Ceritinib

-Delile

• Ngaphambi kokuthatha i-ceritinib,
• I-Ceritinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

I-Ceritinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wamaphaphu weseli (non-small) wamaphaphu (NSCLC) osabalalele kwezinye izingxenye zomzimba. I-Ceritinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

I-Ceritinib iza njenge-capsule kanye ne-tablet ezothathwa ngomlomo. Kuvame ukuthathwa nokudla kanye ngosuku. Thatha i-ceritinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ceritinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uhlanza ngemuva kokuthatha i-ceritinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho we-ceritinib, akuphathe ngeminye imithi, noma akutshele ukuthi uyeke ukuthatha i-ceritinib isikhathi esithile ngesikhathi sokwelashwa kwakho. Lokhu kuzoya ngokuthi umuthi usebenza kanjani kuwe nakunoma imiphi imiphumela emibi ongase ube nayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelapha nge-ceritinib.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ceritinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ceritinib, noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsule e-ceritinib noma amaphilisi. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); i-anagrelide (Agrylin); ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); ama-beta blocker anjenge-atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal) ne-sotalol (Betapace, Sorine, Sotylize); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); imishanguzo ethile yegciwane lesandulela-ngculazi (i-HIV) noma i-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kanye i-saquinavir (i-Invirase); i-chloroquine; i-chlorpromazine; i-cilostazol; i-ciprofloxacin (Cipro); i-citalopram (Celexa); i-clarithromycin; i-clonidine (iCatapres, iKapvay); ama-corticosteroids; i-cyclosporine (Gengraf, Neoral, Sandimmune); i-digoxin (i-Lanoxin); i-diltiazem (iCardizem, iDilacor, iTiazac); i-disopyramide (iNorpace); i-dofetilide (Tikosyn); i-donepezil (i-Aricept); i-dronedarone (iMultaq); i-escitalopram (iLexapro); i-fentanyl (Abstral, Actiq, Duragesic, Fentora, Subsys); i-flecainide (iTambocor); i-fluconazole (iDiflucan); i-haloperidol (iHaldol); ibutilide (Corvert); itraconazole (Onmel, Sporanox, Tolsura); ketoconazole; levofloxacin; i-methadone (i-Dolophine, i-Methadose); moxifloxacin (Avelox); nefazodone; i-ondansetron (iZuplenz, iZofran); i-pentamidine (i-Pentam); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ipimozide (i-Orap); i-pioglitazone (Actos, eDuetact, e-Oseni); procainamide; i-quinidine (ku-Nuedexta); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifater); i-sildenafil (i-Revatio); i-sirolimus (i-Rapamune); i-tacrolimus (i-Astagraf, Prograf); thioridazine; i-vardenafil (i-Levitra, iStaxyn); kanye ne-verapamil (Calan, Covera, Isoptin, Verelan). Eminye imithi eminingi ingaxhumana ne-ceritinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort.
• Tshela udokotela wakho uma uke waba nesifo sikashukela noma ushukela ophakeme wegazi, ukwehluleka kwenhliziyo, ukushaya kwenhliziyo okungajwayelekile, ukwandiswa kwe-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe), izinga eliphansi ye-potassium noma i-magnesium egazini lakho, i-pancreatitis (ukuvuvukala kwamanyikwe), noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Akufanele ukhulelwe ngenkathi uthatha i-ceritinib. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa, futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa onomlingani wesifazane ongakhulelwa, kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngenkathi welashwa futhi okungenani izinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. I-Ceritinib ingalimaza ingane yakho engakazalwa. Uma wena noma umlingani wakho ukhulelwa ngesikhathi sokwelashwa kwakho nge-ceritinib, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-ceritinib futhi okungenani amasonto ama-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-ceritinib.
• kufanele wazi ukuthi ungathola i-hyperglycemia (ukwanda kushukela wakho wegazi) ngenkathi uthatha lo muthi. Tshela udokotela wakho ngokushesha uma unezinye zalezi zimpawu ezilandelayo ngenkathi uthatha i-ceritinib: ukoma ngokweqile, ukuchama kaningi, ukulamba ngokweqile, ukungaboni kahle, ikhanda elibuhlungu, ukucabanga kanzima noma ukugxila, ukuphefumula kunuka njengezithelo, noma ukukhathala.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphakathi kwamahora ayi-12 wedosi yakho elandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ceritinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• isifo sohudo
• ukuhlanza
• ukuqunjelwa
• ubuhlungu besisu
• isilungulela
• ubunzima bokugwinya
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukukhathala
• ukuqubuka
• ukulunywa
• izinguquko embonweni
• imisipha, ithambo, ingalo yangemuva, noma ubuhlungu bomlenze
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• ubuhlungu engxenyeni engenhla yesisu
• ukulimaza noma ukopha okungavamile
• umchamo omnyama
• ukuphuzi kwesikhumba namehlo
• ukuncipha kokudla
• izimpawu ezinjengomkhuhlane
• ukulunywa
• ukuphelelwa umoya
• umkhuhlane, amakhaza, umphimbo obuhlungu, ukukhwehlela okuqhubekayo nokucinana, noma ezinye izimpawu zokutheleleka
• ubuhlungu besifuba noma ukungaphatheki kahle
• izinguquko ekushayeni kwenhliziyo
• ukushaya kwenhliziyo
• isiyezi
• ubumhlophe
• ukuquleka
• ubuhlungu obuqhubekayo obuqala ngaphezulu kwesobunxele noma maphakathi nesisu kepha bungadlulela emuva
• isithuthwane

I-Ceritinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-ceritinib. Udokotela wakho uzophinde ahlele ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuthola ukuthi umdlavuza wakho ungelashwa nge-ceritinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Zykadia^®