Ingabe Kuphephile Futhi Kusemthethweni Ukusetshenziswa Kwesiraphu Ye-Apetamin Ekuzuzeni Isisindo?

-Delile

• Yini i-Apetamin?
• Isebenza kanjani?
• Ingabe kuyasebenza ekuzuzeni isisindo?
• Ingabe i-Apetamin isemthethweni?
• Imiphumela emibi engaba khona ye-Apetamin
• Okubalulekile

Kwabanye abantu, ukuthola isisindo kungaba nzima.

Ngaphandle kokuzama ukudla amakhalori amaningi, ukungabi naluthando kubavimbela ekufinyeleleni imigomo yabo.

Abanye baphendukela kwizithasiselo zokuzuza isisindo, njenge-Apetamin. Kuyisiraphu sevithamini esanda ngokuya phambili esifunwayo sokuthi sikusize ukhuluphale ngokwandisa isifiso sakho sokudla.

Kodwa-ke, ayitholakali ezitolo zezempilo noma kumawebhusayithi ahloniphekile e-United States, okwenza kube nzima ukuthenga. Lokhu kungakwenza uzibuze ukuthi kuphephile yini futhi kusemthethweni.

Lo mbhalo ubuyekeza i-Apetamin, kufaka phakathi ukusetshenziswa kwayo, ukuba semthethweni kwayo, kanye nemiphumela engemihle.

Yini i-Apetamin?

I-Apetamin iyisiraphu yamavithamini emakethwa njengesengezo sokuzuza isisindo. Yakhiwa yi-TIL Healthcare PVT, inkampani eyenza imithi ezinze eNdiya.

Ngokwamalebula wokukhiqiza, isipuni esingu-1 (5 ml) sesiraphu ye-Apetamin siqukethe:

• I-Cyproheptadine hydrochloride: 2 mg
• L-lysine hydrochloride: 150 mg
• I-Pyridoxine (vitamin B6) hydrochloride: 1 mg
• I-Thiamine (i-vitamin B1) i-hydrochloride: 2 mg
• INicotinamide (uvithamini B3): 15 mg
• I-Dexpanthenol (enye indlela kavithamini B5): 4.5 mg

Inhlanganisela ye-lysine, amavithamini, ne-cyproheptadine kuthiwa isiza ukuzuza kwesisindo, noma ngabe eyokugcina kuphela ikhonjisiwe ukuthi ingakhulisa isifiso sokudla njengomphumela wecala (,).

Kodwa-ke, i-cyproheptadine hydrochloride isetshenziswa kakhulu njenge-antihistamine, uhlobo lwesidakamizwa elehlisa izimpawu zokungezwani komzimba njengekhala eligijimayo, ukulunywa, isifuba, namehlo amanzi ngokuvimba i-histamine, into eyenziwa ngumzimba wakho lapho inegciwane (3).

I-Apetamin iyatholakala ngesiraphu nefomu lethebulethi. Isiraphu ngokuvamile iqukethe amavithamini ne-lysine, kanti amaphilisi afaka kuphela i-cyproheptadine hydrochloride.

Isengezo asivunyelwe yi-Food and Drug Administration (FDA) ngenxa yokuphepha nokusebenza ngokukhathazeka, futhi akukho emthethweni ukuyithengisa e-United States nakwamanye amazwe amaningi (4).

Noma kunjalo, amanye amawebhusayithi amancane ayaqhubeka nokuthengisa ama-Apetamin ngokungemthetho.

I-Apetamin imakethwa njengesengezo esikusiza ukuthi ukhuluphale ngokwandisa isifiso sakho sokudla.

Isebenza kanjani?

I-Apetamin ingakhuthaza ukuzuza kwesisindo ngoba iqukethe i-cyproheptadine hydrochloride, i-antihistamine enamandla imiphumela yayo emibi efaka ukwanda kwesifiso sokudla.

Yize kungacaci ukuthi le nto ikhulisa kanjani ukudla, imibono eminingi ikhona.

Okokuqala, i-cyproheptadine hydrochloride ibonakala ikhulisa amazinga we-insulin-like factor factor (IGF-1) ezinganeni ezingaphansi kwesisindo. I-IGF-1 uhlobo lwehomoni exhumene nokuzuza kwesisindo ().

Ngaphezu kwalokho, kubonakala kusebenza ku-hypothalamus, ingxenye encane yobuchopho bakho elawula isifiso sokudla, ukudla, ama-hormone, neminye imisebenzi eminingi yezinto eziphilayo ().

Noma kunjalo, kudingeka izifundo eziningi ukuqonda ukuthi i-cyproheptadine hydrochloride ingakhuphula kanjani isifiso sokudla futhi iholele ekutholeni isisindo.

Ngaphezu kwalokho, isiraphu ye-Apetamin iqukethe i-amino acid l-lysine, exhunywe ekwandeni kwesifiso sokudla ezifundweni zezilwane. Noma kunjalo, izifundo zabantu ziyadingeka ().

Ingabe kuyasebenza ekuzuzeni isisindo?

Yize ucwaningo nge-Apetamin nokuzuza kwesisindo luntuleka, ucwaningo oluningi luthole ukuthi i-cyproheptadine hydrochloride, isithako sayo esiyinhloko, ingasiza ukukhuluphala kwabantu abalahlekelwe wukudla kwabo futhi abasengozini yokungondleki.

Ngokwengeziwe, ucwaningo lwamaviki ayi-12 ezinganeni eziyi-16 nentsha ene-cystic fibrosis (isifo sofuzo esingahle siveze ukulahleka kwesifiso) kuqaphele ukuthi ukuthatha i-cyproheptadine hydrochloride nsuku zonke kwaholela ekukhuleni okukhulu kwesisindo, uma kuqhathaniswa ne-placebo ().

Ukubuyekezwa kwezifundo ezingama-46 kubantu abanezimo ezahlukahlukene kutholile ukuthi le nto ibekezeleleke kahle futhi isize abantu abanesisindo esincane ukukhuluphala. Kodwa-ke, ayizange isize abantu abanezifo eziqhubekayo, njenge-HIV kanye nomdlavuza ().

Ngenkathi i-cyproheptadine ingazuzisa labo abasengozini yokungondleki, ingaholela ekutholeni isisindo ngokweqile kubantu abakhuluphele ngokweqile noma kulabo abanesisindo esinempilo.

Isibonelo, ucwaningo olwenziwe kubantu abangama-499 abavela eDemocratic Republic of Congo luveze ukuthi abangama-73% ababambe iqhaza basebenzisa kabi i-cyproheptadine futhi basengozini yokukhuluphala ngokweqile ().

Ngamafuphi, ngenkathi i-cyproheptadine hydrochloride ingasiza abantu abanesisindo esincane ukukhuluphala, ingabeka umuntu ojwayelekile engcupheni yokukhuluphala, okuyinkinga enkulu emhlabeni wonke.

I-Apetamin iqukethe i-cyproheptadine hydrochloride, engakhuphula iphango njengomphumela wecala. Ngokwethiyori, kungenza lokho ngokukhulisa amazinga e-IGF-1 futhi isebenze endaweni yobuchopho bakho elawula isifiso sokudla nokudla.

Ingabe i-Apetamin isemthethweni?

Ukuthengisa i-Apetamin akukho emthethweni emazweni amaningi, kubandakanya nase-United States.

Lokho kungenxa yokuthi iqukethe i-cyproheptadine hydrochloride, i-antihistamine etholakala kuphela ngemithi kadokotela e-United States ngenxa yezinkinga zokuphepha. Ukusebenzisa kabi le nto kungadala imiphumela emibi, njengokuhluleka kwesibindi nokufa (, 10).

Ngaphezu kwalokho, i-Apetamin ayivunyelwe noma ilawulwa yi-FDA, okusho ukuthi imikhiqizo ye-Apetamin kungenzeka ingaqukathi ngempela okusohlwini lwelebula (,).

I-FDA ikhiphe izaziso zokubanjwa kanye nezixwayiso ngokungenisa i-Apetamin namanye ama-vitamin syrups aqukethe i-cyproheptadine ngenxa yezinkinga zokuphepha nokusebenza kahle (4).

Ukuthengiswa kwe-Apetamin kuvinjelwe emazweni amaningi, kubandakanya nase-United States, njengoba iqukethe i-cyproheptadine hydrochloride, umuthi onikezwa kadokotela kuphela.

Imiphumela emibi engaba khona ye-Apetamin

I-Apetamin inezinkinga eziningi zokuphepha futhi ayikho emthethweni emazweni amaningi, yingakho izitolo ezaziwayo eMelika zingayithengisi.

Noma kunjalo, abantu bayakwazi ukuthola ama-Apetamin angeniswe ngokungemthetho ngokusebenzisa amawebhusayithi amancane, ukufakwa kuhlu okuhlukanisiwe, nezindawo zokuxhumana.

Okukhathaza kakhulu ukuthi iqukethe i-cyproheptadine hydrochloride, umuthi kadokotela kuphela oxhunyaniswe nemiphumela engemihle ehlukahlukene, kufaka phakathi ():

• ubuthongo
• isiyezi
• ukuthuthumela
• ukucasuka
• ukungaboni kahle
• isicanucanu nohudo
• ubuthi besibindi nokwehluleka

Ngaphezu kwalokho, ingasebenzisana notshwala, ujusi wamagilebhisi, kanye nezidakamizwa eziningi, kufaka phakathi ama-anti-depressants, imithi yesifo sikaParkinson, namanye ama-antihistamine (3).

Ngoba i-Apetamin ingeniswa ngokungemthetho e-United States, ayilawulwa yi-FDA. Ngakho-ke, ingaqukatha izinhlobo ezahlukahlukene noma amanani wezithako kunokufakwa kuhlu kwelebula ().

Uma ubheka isimo sayo esingekho emthethweni e-United States nakwamanye amazwe, kanye nemiphumela emibi, kufanele ugweme ukuzama lokhu okungezelelwe.

Esikhundleni salokho, khuluma nomhlinzeki wakho wezokunakekelwa kwezempilo ukuze unqume indlela yokwelashwa ephephe kakhulu nephumelela kakhulu uma unenkinga yokuthola isisindo noma isimo sezokwelapha esinciphisa isifiso sakho sokudla.

I-Apetamin ayikho emthethweni e-United States nakwamanye amazwe amaningi. Futhi, isithako sayo esiyinhloko, i-cyproheptadine hydrochloride, sixhunyaniswe nemiphumela emibi kakhulu futhi sitholakala kuphela ngemithi kadokotela.

Okubalulekile

I-Apetamin yisiraphu samavithamini okuthiwa asiza ukuzuza kwesisindo.

Iqukethe i-cyproheptadine hydrochloride, i-antihistamine kadokotela kuphela engakhuphula ukudla.

Akukho emthethweni ukuthengisa ama-Apetamin e-United States nakwezinye izindawo. Futhi, i-FDA ayiwulawuli futhi ikhiphe izaziso zokubanjwa nokuxwayiswa kokungenisa.

Uma ufuna ukukhuluphala, khuluma nesazi sokudla kanye nomhlinzeki wakho wezokunakekelwa kwezempilo ukuze athuthukise uhlelo oluphephile nolusebenzayo oluhambisana nezidingo zakho, kunokuba uthembele kwizengezo ezingekho emthethweni.