Inaliti ye-Aprepitant / Fosaprepitant

-Delile

• Ngaphambi kokusebenzisa umjovo we-aprepitant noma we-fosaprepitant,
• Umjovo we-Aprepitant kanye nomjovo we-fosaprepitant kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo we-Aprepitant kanye nomjovo we-fosaprepitant kusetshenziswa kanye neminye imishanguzo yokuvimbela isicanucanu nokuhlanza kubantu abadala okungenzeka kungakapheli amahora angama-24 noma izinsuku ezimbalwa ngemuva kokuthola ukwelashwa ngamakhemikhali athile womdlavuza.Umjovo we-Fosaprepitant ungasetshenziswa ezinganeni ezineminyaka engu-6 ubudala nangaphezulu. Imijovo ye-Aprepitant ne-fosaprepitant hhayi ujwayele ukwelapha isicanucanu nokuhlanza osunayo. Imijovo ye-Aprepitant ne-fosaprepitant isesigabeni semithi ebizwa ngama-antiemetics. Basebenza ngokuvimba isenzo se-neurokinin, into yemvelo ebuchosheni ebangela isicanucanu nokuhlanza.

Umjovo we-Aprepitant uza njenge-emulsion (uketshezi) nomjovo we-fosaprepitant uza njengempuphu ezoxutshwa noketshezi futhi inikezwe ngemithambo yegazi (emthanjeni) ngudokotela noma umhlengikazi esikhungweni sezokwelapha. Umjovo we-Aprepitant noma umjovo we-fosaprepitant uvame ukunikezwa njengomthamo wesikhathi esisodwa ngosuku 1 lomjikelezo wokwelashwa ngamakhemikhali, uqeda cishe imizuzu engama-30 ngaphambi kokuqala kwe-chemotherapy. Ezinganeni nasentsheni ethola umjovo we-aprepitant nabantu abadala abathola i-fosaprepitant ngemithi ethile yokwelashwa ngamakhemikhali, i-aprepitant yomlomo nayo inganikezwa ngezinsuku 2 no-3 zomjikelezo wokwelashwa ngamakhemikhali.

Ungase uthole ukusabela ngesikhathi noma ngemuva nje kokuthola umthamo womjovo we-aprepitant noma umjovo we-fosaprepitant. Tshela udokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ngesikhathi noma ngemuva nje kokuthola ukwelashwa: ukuvuvukala ngamehlo akho, ukuqubuka, isifuba, ukulunywa, ukubomvu, ukuqhuma, ukuphefumula kanzima noma ukugwinya, ukuzwa isiyezi noma ukuquleka, noma ukushaya kwenhliziyo okusheshayo noma okubuthakathaka. Udokotela wakho mhlawumbe uzomisa ukumnika, futhi angaphatha ukusabela ngeminye imithi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-aprepitant noma we-fosaprepitant,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-fosaprepitant, aprepitant, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-aprepitant noma umjovo we-fosaprepitant. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-pimozide (Orap). Udokotela wakho mhlawumbe uzokutshela ukuthi ungasebenzisi umjovo we-aprepitant noma fosaprepitant uma uthatha lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); ezinye izinto zokuvikela ezifana ne-itraconazole (i-Onmel, i-Sporanox) ne-ketoconazole; ama-benzodiazepines afana ne-alprazolam (Xanax), midazolam, ne-triazolam (Halcion); imithi ethile yokwelashwa ngamakhemikhali afana ne-ifosfamide (Ifex), i-vinblastine (i-Velban), ne-vincristine (i-Marqibo); carbamazepine (Tegretol, Teril, abanye); i-clarithromycin (i-Biaxin, ku-Prevpac); diltiazem (Cardizem, Cartia, Diltzac, abanye); ezinye ze-HIV protease inhibitors ezifana ne-nelfinavir (i-Viracept) ne-ritonavir (i-Norvir, e-Kaletra, e-Technivie, e-Viekira Pak); nefazodone; ama-steroids afana ne-dexamethasone ne-methylprednisolone (iDepo-medrol, iMedrol, iSolu-medrol); i-phenytoin (iDilantin, Phenytek); kanye ne-rifampin (Rifadin, Rimactane, eRifamate, Rifater). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-aprepitant ne-fosaprepitant, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma usebenzisa izinto zokuvimbela inzalo ze-hormonal (amaphilisi okulawula ukubeletha, amachashazi, izindandatho, okufakelwa, noma imijovo) ngesikhathi sokwelashwa nge-aprepitant noma i-fosaprepitant kufanele futhi usebenzise enye indlela engeyona eye-hormone yokulawula ukubeletha (i-spermicide, ikhondomu) ukugwema ukukhulelwa ngesikhathi ukwelashwa nge-aprepitant noma i-fosaprepitant kanye nenyanga engu-1 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi usebenzisa i-aprepitant noma i-fosaprepitant injection, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Aprepitant kanye nomjovo we-fosaprepitant kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala noma ubuthakathaka
• isifo sohudo
• ubuhlungu, ububomvu, ukulunywa, ubunzima, noma ukuvuvukala endaweni yokujova
• ubuthakathaka, ukuba ndikindiki, ukuhayiza, noma ubuhlungu ezingalweni noma emilenzeni
• ikhanda
• isilungulela

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukuxebuka noma ukushwabana kwesikhumba
• ukuchama kaningi noma okubuhlungu, isidingo esingazelelwe sokuchama ngokushesha

I-Aprepitant ne-fosaprepitant kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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