Avapritinib

-Delile

• Ngaphambi kokuthatha i-avapritinib,
• I-Avapritinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-avapritinib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Avapritinib isetshenziselwa ukwelapha uhlobo oluthile lwesimila esisemathunjini (i-GIST; uhlobo lwesimila esikhula odongeni lwesisu, amathumbu [amathumbu], noma i-esophagus [ithubhu exhuma umphimbo nesisu]) kubantu abadala usakazekele kwezinye izitho zomzimba noma ezingenakususwa ngokuhlinzwa. I-Avapritinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

I-Avapritinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye nsuku zonke esiswini esingenalutho, okungenani ihora eli-1 ngaphambi kanye namahora ama-2 ngemuva kokudla. Thatha i-avapritinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-avapritinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uhlanza ngemuva kokuthatha i-avapritinib, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho anganciphisa umthamo wakho we-avapritinib noma ayeke ukwelashwa kwakho ngokuya ngokuthi umuthi usebenza kanjani kuwe futhi uma uhlangabezana neminye imiphumela emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-avapritinib. Ungayeki ukuthatha i-avapritinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-avapritinib,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-avapritinib, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-avapritinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukusho okulandelayo: aprepitant (Emend); imishanguzo ethize yokubulala izinhlungu efana ne-fluconazole (i-Diflucan), i-itraconazole (i-Onmel, i-Sporanox), noma i-ketoconazole; i-clarithromycin (i-Biaxin, ku-Prevpac); i-diltiazem (Cardizem, Tiazac, abanye); i-erythromycin (E.E.S., Erythrocin, abanye); imishanguzo ethile ye-HIV efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra, abanye), noma i-saquinavir (Invirase); i-modafinil (i-Provigil); nefazodone; oxcarbazepine (Trileptal); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); i-pioglitazone (Actos, e-Actoplus, i-Duetact, e-Oseni); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifater); kanye ne-verapamil (Calan). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.Eminye imishanguzo eminingi ingaxhumana ne-avapritinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba ngubaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho kanye namasonto ayisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa kwenu kanye namasonto ayisithupha ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-avapritinib, shayela udokotela wakho ngokushesha. I-Avapritinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-avapritinib futhi okungenani amasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-avapritinib.
• kufanele wazi ukuthi i-avapritinib ingakwenza ube nesiyezi, ukozele noma ukudideka. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma umthamo olandelayo ungenziwa ngaphansi kwamahora ayisishiyagalombili, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Avapritinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu besisu
• ukuhlanza
• isicanucanu
• isifo sohudo
• isilungulela
• ikhanda
• ukukhathala
• ubunzima bokulala noma ukulala
• ukulahleka kwezinwele
• izinguquko zombala wezinwele
• ukuncipha komzimba
• amehlo anezinyembezi
• izinguquko zokunambitheka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-avapritinib bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuvuvukala kobuso, amehlo, umlomo, noma umphimbo
• ukuvuvukala kwezandla, amaqakala, noma izinyawo
• ukuhlanza igazi noma okokusebenza okubukeka njengezizathu zekhofi noma izitulo ezimnyama ezibomvu noma ezilindile
• ubuhlungu obukhulu bekhanda, izinkinga zokubona, ukozela, ukukhathala ngokweqile, noma ubuthakathaka ohlangothini olulodwa lomzimba wakho
• ukukhohlwa, ukudideka, ukozela, isiyezi, ubunzima bokulala, ukukhuluma kanzima, ukubona izinto ezingekho, noma ukushintsha kwemizwa noma ekuziphatheni
• ukuqubuka
• ukuphelelwa umoya
• umkhuhlane noma ezinye izimpawu zokutheleleka

I-Avapritinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine ekamelweni lokushisa kude nokushisa okuthe xaxa nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi umdlavuza wakho ungelashwa nge-avapritinib. Udokotela wakho angalawula izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-avapritinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Ayvakit^®