Cobimetinib

-Delile

• Ngaphambi kokuthatha i-cobimetinib,
• I-Cobimetinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Cobimetinib isetshenziswa kanye ne-vemurafenib (i-Zelboraf) ukwelapha izinhlobo ezithile ze-melanoma (uhlobo lomdlavuza wesikhumba) ezingalashwa ngokuhlinzwa noma ezisabalalele kwezinye izingxenye zomzimba. I-Cobimetinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

ICobimetinib iza njengethebhulethi ezothathwa ngomlomo noma ngaphandle kokudla. Imvamisa kuthathwa kanye nsuku zonke ezinsukwini zokuqala ezingama-21 zomjikelezo wezinsuku ezingama-28. Thatha i-cobimetinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-cobimetinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uhlanza ngemuva kokuthatha i-cobimetinib ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho we-cobimetinib noma amise ukwelashwa kwakho unomphela noma okwesikhashana. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-cobimetinib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-cobimetinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-cobimetinib, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-cobimetinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-anticoagulants (ama-blood thinner) afana ne-warfarin (Coumadin, Jantoven), carbamazepine (Carbatrol, Epitol, Tegretol), ciprofloxacin (Cipro), clarithromycin (Biaxin, e-Prevpac), efavirenz (Sustiva, in Sustiva, in Atripla), erythromycin (EES, E-Mycin, Erythrocin), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Ketozole, Nizoral), nefazodone, nelfinavir (Viracept), phenytoin Difin (Rifadin, Rimactane, eRifamate, eRifater), kanye ne-ritonavir (Norvir, eKaletra, eViekira Pak). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-cobimetinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSt John's Wort. Ungathathi iSt John's Wort ngenkathi uthatha i-cobimetinib.
• utshele udokotela wakho uma ngabe uke waba nezimo zesikhumba ngaphandle kwe-melanoma; izinkinga zokopha; izinkinga zokubona; noma isiphi isimo esithinta imisipha yakho; noma isifo senhliziyo noma sesibindi.
• kufanele wazi ukuthi i-cobimetinib inganciphisa ukuzala kwabesilisa nabesifazane. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Sebenzisa indlela ethembekile yokulawula ukubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho kanye namaviki ama-2 ngemuva kokuyeka ukuthatha i-cobimetinib. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-cobimetinib, shayela udokotela wakho ngokushesha. I-Cobimetinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-cobimetinib kanye namasonto ama-2 ngemuva komthamo wakho wokugcina.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, i-lip balm kanye ne-sunscreen (i-SPF 30 noma ngaphezulu). I-Cobimetinib ingenza isikhumba sakho sizwele ekukhanyeni kwelanga.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Cobimetinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• izilonda zomlomo
• ukulahleka kwezinwele
• isifo sohudo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka okumboza indawo enkulu yomzimba wakho, amabhamuza, noma isikhumba esikhanyayo
• izinguquko ekubukeni kwesikhumba
• insumpa entsha
• isikhumba esibuhlungu noma isibomvu esibomvu esopha noma esingapholi
• shintsha ngosayizi noma umbala wemvukuzane
• ukopha okungajwayelekile noma ukulinyazwa
• indle noma indle emnyama
• igazi emchameni
• ukopha okungavamile kwesitho sangasese sowesifazane
• ikhanda
• isiyezi
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukukhwehlela noma ukuphefumula
• ukuphelelwa umoya
• ukuvuvukala kobuso, izingalo, imilenze, amaqakala, noma izinyawo
• ukukhathala
• ubuhlungu bemisipha noma ubuthakathaka
• shintsha embonweni, kufaka phakathi ukubona ama-halos (uhlaka olufiphele oluzungeze izinto)
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama (ombala wetiye)
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla

I-Cobimetinib ingakhuphula ubungozi bokuthi uzoba nomdlavuza wesikhumba omusha. Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Cobimetinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ngesikhathi nangemva kokwelashwa. Udokotela wakho uzohlola isikhumba sakho nganoma yiziphi izinguquko ngaphambili, njalo ezinyangeni ezimbili ngesikhathi sokwelashwa kwakho, futhi kuze kube izinyanga eziyisithupha emva kokwelashwa.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Cotellic^®