Ukujova kweGranisetron

-Delile

• Ngaphambi kokusebenzisa umjovo wegranisetron,
• Umjovo weGranisetron ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma ufune ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo we-Granisetron okhishwa ngokushesha usetshenziselwa ukuvikela isicanucanu nokuhlanza okubangelwa i-chemotherapy yomdlavuza nokuvikela nokwelapha isicanucanu nokuhlanza okungenzeka ngemuva kokuhlinzwa. Umjovo we-Granisetron enwetshiwe (osebenza isikhathi eside) usetshenziswa neminye imithi ukuvimbela isicanucanu nokuhlanza okubangelwa umdlavuza i-chemotherapy engahle yenzeke ngokushesha noma ezinsukwini ezimbalwa ngemuva kokuthola imishanguzo ye-chemotherapy. IGranisetron isekilasini lemithi ebizwa nge-5-HT₃ abaphikisi be-receptor. Isebenza ngokuvimba i-serotonin, into yemvelo emzimbeni edala isicanucanu nokuhlanza.

Umjovo wokukhishwa kweGranisetron ngokushesha uza njengesisombululo (uketshezi) ukuze ujovwe ngemithambo (emthanjeni) kanti umjovo wokukhishwa okwandisiwe wegranisetron uza njengoketshezi oluzofakwa ngomgogodla (ngaphansi kwesikhumba). Ukuvimbela isicanucanu nokuhlanza okubangelwa i-chemotherapy yomdlavuza, i-granisetron ekhishwa ngokushesha kanye nemijovo ekhishwa enwetshiwe ivame ukunikezwa ngumhlinzeki wezokunakekelwa kwempilo esibhedlela noma emtholampilo kungakapheli imizuzu engama-30 ngaphambi kokuqala kwe-chemotherapy. Ukuvimbela isicanucanu nokuhlanza okubangelwa ukuhlinzwa, i-granisetron ekhishwa ngokushesha ivame ukunikezwa ngesikhathi sokuhlinzwa. Ukwelapha isicanucanu nokuhlanza okubangelwa ukuhlinzwa, i-granisetron inikezwa ngokushesha nje lapho isicanucanu nokuhlanza kwenzeka.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo wegranisetron,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-granisetron, i-alosetron (Lotronex), i-dolasetron (i-Anzemet), i-ondansetron (i-Zofran, i-Zuplenz), i-palonosetron (i-Aloxi, e-Akynzeo), noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-granisetron. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qinisekisa ukusho noma yikuphi kokulandelayo: amiodarone (Cordarone, Nexterone, Pacerone); i-azithromycin (i-Zithromax), i-chlorpromazine, i-citalopram (i-Celexa); i-clarithromycin (i-Biaxin, ku-Prevpac); i-erythromycin (E.E.S., ERYC, Erythrocin, abanye); i-fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Subsys); ketoconazole (Nizoral); i-lithium (i-Lithobid); imithi yezinkinga zenhliziyo; imithi yokwelapha i-migraines efana ne-almotriptan (Axert), i-eletriptan (i-Relpax), i-frovatriptan (i-Frova), i-naratriptan (i-Amerge), i-rizatriptan (i-Maxalt), i-sumatriptan (i-Imitrex, i-Treximet), ne-zolmitriptan (iZomig); i-mirtazapine (i-Remeron); i-monoamine oxidase (MAO) inhibitors kufaka phakathi i-isocarboxazid (Marplan), i-methylene blue; i-linezolid (iZyvox), i-phenelzine (i-Nardil), i-selegiline (i-Eldepryl, i-Emsam, i-Zelapar), ne-tranylcypromine (i-Parnate); moxifloxacin (Avelox); ipimozide (i-Orap); i-phenobarbital; i-serotonin reuptake inhibitors (SSRIs) ekhethiwe efana ne-citalopram (Celexa), i-escitalopram (Lexapro), i-fluoxetine (i-Prozac, i-Sarafem, e-Symbyax, abanye), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva) ne-sertraline (i-Zoloft) ; i-serotonin-norepinephrine reuptake inhibitors (SNRI) imithi ye-desvenlafaxine (Khedezla, Pristiq), i-duloxetine (i-Cymbalta), i-levomilnacipran (i-Fetzima), ne-venlafaxine; i-sotalol (iBetapace, iSorine); thioridazine; ne-tramadol (i-Conzip, i-Ultram, ku-Ultracet). Uma uthola umjovo okhipha isikhathi eside, phinda utshele udokotela wakho uma uthatha ama-anticoagulants ('blood thinner') afana ne-warfarin (Coumadin, Jantoven); imishanguzo yama-antiplatelet njenge-cilostazol, i-clopidogrel (i-Plavix), i-dipyridamole (i-Persantine, ku-Aggrenox), i-prasugrel (i-Effient), noma i-ticlopidine. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-granisetron, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma usanda kuhlinzwa isisu noma uqunjelwe. Futhi, tshela udokotela wakho uma wena noma omunye emndenini wakho enesifo se-QT eside (isimo esandisa ingozi yokuhlaselwa ukushaya kwenhliziyo okungajwayelekile okungadala ukuquleka noma ukufa ngokuzuma), olunye uhlobo lokushaya kwenhliziyo okungajwayelekile noma inkinga yesigqi senhliziyo, ukungalingani kwe-electrolyte, noma isifo sezinso noma senhliziyo.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-granisetron, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo weGranisetron ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukuqunjelwa
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma ufune ukwelashwa okuphuthumayo:

• isifuba
• ukuqubuka
• ukuqhuma
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ukuphelelwa umoya
• ukuvuvukala kwamehlo, ubuso, umlomo, ulimi, noma umphimbo
• ubuhlungu besifuba
• ububomvu besiza somjovo, ukuvuvukala, noma ukufudumala okunomkhuhlane noma ongenawo (ngomjovo okhululiwe)
• ukopha endaweni yokujova, ukulimaza, noma ubuhlungu (ngomjovo okhululiwe)
• ubuhlungu bendawo esiswini noma ukuvuvukala
• isiyezi, ikhanda elincane, nokuquleka
• izinguquko ekushayeni kwenhliziyo
• ukuyaluza, ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho). izinguquko esimweni sengqondo, noma ikhoma (ukulahlekelwa ukwazi)
• ukuthuthumela, ukulahleka kokuxhumanisa, noma imisipha eqinile noma eshwibayo
• imfiva
• ukujuluka okweqile
• ukudideka
• isicanucanu, ukuhlanza nokuhuda
• isithuthwane

Umjovo weGranisetron ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ikhanda

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ngaphambi kokwenza noma yiluphi uvivinyo lwe-laboratory (ikakhulukazi lezo ezibandakanya i-methylene blue), tshela udokotela wakho nabasebenzi be-laboratory ukuthi uthola umjovo we-granisetron.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Sustol^®