Zonisamide

-Delile

• Ngaphambi kokuthatha i-zonisamide,
• I-Zonisamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Izimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Zonisamide isetshenziswa ngokuhlangana neminye imithi yokwelapha izinhlobo ezithile zokuquleka. UZonisamide usesigabeni semithi ebizwa ngama-anticonvulsants. Isebenza ngokunciphisa umsebenzi kagesi ongajwayelekile ebuchosheni.

UZonisamide uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye noma kabili ngosuku noma ngaphandle kokudla. Ukukusiza ukuthi ukhumbule ukuthatha i-zonisamide, yithathe ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-zonisamide njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-zonisamide futhi akhuphule kancane umthamo wakho, hhayi kaningi ngaphezu kwesisodwa njalo emavikini amabili.

IZonisamide ingakusiza ukulawula isimo sakho kepha ngeke iselaphe. Kungathatha amasonto ama-2 noma ngaphezulu ngaphambi kokuthi uzwe inzuzo ephelele ye-zonisamide. Qhubeka nokuthatha i-zonisamide noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-zonisamide ngaphandle kokukhuluma nodokotela wakho, noma ngabe uhlangabezana nemiphumela emibi njengokushintshwa okungavamile kokuziphatha noma kwemizwelo. Uma ngokungazelelwe uyeka ukuthatha i-zonisamide, ukuquleka kwakho kungahle kube kubi kakhulu. Udokotela wakho mhlawumbe uzokwehlisa umthamo wakho kancane kancane.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-zonisamide futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-zonisamide,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-zonisamide, i-diuretics ('amaphilisi amanzi'), imithi yomlomo yesifo sikashukela, izidakamizwa ze-sulfa, noma eminye imithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi kokulandelayo: amiodarone (Cordarone, Pacerone); ama-antifungal anjenge-itraconazole (Sporanox) ne-ketoconazole (Nizoral); i-carbonic anhydrase inhibitors efana ne-acetazolamide (Diamox) ne-methazolamide; i-clarithromycin (i-Biaxin, ku-Prevpac); i-diltiazem (iCardizem, iDilacor, iTiazac); i-erythromycin (E.E.S., E-Mycin, Erythrocin); i-fluvoxamine (i-Luvox); I-HIV protease inhibitors efana ne-indinavir (Crixivan), nelfinavir (Viracept), ne-ritonavir (Norvir, eKaletra); imishanguzo yezifo zamathumbu ezicasulayo, ukugula okunyakazayo, isifo sikaParkinson, izilonda, noma izinkinga zomchamo; eminye imishanguzo yokuquleka okubalwa i-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin, Phenytek), ne-valproic acid (Depakene, Depakote); nefazodone (Serzone); izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula inzalo, amabala, izindandatho nemijovo); i-pioglitazone (Actos, e-Actoplus, ku-Duetact); i-rifabutin (i-Mycobutin); i-rifampin (i-Rifadin, i-Rimactane); i-troleandomycin (TAO) (ayitholakali e-U.S.); kanye ne-verapamil (Calan, Covera, Isoptin, Verelan). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma ulandela ukudla kwe-ketogenic (ukudla okunamafutha aphezulu, ukudla okuphansi kwe-carbohydrate okusetshenziselwa ukulawula ukuqubuka) noma uma uke waba nezinkinga zokuphefumula, isibindi sezinso, noma isifo samaphaphu. Phinda utshele udokotela wakho uma uhanjiswa yisisu manje, noma uma uhlaselwa yisisu noma kunini ngesikhathi sokwelashwa kwakho.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-zonisamide, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Uma uncelisa ibele ngesikhathi sokwelashwa kwakho, ingane yakho ingathola i-zonisamide ebisi lwebele. Bhekisisa ingane yakho ubuthongo obungavamile noma ukuzuza kwesisindo esibi.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-zonisamide.
• kufanele wazi ukuthi i-zonisamide ingakwenza ukozele. Ungashayeli imoto, sebenzisa imishini, noma wenze imisebenzi eyingozi uze wazi ukuthi lo muthi ukuthinta kanjani.
• kufanele wazi ukuthi i-zonisamide inganciphisa amandla omzimba wokujuluka futhi yenze kube nzima ukuthi umzimba wakho uphole lapho kushisa kakhulu. Lokhu kwenzeka kaningi esimweni sezulu esifudumele nasezinganeni ezithatha i-zonisamide. (Izingane akufanele zivame ukuthatha i-zonisamide, kepha kwezinye izimo, zingabekwa ngudokotela.) Kufanele ugweme ukuchayeka ekushiseni bese ushayela udokotela wakho ngokushesha uma unomkhuhlane kanye / noma ungajuluki njengenjwayelo.
• kufanele wazi ukuthi impilo yakho yengqondo ingashintsha ngezindlela ezingalindelekile futhi ungazibulala (ucabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama ukwenza kanjalo) ngenkathi uthatha i-zonisamide ukwelashwa kwesifo sokuwa, ukugula kwengqondo, noma ezinye izimo. Inani elincane labantu abadala nezingane ezineminyaka engu-5 nangaphezulu (cishe umuntu oyedwa kwabangu-500) abathathe ama-anticonvulsants afana ne-zonisamide ukwelapha izimo ezahlukahlukene phakathi kwezifundo zokwelashwa baba nokuzibulala ngesikhathi belashwa. Abanye balaba bantu bahlakulele imicabango yokuzibulala nokuziphatha kusasele isonto eli-1 ngemuva kokuqala ukuphuza umuthi. Kunobungozi bokuthi ungathola ushintsho empilweni yakho yengqondo uma uthatha imishanguzo yokulwa nezidakamizwa efana ne-zonisamide, kodwa futhi kungenzeka kube nengozi yokuthi uzohlangabezana nezinguquko empilweni yakho yengqondo uma isimo sakho singelashwa. Wena nodokotela wakho nizonquma ukuthi izingozi zokuthatha umuthi we-anticonvulsant zinkulu yini kunezingozi zokungawuthathi umuthi. Wena, umndeni wakho, noma umnakekeli wakho kufanele ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukwethuka; ukuphazamiseka noma ukungahlaliseki; ukucasuka okusha noma okuya kuba kubi, ukukhathazeka, noma ukucindezeleka; ukwenza izinkanuko eziyingozi; ubunzima bokulala noma ukulala; ulaka, intukuthelo, noma ukuziphatha okunodlame; i-mania (i-frenzied, imood ejabule ngokungavamile); ukukhuluma noma ukucabanga ngokufuna ukuzilimaza noma ukuqeda impilo yakho; ukuhoxa kubangani nomndeni; ukukhathazeka ngokufa nokufa; ukuphana ngezinto eziyigugu; noma olunye uguquko olungajwayelekile ekuziphatheni noma emoyeni. Qiniseka ukuthi umndeni wakho noma umnakekeli wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukubiza udokotela uma ungakwazi ukuzifunela ukwelashwa wedwa.

Khuluma nodokotela wakho mayelana nokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Phuza izingilazi zamanzi eziyi-6-8 nsuku zonke ngenkathi welashwa nge-zonisamide.

Khuluma nodokotela wakho ngalokho okufanele ukwenze uma uphuthelwa umthamo we-zonisamide. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Zonisamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ukuncipha komzimba
• izinguquko ekunambithekeni
• isifo sohudo
• ukuqunjelwa
• isilungulela
• umlomo owomile
• ikhanda
• isiyezi
• ukudideka
• ukucasuka
• ubunzima bokulala noma ukulala
• ubunzima ngememori
• ubuhlungu, ukuvutha, ukuba ndikindiki, noma ukuncinza ezandleni noma ezinyaweni
• ukunyakaza kwamehlo okungalawuleki
• ukubona kabili

Eminye imiphumela emibi ingaba mibi. Izimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo, shayela udokotela wakho ngokushesha:

• ukuqubuka
• ukushwabana noma ukuxebuka kwesikhumba
• ukuquleka okuya kuba kubi noma okuhlala isikhathi eside
• ubuhlungu beqolo obungazelelwe
• ubuhlungu besisu
• ubuhlungu lapho uchama
• umchamo onegazi noma omnyama
• umkhuhlane, umphimbo obuhlungu, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka
• izilonda emlonyeni
• ukulinyazwa okulula
• ubunzima bokucabanga ngamagama noma ukukhathazeka ukukhuluma
• ubunzima bokucabanga noma ukugxila
• ukuntuleka kokuxhumana
• ukuhamba kanzima
• ubuthakathaka obukhulu
• ubuhlungu obukhulu bemisipha
• ukukhathala ngokweqile
• ukulahlekelwa isifiso sokudla
• ukushesha, ukuphefumula okungajulile
• ukushaya kwenhliziyo okungajwayelekile
• ukulahlekelwa ukwazi

I-Zonisamide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

I-Zonisamide ingadala i-metabolic acidosis (amazinga aphansi ngokungajwayelekile entweni ethile yemvelo egazini). I-Metabolic acidosis eshiywe ingalashwa isikhathi eside ingakhuphula ubungozi bokuthi ezinye izinkinga zezokwelapha, kufaka phakathi amatshe ezinso nezinkinga zamathambo ezingaholela ekuqhekekeni, zivele. Ukungalashwa kwe-metabolic acidosis nakho kungadala ukukhula okucothayo kanye nokwehla kokuphakama kokugcina ezinganeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-zonisamide.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona.Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ukushaya kwenhliziyo okuhamba kancane
• ukuphefumula kancane
• isiyezi
• ukuquleka
• ikhoma (ukulahlekelwa ukwazi isikhathi esithile)

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zebhu ukuze ahlole impendulo yomzimba wakho ku-zonisamide.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Zonegran^®