Inaliti yeCopanlisib

-Delile

• Ngaphambi kokuthola umjovo we-copanlisib,
• Umjovo weCopanlisib ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

Umjovo weCopanlisib usetshenziselwa ukwelapha abantu abane-follicular lymphoma (FL; umdlavuza wegazi okhula kancane) obuyile ngemuva kokuphathwa izikhathi ezimbili noma ngaphezulu ngeminye imithi. Umjovo weCopanlisib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

Umjovo weCopanlisib uza njengempuphu ezoxutshwa noketshezi bese unikezwa ngenaliti noma ngepayipi elibekwe emthanjeni. Imvamisa ijovwa kancane esikhathini esiyimizuzu engama-60 ngezinsuku eziyi-1,8, kanye nezingu-15 zomjikelezo wokwelashwa wezinsuku ezingama-28.

Umjovo weCopanlisib ungadala umfutho wegazi ophakeme kuze kube amahora angama-8 ngemuva kokufakwa. Udokotela wakho uzohlola ukucindezelwa kwegazi ngaphambi kokuthola ukumnika kanye namahora ambalwa ngemuva kokuqedwa ukumnika. Uma uhlangabezana nalezi zimpawu ezilandelayo ngemuva kokuthola umuthi tshela udokotela wakho ngokushesha: isiyezi, ukuzizwa uphela amandla, ukuphathwa ikhanda noma ukushaya kwenhliziyo.

Udokotela wakho anganciphisa umthamo wakho, abambezele noma amise ukwelashwa kwakho ngomjovo we-copanlisib, noma akuphathe ngemithi eyengeziwe ngokuya ngempendulo yakho emithini kanye neminye imiphumela emibi ohlangabezana nayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-copanlisib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-copanlisib, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-copanlisib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha.Qiniseka ukuthi usho noma ikuphi kokulandelayo: boceprevir (Victrelis); carbamazepine (Carbatrol, Equetro, Tegretol, abanye), clarithromycin (Biaxin, e Prevpac), cobicistat (Tybost, e-Evotaz, Genvoya, Prezcobix, Stribild), conivaptan (Vaprisol), diltiazem (Cardizem, Cartia XT, Dilt i-efavirenz (Sustiva), enzalutamide (Xtandi), idelalisib (Zydelig), indinavir (Crixivan) ne-ritonavir; i-itraconazole (i-Sporonox, i-Onmel), ne-ketoconazole, i-lopinavir ne-ritonavir (eKaletra); mitotane (Lysodren), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), paritaprevir, ritonavir, ombitasvir, kanye / noma dasabuvir (Viekira Pak); i-phenobarbital, i-phenytoin (i-Dilantin, i-Phenytek), i-posaconazole (i-Noxafil), i-rifabutin (i-Mycobutin), i-rifampin (i-Rifadine, e-Rifamate, i-Rifater), i-ritonavir (i-Norvir, e-Kaletra, e-Technivie, e-Viekira Pak), e-Saquase Aptivus) nge-ritonavir; kanye ne-voriconazole (Vfend). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele nomjovo we-copanlisib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma unesifo noma ngabe uke waba neshukela eliphezulu egazini, isifo sikashukela, izinkinga zamaphaphu noma zokuphefumula, umfutho wegazi ophakeme noma isifo sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. Akufanele ukhulelwe ngenkathi uthola umjovo we-copanlisib. Uzodinga ukuthi ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuthi uqale ukuthola le mithi. Sebenzisa ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho ngomjovo we-copanlisib nangenyanga e-1 ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nenyanga engu-1 ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola i-copanlisib, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthola umjovo we-copanlisib, nangenyanga e-1 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-copanlisib.

Ungaphuzi ijusi yamagilebhisi ngenkathi uthola lo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo weCopanlisib ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• ukuhlanza
• izilonda zomlomo, izilonda, noma ubuhlungu
• ukuvutha, ukubhoboza, ukuhayiza, noma ukuzwa ubuthaka esikhunjeni
• ubuhlungu lapho uthinta
• ukuvuvukala kwekhala, umphimbo, noma umlomo
• ukungabi namandla noma amandla

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

• ukopha okungajwayelekile noma ukulinyazwa
• ukukhwehlela okusha noma okuya kuba kubi, ukuphefumula okuncane, noma ukuphefumula kanzima
• ukuqubuka; noma isikhumba esibomvu, sokuluma, sokuxebuka noma sokuvuvukala
• umkhuhlane, umphimbo obuhlungu, amakhaza, noma ezinye izimpawu zokutheleleka
• uzizwe ulambile kakhulu noma womile, uphathwa yikhanda, noma uchama njalo

Umjovo weCopanlisib ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-copanlisib.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-copanlisib.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Aliqopa^®