I-Sunitinib

-Delile

• Ngaphambi kokuthatha i-sunitinib,
• I-Sunitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO noma ZOKUQapha, shayela udokotela wakho ngokushesha:

I-Sunitinib ingadala umonakalo omkhulu noma osongela impilo esibindini. Tshela udokotela wakho uma uke waba nesifo sesibindi noma waba nezinkinga ngesibindi sakho. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukulunywa, amehlo aphuzi nesikhumba, umchamo omnyama, noma ubuhlungu noma ukungahambi kahle endaweni yesisu engenhla. Udokotela wakho kungadingeka anciphise umthamo wakho we-sunitinib noma umise unomphela noma okwesikhashana ukwelashwa kwakho.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda ukuhlolwa kwegazi okuthile ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile yini kuwe ukuthatha i-sunitinib nokuhlola ukuphendula komzimba wakho emithini.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-sunitinib futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-sunitinib.

I-Sunitinib isetshenziselwa ukwelapha izicubu zomzimba ezisemathunjini (i-GIST; uhlobo lwesimila esikhula esiswini, emathunjini (emathunjini), noma esophagus (ishubhu elihlanganisa umphimbo nesisu) kubantu abanezimila ezingazange zelashwe ngempumelelo nge-imatinib ( I-Sunitinib nayo isetshenziselwa ukwelapha i-renal cell carcinoma (RCC, uhlobo lomdlavuza oluqala kumaseli ezinso). I-Sunitinib nayo isetshenziselwa ukuvimbela ukubuya kwe-RCC kubantu une-RCC engakaze isabalale futhi isuswe izinso. I-Sunitinib isetshenziselwa ukwelapha izimila zepancreatic neuroendocrine (i-pNET, uhlobo lwesimila esiqala kumaseli athile wamanyikwe) kubantu abanezimila eziye zaba zimbi kakhulu futhi ezingakwazi ukwelashwa I-Sunitinib isekilasini lemithi ebizwa nge-kinase inhibitors.Isebenza ngokuvimba ukusebenza kweprotheni engajwayelekile ekhombisa ukuthi amangqamuzana omdlavuza ayanda.Lokhu kusiza ekunqandeni noma ekunciphiseni ukusabalala kwamangqamuzana omdlavuza futhi kungasiza nciphisa izicubu.

ISunitinib iza njengephilisi elizothathwa ngomlomo noma ngaphandle kokudla. Ekwelapheni izicubu zomzimba emathunjini (GIST), noma ekwelapheni i-renal cell carcinoma (RCC), i-sunitinib ivame ukuthathwa kanye ngosuku amasonto ama-4 (izinsuku ezingama-28) kulandelwa ikhefu lamaviki amabili ngaphambi kokuqala umjikelezo olandelayo wokulinganisa iphindaphindwe njalo emavikini angu-6 inqobo nje uma udokotela wakho encoma. Ngokuvikela i-RCC, i-sunitinib ivame ukuthathwa kanye ngosuku amasonto ama-4 (izinsuku ezingama-28) kulandelwe ikhefu lamaviki ama-2 ngaphambi kokuqala umjikelezo olandelayo wokulinganisa futhi iphinda njalo emavikini ayisithupha ngemijikelezo engu-9. Ekwelapheni izicubu ze-pancreatic neuroendocrine (pNET), i-sunitinib ivame ukuthathwa kanye ngosuku. Thatha i-sunitinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-sunitinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Musa ukuvula amaphilisi.

Ungadinga ukuthatha iphilisi elilodwa noma amaningi ngasikhathi sinye kuya ngomthamo wakho we-sunitinib.

Udokotela wakho angakhuphula kancane noma anciphise umthamo wakho we-sunitinib ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka nokuthatha i-sunitinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-sunitinib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sunitinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-sunitinib, noma iziphi izithako zamaphilisi e-sunitinib, noma eminye imithi. Buza usokhemisi wakho noma hlola ishidi lemininingwane yeziguli lomkhiqizi (Umhlahlandlela Wezokwelapha) ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic athile afana ne-clarithromycin (Biaxin, e-Prevpac), i-rifampin (i-Rifadin, i-Rimactane, i-Rifamate, i-Rifater), i-rifabutin (i-Mycobutin), i-rifapentine (i-Priftin), ne-telithromycin (i-Ketek); ezinye izinto zokuvikela ezifana ne-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole, ne-voriconazole (i-Vfend); i-dexamethasone; imithi yesifo sikashukela; imishanguzo ethile yegciwane lesandulela ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) ehlanganisa i-atazanavir (i-Reyataz, e-Evotaz), i-indinavir (i-Crixivan), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir, e-Kaletra), ne-saquinavir (i-Invirase); nefazodone; imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, ne-phenytoin (Dilantin, Phenytek). Phinda utshele udokotela wakho uma uthatha noma uthathe i-alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), noma i-zoledronic acid injection (Reclast, Zometa), Eminye imishanguzo nayo ingaxhumana sunitinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho kanye nosokhemisi ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSort John's wort. Ungathathi i-wort yaseSt. John ngenkathi uthatha i-sunitinib.
• utshele udokotela wakho uma uke waba nenkinga yokopha noma wake waba nayo; ihlule legazi emaphashini; ukwelulwa kwesikhawu se-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe); ukushaya kwenhliziyo okuhamba kancane, okusheshayo, noma okungajwayelekile; isifo senhliziyo; ukwehluleka kwenhliziyo; umfutho wegazi ophakeme; ukuquleka; ushukela wegazi ophansi noma isifo sikashukela; amazinga aphansi we-potassium noma i-magnesium egazini lakho; izinkinga ngomlomo wakho, amazinyo noma izinsini; noma izinso, i-thyroid, noma isifo senhliziyo.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngenkathi uthatha i-sunitinib. Uma ungowesifazane, kuzodingeka ukuthi uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa, futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho kwe-sunitinib kanye namasonto ama-4 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukuvimbela inzalo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-sunitinib kanye namasonto ayi-7 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. I-Sunitinib inganciphisa ukuzala kwabesilisa nabesifazane. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-sunitinib, shayela udokotela wakho. I-Sunitinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-sunitinib kanye namasonto ama-4 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa yazisa udokotela noma udokotela wamazinyo ukuthi uthatha i-sunitinib. Udokotela wakho uzokutshela ukuthi uyeke ukuthatha i-sunitinib okungenani amasonto amathathu ngaphambi kokuhlinzwa kwakho okuhleliwe ngoba kungathinta ukuphulukiswa kwesilonda. Udokotela wakho uzokutshela ukuthi uqale nini ukuthatha i-sunitinib futhi ngemuva kokuhlinzwa kwakho.
• kufanele wazi ukuthi i-sunitinib ingadala ukuthi isikhumba sakho siphuzi futhi izinwele zakho zikhanye futhi zilahle umbala. Lokhu kungenzeka kubangelwa umbala ophuzi womuthi futhi akulimazi noma kubuhlungu.
• kufanele wazi ukuthi i-sunitinib ingadala umfutho wegazi ophezulu. Umfutho wegazi lakho kufanele uhlolwe njalo ngenkathi uthatha i-sunitinib.
• kufanele wazi ukuthi i-sunitinib ingadala i-osteonecrosis yomhlathi (i-ONJ, isimo esibi sethambo lomhlathi), ikakhulukazi uma uhlinzwa noma ukwelashwa ngenkathi uthatha umuthi. Udokotela wamazinyo kufanele ahlole amazinyo akho futhi enze noma yiziphi izindlela zokwelashwa ezidingekayo, kufaka phakathi ukuhlanza noma ukulungisa amazinyo okufakelwa angalungile, ngaphambi kokuba uqale ukuthatha i-sunitinib. Qiniseka ukuthi uxubha amazinyo futhi uhlanze umlomo wakho kahle ngenkathi uthatha i-sunitinib. Tshela udokotela wakho noma udokotela wamazinyo uma uke waba nomlomo, amazinyo noma umhlathi; izilonda zomlomo noma ukuvuvukala; ukuba ndikindiki noma umuzwa wobunzima emhlathini; noma yimaphi amazinyo axegayo. Khuluma nodokotela wakho ngaphambi kokuthola noma yikuphi ukwelashwa kwamazinyo ngenkathi uthatha lo muthi.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma uphuthelwa umthamo we-sunitinib ngaphansi kwamahora angu-12, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uthatha umthamo olandelayo ngesikhathi esihleliwe. Kodwa-ke, uma uphuthelwa umthamo ngaphezu kwamahora we-12, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Sunitinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuthakathaka
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• isilungulela
• igesi
• ama-hemorrhoids
• ubuhlungu, ukucasuka, noma ukushisa kwezindebe, ulimi, umlomo noma umphimbo
• umlomo owomile
• shintsha ngendlela izinto ezinambitha ngayo
• ukulahlekelwa isifiso sokudla
• izinguquko zesisindo
• ukulahleka kwezinwele
• izinzipho ezincane, ezinyinyithekayo noma izinwele
• inkulumo engasheshi
• isikhumba esiphaphathekile noma esomile
• eqhaqhazela
• isikhathi esindayo, esingajwayelekile, noma esilahlekile sokuya esikhathini
• ukudana
• ubunzima bokulala noma ukulala
• ukoma, ukuqina, ukuqhekeka, noma ukushwabana kwesikhumba ezintendeni zezandla naphansi kwamathe ezinyawo
• ubuhlungu bemisipha, obuhlangene, beqolo noma bomlenze
• ukopha kaningi
• ukopha ezinsinini zakho
• ukungakhululeki okungavamile emazingeni okushisa abandayo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO noma ZOKUQapha, shayela udokotela wakho ngokushesha:

• ukulimaza noma ukopha okungavamile
• indle enegazi noma emnyama neyokulinda
• igazi emchameni
• hlanza okubomvu ngokugqamile noma okubukeka njengezindawo zekhofi
• ekhwehlela igazi
• ubuhlungu besisu, ukuvuvukala, noma isisa
• ikhanda
• imfiva
• ukuvuvukala, ubumnene, imfudumalo, noma ubomvu bomlenze
• ukuvuvukala kwezinyawo noma kwamaqakala
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• isiyezi noma ukuquleka
• ukunciphisa ukuqapha noma ukugxila
• ukudideka
• ukudana
• uvalo
• isithuthwane
• umbono uyashintsha
• ubuhlungu besifuba noma ingcindezi
• ukukhathala ngokweqile
• ukuphelelwa umoya
• ubuhlungu ngokuphefumula okujulile
• ukuzuza kwesisindo okungaqondakali
• ukuncipha kokuchama
• umchamo onamafu
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, noma umphimbo
• ukuqubuka
• isifuba
• ukushwabana noma ukuxebuka kwesikhumba noma ngaphakathi emlonyeni
• ubunzima bokugwinya noma ukuphefumula
• ukushaqeka

I-Sunitinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile ezinjenge-electrocardiograms (EKG, isivivinyo esiqopha umsebenzi kagesi wenhliziyo), ama-echocardiograms (ukuhlolwa okusebenzisa amaza omsindo ukukala amandla enhliziyo yakho okumpompa igazi), nokuhlolwa komchamo ngaphambi nangesikhathi sokwelashwa kwakho nge-sunitinib ukuze uqiniseke ukuthi kuphephile kuwe ukuthatha i-sunitinib, nokuhlola ukuphendula komzimba wakho emithini.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Ngobuhlakani^®