Zisebenza Nini Izidakamizwa Ze-Biologic?

-Delile

• Ziyini izidakamizwa ze-biologic?
• Izinhlobo ezintathu ze-biologics
• Imithi elwa ne-TNF
• I-Interleukin inhibitors
• Ama-anti-integrin antibodies
• Isinyathelo-up uma kuqhathaniswa nokwelashwa okuphezulu
• Okuqhamuka uma udla imishanguzo
• Ukucatshangelwa okukhethekile
• Isifo sofuba
• Izifo
• Izimo zenhliziyo
• Ezinye izindaba

Ukubuka konke

Isifo sikaCrohn sibangela ukuvuvukala, ukuvuvukala, nokucasuka kulwelwesi lwendlela yokugaya ukudla.

Uma uke wazama ezinye izindlela zokwelapha isifo sikaCrohn, noma noma usanda kutholakala, udokotela wakho angacabanga ngokukunika imishanguzo ye-biologic. I-Biologics yimithi kadokotela esiza ukunciphisa ukuvuvukala okuyingozi esifo sikaCrohn.

Ziyini izidakamizwa ze-biologic?

I-Biologics yimithi eyenziwe ngofuzo ekhomba ama-molecule athile emzimbeni abandakanyeka ekudaleni ukuvuvukala.

Odokotela bavame ukubeka i-biologics kulabo abanesifo se-Crohn's refractory esingaphenduli eminye imithi, noma kubantu abanezimpawu ezinzima. Ngaphambi kwe-biologics, kwakukhona izinketho ezimbalwa zokwelashwa okungezona okwenzelwe abantu abanesifo sokuphikisa.

Izidakamizwa ze-biologic zisebenza ukuletha ngokushesha ukuxolelwa. Ngesikhathi sokuxolelwa, ukuvuvukala kanye nezimpawu zamathumbu kuyaphela. I-Biologics nayo ingasetshenziswa esikhathini eside ukusiza ukugcina izikhathi zokuxolelwa.

Izinhlobo ezintathu ze-biologics

Uhlobo lwe-biologic udokotela wakho asikisela ukuthi luzoxhomeka ebucayi bezimpawu zakho nendawo yesifo. Wonke umuntu wehlukile. Isidakamizwa esithile semvelo singasebenza kangcono kwabanye kunabanye. Kungase kudingeke ukuthi uzame imithi embalwa ngaphambi kokuthola okukusebenzelayo.

Izindlela zokwelapha zebhayoloji zesifo sikaCrohn ziwela kwesinye sezigaba ezintathu: izindlela zokwelapha ze-anti-tumor necrosis factor (anti-TNF), i-interleukin inhibitors, nama-anti-integrin antibodies.

Izindlela zokwelapha ze-Anti-TNF zibhekise kwiprotheni ebandakanyeka ekuvukeleni. Ngesifo sikaCrohn, izindlela zokwelapha ezilwa ne-TNF zisebenza ngokuvimba ukuvuvukala okubangelwa yile proteni emathunjini.

I-Interleukin inhibitors isebenza ngokufanayo, ngokuvimba amaprotheni avela ngokwemvelo abangela ukuvuvukala emathunjini. Ama-anti-integrins avimba amaseli athile omzimba omzimba abangela ukuvuvukala.

I-Biologics inikezwa ngokunqamula (ngenaliti ngesikhumba) noma ngemithambo yegazi (ngethumbu le-IV). Banganikezwa njalo emavikini amabili kuya kwayisishiyagalombili, kuya ngomuthi. Kuzofanele uye esibhedlela noma emtholampilo ukuthola okuningi kwalokhu kwelashwa.

I-FDA igunyaze izidakamizwa eziningana zebhayoloji ukwelapha isifo sikaCrohn.

Imithi elwa ne-TNF

• i-adalimumab (Humira, Exemptia)
• isitifiketi se-certolizumab (Cimzia)
• infliximab (Remicade, Remsima, Inflectra)

I-Interleukin inhibitors

• ustekinumab (Stelara)

Ama-anti-integrin antibodies

• i-natalizumab (Tysabri)
• i-vedolizumab (Entyvio)

Isinyathelo-up uma kuqhathaniswa nokwelashwa okuphezulu

Izindlela zokwelapha ze-Biologic zingaba ithuluzi elinamandla ekwelapheni nasekuphathweni kwesifo sikaCrohn. Kunezindlela ezimbili ezihlukene zokwelashwa kwe-biologic:

• I-Step-up therapy bekuyindlela ejwayelekile kuze kukhishwe imihlahlandlela emisha ngo-2018. Le ndlela isho ukuthi wena nodokotela wakho nizame ezinye izindlela zokwelashwa ngaphambi kokuqala i-biologic.
• Ukwelashwa okuphezulu kuya phansi kusho ukuthi imishanguzo ye-biologic iqale ngaphambi kwesikhathi kunqubo yokwelashwa. Le manje sekuyindlela ekhethwayo ezimweni eziningi zesifo sikaCrohn esilinganiselwe nesinzima.

Kodwa-ke, izindlela ezahlukahlukene zingasebenza kangcono kubantu abahlukile ngokuya ngobukhulu nokuthi isifo sitholakala kuphi.

Okuqhamuka uma udla imishanguzo

I-Biologics ijwayele ukuba nemiphumela engemihle engemibi kangako kuneminye imithi yesifo sikaCrohn, njenge-corticosteroids, ecindezela wonke amasosha omzimba.

Noma kunjalo, kunemiphumela emibi ethile okufanele uyazi ngaphambi kokuthatha umuthi we-biologic.

Eminye imiphumela emibi ejwayelekile ye-biologics ifaka:

• ububomvu, ukuluma, ukulimaza, ubuhlungu, noma ukuvuvukala ezungeze indawo yokujova
• ikhanda
• umkhuhlane noma amakhaza
• ukuphefumula kanzima
• umfutho wegazi ophansi
• isifuba noma ukuqubuka
• ubuhlungu besisu
• ukuhlungu obusemhlane
• isicanucanu
• ukukhwehlela noma umphimbo obuhlungu

Ukucatshangelwa okukhethekile

I-biologics ingahle ingaphephi kuwo wonke umuntu. Khuluma nodokotela wakho uma unesifo sofuba (i-TB), ujwayele ukutheleleka, noma unesimo senhliziyo.

Isifo sofuba

Izidakamizwa ze-Biologic ezisetshenziselwa isifo sikaCrohn zingandisa ingozi yokuvuselela ukutheleleka kwesifo sofuba kubantu abaye bavezwa. I-TB yisifo samaphaphu esibi, esithathelwanayo.

Udokotela wakho kufanele akuhlolele i-TB ngaphambi kokuqala ukwelashwa nge-biologic. Ukutheleleka nge-TB kungalala emzimbeni. Abanye abantu abaye bavezwa yilesi sifo kungenzeka bangasazi.

Uma uke wavezwa yi-TB ngaphambilini, udokotela wakho angancoma ukwelashwa kwe-TB ngaphambi kokuthatha i-biologic.

Izifo

Ama-biologics angehlisa amandla omzimba wokulwa nezinye izifo. Uma ujwayele ukutheleleka, udokotela wakho angase asikisele uhlobo oluthile lokwelashwa.

Izimo zenhliziyo

Imithi elwa ne-TNF ingaba yingozi kubantu abanezimo ezithile zenhliziyo, njengokuhluleka kwenhliziyo. Ukwehluleka kwenhliziyo kulapho inhliziyo ingakwazi ukumpompa igazi elanele ukuhlangabezana nezidingo zomzimba.

Tshela udokotela wakho ngokushesha okukhulu uma uthola ukuphefumula okuncane noma ukuvuvukala kwezinyawo ngenkathi uthatha i-biologic yesifo sikaCrohn. Lokhu kungaba yizimpawu zokwehluleka kwenhliziyo.

Ezinye izindaba

Izindlela zokwelapha ze-biologic kwesinye isikhathi ziye zaxhunyaniswa nezinkinga ezinkulu zempilo. Kubantu abathatha imishanguzo ye-biologic, izinkinga ezilandelayo zezempilo azibikwa kakhulu:

• ukuphazamiseka kwegazi okuthile (ukulimaza, ukopha)
• izinkinga ze-neurological (kufaka phakathi, ukuba ndikindiki, ubuthakathaka, ukushoshozela, noma ukuphazamiseka okubukwayo, njengokufiphala kwamehlo, umbono ophindwe kabili, noma ubumpumputhe obuncane)
• I-lymphoma
• ukulimala kwesibindi
• ukusabela okweqile komzimba

Khuluma nodokotela wakho ukunquma ukwelashwa okungcono kakhulu kuwe nezidingo zakho.