I-Cabozantinib (umdlavuza wesibindi nowezinso)

-Delile

• Ngaphambi kokuthatha i-cabozantinib (Cabometyx),
• ICabozantinib (Cabometyx) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Cabozantinib (Cabometyx) isetshenziselwa ukwelapha i-renal cell carcinoma (RCC; uhlobo lomdlavuza oqala kumaseli ezinso). Ibuye isetshenziswe kanye ne-nivolumab (Opdivo) ukwelapha i-RCC esezingeni eliphakeme ezigulini ezingakatholi ukwelashwa kwe-RCC. ICabozantinib (Cabometyx) ibuye isetshenziselwe ukwelapha i-hepatocellular carcinoma (HCC; uhlobo lomdlavuza wesibindi) kubantu abake baphathwa nge-sorafenib (Nexafar) phambilini. ICabozantinib (Cabometyx) isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukumisa ukusabalala kwamangqamuzana omdlavuza.

ICabozantinib iyatholakala futhi njenge-capsule (Cometriq) yokwelapha uhlobo oluthile lomdlavuza wegilo. Le monograph inika kuphela imininingwane ngamaphilisi e-cabozantinib (i-Cabometyx) ye-RCC ethuthukile noma i-HCC. Uma usebenzisa le mithi yomdlavuza wegilo, funda i-monograph enesihloko esithi cabozantinib (umdlavuza wegilo).

ICabozantinib (Cabometyx) iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku esiswini esingenalutho, okungenani ihora eli-1 ngaphambi namahora ama-2 ngemuva kokudla. Thatha i-cabozantinib (Cabometyx) ngasikhathi sinye nsuku zonke. Ubude bokwelashwa kwakho buncike ekutheni umzimba wakho uphendula kahle kanjani emithini nasemiphumeleni oyitholayo. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-cabozantinib (Cabometyx) njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi egcwele (ama-ounces ayi-8, ama-240 mL) wamanzi. Musa ukuhlukanisa, ukuhlafuna, noma ukuchoboza.

Udokotela wakho anganciphisa umthamo wakho we-cabozantinib (Cabometyx) noma ayeke unomphela noma okwesikhashana ukwelashwa kwakho uma uba nemiphumela emibi kakhulu. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-cabozantinib (Cabometyx).

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-cabozantinib (Cabometyx),

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-cabozantinib (i-Cabometyx, i-Cometriq), noma yimiphi eminye imithi, noma iziphi izithako ezibhebheni ze-cabozantinib Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela nemishanguzo ongayinikiwe, amavithamini, izithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-boceprevir (Victrelis), i-carbamazepine (i-Carbatrol, i-Epitol, i-Equetro, i-Tegretol, i-Teril), i-clarithromycin (i-Biaxin, e-Prevpac), i-conivaptan (i-Vaprisol), i-indinavir (i-Crixivan), i-itraconazole ( ), ketoconazole, nefazodone, nelfinavir (Viracept), phenobarbital, phenytoin (Dilantin, Phenytek), posaconazole (Noxafil), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, Rifater (Rifater), , eKaletra), i-saquinavir (i-Invirase), i-telithromycin (Ketek), ne-voriconazole (i-Vfend). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-cabozantinib (Cabometyx), ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma usanda kuba nokopha okungajwayelekile noma okunzima njengokukhwehlela igazi, ukuhlanza igazi, noma izitulo zokubambezela ezinegazi noma ezimnyama, uma unesilonda esivulekile noma esipholisayo, noma uke waba nomfutho wegazi ophakeme, noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uzodinga ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa nge-cabozantinib. Akufanele ukhulelwe ngesikhathi sokwelashwa kwakho nezinyanga ze-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-cabozantinib (Cabometyx), shayela udokotela wakho ngokushesha. ICabozantinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Udokotela wakho angakutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho nezinyanga ezine ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-cabozantinib (Cabometyx).
• uma uhlinzwa utshele udokotela ukuthi uthatha i-cabozantinib (Cabometyx). Udokotela wakho mhlawumbe uzokutshela ukuthi uyeke ukuthatha i-cabozantinib (Cabometyx) okungenani ezinsukwini ezingama-21 ngaphambi kokuhlinzwa noma inqubo yakho, futhi uzokutshela ukuthi kufanele uqale nini ukuthatha umuthi futhi.
• kufanele wazi ukuthi i-cabozantinib (Cabometyx) ingadala izinkinga ezinkulu ngomhlathi wakho. Udokotela wamazinyo kufanele ahlole amazinyo akho ngaphambi kokuba uqale ukuthatha i-cabozantinib futhi njalo ngesikhathi sokwelashwa kwakho. Qiniseka ukuthi uxubha amazinyo futhi uhlanza umlomo wakho kahle ngenkathi uthatha i-cabozantinib (Cabometyx). Khuluma nodokotela wakho ngaphambi kokuthola noma yikuphi ukwelashwa kwamazinyo ngenkathi uthatha lo muthi. Udokotela wakho uzokutshela ukuthi uyeke ukuthatha i-cabozantinib okungenani izinsuku ezingama-21 ngaphambi kokuhlinzwa kwamazinyo.
• kufanele wazi ukuthi umfutho wegazi wakho ungakhuphuka ngenkathi welashwa nge-cabozantinib. Udokotela wakho mhlawumbe uzoqapha ukucindezela kwegazi lakho ngaphambi nangesikhathi sokwelashwa kwakho.

Ungaphuzi ijusi yamagilebhisi noma udle isithelo samagilebhisi noma yikuphi ukudla noma izithasiselo eziqukethe ubhamubhamu noma ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora angu-12 kuze kufike umthamo wakho olandelayo ohleliwe, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ICabozantinib (Cabometyx) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuqunjelwa
• isicanucanu
• ukuhlanza
• shintsha emandleni okunambitha ukudla
• ububomvu, ukuvuvukala, izilonda, noma ubuhlungu emlonyeni wakho
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukukhathala ngokweqile noma ubuthakathaka
• isikhumba esiphaphathekile
• isikhumba esomile
• ukuqhuma kwemisipha
• ubuhlungu bamalunga, izingalo, noma imilenze
• ukushintsha kwezwi noma ukusikisela
• ukuphulukiswa kwesilonda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubuhlungu besifuba, ingcindezi, noma ukuqina
• ukukhwehlela igazi noma amahlule egazi
• izinto zokuhlanza ezinegazi noma ezibukeka njengezizathu zekhofi
• ukopha kokuya esikhathini okunzima kakhulu kunokujwayelekile
• okubomvu noma okumnyama, isitulo sokulinda
• isifo sohudo
• ukopha okungavamile noma okusindayo noma ukulinyazwa
• indawo yesisu ethambile noma ebuhlungu
• izingalo noma imilenze efudumele, ebomvu, evuvukile, noma ethambile
• ukuvuvukala ngamehlo, izingalo, izandla, imilenze, izinyawo noma amaqakala
• umchamo onamagwebu
• ukuphefumula noma ukukhwehlela
• ikhanda elingalindelekile
• ikhanda elikhanyayo noma ukuquleka
• ukudlikiza
• ukuba ndikindiki noma ukubuthakathaka kobuso, ingalo, noma umlenze ohlangothini olulodwa lomzimba wakho
• ukuhamba ngokuzumayo
• izinkinga zokubona okungazelelwe
• ukudideka
• ubunzima ngokungazelelwe bokucabanga noma ukukhuluma ngokucacile
• ubunzima obungazelelwe ngokulinganisela noma ukuxhumanisa
• isiyezi
• ajuluke ngaphezu kokujwayelekile
• ubuhlungu bomhlathi
• ubuhlungu bamazinyo
• ukukhululeka kwamazinyo
• Izinsini ezivuvukile noma ezibuhlungu
• ukuqubuka
• ububomvu, ubuhlungu, ukuvuvukala, noma ukushisa ezintendeni zezandla noma ematheni
• ukukhathala ngokweqile, isiyezi, ukuquleka, ubuthakathaka, isicanucanu, noma ukuhlanza
• ukuphuzi kwesikhumba noma kwamehlo, ukukhathala ngokweqile, ukuphuma igazi noma ukulimaza kalula, isicanucanu noma ukuhlanza, ubuhlungu besisu esisemaceleni, umchamo onombala omnyama, ukuncipha kwesifiso

ICabozantinib (Cabometyx) ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukulahleka kwememori
• ukudideka
• ukuncipha komzimba

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-cabozantinib (Cabometyx).

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Cabometyx^®