INetupitant nePalonosetron

-Delile

• Ngaphambi kokuthatha i-netupitant ne-palonosetron,
• I-Netupitant ne-palonosetron kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma ufune ukwelashwa okuphuthumayo:

Inhlanganisela ye-netupitant ne-palonosetron isetshenziselwa ukuvimbela isicanucanu nokuhlanza okubangelwa i-cancer chemotherapy. INetupitant isekilasini lemithi ebizwa ngabaphikisi be-neurokinin (NK1). Isebenza ngokuvimba i-neurokinin, into yemvelo ebuchosheni ebangela isicanucanu nokuhlanza. I-Palonosetron isekilasini lemithi ebizwa nge-5-HT₃ abaphikisi be-receptor. Isebenza ngokuvimba i-serotonin, into yemvelo emzimbeni edala isicanucanu nokuhlanza.

Inhlanganisela ye-netupitant ne-palonosetron iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa cishe ihora eli-1 ngaphambi kokuqala kwe-chemotherapy ngokudla noma ngaphandle kokudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-netupitant ne-palonosetron njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-netupitant ne-palonosetron,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-netupitant ne-palonosetron, i-alosetron (i-Lotronex), i-dolasetron (i-Anzemet), i-granisetron (i-Sancuso), i-ondansetron (i-Zofran, i-Zuplenz), noma imiphi eminye imithi, noma iziphi izithako kuma-capsule we-netupitant ne-palonosetron . Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela nemishanguzo ongayinikiwe, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyiphuzayo. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-benzodiazepines kufaka phakathi i-alprazolam (Xanax), midazolam, ne-triazolam (Halcion); imithi ethile ye-chemotherapy efana ne-cyclophosphamide (Cytoxan), i-docetaxel (i-Docefrez, i-Taxotere), i-etoposide, i-ifosfamide (i-Ifex), i-imatinib (i-Gleevec), i-irinotecan (i-Camptosar), i-paclitaxel (i-Taxol), i-vinblastine, i-vincristine, ne-vinvelline i-dexamethasone; i-erythromycin (E.E.S., Ery-tab, abanye); i-fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys); ketoconazole (Nizoral); i-lithium (i-Lithobid); imithi yokwelapha i-migraines efana ne-almotriptan (Axert), i-eletriptan (i-Relpax), i-frovatriptan (i-Frova), i-naratriptan (i-Amerge), i-rizatriptan (i-Maxalt), i-sumatriptan (i-Imitrex), ne-zolmitriptan (iZomig); i-methylene eluhlaza okwesibhakabhaka; i-mirtazapine (i-Remeron); i-monoamine oxidase (MAO) inhibitors kufaka phakathi i-isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), ne-tranylcypromine (iParnate); i-phenobarbital; i-rifampin (iRifadin, iRimactane, eRifater, eRifamate); i-serotonin reuptake inhibitors (SSRIs) ekhethiwe njenge-citalopram (Celexa), i-escitalopram (Lexapro), i-fluoxetine (i-Prozac, i-Sarafem, e-Symbyax), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva) ne-sertraline (i-Zoloft); ne-tramadol (i-Conzip, i-Ultram, ku-Ultracet). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-netupitant ne-palonosetron, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

I-Netupitant ne-palonosetron kufanele zithathwe kuphela ngaphambi kwe-chemotherapy njengokuyalelwa ngudokotela wakho. Akufanele ithathwe ngezikhathi ezihleliwe njalo.

I-Netupitant ne-palonosetron kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubuhlungu besisu
• isilungulela
• ukuqunjelwa
• ubuthakathaka
• ukubomvu kwesikhumba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma ufune ukwelashwa okuphuthumayo:

• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ukuphelelwa umoya
• isiyezi, ikhanda elincane, nokuquleka
• ukushaya kwenhliziyo okusheshayo, okuhamba kancane noma okungajwayelekile
• ukuyaluza
• ukusangana (ukubona izinto noma ukuzwa amazwi angekho)
• imfiva
• ukuqhuma
• ukujuluka okweqile
• ukudideka
• isicanucanu, ukuhlanza nokuhuda
• ukulahleka kokuxhumanisa
• imisipha eqinile noma eshwibayo
• isithuthwane
• ikhoma (ukulahlekelwa ukwazi)

I-Netupitant ne-palonosetron kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese). Lahla noma imuphi umuthi osuphelelwe yisikhathi noma ongasadingeki. Khuluma nosokhemisi wakho ngokulahlwa okufanele kwemithi yakho.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Akynzeo^®