I-Azathioprine

-Delile

• Ngaphambi kokuthatha i-azathioprine,
• I-Azathioprine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha.
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Azathioprine ingakhuphula ubungozi bokuthuthukisa izinhlobo ezithile zomdlavuza, ikakhulukazi umdlavuza wesikhumba kanye ne-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka). Uma uke wafakelwa izinso, kungaba khona ingozi enkulu yokuthi uzoba nomdlavuza noma ngabe ungathathi i-azathioprine. Tshela udokotela wakho uma uke waba nomdlavuza noma wake wawathatha noma wake wawathatha ama-alkylating agents afana ne-chlorambucil (Leukeran), i-cyclophosphamide (i-Cytoxan), noma i-melphalan (Alkeran) yomdlavuza. Ukwehlisa ubungozi bokuthi uzoba nomdlavuza wesikhumba, gwema ukuvezwa yilanga isikhathi eside noma ngokungadingekile futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikrini selanga. Tshela udokotela wakho ngokushesha uma ubona ushintsho esikhunjeni sakho noma kunoma yiziphi izigaxa noma uquqaba noma kuphi emzimbeni wakho.

Abanye besilisa abadala nabancane abathathe i-azathioprine bebodwa noma ngomunye umuthi obizwa nge-tumor necrosis factor (TNF) blocker ukwelapha isifo sikaCrohn (isimo lapho umzimba uhlasela ulwelwesi lomgudu wokugaya ukudla obangela ubuhlungu, isifo sohudo, ukwehla kwesisindo, kanye fever) noma i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulwelwesi lwekholoni [amathumbu amakhulu] ne-rectum) kuthuthukiswe i-hepatosplenic T-cell lymphoma (HSTCL). I-HSTCL wuhlobo lomdlavuza olubi kakhulu oluvame ukudala ukufa esikhathini esifushane. I-Azathioprine ayikavunywa yi-Food and Drug Administration (FDA) ekwelashweni kwesifo sikaCrohn noma i-ulcerative colitis, kepha odokotela kwesinye isikhathi bangabeka i-azathioprine ukwelapha lezi zimo. Uma uba nezimpawu kulezi ngesikhathi sokwelashwa kwakho, shayela udokotela wakho ngokushesha: ubuhlungu besisu; imfiva; ukuncipha kwesisindo okungaqondakali; ukujuluka ebusuku noma ukulimaza okulula noma ukopha.

I-Azathioprine ingadala ukwehla kwenani lamaseli egazi emnkantsheni wakho wamathambo, okungadala izifo ezinkulu noma ezisongela impilo. Ingcuphe yokuthi inani lamaseli egazi onawo lizokwehla liphezulu kakhulu uma unesici sofuzo (esizuzwe njengefa). Udokotela wakho angalawula ukuhlolwa ngaphambi noma ngesikhathi sokwelashwa kwakho ukuze abone ukuthi unale nto engcupheni yini. Ukuthatha imithi ethile kungakhuphula nobungozi bokuthi amaseli akho egazi anciphe, ngakho-ke tshela udokotela wakho uma uthatha noma yikuphi kokulandelayo: i-angiotensin eguqula i-enzyme (ACE) inhibitors efana ne-benazepril (Lotensin), i-captopril, i-enalapril (i-Vasotec), i-fosinopril , lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), Ramipril (Altace), noma i-trandolapril (Mavik); i-trimethoprim ne-sulfamethoxazole (Bactrim, Septra); kanye ne-ribavirin (iCopegus, iRebetol, iVirazole). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukopha okungavamile noma ukulimaza; ukukhathala ngokweqile; isikhumba esiphaphathekile; ikhanda; ukudideka; isiyezi; ukushaya kwenhliziyo okusheshayo; ubunzima bokulala; ubuthakathaka; ukuphelelwa umoya; nomphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka. Udokotela wakho uzo-oda ukuhlolwa ngaphambi, ngesikhathi nangemva kokwelashwa kwakho ukubona ukuthi amaseli akho egazi ayawathinta yini lo muthi.

Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

I-Azathioprine isetshenziswa neminye imithi ukuvimbela ukwenqatshwa kokufakelwa (ukuhlaselwa kwesitho esifakelwe amasosha omzimba) kubantu abathole ukufakelwa izinso. Ibuye isetshenziselwe ukwelapha i-rheumatoid arthritis (isimo lapho umzimba uhlasela khona amalunga ayo, ubangele ubuhlungu, ukuvuvukala, nokulahleka komsebenzi) lapho eminye imithi nokwelashwa kungasizanga. I-Azathioprine isekilasini lemithi ebizwa ngama-immunosuppressants. Isebenza ngokunciphisa ukusebenza kwamasosha omzimba ngakho-ke ngeke ihlasele isitho esitshalwe kabusha noma amalunga.

I-Azathioprine iza njenge-tablet ezothathwa ngomlomo. Imvamisa kuthathwa kanye noma kabili ngosuku ngemuva kokudla. Thatha i-azathioprine ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-azathioprine njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma uthatha i-azathioprine ukwelapha i-rheumatoid arthritis, udokotela wakho angakuqala ngomthamo ophansi futhi akhuphule kancane umthamo wakho ngemuva kwamasonto ayi-6-8 bese kungabi ngaphezu kwesisodwa njalo emavikini amane. Udokotela wakho anganciphisa kancane umthamo wakho lapho isimo sakho silawulwa. Uma uthatha i-azathioprine ukuvimbela ukwenqatshwa kokufakelwa kwezinso, udokotela wakho angakuqala ngomthamo ophezulu futhi wehlise umthamo wakho kancane kancane njengoba umzimba wakho ulungisa ukufakelwa.

I-Azathioprine ilawula isifo samathambo kodwa ayiyelaphi. Kungathatha amasonto afika kwayi-12 ngaphambi kokuthi uzwe inzuzo ephelele ye-azathioprine. I-Azathioprine ivimbela ukwenqatshwa kokufakelwa kuphela uma uthatha umuthi. Qhubeka uthathe i-azathioprine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-azathioprine ngaphandle kokukhuluma nodokotela wakho.

I-Azathioprine ibuye isetshenziselwe ukwelapha i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulwelwesi lwekholoni [amathumbu amakhulu] ne-rectum) nesifo sikaCrohn. Khuluma nodokotela wakho mayelana nezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi kwesinye isikhathi ubekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-azathioprine,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-azathioprine, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-azathioprine. Buza udokotela wakho noma usokhemisi uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo eshiwo esigabeni ESIBALULEKILE SESEXWAYISO nakokulandelayo: i-allopurinol (iZyloprim); ama-aminosalicylates afana ne-mesalamine (i-Apriso, i-Asacol, i-Pentasa, abanye), i-olsalazine (i-Dipentum), ne-sulfasalazine (i-Azulfidine); nama-anticoagulants (’ama-thinner egazi’) afana ne-warfarin (Coumadin). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma unanoma yiluphi uhlobo lokutheleleka, noma uma uke waba nesifo sezinso noma wake waba naso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Kufanele usebenzise ukulawulwa kokubeletha ukuze uqiniseke ukuthi wena noma umlingani wakho ngeke ukhulelwe ngenkathi uthatha lo muthi. Shayela udokotela wakho uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-azathioprine. I-Azathioprine ingalimaza umbungu.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-azathioprine.
• awunawo umuthi wokugoma ngesikhathi noma ngemuva kokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Azathioprine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha.

• ukuqubuka
• imfiva
• ubuthakathaka
• ubuhlungu bemisipha

Lo muthi ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha i-azathioprine.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isicanucanu
• ukuhlanza
• isifo sohudo
• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Azasan^®
• Imuran^®