Ukujova kweDaratumumab

-Delile

• Ngaphambi kokuthola umjovo we-daratumumab,
• Umjovo weDaratumumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo.

Umjovo weDaratumumab usetshenziswa wedwa noma uhlanganiswe neminye imishanguzo yokwelapha i-myeloma eminingi (uhlobo lomdlavuza womnkantsha wethambo) kubantu abasanda kutholakala nakubantu abangazange bathuthuke ngokwelashwa noma abenze ngcono ngemuva kokwelashwa ngeminye imithi kepha isimo kubuyile. UDaratumumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokusiza umzimba ukuthi unciphise noma umise ukukhula kwamangqamuzana omdlavuza.

IDaratumumab iza njengoketshezi (isisombululo) esinikezwa ngemithambo yegazi (emthanjeni) ngudokotela noma umhlengikazi endaweni yokunakekelwa kwezempilo. Udokotela wakho uzonquma ukuthi uzoyithola kangaki i-daratumumab ngokuya ngeminye imithi enganikezwa nempendulo yomzimba wakho kulo muthi.

Udokotela noma umhlengikazi uzokubuka eduze ngenkathi uthola ukumnika futhi ngemuva kwalokho ukuze aqiniseke ukuthi awunampendulo ebucayi kulowo muthi. Uzonikezwa eminye imithi yokusiza ukuvimbela nokwelapha ukusabela ku-daratumumab ngaphambi kokumfakelwa kwakho nangosuku lokuqala nolwesibili ngemuva kokuthola umuthi wakho. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukukhwehlela, ukuqhaqhazela, ukuqina komphimbo nokucasuka, ukulunywa, ukuquleka, noma ikhala eligcwele, ikhanda, ukulunywa, isicanucanu, ukuhlanza, umkhuhlane, ukubanda, ukuqhuma, isifuba, isiyezi, ikhanda elikhanyayo, ukuphefumula kanzima, ukungaphatheki kahle kwesifuba, noma ukuphefumula okuncane.

Udokotela wakho anganciphisa umthamo wakho we-daratumumab noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi ukwelashwa kwakho nge-daratumumab.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-daratumumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-daratumumab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-daratumumab. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma uthola ukumpontshelwa igazi noma uma uke waba nezibiliboco (okuqubuka okubuhlungu okwenzeka ngemuva kokutheleleka nge-herpes zoster noma inkukhu), izinkinga zokuphefumula, i-hepatitis B (igciwane elithelela isibindi futhi lingadala isibindi esibi umonakalo), noma isifo samaphaphu njengesifo esingelapheki se-pulmonary disease (i-COPD; iqembu lezifo zamaphaphu, ezibandakanya i-bronchitis engapheli kanye ne-emphysema).
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ne-daratumumab futhi okungenani izinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokuzalwa okuzokusebenzela. Uma ukhulelwa ngenkathi uthola umjovo we-daratumumab, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-daratumumab.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuthola i-daratumumab, shayela udokotela wakho ngokushesha.

Umjovo weDaratumumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ukuqunjelwa
• isifo sohudo
• ubuhlungu emuva noma ngokuhlanganyela
• ubuhlungu ezingalweni, emilenzeni, noma esifubeni
• ukuncipha kokudla
• ikhanda
• ukuvuvukala kwezandla, amaqakala, noma izinyawo
• ubuhlungu, ukushisa, noma ukuncinza ezandleni noma ezinyaweni
• ukuphazamiseka kwemisipha
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo.

• ukulinyazwa noma ukopha
• imfiva
• ukukhathala ngokweqile
• ukuphuzi kwesikhumba noma kwamehlo

Umjovo weDaratumumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-daratumumab.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi be-laboratory ukuthi uthola noma uthola umjovo we-daratumumab. I-Daratumumab ingathinta imiphumela yokuhlolwa okuthile kwelebhu.

I-Daratumumab ingathinta imiphumela yokuhlolwa kwegazi kuze kube izinyanga eziyi-6 ngemuva komthamo wakho wokugcina. Ngaphambi kokumpontshelwa igazi, tshela udokotela wakho nezisebenzi zaselabhorethri ukuthi uthola noma ujovwa umjovo we-daratumumab. Udokotela wakho uzokwenza ukuhlolwa kwegazi ukufanisa uhlobo lwegazi lakho ngaphambi kokuba uqale ukwelashwa ne-daratumumab.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-daratumumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Darzalex^®