I-Tivozanib

-Delile

• Ngaphambi kokuthatha i-tivozanib,
• I-Tivozanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Tivozanib isetshenziselwa ukwelapha i-renal cell carcinoma (RCC; umdlavuza oqala ezinso) obuyile noma ongaphendulanga kweminye imithi emibili. UTivozanib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza.

UTivozanib uza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye nsuku zonke ngokudla noma ngaphandle kwezinsuku zokuqala ezingama-21 zomjikelezo wezinsuku ezingama-28. Umjikelezo ungaphindwa njengoba kunconywe udokotela wakho. Thatha i-tivozanib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-tivozanib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngengilazi yamanzi; ungavuli.

Udokotela wakho anganciphisa umthamo wakho noma ayeke ukwelashwa kwakho okwesikhashana noma unomphela uma uhlangabezana nemiphumela ethile emibi. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe kanye nemiphumela emibi oyitholayo. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho nge-tivozanib.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-tivozanib,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-tivozanib, i-aspirin, i-tartrazine (udayi ophuzi kokunye ukudla okucutshungulwayo nezidakamizwa), noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsule we-tivozanib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: apalutamide (Erleada), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), enzalutamide (Xtandi), phenytoin (Dilantin, Phenytek), ne-rifampin (Rifadin, Rimactane, eRifamate Isibhamu). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho kanye nosokhemisi ukuthi yimiphi imikhiqizo yamakhambi oyithathayo, ikakhulukazi iSort John's wort. Ungathathi i-wort yaseSt. John ngenkathi uthatha i-tivozanib.
• utshele udokotela wakho uma unesilonda esingapholi noma uma unenkinga yokopha noma uke waba nayo; ihlwili legazi; ukwehluleka kwenhliziyo; isifo senhliziyo; umfutho wegazi ophakeme; ukuquleka; noma inhliziyo, i-thyroid, isifo sezinso noma sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngenkathi uthatha i-tivozanib. Uma ungowesifazane, kuzodingeka ukuthi uhlolwe ukukhulelwa ngaphambi kokuqala ukwelashwa, futhi kufanele usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho kwe-tivozanib kanye nenyanga e-1 ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho kufanele nisebenzise ukuvimbela inzalo ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-tivozanib nangenyanga e-1 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. I-Tivozanib inganciphisa ukuzala kwabesilisa nabesifazane. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-tivozanib, shayela udokotela wakho. I-Tivozanib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-tivozanib nangenyanga e-1 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-tivozanib. Udokotela wakho mhlawumbe uzokutshela ukuthi uyeke ukuthatha i-tivozanib okungenani izinsuku ezingama-24 ngaphambi kokuhlinzwa kwakho okuhleliwe ngoba kungathinta ukuphulukiswa kwesilonda. Udokotela wakho uzokutshela ukuthi uzoqala nini ukuthatha i-tivozanib futhi ngemuva kokuhlinzwa kwakho.
• kufanele wazi ukuthi i-tivozanib ingadala umfutho wegazi ophakeme. Umfutho wegazi lakho kufanele uhlolwe njalo ngenkathi uthatha i-tivozanib.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi imithamo emibili ngosuku olufanayo ukwenza okulahlekile.

I-Tivozanib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• ukuhlanza
• ukukhathala
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukushuba kwezwi
• ukuhlungu obusemhlane
• izilonda zomlomo
• ukukhwehlela
• ukuphelelwa umoya

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukulimaza noma ukopha okungavamile
• indle enegazi noma emnyama neyokulinda
• igazi emchameni
• ukuhlanza noma ukukhwehlela igazi
• ukopha ezinsinini
• ukuquleka, ukuphathwa ikhanda, ukushintsha kombono, noma ukudideka
• ububomvu, ukuvuvukala, nobuhlungu ezandleni kanye / noma ezinyaweni
• ukudideka, ikhanda, isiyezi, ubuhlungu besifuba, noma ukuphefumula okuncane
• ukuphefumula okuncane noma ukuvuvukala kwamaqakala
• ubuhlungu besifuba noma ingcindezi; ukuphazamiseka noma ubuthakathaka ohlangothini olulodwa lomzimba; ubuhlungu ezingalweni, emuva, entanyeni noma emhlathini; kunzima ukukhuluma; ukuphelelwa umoya; ikhanda elibuhlungu ngokuzumayo; izinguquko zombono; noma ukuvuvukala ezingalweni noma emilenzeni

I-Tivozanib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ubuhlungu obukhulu besifuba; ukuphelelwa umoya; ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla; ikhanda; ukudideka; noma ukungaboni kahle

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-tivozanib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Fotivda^®