Inaliti ye-Durvalumab

-Delile

• Ngaphambi kokuthola umjovo we-durvalumab,
• Umjovo we-Durvalumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

I-Durvalumab isetshenziselwa ukwelapha umdlavuza wamaphaphu wamangqamuzana ongewona omncane (i-NSCLC) osabalalela ezicutshini eziseduze futhi ongeke ususwe ngokuhlinzwa kodwa awuzange ube muncu ngemuva kokwelashwa ngeminye imishanguzo yamakhemikhali kanye nokwelashwa ngemisebe. Umjovo we-Durvalumab usetshenziswa futhi ngokuhlangana ne-etoposide (Etopophos) futhi kungaba yi-carboplatin noma i-cisplatin ukwelapha umdlavuza wamaphaphu weseli omncane (ES-SCLC) kubantu abadala abanomdlavuza osabalale emaphashini nakwezinye izingxenye zomzimba. Umjovo we-Durvalumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokusiza amasosha akho omzimba ukwehlisa noma ukumisa ukukhula kwamangqamuzana omdlavuza.

Umjovo we-Durvalumab uza njengoketshezi oluzofakwa emthanjeni ngaphezu kwemizuzu engama-60 ngudokotela noma umhlengikazi esibhedlela noma esikhungweni sezokwelapha. Ekwelapheni umdlavuza we-urothelial noma i-NSCLC, imvamisa unikezwa kanye njalo emavikini ama-2 inqobo nje uma udokotela wakho encoma ukuthi uthole ukwelashwa noma i-NSCLC kuze kube unyaka owodwa. Ekwelapheni i-ES-SCLC, imvamisa inikezwa kanye njalo emavikini ama-3 ngemijikelezo emi-4 neminye imithi, bese kuba yodwa kanye njalo emavikini amane uma nje udokotela wakho ekuncoma ukuthi uthole ukwelashwa.

Umjovo we-Durvalumab ungadala ukusabela okungathi sína noma okusongela ukuphila ngesikhathi sokufakwa. Udokotela noma umhlengikazi uzokubuka eduze ngenkathi uthola ukumnika futhi ngemuva nje kokufakwa ukuze aqiniseke ukuthi awunampendulo emikhulu emithini. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ezingenzeka ngesikhathi noma ngemuva kokumnika: ukugodola noma ukuqhaqhazela, ukulunywa, ukuqubuka, ukuqhuma, ukuphefumula kanzima, isiyezi, umkhuhlane, ukuzwa ukuquleka, ubuhlungu beqolo noma bentamo, noma ukuvuvukala yobuso bakho.

Udokotela wakho anganciphisa ukumnika kwakho, akubambezele noma ayeke ukwelashwa kwakho ngomjovo we-durvalumab, noma akuphathe ngemithi eyengeziwe ngokuya ngempendulo yakho emithini kanye neminye imiphumela emibi ohlangabezana nayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-durvalumab futhi isikhathi ngasinye lapho uthola umthamo. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-durvalumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-durvalumab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-durvalumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke wafakelwa isitho somzimba. Tshela nodokotela wakho uma uke waba nesifo sokuzilimaza (isimo lapho amasosha omzimba ahlasela khona ingxenye enempilo yomzimba) njengesifo sikaCrohn (isimo lapho amasosha omzimba ehlasela ulwelwesi lwendlela yokugaya edala ubuhlungu, isifo sohudo, ukwehla kwesisindo, nomkhuhlane), i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulwelwesi lwekholoni [amathumbu amakhulu] ne-rectum), noma i-lupus (isimo lapho amasosha omzimba ahlasela khona izicubu nezitho eziningi kubandakanya isikhumba, amalunga, igazi, nezinso); noma yiluphi uhlobo lwesifo samaphaphu noma izinkinga zokuphefumula; noma isifo sesibindi. Phinda utshele udokotela wakho uma ngabe welashelwa ukutheleleka njengamanje.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthola umjovo we-durvalumab. Kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ngomjovo we-durvalumab futhi okungenani izinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthola umjovo we-durvalumab, shayela udokotela wakho ngokushesha. Umjovo we-Durvalumab ungalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ngenkathi uthola umjovo we-durvalumab futhi okungenani izinyanga ezintathu ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Durvalumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu bamathambo noma imisipha
• ukuvuvukala kwezingalo noma imilenze yakho
• ukuqunjelwa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukukhwehlela okusha noma okuya kuba kubi, ubuhlungu besifuba, noma ukuphefumula okuncane
• ukuphuzi kamehlo noma kwesikhumba sakho, ukopha noma ukulimaza kalula, ukuncipha kwesifiso sokudla, umchamo omnyama (onemibala yetiye), izinhlungu engxenyeni engaphezulu yesisu, ukukhathala ngokweqile, isicanucanu noma ukugabha
• uhudo, ubuhlungu besisu, noma okumnyama, okulindile, okunamathelayo noma okunokuchitha igazi
• ukuncipha kokuchama, igazi emchameni, ukuvuvukala emaqakaleni, ukuncipha kokudla
• umkhuhlane, ukukhwehlela, ukugodola, umkhuhlane njengezimpawu, ukuchama kaningi noma okubuhlungu, noma ezinye izimpawu zokutheleleka
• ikhanda elingapheli noma ikhanda elingajwayelekile; ukukhathala ngokweqile; ukunciphisa umzimba noma ukuzuza; ukwanda kwendlala noma ukoma; ukuzwa isiyezi noma ukuquleka; ukuzwa ukubanda, ukujula kwezwi, noma ukuqunjelwa; ukulahleka kwezinwele; ushintsho esimweni sokuziphatha noma njengokuncipha kocansi, ukuzwa ukucasuka, ukudideka noma ukukhohlwa; isicanucanu noma ukuhlanza; ubuhlungu besisu
• ukuqubuka, ukulunywa, noma ukushwabana kwesikhumba
• ukuqina kwentamo
• ukufiphala noma ukubona kabili, noma ezinye izinkinga zombono
• ukubomvu kweso noma ubuhlungu

Umjovo we-Durvalumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-durvalumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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