UDarunavir, uCobicistat, i-Emtricitabine, neTenofovir

-Delile

• Ngaphambi kokuthatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir,
• IDarunavir, i-cobicistat, i-emtricitabine, ne-tenofovir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO NOMA IZINYATHELO EZIKHETHEKILE, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo

I-Darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir akufanele isetshenziselwe ukwelapha ukutheleleka ngegciwane le-hepatitis B (HBV; ukutheleleka kwesibindi okuqhubekayo). Tshela udokotela wakho uma unayo noma ucabanga ukuthi ungaba ne-HBV. Udokotela wakho angakuhlola ukuthi unayo yini i-HBV ngaphambi kokuqala nangesikhathi sokwelashwa kwakho nge-darunavir, cobicistat, emtricitabine, ne-tenofovir. Uma une-HBV futhi uthatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir, isimo sakho singase sibe sibi ngokuzumayo lapho uyeka ukuthatha lo muthi. Udokotela wakho uzokuhlola futhi a-oda izivivinyo zebhu njalo ezinyangeni ezimbalwa ngemuva kokuyeka ukuthatha lo muthi ukubona ukuthi i-HBV yakho isiba kubi kakhulu.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-darunavir, cobicistat, emtricitabine, naku-tenofovir.

Khuluma nodokotela wakho ngezingozi zokuthatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir.

Inhlanganisela ye-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir isetshenziselwa ukwelapha ukutheleleka nge-human immunodeficiency virus (HIV) kubantu abadala nasezinganeni ezinesisindo okungenani esingamakhilogremu angama-40 abangazange belashwe ngeminye imishanguzo ye-HIV noma ukubuyisela ukwelashwa kwamanje kwemithi kubantu abathile asebethatha imishanguzo ye-HIV. Inhlanganisela ye-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir isekilasini lemithi ebizwa ngama-antivirals. I-Darunavir, i-emtricitabine, ne-tenofovir zisebenza ngokunciphisa inani le-HIV egazini. ICobicistat isiza ukugcina i-darunavir emzimbeni isikhathi eside ukuze umuthi ube nomthelela omkhulu. Yize ukuhlanganiswa kwe-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir kungeke kuyelaphe i-HIV, le mithi inganciphisa ithuba lakho lokuthola i-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengokutheleleka okunzima noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko endleleni yokuphila kunganciphisa ingozi yokudlulisela igciwane le-HIV kwabanye abantu.

Inhlanganisela ye-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir iza njengethebhulethi ezothathwa ngomlomo. Kuvame ukuthathwa nokudla kanye ngosuku. Thatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir njengoba nje kuyalelwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma unenkinga yokugwinya amaphilisi, ungawahlukanisa abe yizicucu ezimbili nge-tablet-cutter. Thatha amaphilisi okuhlukanisa ngemuva nje kokuwasika. Ungazigcineli ukusetshenziswa kwesikhathi esizayo.

Inhlanganisela ye-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir isiza ukulawula ukutheleleka nge-HIV kepha ayiyelaphi. Qhubeka uthathe i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir, noma imuphi omunye umuthi, imishanguzo ye-sulfa, noma ezinye izithako ezise-darunavir, cobicistat, emtricitabine, kanye namaphilisi e-tenofovir. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha noma iyiphi yale mithi elandelayo: i-alfuzosin (i-Uroxatral); carbamazepine (Carbatrol, Epitol, Tegretol, nabanye); i-cisapride (Propulsid) (ayitholakali e-U.S.); i-colchicine (Colcyrs, Mitigare) kubantu abanezifo zezinso noma zesibindi; i-dronedarone (iMultaq); i-elbasvir ne-grazoprevir (iZepatier); imithi ye-ergot efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergotamine (i-Ergomar, eCafergot, eMigergot), ne-methylergonovine (Methergine); ivabradine (Corlanor); lomitapide (Juxtapid); i-lovastatin (Altoprev); i-lurasidone (Latuda); i-midazolam ngomlomo; naloxegol (Movantik); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ipimozide (i-Orap); i-ranolazine (Ranexa); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); ISt John's wort; i-sildenafil (i-Revatio kuphela, uphawu olusetshenziselwa isifo samaphaphu); simvastatin (Simcor, Zocor, eVytorin); noma i-triazolam (Halcion). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir uma uthatha owodwa noma ngaphezulu wale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic e-aminoglycoside afana ne-gentamicin; imishanguzo yokulwa nobungozi efana ne-isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole, ne-voriconazole (Vfend); imishanguzo efana ne-acyclovir (Sitavig, Zovirax), i-cidofovir, i-ganciclovir (i-cytovene, i-Valcyte), i-valacyclovir (i-Valtrex), ne-valganciclovir (i-Valcyte); ama-antibiotic afana ne-clarithromycin (i-Biaxin, ku-PrevPac), i-erythromycin (i-E.E.S, i-Eryc, i-Ery-Tab), ne-telithromycin (ayisatholakali e-U.S., Ketek); i-apixaban (i-Eliquis); i-artemether ne-lumefantrine (Coartem); i-aspirin neminye imishanguzo yokulwa nokuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); i-benzodiazepines efana ne-clonazepam (i-Klonopin), i-diazepam (i-Diastat, i-Valium), i-estazolam, i-flurazepam, i-midazolam inikezwe ngemithambo (emthanjeni), ne-zolpidem (i-Ambien, iZolpmist); ama-beta blocker anjenge-arvedilol (Coreg), metoprolol (Lopressor, Toprol-XL, eDutoprol), kanye ne-timolol; i-bosentan (iTracleer); i-buprenorphine (iBelbuca, iBuprenex, abanye); i-buprenorphine ne-naloxone (i-Bunavail, i-Suboxone); buspirone; ama-calcium channel blocker afana ne-amlodipine (Norvasc), diltiazem (Cardizem, Diltzac, Tiazac, others), felodipine, nifedipine (Adalat CC, Afeditab CR, Procardia), kanye ne-verapamil (Calan, Verelan, eTarka); i-carvedilol (iCoreg); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet), i-fluvastatin (Lescol), i-pitavastatin (i-Livalo), i-pravastatin (i-Pravachol), ne-rosuvastatin (i-Crestor); i-dasatinib (i-Sprycel); imishanguzo yokudangala njenge-amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), ne-trazodone; i-digoxin (i-Lanoxin); eslicarbazepine (Aptiom); everolimus (Afinitor, Zortress); i-fentanyl (i-Duragesic, i-Subsys); i-fesoterodine (Toviaz); i-irinotecan (iCamptosar); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), ne-quinidine (eNuedexta); imithi evimbela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ne-tacrolimus (Prograf); i-methadone (Methadose); i-nilotinib (iTasigna); izinto zokuvimbela inzalo ngomlomo (’amaphilisi okulawula inzalo); oxcarbazepine (Trileptal); i-oxycodone (Xtampza, ePercodan); i-perphenazine; i-quetiapine (iSeroquel); i-phosphodiesterase (PDE5) inhibitors efana ne-avanafil (Stendra), i-avanafil (i-Stendra); i-sildenafil (i-Viagra), i-tadalafil (i-Adcirca, i-Cialis), ne-vardenafil (i-Levitra, i-Staxyn); i-rifabutin (i-Mycobutin); i-rifapentine (Priftin); i-risperidone (i-Risperdal); i-Rivaroxaban powder (i-Xarelto); i-salmeterol (iSerevent, e-Advair); i-simeprevir (i-Olysio; ayisatholakali e-US); i-solifenacin (i-Vesicare); i-steroids yomlomo noma ehogelwayo efana ne-betamethasone, i-budesonide (i-Pulmicort), i-ciclesonide (i-Alvesco, i-Omnaris, i-Zetonna) i-dexamethasone, i-fluticasone (i-Flonase, i-Flovent, e-Advair), i-methylprednisolone, i-mometasone (i-Asmanex, e-Dulera), ne-triamcinolone; thioridazine; i-ticagrelor (Brilinta); i-tramadol (i-Conzip, i-Ultram); vinblastine; vincristine; kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• Tshela udokotela wakho uma uke waba nezimo okukhulunywe ngazo esigabeni ESIBALULEKILE SESEXWAYISO, noma yiluphi uhlobo lokutheleleka olungapheli noma oluza ludlule njengesifo sofuba (i-TB; uhlobo lokutheleleka kwamaphaphu) noma i-cytomegalovirus (i-CMV; ukutheleleka ngegciwane okungadala izimpawu ezigulini ezinamasosha omzimba abuthakathaka); isifo sikashukela; i-hemophilia (isifo lapho igazi lingagugi ngokwejwayelekile); noma isifo sesibindi noma sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele uma utheleleke nge-HIV noma uma uthatha i-darunavir, i-cobicistat, i-emtricitabine, ne-tenofovir.
• kufanele wazi ukuthi amafutha omzimba wakho angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho, njengasemhlane wakho ongaphezulu, entanyeni (’’ inyathi ’), amabele, nasesizungeze isisu sakho. Ungaqaphela ukulahleka kwamafutha omzimba ebusweni bakho, emilenzeni nasezingalweni.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho. Lokhu kungadala ukuthi ube nezimpawu zalezo zifo. Uma unezimpawu ezintsha noma eziya ziba zimbi phakathi nokwelashwa kwakho nge-darunavir, cobicistat, emtricitabine, ne-tenofovir, qiniseka ukuthi utshela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IDarunavir, i-cobicistat, i-emtricitabine, ne-tenofovir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ikhanda
• ukungakhululeki esiswini
• igesi

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe ezigabeni EZIBALULEKILE ZESEXWAYISO NOMA IZINYATHELO EZIKHETHEKILE, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo

• umchamo omnyama ophuzi noma onsundu; ukunyakaza kwamathumbu okukhanyayo; ukulahlekelwa ukudla; isicanucanu; ukuhlanza; ubuhlungu bendawo yangaphezulu esiswini; noma isikhumba esiphuzi noma amehlo
• ukwanda noma ukwehla kokuchama
• ubuthakathaka; ubuhlungu bemisipha; ukuphefumula okuncane noma ukuphefumula okusheshayo; ubuhlungu besisu ngokuhlanza nokuhlanza; izandla nezinyawo ezibandayo noma eziluhlaza okwesibhakabhaka; isiyezi, ikhanda elikhanyayo; noma ukushaya kwenhliziyo okusheshayo noma okungavamile
• Umphimbo obuhlungu; imfiva; Ukugodola; ukukhwehlela; nezinye izimpawu zokutheleleka
• ukuqubuka okukhulu noma ukuqubuka okukodwa noma okuningi kokulandelayo: imfiva, imisipha noma amajoyinti, amehlo abomvu noma avuvukile, amabhamuza noma isikhumba esikhanyayo, izilonda zomlomo, noma ukuvuvukala kobuso noma intamo

IDarunavir, cobicistat, emtricitabine, ne-tenofovir kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungasusi izikhwama ze-desiccant (drying agent) ezivela esitsheni.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina i-darunavir, i-cobicistat, i-emtricitabine ne-tenofovir zikhona. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Symtuza^®