Crizotinib

-Delile

• Ngaphambi kokuthatha i-crizotinib,
• I-Crizotinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Crizotinib isetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza wamangqamuzana ongewona omncane (i-NSCLC) osabalalele ezicutshini eziseduze noma kwezinye izingxenye zomzimba. Ibuye isetshenziselwe ukwelapha uhlobo oluthile lwe-anaplastic large cell lymphoma (ALCL) ebuyile noma engaphenduli kolunye ukwelashwa (kwabanye) kubantu abadala abathile nezingane ezinonyaka owodwa nangaphezulu. UCrizotinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sento ethile eyenzeka ngokwemvelo engadingeka ukusiza amangqamuzana omdlavuza ukuba ande.

ICrizotinib iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla kabili ngosuku. Thatha i-crizotinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-crizotinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Ungathinti amaphilisi aphukile noma achotshoziwe.

Udokotela wakho angayeka ukwelashwa kwakho okwesikhashana noma unomphela, anciphise umthamo, noma akutshele ukuthi uthathe imithi yakho kaningi uma uhlangabezana nemiphumela emibi ye-crizotinib. Tshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa.

Qhubeka uthathe i-crizotinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-crizotinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-crizotinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-crizotinib, noma imiphi eminye imithi, noma yiziphi izithako kuma-capsule e-crizotinib. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Cordarone, Pacerone); ama-antibiotic athile afana ne-clarithromycin (Biaxin); imishanguzo ethize yokubulala izinhlungu efana ne-itraconaozole (Sporanox), ketoconazole (Nizoral), ne-voriconazole (Vfend); imithi ethile yomfutho wegazi; i-chloroquine (Aralen); i-chlorpromazine (i-Thorazine); i-citalopram (Celexa); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-digoxin (i-Lanoxin); i-dihydroergotamine (i-DHH 45, i-Migranal); i-disopyramide (iNorpace); i-dofetilide (Tikosyn); i-droperidol (Inapsine); i-ergotamine (i-Ergomar, eCafergot, eMigergot); i-erythromycin (i-E.E.S., i-Erythrocin); i-fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); i-flecainide (iTambocor); imishanguzo ethile yegciwane lengculazi (i-HIV) efana ne-atazanavir (Reyataz), indinavir (Crixivan), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir, e-Kaletra), ne-saquinavir (i-Invirase); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, ne-phenytoin (Dilantin); i-mesoridazine (Serentil); i-methadone (i-Dolophine); moxifloxacin (Avelox); nefazodone; ipentamidine (NebuPent, Pentam); ipimozide (i-Orap); i-procainamide (i-Pronestyl); i-quinidine (ku-Nuedexta); i-rifabutin (i-Mycobutin), i-rifampin (i-Rimactane, i-Rifadin, e-Rifater); i-sirolimus (i-Rapamune); i-sotalol (iBetapace); itacrolimus (Prograf); i-telithromycin (Ketek); i-thioridazine (Mellaril); kanye ne-vandetanib (Caprelsa). Eminye imithi eminingi ingase futhi ihlanganyele ne-crizotinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma ngabe uke waba ne-QT syndrome ende (inkinga engavamile yenhliziyo engadala ukushaya kwenhliziyo okungajwayelekile, ukuphelelwa amandla, noma ukufa okungazelelwe), ukushaya kwenhliziyo, ukwehluleka kwenhliziyo, izinkinga zombono, izinkinga zamaphaphu ngaphandle komdlavuza wamaphaphu, noma isibindi noma isifo sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa nge-crizotinib. Uma ungowesifazane, kufanele usebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwakho nezinsuku ezingama-45 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwenu nezinsuku ezingama-90 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho mayelana nokuthi iyiphi indlela yokulawula ukubeletha okufanele uyisebenzise. Uma ukhulelwa ngenkathi uthatha i-crizotinib, shayela udokotela wakho ngokushesha. ICrizotinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngesikhathi sokwelashwa kwakho nezinsuku ezingama-45 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-crizotinib.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-crizotinib.
• kufanele wazi ukuthi i-crizotinib ingadala izinkinga zombono, isiyezi, nokukhathala ngokweqile. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-6 ngaphambi kokuba uhlelelwe ukuthatha umthamo wakho olandelayo, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Crizotinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• izilonda emlonyeni
• shintsha emandleni okunambitha ukudla
• isilungulela
• ikhanda
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni noma ezinyaweni
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphelelwa umoya
• ukukhwehlela
• imfiva
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ubuhlungu besifuba
• ukushaya kwenhliziyo okuhamba kancane
• ukuqubuka
• ubuthakathaka
• ukukhathala ngokweqile
• ubuhlungu engxenyeni engenhla yesisu
• isicanucanu
• ukuhlanza
• ubunzima bokugwinya
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo omnyama
• ukulunywa
• imfiva
• ukopha okungajwayelekile noma ukulinyazwa
• umbono ophindwe kabili noma ofiphele
• izinguquko embonweni
• ukuzwela ekukhanyeni
• ukubona ukukhanya okungazelelwe kokukhanya
• ukubona amaflaya amasha noma akhuphukile (amabala kumbono wakho)

I-Crizotinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze abone ukuthi umdlavuza wakho ungelashwa nge-crizotinib futhi uzophinde a-ode izivivinyo ezithile zelebhu ngesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-crizotinib. Udokotela wakho uzophinde ahlole isilinganiso senhliziyo yakho nomfutho wegazi njalo ngesikhathi sokwelashwa kwakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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