I-Lorlatinib

-Delile

• Ngaphambi kokuthatha i-lorlatinib,
• ILorlatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

ILorlatinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wamaphaphu weseli (non-small cell lung cancer) (NSCLC) oselusabalalele kwezinye izingxenye zomzimba futhi seludlange kakhulu ngemuva kokwelashwa ngeminye imithi ye-chemotherapy. U-Lorlatinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

ILorlatinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-lorlatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-lorlatinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uhlanza ngemuva kokuphuza umuthi, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Ungathathi amaphilisi asephukile noma aqhekekile.

Udokotela wakho anganciphisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela kuye ngokuthi unemiphi imiphumela emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-lorlatinib.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-lorlatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-lorlatinib, noma imuphi omunye umuthi, noma iziphi izithako kumaphilisi e-lorlatinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-carbamazepine (Epitol, Equetro, Carbatrol, Tegretol, Teril), efavirenz (Sustiva, e-Atripla), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), pioglitazone (Actos, in Actop, in Actop, in Actop ), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifamate, Rifater), noma iSt John's wort. Udokotela wakho uzokutshela ukuthi ungathathi i-lorlatinib uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: alprazolam (Xanax); ama-calcium channel blocker afana ne-amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), kanye ne-verapamil (Calan, Covera); imithi ethile yokwelapha i-cholesterol ephezulu njenge-atorvastatin (Lipitor) ne-lovastatin (Mevacor); i-clarithromycin (i-Biaxin, ku-Prevpac); i-cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); i-erythromycin (E.E.S, Erytab, Eryped); imishanguzo ethile yokwelapha i-HIV kubandakanya i-atazanavir (Reyataz, e-Evotaz), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra, e Technivie), noma i-saquinavir (Invirase); itraconazole (Onmel, Sporanox); ketoconazole; i-midazolam; nefazodone; izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo); i-quinidine (ku-Nuedexta); i-sildenafil (i-Revatio, i-Viagra); i-sirolimus (i-Rapamune); itacrolimus (Prograf); i-tadalafil (i-Adcirca, i-Cialis); i-trazodone; i-triazolam (iHalcion); noma i-vardenafil (i-Levitra, iStaxyn). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-lorlatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma uke waba nokushaya kwenhliziyo okungajwayelekile, ukudangala, ukuqumba, amazinga aphezulu e-cholesterol nezinye izinto ezinamafutha egazini, noma isifo samaphaphu.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. ILorlatinib ingahle iphazamise isenzo semithi yokuvimbela inzalo yamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa, noma imijovo), ngakho-ke akufanele usebenzise lokhu njengendlela yakho kuphela yokulawula ukubeletha ngenkathi welashwa. Kufanele usebenzise ukulawulwa kokuzalwa okungenayo i-hormonal njengendlela yokuvimbela (idivaysi evimbela isidoda ukuba singene esibelethweni njengekhondomu noma i-diaphragm). Buza udokotela wakho ukuthi akusize ukhethe indlela yokulawula ukubeletha ezokusebenzela. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi kufanele usebenzise ukulawulwa kokubeletha okungewona okwamahomoni ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena kanye nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa futhi izinyanga ezintathu ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-lorlatinib, shayela udokotela wakho ngokushesha. ILorlatinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-lorlatinib nezinsuku eziyi-7 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa okwesikhashana ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-lorlatinib.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungakapheli amahora ama-4 womthamo olandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ILorlatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuzuza kwesisindo
• ubuhlungu bemisipha, obuhlangene noma obuya emuva
• isifo sohudo
• ukuqunjelwa
• isicanucanu
• ukuhlanza
• ukukhathala
• ikhanda
• umbono uyashintsha
• ukuqubuka noma ukulunywa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuvuvukala ezingalweni, emilenzeni, ezandleni nasezinyaweni
• ukuphefumula kanzima
• ukuphefumula, ukukhwehlela, noma umkhuhlane
• ukuba ndikindiki nokushoshozela emalungeni noma ezingalweni nasemilenzeni
• ubunzima bokucabanga noma ukudideka
• isithuthwane
• ukubona izinto noma ukuzwa amazwi engekho
• ukushintsha kwemizwa, ukuzizwa udabukile noma ukhathazekile
• izinkinga ngokukhuluma
• ubunzima bokulala noma ukulala
• amaphupho angavamile noma amaphupho amabi
• isiyezi, ukuzizwa uphela amandla, noma ukushaya kwenhliziyo okungajwayelekile

ILorlatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu kanye ne-electrocardiogram (ECG; ukuhlolwa okulinganisa umsebenzi kagesi enhliziyweni) ngaphambi nangesikhathi sokwelashwa kwakho ukuphendula impendulo yomzimba wakho ku-lorlatinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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