Inaliti ye-Rituximab

-Delile

• Ngaphambi kokuthola umkhiqizo womjovo we-rituximab,
• Imikhiqizo yomjovo we-Rituximab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

Umjovo we-Rituximab, umjovo we-rituximab-abbs, kanye nomjovo we-rituximab-pvvr yimithi ye-biologic (imishanguzo eyenziwe ngezinto eziphilayo). Umjovo we-Biosimilar rituximab-abbs kanye nomjovo we-rituximab-pvvr ufana kakhulu nomjovo we-rituximab futhi usebenza ngendlela efanayo nomjovo we-rituximab emzimbeni. Ngakho-ke, igama elithi imikhiqizo ye-rituximab lizosetshenziselwa ukumela le mithi kule ngxoxo.

Ungathola ukusabela okungathi sína ngenkathi uthola noma kungakapheli amahora angama-24 ngemuva kokuthola umthamo womkhiqizo womjovo we-rituximab. Lokhu kuphendula kuvame ukwenzeka ngesikhathi somthamo wokuqala womkhiqizo womjovo we-rituximab futhi kungadala ukufa. Uzothola isilinganiso ngasinye somkhiqizo womjovo we-rituximab esikhungweni sezokwelapha, futhi udokotela noma umhlengikazi uzokuqapha ngokucophelela ngenkathi uthola umuthi. Uzothola imithi ethile yokusiza ukuvimbela ukusabela okweqile ngaphambi kokuthola umthamo ngamunye womkhiqizo womjovo we-rituximab. Tshela udokotela wakho uma ngabe uke waphendula ngomkhiqizo we-rituximab noma uma uke waba nokushaya kwenhliziyo okungajwayelekile, ubuhlungu besifuba, ezinye izinkinga zenhliziyo, noma izinkinga zamaphaphu. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho noma omunye umhlinzeki wezokunakekelwa kwempilo ngokushesha: isifuba; ukuqubuka; ukulunywa; ukuvuvukala kwezindebe, ulimi, noma umphimbo; ubunzima bokuphefumula noma ukugwinya; isiyezi; ukuquleka; ukuphefumula, ukuphefumula; ikhanda; ukushaya kwenhliziyo noma okungajwayelekile; ukushaya ngamandla noma okubuthakathaka; isikhumba esiphaphathekile noma esiluhlaza okwesibhakabhaka; ubuhlungu esifubeni obungasakazeka kwezinye izingxenye zomzimba ongaphezulu; ubuthakathaka; noma ukujuluka okusindayo.

Imikhiqizo yomjovo we-Rituximab idale ukusabela okukhulu kwesikhumba nomlomo. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: izilonda ezibuhlungu noma izilonda esikhunjeni, ezindebeni, noma emlonyeni; amabhamuza; ukuqubuka; noma ukuxebuka isikhumba.

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi) kepha ungabi nazimpawu zesifo. Kulokhu, ukuthola umkhiqizo womjovo we-rituximab kungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka okunzima, kufaka phakathi ukutheleleka kwegciwane le-hepatitis B. Udokotela wakho uzoku-oda ukuhlolwa kwegazi ukuze abone ukuthi unesifo esingasebenzi se-hepatitis B esingasebenzi. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngomkhiqizo womjovo we-rituximab. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, ubuhlungu bemisipha, ubuhlungu besisu, noma umchamo omnyama.

Abanye abantu abathole umkhiqizo womjovo we-rituximab bahlakulele i-leukoencephalopathy eqhubekayo (i-PML); ukutheleleka okungajwayelekile kobuchopho okungenakulashwa, ukuvinjelwa, noma ukwelashwa okuvame ukubangela ukufa noma ukukhubazeka okukhulu) ngesikhathi noma ngemuva kokwelapha kwabo. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: izinguquko ezintsha noma ezingazelelwe ekucabangeni noma ekudidekeni; ubunzima bokukhuluma noma ukuhamba; ukulahlekelwa ibhalansi; ukuphelelwa amandla; izinguquko ezintsha noma ezingazelelwe embonweni; noma ezinye izimpawu ezingavamile eziqubuka kungazelelwe.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumkhiqizo womjovo we-rituximab.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-rituximab futhi isikhathi ngasinye lapho uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umkhiqizo womjovo we-rituximab.

Imikhiqizo yomjovo we-Rituximab isetshenziswa yodwa noma ngeminye imithi yokwelapha izinhlobo ezahlukahlukene ze-non-Hodgkin's lymphoma (NHL; uhlobo lomdlavuza oluqala ngohlobo lwamaseli amhlophe egazi avame ukulwa nokutheleleka). Imikhiqizo yomjovo we-Rituximab nayo isetshenziswa neminye imithi yokwelapha i-lymphocytic leukemia (CLL; uhlobo lomdlavuza wamaseli amhlophe egazi). Umjovo we-Rituximab (Rituxan) nawo usetshenziswa ne-methotrexate (Otrexup, Rasuvo, Xatmep, others) ukwelapha izimpawu zesifo samathambo (RA; isimo lapho umzimba uhlasela khona amalunga ayo, ubangele ubuhlungu, ukuvuvukala, nokulahleka komsebenzi) kubantu abadala asebevele belashwa ngohlobo oluthile lomuthi obizwa nge-tumor necrosis factor (TNF) inhibitor. Umjovo we-Rituximab (i-Rituxan, i-Ruxience) uyasetshenziswa nakwabadala nezingane ezineminyaka engu-2 nangaphezulu kanye neminye imithi yokwelapha i-granulomatosis nge-polyangiitis (i-Wegener's Granulomatosis) ne-microscopic polyangiitis, okuyizimo lapho umzimba uhlasela khona imithambo yayo nokunye imithambo yegazi, edala ukulimala kwezitho, njengenhliziyo namaphaphu. Umjovo we-Rituximab (i-Rituxan) usetshenziselwa ukwelapha i-pemphigus vulgaris (isimo esidala amabhamuza abuhlungu esikhunjeni nasekuthambekeni komlomo, impumulo, umphimbo nezitho zangasese). Imikhiqizo yokujova i-Rituximab isesigabeni semithi ebizwa ngama-antibody monoclonal. Baphatha izinhlobo ezahlukahlukene ze-NHL ne-CLL ngokubulala amangqamuzana omdlavuza. Imikhiqizo ethile yomjovo we-rituximab nayo ilapha i-rheumatoid arthritis, i-granulomatosis ene-polyangiitis, i-microscopic polyangiitis, ne-pemphigus vulgaris ngokuvimba ukusebenza kwengxenye yesistimu yomzimba engalimaza amalunga, imithambo, neminye imithambo yegazi.

Imikhiqizo yomjovo we-Rituximab iza njengesisombululo (uketshezi) ukujova emthanjeni. Imikhiqizo yomjovo we-Rituximab ilawulwa udokotela noma umhlengikazi ehhovisi lezokwelapha noma esikhungweni sokumnika. Isikhathi sakho sokulinganisa sizoncika esimweni onaso, eminye imithi oyisebenzisayo, nokuthi umzimba wakho uphendula kahle kanjani ekwelashweni.

Imikhiqizo yomjovo we-Rituximab kufanele inikezwe kancane kancane emthanjeni. Kungathatha amahora ambalwa noma ngaphezulu ukuthola umthamo wakho wokuqala womkhiqizo womjovo we-rituximab, ngakho-ke kufanele uhlele ukuchitha usuku lonke ehhovisi lezokwelapha noma esikhungweni sokumnika. Ngemuva kwesilinganiso sokuqala, ungathola umkhiqizo womjovo we-rituximab ngokushesha okukhulu. , kuya ngokuthi uphendula kanjani ekwelashweni.

Ungase ube nezimpawu ezinjengomkhuhlane, ukuqhaqhazela, ukukhathala, ikhanda, noma isicanucanu ngenkathi uthola umthamo womkhiqizo we-rituximab, ikakhulukazi umthamo wokuqala. Tshela udokotela wakho noma omunye umhlinzeki wezokunakekelwa kwezempilo uma uhlangabezana nalezi zimpawu ngenkathi uthola imithi yakho. Udokotela wakho angakunikeza eminye imithi ukusiza ukuvimbela noma ukukhulula lezi zimpawu. Udokotela wakho uzokutshela ukuthi uthathe le mithi ngaphambi kokuthola umthamo ngamunye womkhiqizo we-rituximab.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umkhiqizo womjovo we-rituximab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-rituximab, i-rituximab-abbs, i-rituximab-pvvr, noma imiphi eminye imithi, noma iziphi izithako emikhiqizweni yomjovo we-rituximab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: adalimumab (Humira); isitifiketi (Cimzia); i-etanercept (Enbrel); i-golimumab (iSimponi); infliximab (i-Remicade); eminye imishanguzo yesifo samathambo; nemithi ecindezela amasosha omzimba njenge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune, Torisel), ne-tacrolimus (Envarsus, Prograf). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unezinye zezimo ezishiwo esigabeni ESIBALULEKILE SESEXWAYISO futhi uma uke waba nesifo sokusha kwesibindi kohlobo C noma amanye amagciwane anjenge-pox, i-herpes (igciwane elingadala izilonda ezibandayo noma ukuqubuka kwamabhamuza esithweni sangasese indawo), ama-shingles, igciwane le-West Nile (igciwane elisakazwa ngokulunywa omiyane futhi lingadala izimpawu ezimbi), i-parvovirus B19 (isifo sesihlanu; igciwane elivamile ezinganeni ezivame ukudala izinkinga ezinkulu kwabanye abantu abadala), noma i-cytomegalovirus (a i-virus ejwayelekile evame ukudala kuphela izimpawu ezinzima kubantu abanamasosha omzimba abuthakathaka noma abanesifo lapho bezalwa), noma isifo sezinso.Phinda utshele udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka manje noma uma uke waba nokutheleleka okungeke kwaphela noma ukutheleleka okuzayo nokudlulayo.
• utshele udokotela wakho uma ukhulelwe noma uma uhlela ukukhulelwa. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ngomkhiqizo womjovo we-rituximab nezinyanga eziyi-12 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokuzalwa okuzokusebenzela. Uma ukhulelwa ngenkathi usebenzisa umkhiqizo womjovo we-rituximab, shayela udokotela wakho. I-Rituximab ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho ngomkhiqizo womjovo we-rituximab nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina.
• buza udokotela wakho ukuthi kufanele yini uthole noma yimiphi imigomo ngaphambi kokuba uqale ukwelashwa ngomkhiqizo womjovo we-rituximab. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti yokuthola umkhiqizo womjovo we-rituximab, shayela udokotela wakho khona manjalo.

Imikhiqizo yomjovo we-Rituximab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ubuhlungu emuva noma ngokuhlanganyela
• ukuqhuma
• ukujuluka ebusuku
• uzizwe ukhathazeke ngokweqile noma ukhathazekile

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukulimaza noma ukopha okungavamile
• umphimbo obuhlungu, ikhala eligobayo, ukukhwehlela, umkhuhlane, ukubanda, noma ezinye izimpawu zokutheleleka
• indlebe
• ukuchama kabuhlungu
• ububomvu, isisa, ukuvuvukala noma ukufudumala kwendawo yesikhumba
• ukuqina kwesifuba

Imikhiqizo yomjovo we-Rituximab ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Rituxan^® (rituximab)
• Ubuhlakani^® (i-rituximab-pvvr)
• Truxima^® (i-rituximab-abbs)