I-Decitabine neCedazuridine

-Delile

• Ngaphambi kokuthatha i-decitabine ne-cedazuridine,
• I-Decitabine ne-cedazuridine kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Inhlanganisela ye-decitabine ne-cedazuridine isetshenziselwa ukwelapha izinhlobo ezithile ze-myelodysplastic syndrome (izimo lapho umnkantsha ukhiqiza amangqamuzana egazi angafakwanga kahle futhi angavezi amaseli egazi anempilo anele), kufaka phakathi i-myelomonocytic leukemia (CMML) engapheli kubantu abadala. I-Decitabine isekilasini lemithi ebizwa ngama-hypomethylation agents. Isebenza ngokusiza umnkantsha wethambo ukukhiqiza amangqamuzana egazi ajwayelekile nangokubulala amaseli angajwayelekile emnkantsheni wethambo. I-Cedazuridine isekilasini lemithi ebizwa nge-cytidine deaminase inhibitors. Kuyasiza ukukhulisa inani le-decitabine emzimbeni ukuze umuthi ube nomthelela omkhulu.

Inhlanganisela ye-decitabine ne-cedazuridine iza njengethebhulethi ezothathwa ngomlomo. Imvamisa ithathwa ngesisu esingenalutho ezinsukwini ezi-5 zokuqala zomjikelezo wezinsuku ezingama-28. Ungadli ukudla amahora amabili ngaphambi nangamahora amabili ngemuva komthamo ngamunye. Uhlobo lwemijikelezo yezinsuku ezingama-28 lungaphindwa njengoba kunconywe udokotela wakho ngokuya ngempendulo yomzimba wakho kulo muthi. Ukwelashwa kufanele kuvunyelwe ukunikezwa okungenani imijikelezo emi-4 kepha kungaqhubeka uma udokotela wakho enquma ukuthi uzozuza ekwelashweni okwengeziwe.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Uma uhlanza ngemuva kokuthatha i-decitabine ne-cedazuridine, ungathathi omunye umthamo. Qhubeka nesimiso sakho sokulinganisa okuvamile.

Udokotela wakho uzokunika imithi yokuvikela isicanucanu nokuhlanza ngaphambi kokuthola umthamo ngamunye we-decitabine ne-cedazuridine.

Udokotela wakho anganciphisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-decitabine ne-cedazuridine.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-decitabine ne-cedazuridine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-decitabine, cedazuridine, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-decitabine kanye ne-cedazuridine. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma uke waba nesifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha okusebenzayo ngenkathi nithatha i-decitabine ne-cedazuridine futhi izinyanga ezintathu ngemuva komthamo wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha lo muthi, shayela udokotela wakho. I-Decitabine ne-cedazuridine zingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-decitabine ne-cedazuridine namasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthatha i-decitabine ne-cedazuridine.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-decitabine ne-cedazuridine.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma kube ngaphansi kwamahora angu-12 kusukela lapho bekuhlelelwe ukuthatha umthamo, thatha umthamo ongabanjwanga esiswini esingenalutho ngokushesha nje lapho usikhumbula. Uma sekudlule amahora angaphezu kwe-12, yeqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa esivamile ukuqedela amanani we-5 nsuku zonke emjikelezweni. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Decitabine ne-cedazuridine kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala ngokweqile
• isikhumba esiphaphathekile
• ukuqunjelwa
• isifo sohudo
• isicanucanu
• ukuhlanza
• ubuhlungu besisu
• ukuncipha komzimba
• ukulahlekelwa isifiso sokudla
• ubuhlungu obuhlangene noma besisipha
• isiyezi
• Iwela phansi
• ikhanda
• ubunzima bokulala noma ukulala
• izilonda ezibuhlungu emlonyeni, noma olimini noma ezindebeni
• ukuvuvukala kwezandla, izinyawo, amaqakala, imilenze ephansi, noma isisu
• ukuluma, ukuba ndikindiki, nobuhlungu ezandleni noma ezinyaweni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, ukubanda, ukukhwehlela, ubuhlungu bomzimba, noma ezinye izimpawu zokutheleleka
• ukopha okungavamile noma ukulimaza, ukuphuma kwamakhala, noma izinsini ezophayo
• ukushaya kwenhliziyo okusheshayo noma okushaya ngamandla
• ukuphelelwa umoya
• ukuqubuka

I-Decitabine ne-cedazuridine kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-decitabine ne-cedazuridine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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