IMethotrexate

-Delile

• Ngaphambi kokuthatha i-methotrexate,
• I-Methotrexate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

IMethotrexate ingadala imiphumela emibi kakhulu, esongela impilo. Kufanele uthathe i-methotrexate kuphela ukwelapha umdlavuza noma ezinye izimo ezinzima kakhulu futhi ezingakwazi ukwelashwa ngeminye imithi. Khuluma nodokotela wakho ngezingozi zokuthatha i-methotrexate ngesimo sakho.

Tshela udokotela wakho uma uke waba nakho uketshezi oludlulele esiswini sakho noma endaweni ezungeze amaphaphu akho futhi uma uke waba nesifo sezinso noma wake waba naso. Tshela nodokotela wakho uma uthatha izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-aspirin, i-choline magnesium trisalicylate (iTricosal, Trilisate), ibuprofen (Advil, Motrin), i-magnesium salicylate (iDoan's), naproxen (Aleve, Naprosyn), noma salsalate. Lezi zimo nemithi kungakhuphula ubungozi bokuthi uzoba nemiphumela emibi kakhulu ye-methotrexate. Udokotela wakho uzokuqapha ngokucophelela futhi angadinga ukukunikeza umthamo ophansi we-methotrexate noma ayeke ukwelashwa kwakho nge-methotrexate.

I-Methotrexate ingadala ukwehla kwenani lamaseli egazi enziwe ngomnkantsha wakho. Tshela udokotela wakho uma ngabe uke waba nenombolo ephansi yanoma yiluphi uhlobo lwamaseli egazi noma enye inkinga ngamaseli akho egazi. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: umphimbo obuhlungu, amakhaza, umkhuhlane, noma ezinye izimpawu zokutheleleka; ukulimaza noma ukopha okungavamile; ukukhathala ngokweqile; isikhumba esiphaphathekile; noma ukuphefumula okuncane.

I-Methotrexate ingadala ukulimala kwesibindi, ikakhulukazi uma iphuzwa isikhathi eside. Uma uphuza noma uphuze kakhulu utshwala noma uma uke waba nesifo sesibindi, udokotela wakho angakutshela ukuthi ungathathi i-methotrexate ngaphandle kokuthi unomdlavuza osongela impilo ngoba kunengozi enkulu yokuthi ukuthuthukisa ukulimala kwesibindi. Ingozi yokuthi uzoba nokulimala kwesibindi ingaphakama futhi uma usumdala, ukhuluphele noma unesifo sikashukela. Tshela udokotela wakho uma ngabe uthatha noma imuphi wale mithi elandelayo: i-acitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), noma i-tretinoin (Vesanoid). Buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-methotrexate. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: isicanucanu, ukukhathala ngokweqile, ukungabi namandla, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engaphezulu kwesokudla yesisu, ukuphuzi kwesikhumba noma kwamehlo, noma izimpawu ezifana nomkhuhlane. Udokotela wakho angalawula ama-biopsies wesibindi (ukususwa kocezu oluncane lwezicubu zesibindi ukuze kuhlolwe elabhorethri) ngaphambi nangesikhathi sokwelashwa kwakho nge-methotrexate.

I-Methotrexate ingadala ukulimala kwamaphaphu. Tshela udokotela wakho uma uke waba nesifo samaphaphu noma wake waba naso. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukukhwehlela owomile, umkhuhlane noma ukuphefumula okuncane.

I-Methotrexate ingadala umonakalo emgqeni womlomo wakho, isisu noma amathumbu. Tshela udokotela wakho uma uke waba nezilonda zesisu noma i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulolwelwesi lwekholoni [amathumbu amakhulu] ne-rectum). Uma uhlangabezana nalezi zimpawu ezilandelayo, yeka ukuthatha i-methotrexate bese ushayela udokotela wakho ngokushesha: izilonda zomlomo, isifo sohudo, okumnyama, okulindile, noma indle enegazi, noma uhlanze olunegazi noma olubukeka njengezizathu zekhofi.

Ukuthatha i-methotrexate kungandisa ingozi yokuthi uzoba ne-lymphoma (umdlavuza oqala kumaseli amasosha omzimba). Uma uthuthukisa i-lymphoma, ingahle ihambe ngaphandle kokwelashwa lapho uyeka ukuthatha i-methotrexate, noma kungadinga ukwelashwa nge-chemotherapy.

Uma uthatha i-methotrexate ukwelapha umdlavuza, ungahle ube nezinkinga ezithile njengoba i-methotrexate isebenza ukuqeda amangqamuzana omdlavuza. Udokotela wakho uzokuqapha ngokucophelela futhi aphathe lezi zinkinga uma zenzeka.

I-Methotrexate ingadala ukusabela kwesikhumba okungathi sína noma okusongela ukuphila. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, ukuqubuka, amabhamuza, noma isikhumba esikhanyayo.

IMethotrexate inganciphisa ukusebenza kwamasosha akho omzimba, futhi ungahlaselwa izifo ezimbi. Tshela udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka futhi uma ngabe uke waba nanoma yisiphi isimo esithinta amasosha akho omzimba. Udokotela wakho angakutshela ukuthi akufanele uthathe i-methotrexate ngaphandle uma unomdlavuza osongela impilo. Uma uhlangabezana nezimpawu zokutheleleka ezifana nomphimbo obuhlungu, ukukhwehlela, imfiva, noma amakhaza, shayela udokotela wakho ngokushesha.

Uma uthatha i-methotrexate ngenkathi uphathwa ngemithi yokwelashwa ngemisebe yomdlavuza, i-methotrexate ingakhuphula ubungozi bokuthi ukwelashwa ngemisebe kuzolimaza isikhumba sakho, amathambo, noma ezinye izingxenye zomzimba wakho.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-methotrexate nokwelapha imiphumela engemihle ngaphambi kokuba ibe nzima.

Tshela udokotela wakho uma wena noma umlingani wakho ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuba uqale ukuthatha i-methotrexate. Sebenzisa indlela ethembekile yokulawula ukubeletha ukuze wena noma umlingani wakho ungakhulelwa ngesikhathi noma ngemuva nje kokwelapha kwakho. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele niqhubeke nokusebenzisa ukubeletha izinyanga ezintathu ngemuva kokuyeka ukuthatha i-methotrexate. Uma ungowesifazane, kufanele uqhubeke nokusebenzisa ukubeletha uze ube nesikhathi esisodwa sokuya esikhathini esaqala ngemuva kokuyeka ukuthatha i-methotrexate. Uma wena noma umlingani wakho ukhulelwa, shayela udokotela wakho ngokushesha. I-Methotrexate ingadala ingozi noma ukufa embungwini.

I-Methotrexate isetshenziselwa ukwelapha i-psoriasis enamandla (isifo sesikhumba lapho kwakhiwa khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba) ezingalawulwa ngezinye izindlela zokwelapha. I-Methotrexate nayo isetshenziswa kanye nokuphumula, ukwelashwa ngokomzimba, futhi kwesinye isikhathi eminye imithi yokwelapha i-rheumatoid arthritis enamandla kakhulu (i-RA; isimo lapho umzimba uhlasela khona amalunga ayo, ubangele ubuhlungu, ukuvuvukala, nokulahleka komsebenzi) ongalawulwa eminye imithi ethile. I-Methotrexate nayo isetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza kufaka phakathi umdlavuza oqala ezicutshini ezakha iqanda elikhulelwe esibelethweni, umdlavuza webele, umdlavuza wamaphaphu, umdlavuza othile wekhanda nentamo, izinhlobo ezithile ze-lymphoma, ne-leukemia (umdlavuza lokho kuqala kumaseli egazi amhlophe). IMethotrexate isekilasini lemithi ebizwa ngama-antimetabolites. IMethotrexate yelapha umdlavuza ngokunciphisa ukukhula kwamangqamuzana omdlavuza. IMethotrexate iphatha i-psoriasis ngokubambezela ukukhula kwamaseli esikhumba ukumisa izikali ekwakheni. I-Methotrexate ingaphatha isifo samathambo ngokunciphisa ukusebenza kwesistimu yomzimba.

IMethotrexate iza njengethebhulethi ezothathwa ngomlomo. Udokotela wakho uzokutshela ukuthi kufanele uthathe imethotrexate kangaki. Isheduli incike esimweni onaso nokuthi umzimba wakho uphendula kanjani emithini.

Udokotela wakho angakutshela ukuthi uthathe i-methotrexate kusheduli ejikelezayo eshintsha izinsuku ezimbalwa lapho uthatha i-methotrexate ngezinsuku noma amasonto ambalwa lapho ungawuthathi khona umuthi. Landela lezi zinkombandlela ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma ungazi ukuthi uyiphuza nini imithi yakho.

Uma uthatha i-methotrexate ukwelapha i-psoriasis noma i-rheumatoid arthritis, udokotela wakho angakutshela ukuthi uthathe imithi kanye ngesonto. Naka kakhulu izinkomba zikadokotela wakho. Abanye abantu abathathe ngephutha i-methotrexate kanye nsuku zonke esikhundleni sokuthi kanye ngesonto babe nemiphumela emibi kakhulu noma bafe.

Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-methotrexate njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uthatha i-methotrexate ukwelapha i-psoriasis noma i-rheumatoid arthritis, udokotela wakho angakuqala ngomthamo ophansi womuthi futhi akhuphule kancane umthamo wakho. Landela lezi zinkomba ngokucophelela.

Uma uthatha i-methotrexate ukwelapha i-rheumatoid arthritis, kungathatha amasonto amathathu kuya kwayisithupha ukuze izimpawu zakho ziqale ukuthuthuka, namasonto ayi-12 noma ngaphezulu ukuze uzizwe ngokugcwele ngemethotrexate. Qhubeka uthathe i-methotrexate noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-methotrexate ngaphandle kokukhuluma nodokotela wakho.

I-Methotrexate kwesinye isikhathi isetshenziselwa ukwelapha isifo sikaCrohn (isimo lapho amasosha omzimba ehlasela ulwelwesi lwendlela yokugaya ukudla, edala ubuhlungu, isifo sohudo, ukwehla kwesisindo nomkhuhlane), i-multiple sclerosis (MS; isimo lapho amasosha omzimba ehlasela khona izinzwa, kubangela ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngokubona, ukukhuluma, nokulawula isinye), nezinye izifo ezizimele (izimo ezikhula lapho amasosha omzimba ehlasela amaseli aphilile emzimbeni ngephutha). Buza udokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-methotrexate,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-methotrexate, noma imiphi eminye imithi, noma yiziphi izithako kumaphilisi e-methotrexate. Buza udokotela wakho noma usokhemisi uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SESEXWAYISO nakokulandelayo: ama-antibiotic athile afana ne-chloramphenicol (i-chloromycetin), i-penicillin, ne-tetracyclines; i-folic acid (etholakala yodwa noma njengesithako kwamanye amavithamini); eminye imishanguzo yesifo samathambo; i-phenytoin (iDilantin); ama-probenecid (i-Benemid); i-sulfonamides efana ne-co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), kanye ne-sulfisoxazole (Gantrisin); kanye ne-theophylline (Theochron, Theolair). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke waba nanoma yimiphi imibandela eshiwo esigabeni ESIBALULEKILE SESEXWAYISO noma izinga eliphansi le-folate egazini lakho.
• ungancelisi ibele ngenkathi uthatha i-methotrexate.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-methotrexate.
• hlela ukugwema ukuvezwa ukukhanya kwelanga okungadingekile noma isikhathi eside noma ukukhanya kwe-ultraviolet (imibhede yokushuka kanye nezibani zelanga) nokugqoka izimpahla zokuzivikela, izibuko zelanga, kanye nesikrini selanga. IMethotrexate ingenza isikhumba sakho sizwele ekukhanyeni kwelanga noma ekukhanyeni kwe-ultraviolet. Uma une-psoriasis, izilonda zakho zingase zibe zimbi kakhulu uma ubeka isikhumba sakho elangeni ngenkathi uthatha i-methotrexate.
• awunayo imigomo ngesikhathi sokwelashwa kwakho nge-methotrexate ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Methotrexate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isiyezi
• ukozela
• ikhanda
• uvuvukele, izinsini zethenda
• ukuncipha kokudla
• amehlo abomvu
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukungaboni kahle noma ukulahleka kombono kungazelelwe
• isithuthwane
• ukudideka
• ubuthakathaka noma ubunzima bokuhambisa uhlangothi olulodwa noma zombili zomzimba
• ukulahlekelwa ukwazi

I-Methotrexate ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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