Umjovo weBusulfan

-Delile

• Ngaphambi kokuthola umjovo we-busulfan,
• I-Busulfan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo weBusulfan ungadala ukwehla okukhulu kwenani lamaseli egazi emnkantsheni wakho wethambo. Tshela udokotela kanye nosokhemisi ngayo yonke imithi oyiphuzayo. Uma uthola i-busulfan neminye imithi engadala ukubalwa kwegazi okuphansi, imiphumela emibi yemithi ingaba mibi kakhulu. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, umphimbo obuhlungu, ukukhwehlela okuqhubekayo nokuminyana, noma ezinye izimpawu zokutheleleka; ukopha okungavamile noma ukulinyazwa.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda ukuhlolwa kwelabhorethri ngaphambi, ngesikhathi nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-busulfan ukubona ukuthi amaseli akho egazi ayathinteka yini yilomuthi.

IBusulfan ingakhuphula ubungozi bokuthi uzoba neminye imidlavuza. Khuluma nodokotela wakho ngezingozi zokuthola i-busulfan.

Umjovo weBusulfan usetshenziselwa ukwelapha uhlobo oluthile lwe-leukemia engapheli (i-CML; uhlobo lomdlavuza wamangqamuzana amhlophe egazi) ngokuhlangana neminye imithi yokubhubhisa umnkantsha namaseli omdlavuza ukulungiselela ukufakelwa umnkantsha wethambo. UBusulfan usesigabeni semithi ebizwa ngama-alkylating agents. Isebenza ngokunciphisa noma ukumisa ukukhula kwamangqamuzana omdlavuza emzimbeni wakho.

IBusulfan iza njengesisombululo (uketshezi) okufanele sinikezwe ngemithambo (emthanjeni) ngaphezu kwamahora ama-2 ngudokotela noma umhlengikazi esikhungweni sezokwelapha. Imvamisa inikezwa njalo emahoreni ayisithupha izinsuku ezine (ngenani eliphelele lama-16) ngaphambi kokufakelwa komnkantsha.

Umjovo weBusulfan ungadala ukuquleka ngesikhathi sokwelapha ngemithi. Udokotela wakho uzokunika omunye umuthi ozosiza ukuvimbela ukuqubuka ngaphambi nangesikhathi sokwelapha ngomjovo we-busulfan.

Umjovo weBusulfan ubuye usetshenziswe ngokuhlangana nezinye izidakamizwa ukubhubhisa umnkantsha wethambo namaseli womdlavuza ukulungiselela ukufakelwa umnkantsha wethambo kubantu abanezinye izinhlobo zomdlavuza.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-busulfan,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-busulfan, noma imuphi omunye umuthi, noma yiziphi izithako zomjovo we-busulfan. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-acetaminophen (iTylenol); i-clozapine (Clozaril, FazaClo); i-cyclosporine (iSandimmune, iGengraf, Neoral); itraconazole (Sporanox); imithi yokugula ngengqondo kanye nesicanucanu; noma i-meperidine (i-Demerol). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-busulfan, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi wake wathola ukwelashwa ngemisebe noma enye i-chemotherapy noma wake waquleka noma walimala ekhanda.
• kufanele wazi ukuthi i-busulfan ingaphazamisa umjikelezo ojwayelekile wokuya esikhathini (isikhathi) kwabesifazane, ingamisa ukukhiqizwa kwesidoda emadodeni, futhi ingadala ukungabi nenzalo (ubunzima bokukhulelwa). Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma ukuncelisa. Akufanele uhlele ukuba nezingane ngenkathi uthola i-chemotherapy noma isikhashana ngemuva kokwelashwa. (Khuluma nodokotela wakho ukuthola eminye imininingwane.) Sebenzisa indlela ethembekile yokulawula inzalo ukuvimbela ukukhulelwa. Uma ukhulelwa ngenkathi uthola i-busulfan, shayela udokotela wakho ngokushesha. IBusulfan ingalimaza umbungu.

I-Busulfan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• isifo sohudo
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukuqunjelwa
• izilonda emlonyeni nasemphinjeni
• umlomo owomile
• ikhanda
• ubunzima bokulala noma ukulala
• uzizwe ukhathazeke ngokweqile noma ukhathazekile
• isiyezi
• ukuvuvukala kobuso, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ubuhlungu besifuba
• ubuhlungu obuhlangene, besisipha noma beqolo
• ukuqubuka
• ukuluma nesikhumba esomile
• isikhumba esimnyama
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• emnyama, izitulo zokubambezeleka
• umchamo obomvu
• ukuhlanza
• ubuhlungu besisu
• ukukhathala okungajwayelekile noma ubuthakathaka
• ukuphefumula kanzima
• isithuthwane

I-Busulfan ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Le mithi izogcinwa esibhedlela noma esikhungweni sezokwelapha lapho uthola khona umthamo ngamunye

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• emnyama, izitulo zokubambezeleka
• umchamo obomvu
• ukulimaza noma ukopha okungavamile
• ukukhathala okungajwayelekile noma ubuthakathaka

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Busulfex^® Ukujova

• IBusulphan