Umlobi: Clyde Lopez
Usuku Lokudalwa: 26 Ujulayi 2021
Ukuvuselela Usuku: 16 Unovemba 2024
Anonim
Methimazole and Propylthiouracil (PTU) - Mechanism of Action, Indications, and Side Effects
Ividiyo: Methimazole and Propylthiouracil (PTU) - Mechanism of Action, Indications, and Side Effects

-Delile

I-Propylthiouracil ingadala ukulimala okukhulu kwesibindi kubantu abadala nasezinganeni. Abanye abantu abathathe i-propylthiouracil badinga ukufakelwa isibindi kanti abanye abantu bafe ngenxa yokulimala kwesibindi. Ngenxa yale ngozi, i-propylthiouracil kufanele inikezwe kuphela abantu abangakwazi ukuthola ezinye izindlela zokwelashwa njengokuhlinzwa, iodine enemisebe, noma umuthi ohlukile obizwa ngokuthi i-methimazole (Tapazole). I-Propylthiouracil inganikezwa futhi abesifazane ezinyangeni zokuqala (cishe amasonto ayi-12) bekhulelwe ngoba i-methimazole ingadala ukukhubazeka kokuzalwa uma isetshenziswa kule ngxenye yokukhulelwa.

Uma uthatha i-propylthiouracil, shayela udokotela wakho ngokushesha uma uba nezimpawu ezilandelayo: umkhuhlane, ukungathandi ukudla, isicanucanu, ukuhlanza, ukukhathala, ukulunywa, umchamo omnyama, indle enombala okhanyayo noma okhanyayo, ukuphuzi kwesikhumba noma kwamehlo, noma ubuhlungu engxenyeni engenhla kwesokudla yesisu.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-propylthiouracil futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm).


I-Propylthiouracil isetshenziselwa ukwelapha i-hyperthyroidism (isimo esenzeka lapho indlala yegilo ikhiqiza i-hormone yegilo eningi kakhulu, isheshisa imetabolism yomzimba, futhi idale izimpawu ezithile) kubantu abadala kanye nezingane ezineminyaka engu-6 noma ngaphezulu. I-Propylthiouracil isekilasini lemithi ebizwa ngama-antithyroid agents. Isebenza ngokumisa indlala yegilo ekwenzeni i-hormone yegilo.

I-Propylthiouracil iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kathathu ngosuku, kanye njalo emahoreni ayisishiyagalombili. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-propylthiouracil njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho anganciphisa umthamo wakho wepropylthiouracil uma isimo sakho silawulwa.

Qhubeka nokusebenzisa i-propylthiouracil noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-propylthiouracil ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.


Ngaphambi kokuthatha i-propylthiouracil,

  • Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-propylthiouracil, noma imiphi eminye imithi, noma yiziphi izithako ezikumaphilisi e-propylthiouracil. Buza udokotela wakho noma usokhemisi noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
  • Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-anticoagulants ('ama-blood thinner') afana ne-warfarin (Coumadin), ama-beta blockers anjenge-atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), kanye nepropranolol (Inderal); i-digoxin (Digitek, Lanoxin), ne-theophylline (Theo-24, Theochron, Theolair). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-propylthiouracil, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke eminye imishanguzo oyiphuzayo, noma ingaveli kulolu hlu.
  • Tshela udokotela wakho uma uke waba ne-leukopenia (wehla amaseli amhlophe egazi), i-thrombocytopenia (yehlisa amaplatelets), noma i-aplastic anemia (isimo lapho umzimba ungenzi amaseli egazi amasha ngokwanele), noma ezinye izimo ezibanga izinombolo eziphansi amangqamuzana abomvu egazi, amaseli amhlophe egazi, noma amaplatelets; noma isifo sesibindi.
  • tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-propylthiouracil, shayela udokotela wakho. Udokotela wakho angakutshela ukuthi uthathe i-propylthiouracil ezinyangeni zokuqala zokukhulelwa kwakho bese ekushintshela ku-methimazole kukho konke ukukhulelwa kwakho. I-Propylthiouracil ingadala izinkinga ezinzima zesibindi kwabesifazane abakhulelwe futhi ingalimaza umbungu.
  • uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-propylthiouracil.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.


Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Propylthiouracil ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

  • ukulahleka kwezinwele
  • kunzima ukunambitha ukudla
  • ukuba ndikindiki, ukushiswa, noma ukushaywa izandla noma izinyawo
  • ubuhlungu obuhlangene noma besisipha
  • isiyezi
  • ukuvuvukala kwentamo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha:

  • umphimbo obuhlungu, umkhuhlane, amakhaza, ukukhwehlela, noma ezinye izimpawu zokutheleleka
  • ikhanda
  • ukuqubuka kwesikhumba, isifuba, amabhamuza, izigaxa noma ukuxebuka
  • umchamo omnyama, onombala wokugqwala, onsundu noma onamagwebu
  • ukuvuvukala kobuso, amehlo, isisu, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
  • ubuhlungu besifuba
  • ukuphefumula okuncane noma ukuphefumula
  • ekhwehlela igazi

I-Propylthiouracil ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

  • isicanucanu
  • ukuhlanza
  • ubuhlungu besisu
  • ikhanda
  • imfiva
  • ubuhlungu obuhlangene
  • ukulunywa
  • ukuvuvukala kwezandla, izingalo, izinyawo, amaqakala, noma imilenze engezansi
  • umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka
  • ukulimaza noma ukopha okungavamile
  • ukushwabana noma ukuxebuka kwesikhumba
  • ukuba ndikindiki, ukushiswa noma ukuncinza kwezandla noma kwezinyawo
  • ukuphuzi kwesikhumba noma kwamehlo
  • ukulahlekelwa isifiso sokudla
  • ubuhlungu engxenyeni engenhla kwesokudla yesisu
  • ukulunywa
  • ukulimaza noma ukopha okungavamile
  • ukukhathala ngokweqile
  • ubuthakathaka

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zebhu ukuze ahlole impendulo yomzimba wakho ku-propylthiouracil.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla.Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

  • I-Propycil
  • I-PTU

Lo mkhiqizo onophawu alusekho emakethe. Ezinye izindlela ezijwayelekile zingatholakala.

Kugcine ukubuyekezwa - 07/15/2017

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