Ukuguguleka kwamathambo ngeRheumatoid Arthritis: Ukuvimbela Nokuphatha

-Delile

• Ukubuka konke
• Kungani kwenzeka ukuguguleka kwamathambo?
• Ungakuphatha kanjani ukuguguleka kwamathambo ngeRA
• Ukuvimbela ukuguguleka kwamathambo ngeRA
• Ukuthatha

Ukubuka konke

I-Rheumatoid arthritis (RA) yisifo esingelapheki sokuvuvukala esithinta abantu baseMelika ababalelwa ezigidini eziyi-1.3, ngokwe-American College of Rheumatology.

I-RA yisifo sokuzilimaza komzimba lapho amasosha omzimba ahlasela ngephutha izicubu zomzimba namaseli akhe. Lesi sifo sihlukile kwezinye izimo zokuzivikela komzimba ngoba sithinta ikakhulu ulwelwesi lwamajoyinti.

Lesi sifo esiqhubekayo asibangeli ukuvuvukala okuhlangene kuphela, kepha singaholela ekulimaleni nasekukhubekeni kwamalunga. Umonakalo ungumphumela wokuguguleka kwamathambo.

Ukuguguleka kwamathambo kuyisici esiyinhloko seRA.Ubungozi buyanda ngobukhulu besifo futhi bubonakala ngokulahleka kwethambo ezingxenyeni ezithile zomzimba.

Noma lungekho ikhambi ngeRA, kungenzeka ukuphatha nokunciphisa ukukhula kokuguguleka kwamathambo. Nakhu okudingeka ukwazi ngokuguguleka kwamathambo, kufaka phakathi amathiphu wokuvimbela nokuphatha.

Kungani kwenzeka ukuguguleka kwamathambo?

I-RA ibangela ukuvuvukala okungapheli, okuholela ekugugulekeni kwamathambo kancane kancane. Izimpawu ze-RA zakudala zifaka amalunga okuvuvukala, ukuqina kwamalunga, nobuhlungu obuhlangene. Abanye abantu banakho ukukhathala nokulahlekelwa isifiso sokudla.

I-RA ivame ukuthinta amalunga amancane njengezandla, izinyawo, neminwe yakho, ngakho-ke ukuguguleka kwamathambo kungenzeka kula malungu. Kungathinta namanye amalunga omzimba wakho njengamadolo akho, izindololwane, izinkalo namahlombe.

Ukuguguleka kwamathambo neRA kuxhumene ngoba ukuvuvukala okungapheli kuvusa ama-osteoclast, angamaseli adiliza izicubu zamathambo. Lokhu kuholela enqubeni eyaziwa ngokuthi ukubuyiselwa kwamathambo.

Imvamisa, ukubuyiselwa kwamathambo kuyingxenye yokulawulwa okujwayelekile kwamaminerali adingekayo ukulinganisa ukugcinwa, ukulungiswa nokulungiswa kwamathambo. Le nqubo, nokho, ayilingani kubantu abane-RA, okuholela ekonakaleni okusheshayo kwezicubu ezinamaminerali.

Ukuguguleka kwamathambo nakho kungenzeka uma kunenani elikhulu lama-cytokines okuvuvukala emzimbeni. Amaseli akhipha lawa maprotheni amancane ukuvuselela amasosha omzimba ukulwa nezifo.

Kwesinye isikhathi, noma kunjalo, umzimba ukhipha inani eliningi ngokweqile lama-cytokines. Lokhu kungadala ukuvuvukala nokuvuvukala, futhi ekugcineni kulimale amalunga, amathambo nezicubu.

Ungakuphatha kanjani ukuguguleka kwamathambo ngeRA

Ukuguguleka kwamathambo kungakhula kusenesikhathi futhi kube kubi ngokuqhubekayo. Kwabanye abantu, ukuguguleka kwamathambo kungaqala kungakapheli amasonto okutholakele i-RA. Cishe amaphesenti ayi-10 wabantu abathola ukuxilongwa kwe-RA banokuguguleka ngemuva kwamasonto ayisishiyagalombili. Ngemuva konyaka owodwa, abantu abangamaphesenti angama-60 babhekana nokuguguleka.

Njengoba ukuguguleka kwamathambo okuqhubekayo kungadala ukukhubazeka, ukwehlisa ijubane noma ukuphulukisa ukuguguleka kungasiza ekuthuthukiseni ikhwalithi yempilo yakho. Kodwa-ke, lapho ukuguguleka kwenzeka, kuyaqabukela kuguquka.

Akunakwenzeka, noma kunjalo. Kube khona eminye imibiko exhumanisa ukusetshenziswa kwemishanguzo yokuguqula izifo (i-DMARD) enekhono lokwehlisa ukuqhubekela phambili kokuguguleka kwamathambo.

Noma yiliphi ithuba lokulungisa noma lokuphulukisa ukuguguleka kwamathambo liqala ngokulawula ukuvuvukala. Ama-DMARD imvamisa ayindlela yokwelashwa komugqa wokuqala we-RA. Yize imishanguzo yezinhlungu ingaphatha izimpawu ezinjengezinhlungu nokuqina, ama-DMARD akhomba amaseli athile amasosha omzimba abhekene nokukhuthaza ukuvuvukala.

Lokhu kungasiza i-RA ukungena ekuxolelweni nasekuqhubekeni kwesifo kancane. Le mithi futhi ingamisa ukuguguleka kwamathambo futhi isize ukulungisa noma yikuphi ukuguguleka okukhona, yize imithi ingahle ingalungisi ngokuphelele amathambo.

Ama-DMARD wendabuko aqukethe imishanguzo yomlomo neyokujova efana ne-methotrexate.

Lapho le mithi ingakwazi ukulawula ukuvuvukala, udokotela wakho angancoma ukuthi ushintshele ku-biologic enjenge:

• isitifiketi (Cimzia)
• i-etanercept (Enbrel)
• i-adalimumab (Humira)
• i-abatacept (i-Orencia)
• infliximab (i-Remicade)
• golimumab (Simponi)

I-Biologics uhlobo oluhlukile lwe-DMARD. Ngaphezu kokukhomba amaseli omzimba athile abangela ukuvuvukala, avimba amakhemikhali afana nama-cytokines akhombisa noma akhuthaze ukuvuvukala.

Lapho ukuvuvukala sekulawulwa, ukuguguleka kwethambo nakho kungancipha futhi kuqale ukuphola. Ukulawula ukuvuvukala nakho kubalulekile ngoba ukuvuvukala okuncane kunciphisa ukukhuthazwa kwama-osteoclasts. Nakho lokhu kunganciphisa ukuguguleka kwamathambo.

Udokotela wakho futhi angancoma ukwelashwa ukucindezela ama-osteoclasts. Lokhu kufaka phakathi imishanguzo eqeda ukwelashwa ephatha ukulahleka kwethambo nezinye izinkinga zamathambo, njenge-bisphosphonates ne-denosumab (i-Xgeva, i-Prolia).

Ukuvimbela ukuguguleka kwamathambo ngeRA

Ukuguguleka kwamathambo kuyisici esiyinhloko seRA futhi ungahle ungakwazi ukukuvimbela ngokuphelele. Kodwa-ke, ukwelapha ukuvuvukala ngaphambi kwesikhathi kungenye yezindlela ezinhle kakhulu zokuvikela amalunga akho. Khuluma nodokotela wakho ngezimpawu ezinjengezinhlungu ezihlangene kanye nokuqina, ubomvu, ukukhathala okungapheli, ukunciphisa umzimba, noma umkhuhlane osezingeni eliphansi.

Kukhona futhi phakathi kokuguguleka kwamathambo nokuxinana kwamaminerali aphansi. Ngakho-ke, ukugcina amathambo enempilo nakho kungavimbela noma kwehlise ukuguguleka kwamathambo.

Ezinye izindlela zokuqinisa amathambo akho zifaka:

• Cabanga ukuthatha izithako ze-calcium nevithamini D. Abantu abadala badinga cishe ama-milligram ayi-1000 (mg) we-calcium ngosuku, kanye namayunithi angama-600 wamazwe omhlaba (IU) kavithamini D usuku ngalunye, ngokusho kweMayo Clinic. Ngaphambi kokuqala noma yiziphi izithako ezintsha, khuluma nodokotela wakho.
• Vivinya umzimba njalo. Ukuvivinya umzimba njalo kungaqinisa imisipha yakho futhi kukhuthaze amathambo aqinile. Qala kancane futhi ufake inhlanganisela yokuzivocavoca kwe-cardio nemisebenzi yokuqeqesha amandla. Ukuzivocavoca okunomthelela ophansi njengokuhamba, i-yoga, nokubhukuda izindawo ezinhle zokuqala.
• Yeka ukubhema. Ukusetshenziswa kukagwayi kungenza buthakathaka amathambo akho, kanjalo nokuphuza kakhulu utshwala. Bheka izindlela zokuyeka ukubhema, futhi unciphise ukuphuza kwakho utshwala. Ngokuvamile, abesifazane akufanele baphuze okungaphezu kwesisodwa ngosuku, futhi amadoda kufanele anciphise ukuphuza kwabo iziphuzo ezimbili ngosuku.
• Lungisa imithi yakho. Ukusetshenziswa kwesikhathi eside kweminye imithi elapha ukuvuvukala, njenge-prednisone ne-methotrexate, nakho kungalimaza amathambo akho. Khuluma nodokotela wakho mayelana nokunciphisa isilinganiso sakho noma ukushintshela emithini ehlukile lapho ukuvuvukala kuphethwe kahle.

Ukuthatha

Ukuguguleka kwamathambo kuyinto ejwayelekile kubantu abaphila ne-RA. Ukwehla kokuvuvukala kungakusiza uzizwe ungcono futhi uvimbele ukuqhubeka. Ukuqala ukwelashwa kusenesikhathi kungakhuphula izinga lempilo yakho futhi kwehlise nengozi yokukhubazeka.