I-Elexacaftor, iTezacaftor, ne-Ivacaftor

-Delile

• Ngaphambi kokuthatha inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor,
• Ukuhlanganiswa kwe-elexacaftor, tezacaftor, ne-ivacaftor kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor isetshenziselwa ukwelapha izinhlobo ezithile ze-cystic fibrosis (isifo esizalwa naso esidala izinkinga ngokuphefumula, ukugaya ukudla nokuzala) kubantu abadala nezingane ezineminyaka engu-12 nangaphezulu. Kufanele isetshenziswe kuphela kubantu abanokwakheka okuthile kofuzo. Udokotela wakho angalawula ukuhlolwa kwegazi ukusiza ukunquma ukuthi le mithi ikulungele yini. I-Elexacaftor ne-tezacaftor basesigabeni semithi ebizwa ngokuthi i-cystic fibrosis transmembrane conductance regulator (CFTR) yokulungisa. I-Ivacaftor isekilasini lemithi ebizwa nge-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Le mithi isebenza ngokuthuthukisa ukusebenza kweprotheni emzimbeni ukunciphisa ukwakheka kwamafinyila aminyene emaphashini nokuthuthukisa ezinye izimpawu ze-cystic fibrosis.

Inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor iza njengamaphilisi okuzothathwa ngomlomo. Umthamo ngamunye wansuku zonke unezinhlobo ezahlukene zamaphilisi: ithebhulethi eyodwa inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor kanti enye ithebhulethi i-ivacaftor. Thatha i-elexacaftor, i-tezacaftor, ne-ivacaftor (amaphilisi ama-orange awu-2) njalo ekuseni ngokudla okunamafutha kanye ne-ivacaftor (ithebhulethi eli-1 eliluhlaza okwesibhakabhaka) njalo kusihlwa ngokudla okunamafutha, ukwahlukana ngamahora ayi-12. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha le mithi ngendlela eqondiswe ngayo. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Thatha inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor enokudla okunamafutha njengamaqanda, ibhotela, amantongomane, ibhotela lamantongomane, i-pizza yoshizi, nemikhiqizo yobisi lonke (njengobisi lonke, ushizi, ne-yogurt). Khuluma nodokotela wakho mayelana nokunye ukudla okunamafutha ongakudla nale mithi.

Inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor isebenza ukulawula i-cystic fibrosis, kepha ayiyelaphi.Qhubeka nokuphuza le mithi noma ngabe uzizwa uphilile. Ungayeki ukuthatha le mithi ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor,

• Tshela udokotela wakho kanye nosokhemisi uma ungenwe i-elexacaftor, i-tezacaftor, ne-ivacaftor noma imuphi omunye umuthi, noma iziphi izithako ezise-elexacaftor, tezacaftor, nakumaphilisi e-ivacaftor. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic athile afana ne-clarithromycin (Biaxin, e-PrevPac) ne-erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin); ezinye izinto zokuvikela ezifana ne-fluconazole (i-Diflucan), i-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole, i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet), i-fluvastatin (Lescol), i-lovastatin (i-Altoprev), i-pravastatin (i-Pravachol), i-rosuvastatin (i-Crestor), ne-simvastatin (i-Zocor, e-Vytorin); i-cyclosporine (Gengraf, Neoral, Sandimmune); i-digoxin (i-Lanoxin); everolimus (Afinitor, Zortress); i-glimepiride (i-Amaryl); i-glipizide (iGlucotrol); i-glyburide (i-Diabeta); izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula inzalo, amabala, izindandatho, okufakelwa emzimbeni noma imijovo); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, ne-phenytoin (Dilantin, Phenytek); nateglinide; i-repaglinide; i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, eRifamate, eRifater, eRimactane); i-sirolimus (i-Rapamune); tacrolimus (Astagraf, Prograf), noma warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-elexacaftor, tezacaftor, noma i-ivacaftor, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-wort yaseSt.John ngenkathi uthatha inhlanganisela ye-elexacaftor, tezacaftor, ne-ivacaftor.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha inhlanganisela ye-elexacaftor, tezacaftor, ne-ivacaftor, shayela udokotela wakho.
• kufanele wazi ukuthi le mithi ingakwenza ukozele. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi le mithi ikuthinta kanjani.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha le mithi.

Uma ukhumbula umthamo ophuthelwe ekuseni noma kusihlwa kungakapheli amahora angu-6 wesikhathi obehlelelwe ukuwuthatha, thatha umthamo ongabanjwanga ngaso leso sikhathi ngokudla okuqukethe amanoni bese uqhubeka nohlelo lwakho olujwayelekile lokulinganisa. Kodwa-ke, uma kudlule amahora angaphezu kwayi-6 kusukela ngesikhathi esihleliwe sokuthatha umthamo wakho wasekuseni, thatha umthamo ophuthelwe ekuseni ngokushesha bese weqa umthamo wakusihlwa, bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Uma sekudlule amahora angaphezu kwayi-6 kusukela ngesikhathi esihleliwe sokuthatha umthamo wakusihlwa, weqa umthamo wakusihlwa ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okuvamile. Ungathathi imithamo yasekuseni neyantambama ndawonye ukwenza ongakutholi.

Ukuhlanganiswa kwe-elexacaftor, tezacaftor, ne-ivacaftor kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ikhala eligobayo, ukuthimula, nokucinana; imfiva; ukukhwehlela; noma ezinye izimpawu zokutheleleka
• ubuhlungu besisu noma ukuvuvukala
• isifo sohudo
• ukuqubuka
• igesi
• iso elibomvana
• ukulunywa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphuzi kwesikhumba noma kwamehlo
• ukulahlekelwa isifiso sokudla
• isicanucanu
• ukuhlanza
• indle ephaphathekile
• ubuhlungu besisu
• umchamo omnyama

Inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor ingadala ukonakala (ukugcwala kwe-lens yeso okungadala izinkinga zombono) ezinganeni nasebusheni. Izingane nentsha ethatha i-elexacaftor, i-tezacaftor, ne-ivacaftor kufanele babonane nodokotela wamehlo ngaphambi nangesikhathi belashwa. Khuluma nodokotela wengane yakho ngezingozi zokunikeza ingane yakho i-elexacaftor, tezacaftor, ne-ivacaftor.

Inhlanganisela ye-elexacaftor, i-tezacaftor, ne-ivacaftor ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwamehlo (kwezingane nentsha) kanye nokuhlolwa okuthile kwelebhu njengokuhlolwa kwesibindi ngaphambi nangesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-elexacaftor, tezacaftor, ne-ivacaftor.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Trikafta^®