Ukujova kwe-Ustekinumab

-Delile

• Ngaphambi kokuthola umjovo we-ustekinumab,
• Umjovo we-Ustekinumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

Umjovo we-Ustekinumab usetshenziselwa ukwelapha i-plaque psoriasis ngokulinganisela (isifo sesikhumba lapho kwakhiwa khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba) kubantu abadala nezingane ezineminyaka engu-6 noma ngaphezulu abangazuza emithini yokwelashwa noma i-phototherapy (ukwelashwa okubandakanya ukudalula isikhumba ekukhanyeni kwe-ultraviolet). Ibuye isetshenziswe yodwa noma ihlanganiswe ne-methotrexate (Otrexup, Rasuvo, Trexall) ukwelapha i-psoriatic arthritis (isimo esidala ubuhlungu bamalunga nokuvuvukala nezikali esikhunjeni) kubantu abadala. Umjovo we-Ustekinumab uphinde usetshenziselwe ukwelapha isifo sikaCrohn (isimo lapho umzimba uhlasela ulwelwesi lwendlela yokugaya ukudla, ubangele ubuhlungu, isifo sohudo, ukwehla kwesisindo, nomkhuhlane) kubantu abadala. Umjovo we-Ustekinumab uphinde usetshenziselwe ukwelapha i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulwelwesi lwekholoni [amathumbu amakhulu] ne-rectum) kubantu abadala. Umjovo we-Ustekinumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokumisa ukusebenza kwamaseli athile emzimbeni abangela izimpawu ze-plaque psoriasis, i-psoriatic arthritis, isifo sikaCrohn, nesifo sezilonda emathunjini.

I-Ustekinumab iza njengesisombululo (uketshezi) ukujova ngomgogodla (ngaphansi kwesikhumba) noma ngemithambo (emthanjeni). Ekwelapheni i-plaque psoriasis ne-psoriatic arthritis, kuvamise ukujojelwa ngomgogodla njalo emasontweni amane emithamo emibili yokuqala bese njalo njalo emavikini ayi-12 inqobo nje uma ukwelashwa kuqhubeka. Ekwelapheni isifo sikaCrohn kanye nesilonda esilimaza ulcerative, kuvamise ukujova ngomjovo womthamo wokuqala bese unikezwa ngomgogodla njalo emasontweni ayisishiyagalombili uma nje ukwelashwa kuqhubeka.

Uzothola umthamo wakho wokuqala ongaphansi komjovo we-ustekinumab ehhovisi likadokotela wakho. Ngemuva kwalokho, udokotela wakho angaqhubeka nokukunika imijovo noma akuvumele ukuthi ujove umjovo we-ustekinumab ngokwakho noma ube nomnakekeli owenza imijovo. Cela udokotela wakho noma usokhemisi ukuthi akubonise noma umuntu ozokwenza imijovo yokujova ustekinumab. Ngaphambi kokusebenzisa umjovo we-ustekinumab okokuqala, funda imiyalelo ebhaliwe eza nayo.

Uma umuthi wakho ufika ngesirinji noma isitsha esivuthiwe, sebenzisa isirinji ngayinye noma isitsha esisodwa kanye bese ujova sonke isisombululo esirinji. Noma ngabe kusekhona isixazululo esisele esirinji noma edivayisini, ungasisebenzisi futhi. Lahla izinaliti, imijovo, namadivayisi esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Unganyakazisi isirinji noma isitsha esivuthiwe esine-ustekinumab.

Njalo bheka isisombululo se-ustekinumab ngaphambi kokusijova. Hlola ukuthi usuku lokuphelelwa yisikhathi aludlulanga nokuthi uketshezi lucacile noma luphuzi kancane. Uketshezi lungaqukatha izinhlayiya ezimbalwa ezimhlophe ezibonakalayo. Ungasebenzisi i-vial noma isirinji efakiwe uma ilimele, iphelelwe yisikhathi, iqandisiwe, noma uma uketshezi lunamafu noma luqukethe izinhlayiya ezinkulu.

Ungafaka umjovo we-ustekinumab ngomgogodla noma ikuphi ngaphambili kwamathanga akho (umlenze ongaphezulu), izingalo ezingaphandle, izinqe, noma isisu (isisu) ngaphandle kwenkaba yakho nendawo engamasentimitha ama-5 ukuyizungeza. Ukwehlisa amathuba okuba buhlungu noma okubomvu, sebenzisa isiza esihlukile ngomjovo ngamunye. Ungafaki endaweni lapho isikhumba sithambile, silimele, sibomvu, noma siqinile noma lapho unezibazi noma izimpawu zokwelula.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-ustekinumab. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-ustekinumab,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-ustekinumab, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-ustekinumab. Uma uzosebenzisa isirinji esivele ifakiwe, tshela udokotela wakho uma wena noma umuntu ozojova umuthi onenkinga ye-latex noma i-rubber. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (ama-thinner egazi) njenge-warfarin (i-Coumadin, i-Jantoven) nemithi ecindezela amasosha omzimba njenge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup , Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), kanye ne-tacrolimus (Astagraf, Envarsus, Prograf); noma i-oral steroids efana ne-dexamethasone (Hemady), i-methylprednisolone (i-Medrol), ne-prednisone (i-Rayos). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma ngabe uke waba nanoma yiluphi uhlobo lomdlavuza noma wake waba nalo. Phinda utshele udokotela wakho uma ngabe uthola noma uthola i-phototherapy noma ama-allergy shots (uchungechunge lwemijovo olunikezwa njalo ukuvimbela umzimba ekuthintekeni kokungezwani komzimba nezinto ezithile).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola umjovo we-ustekinumab, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa umjovo we-ustekinumab.
• thintana nodokotela wakho ukuze ubone uma ngabe udinga ukuthola noma yimiphi imigomo. Kubalulekile ukuthi yonke imishanguzo yokugoma ilungele iminyaka yakho ngaphambi kokuqala ukwelashwa kwakho ngomjovo we-ustekinumab. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho. Kubaluleke kakhulu ukungawutholi umuthi wokugoma we-BCG unyaka owodwa ngaphambi kokwelashwa kwakho, ngesikhathi sokwelashwa kwakho, nangonyaka owodwa ngemuva kokwelashwa kwakho. Futhi khuluma nodokotela wakho uma noma ngubani ekhaya lakho edinga ukuthola umuthi wokugoma ngesikhathi sokwelashwa kwakho ngomjovo we-ustekinumab.
• kufanele wazi ukuthi umjovo we-ustekinumab unganciphisa ikhono lakho lokulwa nokutheleleka kusuka kubhaktheriya, amagciwane, nesikhunta futhi kwandise ingozi yokuthi uzothola ukutheleleka okungathi sína noma okusongela ukuphila. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma une noma ucabanga ukuthi ungahle ube nolunye uhlobo lokutheleleka manje. Lokhu kufaka izilonda zesikhumba ezintsha noma ezishintshayo, ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifikayo (ezifana nezilonda ezibandayo), kanye nezifo ezingapheli ezingapheli. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva nje kokwelashwa kwakho ngomjovo we-ustekinumab, shayela udokotela wakho ngokushesha: ubuthakathaka; ukujuluka; Ukugodola; ubuhlungu bemisipha; Umphimbo obuhlungu; ukukhwehlela; ukuphelelwa umoya; imfiva; ukuncipha komzimba; ukukhathala ngokweqile; izimpawu ezinjengomkhuhlane; isikhumba esifudumele, esibomvu, noma esibuhlungu; ukuchama okubuhlungu, okunzima, noma okuvamile; isifo sohudo; ubuhlungu besisu; noma ezinye izimpawu zokutheleleka.
• kufanele wazi ukuthi ukusebenzisa umjovo we-ustekinumab kwandisa ubungozi bokuthi uzoba nesifo sofuba (i-TB; isifo esibucayi samaphaphu), ikakhulukazi uma usuvele ungenwe yisifo sofuba kodwa ungenazo izimpawu zesifo. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma ngabe uhlala ezweni lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB. Udokotela wakho uzokuhlolela isikhumba ukuze abone ukuthi une-TB engasebenzi yini. Uma kunesidingo, udokotela wakho uzokunika imithi yokwelapha lesi sifo ngaphambi kokuqala ukusebenzisa umjovo we-ustekinumab. Uma unezinye zalezi zimpawu ezilandelayo ze-TB, noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ubuhlungu besifuba, ukukhwehlela igazi noma amafinyila, ubuthakathaka noma ukukhathala, ukwehla kwesisindo, ukungathandi ukudla, Ukugodola, umkhuhlane, noma ukujuluka ebusuku.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Sebenzisa umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uqhubeka nesimiso sakho sokulinganisa okuvamile. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile.

Umjovo we-Ustekinumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukugijima, ikhala eligxishiwe, noma ukuthimula
• ukukhathala
• ububomvu noma ukucasuka endaweni yomjovo
• isicanucanu
• ukuhlanza
• ubuhlungu obuhlangene

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• isithuthwane
• ukudideka
• umbono uyashintsha
• ngizizwe ngiphela amandla
• ukuqubuka
• ukulunywa
• isifuba
• ukuvuvukala kobuso, amajwabu amehlo, ulimi, noma umphimbo
• ukuphefumula kanzima
• ukuqina esifubeni noma emphinjeni

Umjovo we-Ustekinumab ungakhuphula ubungozi bokuthi uzoba nomdlavuza. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi.

Umjovo we-Ustekinumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina izitsha ze-ustekinumab kanye nemijovo ekhethiwe esiqandisini, kodwa ungaziqandisi.Gcina izitsha noma imijovo ekhethiwe iqonde emabhokisini abo okuqala ukuwavikela ekukhanyeni. Lahla noma imuphi umuthi osuphelelwe yisikhathi noma ongasadingeki. Khuluma nosokhemisi wakho ngokulahlwa okufanele kwemithi yakho.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-ustekinumab.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UStenara^®