Injection yeTrastuzumab

-Delile

• Ngaphambi kokuthola umkhiqizo womjovo we-trastuzumab,
• Umjovo weTrastuzumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

Umjovo we-Trastuzumab, umjovo we-trastuzumab-anns, umjovo we-trastuzumab-dkst, nomjovo we-trastuzumab-qyyp yimithi ye-biologic (imithi eyenziwe ngezinto eziphilayo). Umjovo we-Biosimilar trastuzumab-anns, umjovo we-trastuzumab-dkst, nomjovo we-trastuzumab-qyyp ufana kakhulu nomjovo we-trastuzumab futhi usebenza ngendlela efanayo nomjovo we-trastuzumab emzimbeni. Ngakho-ke, igama elithi imikhiqizo yomjovo we-trastuzumab lizosetshenziselwa ukumela le mithi kule ngxoxo.

Imikhiqizo yomjovo weTrastuzumab ingadala izinkinga zenhliziyo ezinkulu noma ezisongela impilo. Tshela udokotela wakho uma uke waba nesifo senhliziyo noma wake waba naso. Udokotela wakho uzo-oda ukuhlolwa ngaphambi nangesikhathi sokwelashwa kwakho ukuze abone ukuthi ngabe inhliziyo yakho isebenza kahle ngokwanele yini ukuthi uthole ngokuphepha umkhiqizo womjovo we-trastuzumab. Tshela udokotela wakho kanye nosokhemisi uma welashwa ngemithi yokwelapha ngemisebe esifubeni sakho noma ngemithi ye-anthracycline yomdlavuza efana ne-daunorubicin (Daunoxome, Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), ne-idarubicin (Idamycin). Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhwehlela; ukuphelelwa umoya; ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala noma imilenze engezansi; ukukhuluphala (ngaphezu kwamakhilogremu ama-5 [cishe ama-2.3 kilograms] ngamahora angama-24); isiyezi; ukulahlekelwa ukwazi; noma ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla.

Imikhiqizo yomjovo we-Trastuzumab ingadala ukusabela okunamandla noma okusongela impilo okungenzeka ngenkathi kunikezwa umuthi noma kufikela emahoreni angama-24 ngemuva kwalokho. Imikhiqizo yomjovo weTrastuzumab nayo ingadala umonakalo omkhulu wamaphaphu. Tshela udokotela wakho uma uke waba nesifo samaphaphu noma wake waba nesifo emaphashini, ikakhulukazi uma sikudalile ukuthi uphefumule kanzima. Udokotela wakho uzokubuka ngokucophelela lapho uthola umkhiqizo womjovo we-trastuzumab ukuze ukwelashwa kwakho kuphazamiseke uma uthola ukusabela okungathi sína. Uma unezinye zalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: umkhuhlane, ukugodola, isicanucanu, ukuhlanza, ubuhlungu, ikhanda, isiyezi, ubuthakathaka, ukuqubuka, isifuba, ukulunywa, ukuqina komphimbo; noma ukuphefumula kanzima noma ukugwinya.

Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Imikhiqizo yomjovo weTrastuzumab ingalimaza ingane yakho engakazalwa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga eziyi-7 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngesikhathi sokwelashwa kwakho ngomjovo we-trastuzumab, shayela udokotela wakho ngokushesha.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho kumkhiqizo womjovo we-trastuzumab.

Khuluma nodokotela wakho ngezingozi zokuthola umkhiqizo womjovo we-trastuzumab.

Imikhiqizo yomjovo we-Trastuzumab isetshenziswa neminye imithi noma ngemuva kokuthi eminye imithi isetshenziselwe ukwelapha uhlobo oluthile lomdlavuza webele oselusabalele kwezinye izingxenye zomzimba. Imikhiqizo yomjovo weTrastuzumab nayo iyasetshenziswa ngesikhathi nangemva kokwelashwa ngeminye imishanguzo ukunciphisa amathuba okuthi uhlobo oluthile lomdlavuza webele lubuye. Imikhiqizo yokujova i-Trastuzumab nayo iyasetshenziswa neminye imithi yokwelapha izinhlobo ezithile zomdlavuza wesisu osabalalele kwezinye izingxenye zomzimba. I-Trastuzumab isekilasini lemithi ebizwa ngama-antibody monoclonal. Isebenza ngokumisa ukukhula kwamangqamuzana omdlavuza.

Imikhiqizo yomjovo weTrastuzumab iza njengoketshezi noma njengempuphu ezohlanganiswa noketshezi oluzofakwa emthanjeni ngudokotela noma umhlengikazi esibhedlela noma esikhungweni sezokwelapha. Lapho umkhiqizo womjovo we-trastuzumab usetshenziselwa ukwelapha umdlavuza webele osusakazekile, uvame ukunikezwa kanye ngesonto. Lapho umkhiqizo womjovo we-trastuzumab usetshenziselwa ukuvimbela ukubuya komdlavuza webele, uvame ukunikezwa kanye ngesonto ngesikhathi sokwelashwa neminye imishanguzo ye-chemotherapy, bese kuthi kanye njalo emavikini amathathu ngemuva kokwelashwa neminye imithi kuqediwe kuze kube amasonto angama-52. Lapho umkhiqizo womjovo we-trastuzumab usetshenziselwa ukwelapha umdlavuza wesisu, uvame ukunikezwa kanye njalo emavikini amathathu. Ubude bokwelashwa kwakho buncike ekutheni umzimba wakho uphendula kahle kanjani emithini nasemiphumeleni oyitholayo.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umkhiqizo womjovo we-trastuzumab,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-trastuzumab, trastuzumab-anns, trastuzumab-dkst, trastuzumab-qyyp imithi eyenziwe ngamaphrotheni ama-Chinese ovary cell aseChina, noma imiphi eminye imithi, noma i-benzyl alcohol. Buza usokhemisi wakho uma ungenaso isiqiniseko sokuthi umuthi owugulisayo wenziwe ngamaphrotheni ama-Chinese hamster ovary cell noma uqukethe i-benzyl alcohol.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma ngabe uke waba nanoma yimiphi imibandela eshiwo esigabeni ESIBALULEKILE SEXWAYISO noma esinye isimo sezokwelapha.
• tshela udokotela wakho uma uncelisa.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umkhiqizo womjovo we-trastuzumab.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Shayela udokotela wakho khona manjalo uma ungakwazi ukugcina i-aphoyintimenti yokuthola umthamo womkhiqizo womjovo we-trastuzumab.

Umjovo weTrastuzumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• isilungulela
• ukulahlekelwa isifiso sokudla
• emuva, ithambo, amalunga, noma imisipha
• ubunzima bokulala noma ukulala
• ukushisa okushisayo
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezingalweni, ezandleni, ezinyaweni noma emilenzeni
• izinguquko ekubukekeni kwezipikili
• induna
• ukudana

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• umphimbo obuhlungu, umkhuhlane, amakhaza, ubunzima bokuchama, ubuhlungu lapho uchama, nezinye izimpawu zokutheleleka
• ukuphuma kwamakhala kanye nokunye ukulimaza noma ukopha okungavamile
• ukukhathala ngokweqile
• isikhumba esiphaphathekile
• isicanucanu; ukuhlanza; ukulahlekelwa ukudla; ukukhathala; ukushaya kwenhliziyo okusheshayo; umchamo omnyama; ukuncipha kwenani lomchamo; ubuhlungu besisu; ukuquleka; ukusangana; noma amajaqamba kanye nama-spasms

Umjovo weTrastuzumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Udokotela wakho angalawula izivivinyo ezithile zebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-trastuzumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UHerceptin^® (trastuzumab)
• I-Kanjinti^® (trastuzumab-unyaka)
• Ogivri^® (trastuzumab-dkst)
• Trazimera^®(trastuzumab-qyyp)