu. Kufanele ubuyele kudokotela wakho ukuze ayohlolwa noma enze i-ultrasound izinsuku eziyi-7 kuya kwezingu-14 ngemuva kokuthatha i-mifepristone ukuqinisekisa ukuthi ukukhulelwa sekuphelile nokuhlola inani lokopha. Thatha i-mifepristone ngqo njengoba iqondisiwe.

I-Mifepristone nayo kwesinye isikhathi isetshenziselwa ukuqeda ukukhulelwa lapho sekudlule izinsuku ezingaphezu kwezingama-70 kusukela esikhathini sokugcina sokuya esikhathini sowesifazane; njengendlela yokuvimbela inzalo ephuthumayo ngemuva kocansi olungavikelekile (‘ipilisi yokusa ekuseni’); ukwelapha izimila zobuchopho, i-endometriosis (ukukhula kwezicubu zesibeletho ngaphandle kwesibeletho), noma i-fibroids (izicubu ezingenasifo esisesibeletho); noma ukwenza umsebenzi (ukusiza ukuqala inqubo yokuzalwa kowesifazane okhulelwe). Khuluma nodokotela wakho ngezingozi ezingenzeka zokusebenzisa lesi sidakamizwa ngesimo sakho.

Ngaphambi kokuthatha i-mifepristone,

• Tshela udokotela wakho uma uxabana ne-mifepristone (isifuba, ukuqubuka, ukulunywa, ukuvuvukala kobuso, amehlo, umlomo, umphimbo, izandla; ukuphefumula kanzima noma ukugwinya); i-misoprostol (iCytotec, ku-Arthrotec); amanye ama-prostaglandin afana ne-alprostadil (Caverject, Edex, Muse, abanye), carboprost tromethamine (Hemabate), dinoprostone (Cervidil, Prepidil, Prostin E2), epoprostenol (Flolan, Veletri), latanoprost (Xalatan), treprostinilodulin (Orenitram, Orenitram ); noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-mifepristone. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-corticosteroids efana ne-beclomethasone (Beconase, QNASL, QVAR), betamethasone (Celestone), budesonide (Entocort, Pulmicort, Uceris), cortisone, dexamethasone, fludrocortisone, flunisolide (Aerospan HFA), Fluticasone , Veramyst, others), hydrocortisone (Cortef, Solu-Cortef, U-Cort, others), methylprednisolone (Medrol, Depo-Medrol), prednisolone (Omnipred, Prelone, abanye), prednisone (Rayos), ne-triamcinolone (Kenalog, abanye ). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-mifepristone.
• tshela udokotela wakho ukuthi imiphi eminye imishanguzo kadokotela neyokungabhaliswanga, amavithamini, nezithako zokudla okunomsoco okwenzayo. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO nokunye okulandelayo: i-benzodiazepines efana ne-alprazolam (Xanax), i-diazepam (i-Diastat, i-Valium), i-midazolam, noma i-triazolam (i-Halcion); buspirone; ama-calcium channel blocker afana ne-amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, nifedipine (Adalat, Afeditab CR, Procardia), nisoldipine (Sular), noma verapamil (Calan, Verelan, in Tarka); carbamazepine (Equetro, Tegretol, Teril, nabanye); i-chlorpheniramine (i-antihistamine ngokukhwehlela nemikhiqizo ebandayo); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet), lovastatin (Altoprev, ku-Advicor), noma i-simvastatin (Simcor, Zocor, eVytorin); i-clarithromycin (i-Biaxin, ku-Prevpac); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-erythromycin (E.E.S., Erythrocin, abanye); i-haloperidol; i-furosemide; I-HIV protease inhibitors efana ne-indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, eKaletra, abanye), noma i-saquinavir (i-Invirase); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); i-methadone (i-Dolophine, i-Methadose); nefazodone; i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ipimozide (i-Orap); i-propranolol (iHemangeol, i-Inderal, i-Innopran); i-quinidine (ku-Nuedexta); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-rifabutin (i-Mycobutin); tacrolimus (Astagraf, Prograf, Protopic, abanye); i-tamoxifen (i-Soltamox); i-trazodone; noma i-vincristine (Marqibo Kit). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma ngabe uke wakhulelwa i-ectopic ('ukukhulelwa kwe-tubal' noma ukukhulelwa ngaphandle kwesibeletho), ukwehluleka kwe-adrenal (izinkinga ngezindlala zakho ze-adrenal), noma i-porphyria (isifo segazi esizuzwe njengefa esingadala izinkinga zesikhumba noma zesistimu yezinzwa ). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-mifepristone. Futhi, tshela udokotela wakho uma ngabe ufake i-intrauterine device (IUD). Kumele isuswe ngaphambi kokuthi uthathe i-mifepristone.
• kufanele wazi ukuthi kungenzeka ukuthi i-mifepristone ngeke ikuqede ukukhulelwa kwakho. Udokotela wakho uzohlola ukuqinisekisa ukuthi ukukhulelwa kwakho sekuphelile lapho ubuyela ekuqokweni kwakho kokulandela ngemuva kokuthatha i-mifepristone. Uma usakhulelwe ngemuva kokuthatha i-mifepristone, kunethuba lokuthi ingane yakho ingazalwa inokukhubazeka kokuzalwa. Uma ukukhulelwa kwakho kungakapheli ngokuphelele, udokotela wakho uzoxoxa ngezinye izinketho okufanele uzicabangele. Ungakhetha ukulinda, uthathe omunye umthamo we-misoprostol noma uhlinzwe ukuqeda ukukhulelwa. Uma uthatha umthamo ophindaphindiwe we-misoprostol, kufanele ube nokuhambela okulandelayo nodokotela wakho ezinsukwini eziyi-7 ngemuva kwalowo mthamo ukuze uqiniseke ukuthi ukukhulelwa kwakho sekuphelile.

• tshela udokotela wakho uma uncelisa.

• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthathe i-mifepristone.
• kufanele wazi ukuthi ngemuva kokuqeda ukukhulelwa nge-mifepristone, ungaphinda ukhulelwe khona lapho, ngisho nangaphambi kokuba isikhathi sakho sibuye. Uma ungafuni ukukhulelwa futhi, kufanele uqale ukusebenzisa ukuvimbela ukukhulelwa ngokushesha nje lapho lokhu kukhulelwa kuphela noma ngaphambi kokuba uqale ukuya ocansini futhi.

Ungathathi i-mifepristone ngejusi yamagilebhisi. Khuluma nodokotela wakho ngokuphuza ijusi lamagilebhisi ngemuva kokuthatha lo muthi.

Uzothatha kuphela i-mifepristone ehhovisi likadokotela noma emtholampilo wakho, ngakho-ke akudingeki ukhathazeke ngokukhohlwa ukuthatha umthamo ekhaya.

I-Mifepristone ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukopha kwesitho sangasese sowesifazane noma ukubala
• amajaqamba
• ubuhlungu be-pelvic
• ukushiswa kwesitho sangasese sowesifazane, ukulunywa, noma ukukhipha
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi izimpawu ezishiwo esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha.

I-Mifepristone ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Udokotela wakho uzogcina umuthi ehhovisi lakhe.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isiyezi
• ukuquleka
• ukungaboni kahle
• isicanucanu
• ukukhathala
• ubuthakathaka
• ukuphelelwa umoya
• ukushaya kwenhliziyo okusheshayo

Kufanele uthole i-mifepristone kuphela kudokotela oqinisekisiwe futhi usebenzise le mithi kuphela ngenkathi unakekelwa udokotela. Akufanele uthenge i-mifepristone kweminye imithombo, njenge-Intanethi, ngoba uzodlula izivikelo ezibalulekile zokuvikela impilo yakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Mifeprex^®

• RU-486