I-Venetoclax

-Delile

• Ngaphambi kokuthatha i-venetoclax,
• IVenetoclax ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

IVenetoclax isetshenziswa yodwa noma ihlanganiswe ne-obinutuzumab (Gazyva) noma i-rituximab (i-Rituxan) ukwelapha izinhlobo ezithile ze-leukemia engapheli (i-CLL; uhlobo lomdlavuza oluqala kumaseli egazi amhlophe) noma izinhlobo ezithile ze-lymphocytic lymphoma (SLL; uhlobo lomdlavuza oqala kakhulu kuma-lymph node). Ibuye isetshenziswe ngokuhlanganiswa ne-azacitidine (Vidaza), i-decitabine (i-Dacogen), noma i-cytarabine njengokwelashwa kokuqala kwe-acute myeloid leukemia (AML; uhlobo lomdlavuza oluqala kumaseli amhlophe egazi) kubantu abaneminyaka engama-75 noma asebekhulile, noma kubantu abadala abanezimo zezempilo ezibavimbela ukuthi baphathwe ngeminye imithi yokwelapha ngamakhemikhali. IVenetoclax isekilasini lemithi ebizwa nge-B-cell lymphoma-2 (BCL-2) inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni ethile emzimbeni esiza amangqamuzana omdlavuza aphile. Lokhu kusiza ukubulala amangqamuzana omdlavuza.

IVenetoclax iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla namanzi kanye ngosuku. Thatha i-venetoclax ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-venetoclax njengoba nje uqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokuthatha i-venetoclax, ungaphindi umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho mhlawumbe uzokuqala ngomthamo ophansi we-venetoclax futhi akhuphule kancane umthamo wakho, hhayi ngaphezu kwesisodwa njalo ngesonto emavikini okuqala ama-5 uma welashelwa i-CLL noma i-SLL, kanye kanye ngosuku ngezinsuku zokuqala ezi-3 noma ezi-4 uma welashelwa i-AML.

Udokotela wakho angadinga ukuphazamisa noma ayeke ukwelashwa kwakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-venetoclax. Ngemiphumela ethile emibi, udokotela wakho angakutshela ukuthi uqale ukuthatha i-venetoclax kumthamo ophansi.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-venetoclax futhi njalo lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-venetoclax,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-venetoclax, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-venetoclax. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-clarithromycin, conivaptan (Vaprisol), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, lopinavir (e-Kaletra), posaconazole (Noxafil), ritonavir (Norvir, eKaletra, Technivie ), noma i-voriconazole (Vfend). Udokotela wakho angakutshela ukuthi ungathathi i-venetoclax uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: amiodarone (Nexterone, Pacerone), bosentan (Tracleer), captopril, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), carvedilol (Coreg), ciprofloxacin (Cipro), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Lanoxin), diltiazem (Cardizem, Cartia XT, Diltzac, Taztia, Tiazac), dronedarone (Multaq), efavirenz (Sustiva, e-Atripla), erythromycin (EES, Eryc, Eryped, Ery-tab, ), etravirine (Intelence), everolimus (Afinitor, Zortress), felodipine, fluconazole (Diflucan), modafinil (Nuvigil, Provigil), nafcillin (Nallpen), phenytoin (Dilantin, Phenytek), quinidine (e-Nuedexta), , rifampin (Rifadin, Rimactane, eRifamate, Rifater), sirolimus (Rapamune), ticagrelor (Brilinta), verapamil (Calan, Verelan, eTarka), noma warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-venetoclax, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi i-quercetin noma iSt John's wort.
• Tshela udokotela wakho uma uke waba nezinkinga ngamazinga akho e-potassium, i-phosphorus, noma i-calcium egazini lakho; amazinga aphezulu e-uric acid egazini lakho; i-gout (uhlobo lwesifo samathambo olubangelwa amakristalu abekwe emajoyintini); noma isifo sezinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungakhulelwa, kuzodingeka ukuthi uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa nge-venetoclax. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nezinsuku ezingama-30 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-venetoclax, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Musa ukuncelisa lapho uthatha i-venetoclax nangesonto elingu-1 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-venetoclax.
• awunawo umuthi wokugoma ngaphambi, ngesikhathi, noma ngemuva kokwelashwa nge-venetoclax ngaphandle kokukhuluma nodokotela wakho.
• kufanele wazi ukuthi ungathola i-tumor lysis syndrome (i-TLS; isimo esibangelwa ukuwohloka okusheshayo kwamangqamuzana omdlavuza angadala ukwehluleka kwezinso nezinye izinkinga) ngenkathi welashwa nge-venetoclax. Lokhu kungenzeka ukuthi kwenzeke lapho uqala ukwelashwa, futhi isikhathi ngasinye lapho umthamo wakho wanda. Ukusiza ukunciphisa ingozi yakho yokuthola i-TLS kufanele uphuze okungenani izingilazi eziyisithupha kuya kweziyi-8 (ama-ounces angama-48 kuye kwangama-64) ngosuku ngosuku lwezinsuku ezi-2 ngaphambi nangosuku lomthamo wakho wokuqala, futhi isikhathi ngasinye lapho umthamo wakho wanda. Ngaphezu kwalokho udokotela wakho uzokunika umuthi okufanele uwuthathe ngaphambi kokuqala nangesikhathi sokwelashwa kwakho ukusiza ukuvimbela lo mphumela oseceleni. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ze-TLS shayela udokotela wakho ngokushesha: umkhuhlane, ukugodola, isicanucanu, ukuhlanza, ukudideka, ukuphefumula okuncane, ukuxhuzula, ukushaya kwenhliziyo okungajwayelekile, umchamo omnyama noma onamafu, ukukhathala okungavamile, noma ubuhlungu bemisipha noma obuhlangene.

Ungadli i-grapefruit, i-starfruit, noma amawolintshi aseSeville (kwesinye isikhathi asetshenziswa kuma-marmalade), noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma ukhumbula umthamo ongabanjwanga kungakapheli amahora ayisishiyagalombili ngesikhathi obehlelelwe ukuwuthatha, thatha umthamo ongabanjwanga ngokushesha. Kodwa-ke, uma kudlule amahora angaphezu kwangu-8 kusukela esikhathini ovame ukuthatha ngaso i-venetoclax, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uphuthelwa ukuthatha i-venetoclax izinsuku ezingaphezu kwezingu-7, kufanele ushayele udokotela wakho ngaphambi kokuthatha eminye imithi. Udokotela wakho angafuna ukuqala kabusha imithi yakho ngomthamo ophansi.

IVenetoclax ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• isicanucanu
• ukuhlanza
• ukuncipha kokudla
• ukukhathala ngokweqile
• ukuvuvukala kwezingalo noma izandla zakho
• ukuhlungu obusemhlane
• ubuhlungu bethambo, imisipha, noma amalunga
• ubuhlungu besisu
• ukuvuvukala noma izilonda emlonyeni
• ubuhlungu bomlomo noma bomphimbo
• ikhanda
• ikhala eligobayo noma eligcwele, ukukhwehlela
• ukuphelelwa umoya
• isiyezi
• ukuqubuka
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• umkhuhlane wedwa noma uhambisana nomphimbo obuhlungu, ukukhwehlela, ukubanda, ukufudumala, ukubomvu, isikhumba esibuhlungu noma esivuvukile, ukuchama okuphuthumayo, okuvamile, noma okubuhlungu, nezinye izimpawu zokutheleleka
• ukuncipha kokuchama
• ukuvuvukala kwemilenze yakho, amaqakala, noma izinyawo
• ukopha okungavamile noma okusindayo noma ukulinyazwa
• isikhumba esiphaphathekile, ukuphefumula okuncane, isiyezi, ukukhathala ngokweqile, ukushaya kwenhliziyo okusheshayo

IVenetoclax ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ingabe hhayi thumela umuthi esitsheni esihlukile. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-venetoclax.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Venclexta^®