I-Apalutamide

-Delile

• Ngaphambi kokuthatha i-apalutamide,
• I-Apalutamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Apalutamide isetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza wendlala yesinye (umdlavuza emadodeni oqala endlaleni yesinye [indlala yokuzala yowesilisa]) bese usabalalela kwezinye izingxenye zomzimba noma ongakasakazeli kwezinye izingxenye zomzimba kodwa ongakaze wasizwa ngezinye izindlela zokwelashwa. I-Apalutamide isekilasini lemithi ebizwa nge-androgen receptor inhibitors. Isebenza ngokuvimba imiphumela ye-androgen (i-hormone yokuzala yowesilisa) ukunqanda ukukhula nokusabalala kwamangqamuzana omdlavuza.

I-Apalutamide iza njengethebhulethi ukuthatha ngomlomo. Imvamisa kuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Thatha i-apalutamide ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-apalutamide njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Uma ungeke ukwazi ukuwagwinya wonke amaphilisi, beka wonke amaphilisi ku-120 mL (ama-ounces ama-4) we-appleauce ngokugovuza; nokho, ungawaphuli amaphilisi. Linda imizuzu engu-15 bese uvuselela ingxube namaphilisi kuze kuhlanganiswe kahle ngaphandle kwezinhlamvu ezisele. Usebenzisa isipuni, gwinya ingxube ngokushesha. Hlanza isitsha nge-60 mL (2 ounces) wamanzi bese uthatha ingxube ngokushesha. Hlanza isitsha futhi ngamamililitha angama-60 wamanzi ukuqinisekisa ukuthi umthamo wonke uthathiwe. Gwinya yonke ingxube ngokushesha noma kungakapheli ihora elilodwa lokulungiselela. Ungayigcini le ngxube ukuze uyisebenzise esikhathini esizayo.

Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-apalutamide isikhashana noma wehlise umthamo wakho uma uba nemiphumela emibi ngesikhathi sokwelashwa kwakho. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-apalutamide.

Uma udokotela wakho enikeze omunye umuthi onjenge goserelin (Zoladex), histrelin (Supprelin LA, Vantas), leuprolide (Eligard, Lupron, in Lupaneta Pack), noma i-triptorelin (Trelstar, Triptodur) ukwelapha umdlavuza wakho wendlala yabesilisa qhubeka nokuthola lo muthi ngenkathi welashwa nge-apalutamide.

Qhubeka uthathe i-apalutamide noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-apalutamide ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-apalutamide,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-apalutamide, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-apalutamide. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-anticoagulants ('ama-blood thinner') afana ne-warfarin (Coumadin), fexofenadine (Allegra), gemfibrozil (Lopid), itraconazole (Onmel, Sporanox, Tolsura), ketoconazole (Nizoral), omeprazole ( , eYosprala, Zegerid), midazolam (Nayzilam, Seizalam), rifampin (Rifadin, Rimactane, eRifamate, eRifater), rosuvastatin (Crestor, Ezallor). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingaxhumana ne-apalutamide, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke waba nezinkinga zenhliziyo njengokuhlaselwa yinhliziyo, i-angina (ubuhlungu besifuba), ukwehluleka kwenhliziyo, noma umfutho wegazi ophakeme noma isifo sohlangothi noma i-ministroke. Futhi, tshela udokotela wakho uma uke waquleka, walimala ebuchosheni, isimila ebuchosheni, i-cholesterol ephezulu, isifo sikashukela noma i-osteoporosis.
• kufanele wazi ukuthi i-apalutamide isetshenziselwa amadoda kuphela. Abesifazane akufanele bathathe le mithi, ikakhulukazi uma bekhulelwe noma bengakhulelwa noma bencelisa. Uma ithathwa ngabesifazane abakhulelwe, i-apalutamide ingalimaza umbungu. Uma owesifazane okhulelwe ethatha i-apalutamide, kufanele abize udokotela wakhe ngokushesha.
• uma umlingani wakho ekhulelwe, kufanele usebenzise ikhondomu noma nini lapho uya ocansini ngesikhathi sokwelashwa kwakho ne-apalutamide nezinyanga ezintathu ngemuva komthamo wakho wokugcina. Uma umlingani wakho engakhulelwe kodwa engakhulelwa, kufanele usebenzise ikhondomu nolunye uhlobo lokulawula ukubeletha noma nini lapho uya ocansini ngesikhathi sokwelashwa kwakho nezinyanga ezintathu ngemuva komthamo wakho wokugcina. Unganikeli ngesidoda noma isidoda ngenkathi uthatha i-apalutamide nezinyanga ezi-3 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi i-apalutamide ingadala ukuquleka. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• kufanele wazi ukuthi i-apalutamide ingadala ukuthi imisipha namathambo akho abe buthakathaka, okungakhuphula ubungozi bokuwa nokuphuka kwethambo.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma ungakhumbuli kuze kube usuku olulandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ongaphezu kowodwa ngosuku olulodwa futhi ungathathi umthamo ophindwe kabili ukwenzela owulahlekile.

I-Apalutamide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuthakathaka
• ukukhathala
• ubuhlungu obuhlangene
• ubuthakathaka bemisipha noma ukuqina
• isifo sohudo
• isicanucanu
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukushisa okushisayo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isithuthwane
• ukulahlekelwa ukwazi
• ukuvuvukala kwezingalo, imilenze, izandla, noma izinyawo
• ukuwa
• ubuhlungu besifuba
• ukuphelelwa umoya
• ukuba ndikindiki noma ukubuthakathaka kobuso, ingalo, noma umlenze, ikakhulukazi ohlangothini olulodwa lomzimba; kunzima ukukhuluma noma ukuqonda; ubunzima bokubona kwelinye noma womabili amehlo; isiyezi; ukulahlekelwa ibhalansi noma ukuxhumanisa; noma ukuhamba kanzima
• ukuqubuka
• ukukhukhumala kwesikhumba, ukuxebuka, noma ubomvu ngomkhuhlane noma ngaphandle kwawo

I-Apalutamide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-apalutamide.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Erleada^®