I-Etravirine

-Delile

• Ngaphambi kokuthatha i-etravirine,
• I-Etravirine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-etravirine bese ushayela udokotela wakho ngokushesha:

I-Etravirine isetshenziswa kanye neminye imithi yokwelapha ukutheleleka ngegciwane lesandulela ngculazi (i-HIV) kubantu abadala nasezinganeni ezineminyaka engu-2 nangaphezulu ezingasasizi ngokuthatha eminye imishanguzo ye-HIV. I-Etravirine isekilasini lemithi ebizwa nge-non-nucleoside reverse transcriptase inhibitors (NNRTIs). Isebenza ngokunciphisa inani le-HIV egazini. Yize i-etravirine ingayelaphi i-HIV, ingahle yehlise amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezinqala noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko empilweni kunganciphisa ubungozi bokudlulisela (ukusabalalisa) igciwane le-HIV kwabanye abantu.

I-Etravirine iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngemuva kokudla kabili ngosuku. Thatha i-etravirine ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-etravirine njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngoketshezi, njengamanzi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma unenkinga yokugwinya amaphilisi, angahle ancibilikiswe emanzini. Ukuzilungiselela, engeza amaphilisi kusipuni esisodwa (5 ml) samanzi (amanzi kuphela, ungasebenzisi noma yiluphi olunye uhlobo luketshezi) noma okungenani uketshezi olwanele ukumboza umuthi, bese unyakazisa kuze kuvele ingxube yobisi. Bese ufaka isipuni esisodwa (15 mL) soketshezi njengamanzi noma ungasebenzisa isiphuzo esifana nejusi lewolintshi noma ubisi ukuthuthukisa ukunambitheka. Ingabe hhayi hlanganisa amaphilisi noketshezi olufudumele noma olushisayo noma isiphuzo esinekhabhoni njengesoda. Phuza ingxube ngokushesha. Hlanza ingilazi ngamanzi, ijusi lewolintshi, noma ubisi bese ugwinya konke okuqukethwe. Phinda inqubo yokuhlanza nokugwinya ingxube ye-rinse izikhathi eziningana ukuze uqiniseke ukuthi umthamo wonke uyathathwa.

I-Etravirine iyasiza ukulawula ukutheleleka nge-HIV kepha ayiyelaphi. Qhubeka nokuphuza i-etravirine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-etravirine ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-etravirine noma uphuthelwe imithamo, isimo sakho singaba nzima ukwelashwa. Lapho ukunikezwa kwakho kwe-etravirine kuqala ukwehla, thola okuningi kudokotela wakho noma ekhemisi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-etravirine,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-etravirine, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-etravirine. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho lokhu okulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); antiarrhythmics (imithi yokwelapha ukushaya kwenhliziyo okungajwayelekile) kufaka phakathi i-amiodarone (Nexterone, Pacerone), bepridil (Vascor), disopyramide (Norpace), flecainide (Tambocor), lidocaine (Xylocaine), mexiletine (Mexitil), propafenone (Rythmol), ne-quinidine ); imithi ethile yokwelapha ukuquleka okufana ne-carbamazepine (Carbatrol, Tegretol, Teril), phenobarbital (Luminal), ne-phenytoin (Dilantin, Phenytek); i-clarithromycin (i-Biaxin, ku-Prevpac); imithi yokwehlisa i-cholesterol (ama-statins) afaka i-atorvastatin (Lipitor), i-fluvastatin (i-Lescol), i-lovastatin (i-Advicor, i-Altoprev, i-Mevacor), i-rosuvastatin (i-Crestor), ne-simvastatin (i-Vytorin, i-Zocor); i-clopidogrel (i-Plavix); diazepam (Valium); i-dexamethasone; imithi ethile ecindezela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), kanye ne-tacrolimus (Prograf); imithi yokwelapha ukungasebenzi kahle kwe-erectile kufaka phakathi i-sildenafil (Viagra), i-tadalafil (i-Cialis), ne-vardenafil (i-Levitra); imithi yokwelapha izifo ezikhunta okubandakanya i-fluconazole (i-Diflucan), i-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-methadone (i-Dolophine); eminye imithi yokwelapha i-HIV kufaka phakathi i-amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, e-Atripla), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Virac) ne-nevirapine (Viramune) ritonavir (Norvir, eKaletra), ne-tipranavir (Aptivus); i-rifabutin (i-Mycobutin); i-rifampin (i-Rifadin, i-Rifater, i-Rifamate); kanye ne-rifapentine (Priftin). Eminye imithi eminingi ingaxhumana ne-etravirine, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Ungaqali ukusebenzisa noma imiphi imithi emisha ngenkathi uthatha i-etravirine ngaphandle kokukhuluma nodokotela noma usokhemisi kuqala.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma ngabe uke waba nesifo sesibindi, noma i-hepatitis.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-etravirine, shayela udokotela wakho.
• akufanele uncelise ibele uma utheleleke nge-HIV noma uthatha i-etravirine.
• kufanele wazi ukuthi amafutha omzimba wakho angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho njengamabele akho, intamo, isifuba, isisu, nomhlane ongaphezulu. Ukulahleka kwamafutha emilenzeni, ezingalweni nasebusweni nakho kungenzeka.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho. Lokhu kungadala ukuthi ube nezimpawu zalezo zifo. Uma unezimpawu ezintsha noma eziba nzima ngemuva kokuqala ukwelashwa nge-etravirine, qiniseka ukuthi utshela udokotela wakho.

Khuluma nodokotela wakho mayelana nokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma ukhumbula ukuthi uphuthelwe ukuthatha umthamo ngaphakathi kwamahora angu-6 wesikhathi ovame ukuthatha i-etravirine, thatha umthamo ongabanjwanga ngemuva kokudla ngokushesha okukhulu, bese uthatha umthamo olandelayo ngesikhathi esihleliwe njalo. Kodwa-ke, uma ukhumbula ngaphezu kwamahora angu-6 ngemuva kwesikhathi lapho uvame ukuthatha umthamo wakho, linda bese uthatha umthamo olandelayo we-etravirine ngokuya ngohlelo lwakho olujwayelekile lokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Etravirine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• isifo sohudo
• ikhanda
• ukwanda kwengcindezi yegazi
• ubuhlungu, ukuvutha, ukuba ndikindiki, noma ukuncinza ezandleni noma ezinyaweni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-etravirine bese ushayela udokotela wakho ngokushesha:

• ukuqubuka
• ububomvu, izigaxa, noma amabhamuza esikhunjeni noma emlonyeni
• ububomvu noma ukuvuvukala kwamehlo
• ukuvuvukala kobuso
• umphimbo obuhlungu, ukukhwehlela, umkhuhlane, ukubanda, noma ezinye izimpawu zokutheleleka
• ukugula okuvamile
• ukukhathala
• ubuhlungu bemisipha noma obuhlangene
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• indle enombala okhanyayo
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukulahlekelwa isifiso sokudla

I-Etravirine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina izikhwama ezintathu ze-desiccant (drying agent) ebhodleleni lemithi ukugcina amaphilisi omile. Ungazidli izikhwama ze-desiccant.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-etravirine.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthatha i-etravirine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Gcina uhlu lwemithi yakho bese uyikhombisa udokotela kanye nosokhemisi lapho uthola umuthi omusha.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Ukungabi namandla^®