I-Lapatinib

-Delile

• Ngaphambi kokuthatha i-lapatinib,
• ILapatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESixwayiso noma isigaba SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

ILapatinib ingadala ukulimala kwesibindi okungaba nzima noma kusongele impilo. Ukulimala kwesibindi kungenzeka ngemuva kwezinsuku ezimbalwa noma ngemuva kwezinyanga ezimbalwa ngemuva kokuqala ukwelashwa nge-lapatinib. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukulunywa, ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama, ubuhlungu engxenyeni engaphezulu kwesokudla yesisu, ukopha okungavamile noma ukulimaza, noma izitulo eziphaphathekile noma ezimnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zaselabhorethri ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi kungenzeka yini ukuthi isibindi sakho sonakaliswe noma sonakaliswe yi-lapatinib.

Khuluma nodokotela wakho ngezingozi zokuthatha i-lapatinib.

ILapatinib isetshenziswa ne-capecitabine (Xeloda) ukwelapha uhlobo oluthile lomdlavuza webele osezingeni eliphakeme kubantu asebevele belashwa ngeminye imithi yokwelapha ngamakhemikhali. ILapatinib ibuye isetshenziswe ne-letrozole (Femara) ukwelapha uhlobo oluthile lomdlavuza webele kwabesifazane abangemva kokuya esikhathini (abesifazane abaye babhekana noshintsho lwempilo, ukuphela kwezikhathi zokuya esikhathini) okusabalele nakwezinye izingxenye zomzimba. ILapatinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

ILapatinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku, okungenani ihora eli-1 ngaphambi noma ihora eli-1 ngemuva kokudla. Lapho i-lapatinib isetshenziselwa ukwelapha umdlavuza webele osezingeni eliphakeme noma we-metastatic, imvamisa unikezwa kanye ngosuku ngezinsuku 1 kuya ku-21 (kanye ne-capecitabine ngezinsuku 1 kuya ku-14) zomjikelezo wezinsuku ezingama-21. Umjikelezo ungaphindwa njengoba kunconywe udokotela wakho. Lapho i-lapatinib isetshenziselwa ukwelapha umdlavuza webele kwabesifazane be-postmenopausal, imvamisa inikezwa kanye ngosuku kanye ne-letrozole. Thatha wonke amaphilisi e-lapatinib ngomthamo wakho wansuku zonke ngasikhathi sinye ngosuku; ungahlukanisi amaphilisi ukuze uthathe imithamo ehlukile. Thatha i-lapatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-lapatinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho angakhuphula noma anciphise kancane umthamo wakho we-lapatinib ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe nanoma yimiphi imiphumela emibi ongayithola. Qhubeka uthathe i-lapatinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-lapatinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-lapatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-lapatinib, noma imuphi omunye umuthi, noma iziphi izithako ezisemaphilisi e-lapatinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic athile afana ne-clarithromycin (i-Biaxin, e-Prevpac), i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin), i-moxifloxacin (i-Avelox), i-rifabutin (i-Mycobutin), i-rifampin (i-Rifadin, e-Rifamate, e I-Rifater, i-Rimactane), i-rifapentine (i-Priftin), i-sparfloxacin (i-Zagam) (ayitholakali e-US), ne-telithromycin (Ketek); ama-antifungals afana ne-itraconazole (Sporanox), ketoconazole (Nizoral), ne-voriconazole (Vfend); ama-calcium channel blocker anjenge-amlodipine (Norvasc, eCaduet naseLotrel), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil, eLexxel), nifedipine (Adalat, Nifedical XL, Procardia, abanye), nisoldipine (Sular) , kanye ne-verapamil (Calan, Isoptin, Verelan, abanye); i-cisapride (Propulsid) (ayitholakali e-U.S.); i-dexamethasone (i-Decadron, i-Dexpak); imithi ethile yokudangala efana ne-nefazodone; imishanguzo ethile yamakhemikhali afaka i-daunorubicin (Cerubidine, DaunoXome), doxorubicin (Adriamycin, Doxil, Rubex), epirubicin (Ellence), idarubicin (Idamycin), tamoxifen (Nolvadex), valrubicin (Valstar), vinblastine, imishanguzo ethile yegciwane lesandulela-ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efaka i-atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra), ne-saquinavir (Invirase); imishanguzo yokushaya kwenhliziyo okungajwayelekile kubandakanya i-amiodarone (Cordarone), i-disopyramide (i-Norpace), i-dofetilide (iTikosyn), i-procainamide (i-Procanbid), i-quinidine, ne-sotalol (i-Betapace, i-Betapace AF, i-Sorine); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), ne-phenytoin (Dilantin, Phenytek); ipimozide (i-Orap); futhi thioridazine. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-lapatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho kanye nosokhemisi ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSort John's wort.
• utshele udokotela wakho uma ngabe uke waba nokushaya kwenhliziyo okuhamba kancane, okusheshayo, noma okungajwayelekile; isikhathi se-QT eside (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa ngokuzuma); izinga eliphansi le-magnesium noma i-potassium egazini lakho; noma isifo senhliziyo noma samaphaphu.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kuzofanele wenze ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa. Uma ungowesifazane okwaziyo ukukhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina. Uma ungowesilisa nomlingani wesifazane ongakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nangesonto eli-1 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-lapatinib, shayela udokotela wakho ngokushesha. ILapatinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ngenkathi uthatha i-lapatinib kanye neviki elingu-1 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi i-lapatinib ivame ukudala isifo sohudo, esingaba nzima. Shayela udokotela wakho uma unesifo sohudo ngenkathi uthatha i-lapatinib. Udokotela wakho angakutshela ukuthi uphuze iziphuzo eziningi, wenze izinguquko ekudleni kwakho, futhi uphuze nemithi yokulawula isifo sohudo nokuvimbela ukomisa (ukulahleka kwamanzi amaningi emzimbeni wakho). Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo zokoma: ukoma ngokweqile, umlomo owomile kanye / noma isikhumba, ukuncipha kokuchama, amehlo ashonile, noma ukushaya kwenhliziyo okusheshayo.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ophuthelwe ngokushesha uma uwukhumbula ngalolo suku. Kodwa-ke, uma ungakhumbuli kuze kube usuku olulandelayo, uma ungakhumbuli ukuthi ngabe uwuthathile yini umuthi, noma uma uhlanza umuthi wakho, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa ngezikhathi ezithile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ILapatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isilungulela
• izilonda ezindebeni, emlonyeni, noma emphinjeni
• ukulahlekelwa isifiso sokudla
• okubomvu, okubuhlungu, okundikindiki, noma okuthambisa izandla nezinyawo
• isikhumba esomile
• ubuhlungu ezingalweni, emilenzeni, noma emuva
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESixwayiso noma isigaba SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha:

• ukuphelelwa umoya
• ukukhwehlela okomile
• ukukhwehlela isikhwehlela esibomvana noma esinegazi
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ubuthakathaka
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuqubuka
• imfiva
• isikhumba esishayayo noma esikhanyayo

ILapatinib ingashintsha indlela inhliziyo yakho eshaya futhi iphampa ngayo igazi emzimbeni wakho. Udokotela wakho uzokuqapha ngokucophelela ukuze abone ukuthi ngabe i-lapatinib iyithintile yini inhliziyo yakho. Khuluma nodokotela wakho ngezingozi zokuthatha i-lapatinib.

ILapatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isifo sohudo
• ukuhlanza

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Tykerb^®